Incidental Mutation 'R7755:Mrgprf'
ID 597499
Institutional Source Beutler Lab
Gene Symbol Mrgprf
Ensembl Gene ENSMUSG00000031070
Gene Name MAS-related GPR, member F
Synonyms MrgF
MMRRC Submission 045811-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R7755 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 144854646-144863294 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 144862380 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 314 (L314P)
Ref Sequence ENSEMBL: ENSMUSP00000033386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033386] [ENSMUST00000117718]
AlphaFold Q8VCJ6
Predicted Effect probably damaging
Transcript: ENSMUST00000033386
AA Change: L314P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000033386
Gene: ENSMUSG00000031070
AA Change: L314P

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 52 189 4.5e-7 PFAM
Pfam:7tm_1 61 291 2.4e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117718
Meta Mutation Damage Score 0.6951 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G A 12: 71,236,187 (GRCm39) M1179I probably benign Het
4930402F06Rik T C 2: 35,266,349 (GRCm39) Y107C probably damaging Het
Aff4 T C 11: 53,289,206 (GRCm39) S452P probably damaging Het
Astn2 T C 4: 65,712,795 (GRCm39) D615G probably damaging Het
Begain A G 12: 109,018,802 (GRCm39) L215P probably benign Het
Carf T A 1: 60,187,214 (GRCm39) S606T probably benign Het
Cngb3 A T 4: 19,461,684 (GRCm39) T522S probably benign Het
Ctsll3 A T 13: 60,948,219 (GRCm39) F153I probably damaging Het
Cubn G A 2: 13,284,889 (GRCm39) T3509I probably benign Het
Dmrta1 T C 4: 89,580,170 (GRCm39) S377P probably benign Het
Dnmbp G A 19: 43,838,525 (GRCm39) A659V probably benign Het
Dspp TGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCAACAGCAGTGACAGCAG TGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCAACAGCAGTGACAGCAG 5: 104,326,227 (GRCm39) probably benign Het
Dync2h1 T C 9: 7,015,490 (GRCm39) D3598G probably benign Het
Elp1 T C 4: 56,774,552 (GRCm39) N779S possibly damaging Het
Flot2 T C 11: 77,940,339 (GRCm39) F29L probably benign Het
Hectd1 A T 12: 51,849,003 (GRCm39) I367K possibly damaging Het
Ivl T A 3: 92,479,317 (GRCm39) K249N probably damaging Het
Khnyn A G 14: 56,125,425 (GRCm39) T503A probably damaging Het
Mbd4 T A 6: 115,821,546 (GRCm39) I490F probably damaging Het
Mlip T C 9: 77,136,838 (GRCm39) T690A probably benign Het
Mmp1a T A 9: 7,467,005 (GRCm39) D227E possibly damaging Het
Ndufb9 T G 15: 58,808,255 (GRCm39) Y80* probably null Het
Neto2 C T 8: 86,396,285 (GRCm39) R155H probably damaging Het
Npat T A 9: 53,470,470 (GRCm39) N365K possibly damaging Het
Nsl1 G A 1: 190,795,380 (GRCm39) V49M probably benign Het
Nudt21 T A 8: 94,749,493 (GRCm39) Y191F probably benign Het
Or2w25 A G 11: 59,504,467 (GRCm39) R226G probably damaging Het
Or8b54 T G 9: 38,687,073 (GRCm39) I174S possibly damaging Het
Pcdh18 T C 3: 49,709,278 (GRCm39) Y679C possibly damaging Het
Pkd1l3 A G 8: 110,356,798 (GRCm39) D741G possibly damaging Het
Pkhd1 T C 1: 20,617,717 (GRCm39) D956G probably damaging Het
Poglut2 T C 1: 44,157,733 (GRCm39) probably benign Het
Pparg C T 6: 115,440,067 (GRCm39) P214S probably damaging Het
Ppargc1a T A 5: 51,630,883 (GRCm39) Y582F unknown Het
Prdm9 C T 17: 15,765,226 (GRCm39) C518Y probably damaging Het
Rangrf T A 11: 68,864,540 (GRCm39) E2V probably damaging Het
Rpl19 T C 11: 97,919,193 (GRCm39) I45T probably benign Het
Rtn4rl2 T C 2: 84,702,807 (GRCm39) D255G possibly damaging Het
Shld2 T C 14: 33,970,847 (GRCm39) K627E probably damaging Het
Sirt3 T C 7: 140,457,963 (GRCm39) D62G Het
Slc22a30 T C 19: 8,314,133 (GRCm39) T518A probably damaging Het
Slc40a1 T C 1: 45,950,466 (GRCm39) T329A probably damaging Het
Slc6a17 C T 3: 107,381,671 (GRCm39) G470D probably damaging Het
Syne2 A T 12: 76,044,181 (GRCm39) I3923L probably benign Het
Tiam2 C T 17: 3,471,591 (GRCm39) S411L probably benign Het
Ticam1 A G 17: 56,577,182 (GRCm39) C638R unknown Het
Tnrc6c A G 11: 117,648,912 (GRCm39) T1528A probably benign Het
Ufl1 A G 4: 25,262,274 (GRCm39) I404T probably benign Het
Usp43 A T 11: 67,782,294 (GRCm39) S375T possibly damaging Het
Vmn2r88 C G 14: 51,650,503 (GRCm39) A72G probably benign Het
Vmn2r91 A T 17: 18,330,311 (GRCm39) I532F possibly damaging Het
Vmn2r95 T C 17: 18,644,367 (GRCm39) M1T probably null Het
Xirp2 T C 2: 67,345,526 (GRCm39) V2589A probably benign Het
Zfp128 C T 7: 12,624,240 (GRCm39) Q203* probably null Het
Other mutations in Mrgprf
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0973:Mrgprf UTSW 7 144,861,993 (GRCm39) missense probably damaging 0.96
R1709:Mrgprf UTSW 7 144,861,954 (GRCm39) missense probably benign 0.07
R4643:Mrgprf UTSW 7 144,862,242 (GRCm39) missense probably benign 0.39
R5631:Mrgprf UTSW 7 144,862,283 (GRCm39) missense probably benign 0.02
R5965:Mrgprf UTSW 7 144,861,168 (GRCm39) intron probably benign
R7147:Mrgprf UTSW 7 144,862,128 (GRCm39) missense possibly damaging 0.59
R7291:Mrgprf UTSW 7 144,861,206 (GRCm39) missense unknown
R8826:Mrgprf UTSW 7 144,862,046 (GRCm39) missense probably benign 0.16
R8881:Mrgprf UTSW 7 144,861,999 (GRCm39) missense probably benign
R9112:Mrgprf UTSW 7 144,861,503 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCTACTTGGGGATCGACTGG -3'
(R):5'- GAGTGTTAAGGCAGGTCTTCTCC -3'

Sequencing Primer
(F):5'- GGGATCGACTGGTTCCTCTTC -3'
(R):5'- TTCTCCCTGGCAGCACAG -3'
Posted On 2019-11-26