Incidental Mutation 'R7757:Nudt16'
ID 597622
Institutional Source Beutler Lab
Gene Symbol Nudt16
Ensembl Gene ENSMUSG00000032565
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 16
Synonyms 2900006H04Rik, 2810047L04Rik, 2310041H06Rik
MMRRC Submission 045813-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R7757 (G1)
Quality Score 213.009
Status Validated
Chromosome 9
Chromosomal Location 105128903-105131824 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 105131561 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 47 (M47R)
Ref Sequence ENSEMBL: ENSMUSP00000035179 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035179]
AlphaFold Q6P3D0
Predicted Effect probably damaging
Transcript: ENSMUST00000035179
AA Change: M47R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035179
Gene: ENSMUSG00000032565
AA Change: M47R

Pfam:NUDIX 19 146 1.5e-7 PFAM
low complexity region 169 182 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000185533
Predicted Effect probably null
Transcript: ENSMUST00000186925
Predicted Effect probably null
Transcript: ENSMUST00000186925
Meta Mutation Damage Score 0.8262 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 96% (70/73)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G A 12: 71,189,413 (GRCm38) M1179I probably benign Het
6430550D23Rik T C 2: 156,003,431 (GRCm38) T18A possibly damaging Het
Acox2 T C 14: 8,230,166 (GRCm38) N659S probably damaging Het
Agk T C 6: 40,376,278 (GRCm38) V192A possibly damaging Het
Ap3b1 T A 13: 94,528,158 (GRCm38) probably null Het
Bche T A 3: 73,701,121 (GRCm38) D324V probably damaging Het
Bsn A G 9: 108,114,740 (GRCm38) I1271T possibly damaging Het
Capn12 T C 7: 28,882,821 (GRCm38) L120P probably damaging Het
Cep290 T A 10: 100,563,434 (GRCm38) S2273T probably benign Het
Ckap4 T C 10: 84,528,467 (GRCm38) E244G probably damaging Het
Clcn7 T C 17: 25,156,822 (GRCm38) Y545H probably damaging Het
Cmya5 T A 13: 93,098,272 (GRCm38) T103S possibly damaging Het
Cplane1 A T 15: 8,252,227 (GRCm38) E2850V unknown Het
Cpne9 G A 6: 113,284,445 (GRCm38) V121M possibly damaging Het
Csmd2 T A 4: 128,483,456 (GRCm38) I2043N Het
Disc1 A G 8: 125,087,504 (GRCm38) T36A probably benign Het
Disp2 T C 2: 118,790,910 (GRCm38) Y708H probably damaging Het
Dnah3 A T 7: 119,971,215 (GRCm38) probably null Het
Dnah3 A G 7: 120,071,570 (GRCm38) V635A probably benign Het
Dync1li1 A G 9: 114,709,277 (GRCm38) H234R possibly damaging Het
Egfr T C 11: 16,889,966 (GRCm38) V660A possibly damaging Het
Epb42 T C 2: 121,027,719 (GRCm38) R253G possibly damaging Het
Fat2 T A 11: 55,311,421 (GRCm38) T276S probably benign Het
Fcho2 A G 13: 98,764,503 (GRCm38) probably null Het
Ginm1 A T 10: 7,779,355 (GRCm38) I41N probably damaging Het
Gm4744 A G 6: 40,950,433 (GRCm38) probably benign Het
Gm49368 C T 7: 128,112,226 (GRCm38) R701C probably damaging Het
Gpr37 T A 6: 25,688,208 (GRCm38) I297F probably benign Het
Gprc5a T A 6: 135,079,344 (GRCm38) I263N possibly damaging Het
Gys2 A T 6: 142,454,451 (GRCm38) S345T probably benign Het
Hk2 T C 6: 82,742,915 (GRCm38) M255V possibly damaging Het
Ibtk A C 9: 85,697,237 (GRCm38) S1202A possibly damaging Het
Il23r T G 6: 67,423,981 (GRCm38) D455A probably benign Het
Irs2 T A 8: 11,006,522 (GRCm38) K637* probably null Het
Jak2 T C 19: 29,283,546 (GRCm38) V314A probably benign Het
Mei1 C T 15: 82,082,623 (GRCm38) probably benign Het
Mill1 T C 7: 18,262,466 (GRCm38) M69T probably benign Het
Mms22l T C 4: 24,598,884 (GRCm38) probably null Het
Mup8 T A 4: 60,220,333 (GRCm38) Q133L probably benign Het
Mup8 C A 4: 60,220,332 (GRCm38) Q133H probably benign Het
Mycbp2 A T 14: 103,191,619 (GRCm38) Y2374N probably damaging Het
Nbeal1 A T 1: 60,257,450 (GRCm38) K1166N probably damaging Het
Nlrc4 T A 17: 74,448,196 (GRCm38) R8S probably benign Het
Nrcam C T 12: 44,549,898 (GRCm38) Q25* probably null Het
Nup62 T C 7: 44,828,995 (GRCm38) S145P probably benign Het
Or10d1 A G 9: 39,572,465 (GRCm38) W265R probably benign Het
Or4c117 T C 2: 89,124,989 (GRCm38) I247M possibly damaging Het
Osbpl1a A T 18: 12,933,600 (GRCm38) V34D probably benign Het
Otogl T A 10: 107,876,921 (GRCm38) N521Y probably damaging Het
Pcdhb14 T A 18: 37,449,834 (GRCm38) D664E possibly damaging Het
Pex5l T C 3: 33,082,151 (GRCm38) probably benign Het
Pkhd1 A G 1: 20,562,415 (GRCm38) L592P probably damaging Het
Plxdc2 A G 2: 16,729,376 (GRCm38) H480R probably benign Het
Rnf216 T A 5: 143,080,236 (GRCm38) K532N probably damaging Het
Schip1 C A 3: 68,617,695 (GRCm38) Q358K probably damaging Het
Sdc2 A T 15: 33,028,087 (GRCm38) E117V possibly damaging Het
Septin11 A T 5: 93,171,464 (GRCm38) probably null Het
Shprh A T 10: 11,162,180 (GRCm38) E420V probably benign Het
Ska1 T A 18: 74,196,973 (GRCm38) H232L probably benign Het
Slc36a4 A G 9: 15,719,660 (GRCm38) N25S possibly damaging Het
Slitrk3 G A 3: 73,050,839 (GRCm38) T200M probably damaging Het
Smad2 C T 18: 76,288,013 (GRCm38) H138Y probably benign Het
Snx21 T C 2: 164,786,165 (GRCm38) S34P probably damaging Het
Sos2 A G 12: 69,648,585 (GRCm38) V126A probably damaging Het
Srcap C T 7: 127,530,794 (GRCm38) T596I probably damaging Het
Stk31 T G 6: 49,406,943 (GRCm38) probably null Het
Stox1 T C 10: 62,663,964 (GRCm38) D939G probably damaging Het
Syne2 G T 12: 76,061,779 (GRCm38) C979F possibly damaging Het
Tanc2 C A 11: 105,776,858 (GRCm38) N88K possibly damaging Het
Tll2 A T 19: 41,096,008 (GRCm38) V677E probably damaging Het
Ttn T C 2: 76,918,490 (GRCm38) T4072A probably benign Het
Unc13b CAGAGC CAGAGCGAGAGC 4: 43,177,341 (GRCm38) probably benign Het
Unc13b AGAGCC AGAGCCCGAGCC 4: 43,177,330 (GRCm38) probably benign Het
Vmn2r43 A T 7: 8,255,254 (GRCm38) F320Y possibly damaging Het
Zscan4f G T 7: 11,401,278 (GRCm38) G204* probably null Het
Other mutations in Nudt16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Nudt16 APN 9 105,131,508 (GRCm38) missense probably benign 0.02
R5960:Nudt16 UTSW 9 105,131,499 (GRCm38) missense possibly damaging 0.95
R8219:Nudt16 UTSW 9 105,130,437 (GRCm38) missense probably damaging 1.00
RF018:Nudt16 UTSW 9 105,131,699 (GRCm38) missense probably damaging 1.00
X0009:Nudt16 UTSW 9 105,130,476 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-11-26