Incidental Mutation 'R7755:Vmn2r91'
| ID |
597525 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r91
|
| Ensembl Gene |
ENSMUSG00000091206 |
| Gene Name |
vomeronasal 2, receptor 91 |
| Synonyms |
EG665210 |
| MMRRC Submission |
045811-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
R7755 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18305319-18356905 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 18330311 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 532
(I532F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127465
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172359]
|
| AlphaFold |
E9Q2U5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000172359
AA Change: I532F
PolyPhen 2
Score 0.877 (Sensitivity: 0.83; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: I532F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
462 |
2.2e-38 |
PFAM |
|
Pfam:NCD3G
|
510 |
564 |
6.7e-20 |
PFAM |
|
Pfam:7tm_3
|
597 |
832 |
2.1e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
98% (52/53) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
G |
A |
12: 71,236,187 (GRCm39) |
M1179I |
probably benign |
Het |
| 4930402F06Rik |
T |
C |
2: 35,266,349 (GRCm39) |
Y107C |
probably damaging |
Het |
| Aff4 |
T |
C |
11: 53,289,206 (GRCm39) |
S452P |
probably damaging |
Het |
| Astn2 |
T |
C |
4: 65,712,795 (GRCm39) |
D615G |
probably damaging |
Het |
| Begain |
A |
G |
12: 109,018,802 (GRCm39) |
L215P |
probably benign |
Het |
| Carf |
T |
A |
1: 60,187,214 (GRCm39) |
S606T |
probably benign |
Het |
| Cngb3 |
A |
T |
4: 19,461,684 (GRCm39) |
T522S |
probably benign |
Het |
| Ctsll3 |
A |
T |
13: 60,948,219 (GRCm39) |
F153I |
probably damaging |
Het |
| Cubn |
G |
A |
2: 13,284,889 (GRCm39) |
T3509I |
probably benign |
Het |
| Dmrta1 |
T |
C |
4: 89,580,170 (GRCm39) |
S377P |
probably benign |
Het |
| Dnmbp |
G |
A |
19: 43,838,525 (GRCm39) |
A659V |
probably benign |
Het |
| Dspp |
TGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCAACAGCAGTGACAGCAG |
TGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAGCGACAGCAGCAACAGCAGTGACAGCAG |
5: 104,326,227 (GRCm39) |
|
probably benign |
Het |
| Dync2h1 |
T |
C |
9: 7,015,490 (GRCm39) |
D3598G |
probably benign |
Het |
| Elp1 |
T |
C |
4: 56,774,552 (GRCm39) |
N779S |
possibly damaging |
Het |
| Flot2 |
T |
C |
11: 77,940,339 (GRCm39) |
F29L |
probably benign |
Het |
| Hectd1 |
A |
T |
12: 51,849,003 (GRCm39) |
I367K |
possibly damaging |
Het |
| Ivl |
T |
A |
3: 92,479,317 (GRCm39) |
K249N |
probably damaging |
Het |
| Khnyn |
A |
G |
14: 56,125,425 (GRCm39) |
T503A |
probably damaging |
Het |
| Mbd4 |
T |
A |
6: 115,821,546 (GRCm39) |
I490F |
probably damaging |
Het |
| Mlip |
T |
C |
9: 77,136,838 (GRCm39) |
T690A |
probably benign |
Het |
| Mmp1a |
T |
A |
9: 7,467,005 (GRCm39) |
D227E |
possibly damaging |
Het |
| Mrgprf |
T |
C |
7: 144,862,380 (GRCm39) |
L314P |
probably damaging |
Het |
| Ndufb9 |
T |
G |
15: 58,808,255 (GRCm39) |
Y80* |
probably null |
Het |
| Neto2 |
C |
T |
8: 86,396,285 (GRCm39) |
R155H |
probably damaging |
Het |
| Npat |
T |
A |
9: 53,470,470 (GRCm39) |
N365K |
possibly damaging |
Het |
| Nsl1 |
G |
A |
1: 190,795,380 (GRCm39) |
V49M |
probably benign |
Het |
| Nudt21 |
T |
A |
8: 94,749,493 (GRCm39) |
Y191F |
probably benign |
Het |
| Or2w25 |
A |
G |
11: 59,504,467 (GRCm39) |
R226G |
probably damaging |
Het |
| Or8b54 |
T |
G |
9: 38,687,073 (GRCm39) |
I174S |
possibly damaging |
Het |
| Pcdh18 |
T |
C |
3: 49,709,278 (GRCm39) |
Y679C |
possibly damaging |
Het |
| Pkd1l3 |
A |
G |
8: 110,356,798 (GRCm39) |
D741G |
possibly damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,617,717 (GRCm39) |
D956G |
probably damaging |
Het |
| Poglut2 |
T |
C |
1: 44,157,733 (GRCm39) |
|
probably benign |
Het |
| Pparg |
C |
T |
6: 115,440,067 (GRCm39) |
P214S |
probably damaging |
Het |
| Ppargc1a |
T |
A |
5: 51,630,883 (GRCm39) |
Y582F |
unknown |
Het |
| Prdm9 |
C |
T |
17: 15,765,226 (GRCm39) |
C518Y |
probably damaging |
Het |
| Rangrf |
T |
A |
11: 68,864,540 (GRCm39) |
E2V |
probably damaging |
Het |
| Rpl19 |
T |
C |
11: 97,919,193 (GRCm39) |
I45T |
probably benign |
Het |
| Rtn4rl2 |
T |
C |
2: 84,702,807 (GRCm39) |
D255G |
possibly damaging |
Het |
| Shld2 |
T |
C |
14: 33,970,847 (GRCm39) |
K627E |
probably damaging |
Het |
| Sirt3 |
T |
C |
7: 140,457,963 (GRCm39) |
D62G |
|
Het |
| Slc22a30 |
T |
C |
19: 8,314,133 (GRCm39) |
T518A |
probably damaging |
Het |
| Slc40a1 |
T |
C |
1: 45,950,466 (GRCm39) |
T329A |
probably damaging |
Het |
| Slc6a17 |
C |
T |
3: 107,381,671 (GRCm39) |
G470D |
probably damaging |
Het |
| Syne2 |
A |
T |
12: 76,044,181 (GRCm39) |
I3923L |
probably benign |
Het |
| Tiam2 |
C |
T |
17: 3,471,591 (GRCm39) |
S411L |
probably benign |
Het |
| Ticam1 |
A |
G |
17: 56,577,182 (GRCm39) |
C638R |
unknown |
Het |
| Tnrc6c |
A |
G |
11: 117,648,912 (GRCm39) |
T1528A |
probably benign |
Het |
| Ufl1 |
A |
G |
4: 25,262,274 (GRCm39) |
I404T |
probably benign |
Het |
| Usp43 |
A |
T |
11: 67,782,294 (GRCm39) |
S375T |
possibly damaging |
Het |
| Vmn2r88 |
C |
G |
14: 51,650,503 (GRCm39) |
A72G |
probably benign |
Het |
| Vmn2r95 |
T |
C |
17: 18,644,367 (GRCm39) |
M1T |
probably null |
Het |
| Xirp2 |
T |
C |
2: 67,345,526 (GRCm39) |
V2589A |
probably benign |
Het |
| Zfp128 |
C |
T |
7: 12,624,240 (GRCm39) |
Q203* |
probably null |
Het |
|
| Other mutations in Vmn2r91 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00983:Vmn2r91
|
APN |
17 |
18,325,820 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01121:Vmn2r91
|
APN |
17 |
18,356,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01464:Vmn2r91
|
APN |
17 |
18,327,864 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL02003:Vmn2r91
|
APN |
17 |
18,327,921 (GRCm39) |
missense |
probably benign |
|
|
IGL02709:Vmn2r91
|
APN |
17 |
18,325,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02795:Vmn2r91
|
APN |
17 |
18,305,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02813:Vmn2r91
|
APN |
17 |
18,356,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02830:Vmn2r91
|
APN |
17 |
18,356,884 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03130:Vmn2r91
|
APN |
17 |
18,330,373 (GRCm39) |
splice site |
probably benign |
|
|
BB006:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0164:Vmn2r91
|
UTSW |
17 |
18,326,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Vmn2r91
|
UTSW |
17 |
18,325,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1142:Vmn2r91
|
UTSW |
17 |
18,356,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Vmn2r91
|
UTSW |
17 |
18,326,405 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1992:Vmn2r91
|
UTSW |
17 |
18,356,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2182:Vmn2r91
|
UTSW |
17 |
18,325,691 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2424:Vmn2r91
|
UTSW |
17 |
18,356,431 (GRCm39) |
nonsense |
probably null |
|
|
R2512:Vmn2r91
|
UTSW |
17 |
18,356,048 (GRCm39) |
missense |
probably benign |
|
|
R2885:Vmn2r91
|
UTSW |
17 |
18,325,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2909:Vmn2r91
|
UTSW |
17 |
18,356,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3009:Vmn2r91
|
UTSW |
17 |
18,325,717 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3079:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3080:Vmn2r91
|
UTSW |
17 |
18,355,973 (GRCm39) |
splice site |
probably null |
|
|
R3434:Vmn2r91
|
UTSW |
17 |
18,330,370 (GRCm39) |
splice site |
probably benign |
|
|
R3723:Vmn2r91
|
UTSW |
17 |
18,305,540 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3829:Vmn2r91
|
UTSW |
17 |
18,325,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3846:Vmn2r91
|
UTSW |
17 |
18,327,860 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4118:Vmn2r91
|
UTSW |
17 |
18,330,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4285:Vmn2r91
|
UTSW |
17 |
18,356,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4729:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4793:Vmn2r91
|
UTSW |
17 |
18,325,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4932:Vmn2r91
|
UTSW |
17 |
18,356,751 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5016:Vmn2r91
|
UTSW |
17 |
18,330,322 (GRCm39) |
nonsense |
probably null |
|
|
R5018:Vmn2r91
|
UTSW |
17 |
18,356,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Vmn2r91
|
UTSW |
17 |
18,356,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5815:Vmn2r91
|
UTSW |
17 |
18,326,464 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6146:Vmn2r91
|
UTSW |
17 |
18,356,518 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6187:Vmn2r91
|
UTSW |
17 |
18,326,888 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6426:Vmn2r91
|
UTSW |
17 |
18,355,865 (GRCm39) |
splice site |
probably null |
|
|
R6450:Vmn2r91
|
UTSW |
17 |
18,305,527 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6767:Vmn2r91
|
UTSW |
17 |
18,327,807 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6986:Vmn2r91
|
UTSW |
17 |
18,356,271 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7112:Vmn2r91
|
UTSW |
17 |
18,325,880 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7178:Vmn2r91
|
UTSW |
17 |
18,356,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7330:Vmn2r91
|
UTSW |
17 |
18,326,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7380:Vmn2r91
|
UTSW |
17 |
18,356,838 (GRCm39) |
nonsense |
probably null |
|
|
R7397:Vmn2r91
|
UTSW |
17 |
18,356,060 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7625:Vmn2r91
|
UTSW |
17 |
18,325,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7739:Vmn2r91
|
UTSW |
17 |
18,356,080 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7749:Vmn2r91
|
UTSW |
17 |
18,356,540 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7929:Vmn2r91
|
UTSW |
17 |
18,327,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7981:Vmn2r91
|
UTSW |
17 |
18,327,887 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8211:Vmn2r91
|
UTSW |
17 |
18,326,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8325:Vmn2r91
|
UTSW |
17 |
18,356,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8781:Vmn2r91
|
UTSW |
17 |
18,305,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8974:Vmn2r91
|
UTSW |
17 |
18,325,636 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9047:Vmn2r91
|
UTSW |
17 |
18,326,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9048:Vmn2r91
|
UTSW |
17 |
18,356,122 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9109:Vmn2r91
|
UTSW |
17 |
18,327,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Vmn2r91
|
UTSW |
17 |
18,356,819 (GRCm39) |
nonsense |
probably null |
|
|
R9555:Vmn2r91
|
UTSW |
17 |
18,325,792 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9616:Vmn2r91
|
UTSW |
17 |
18,356,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTAGGTGTTAACAACAGTACTTTGC -3'
(R):5'- GTGGCACTGTCCAATGTAAAGC -3'
Sequencing Primer
(F):5'- ACAACAGTACTTTGCTTTTCAGTG -3'
(R):5'- AGCTATTTCAAGGGGATGATGATG -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation