|Institutional Source||Beutler Lab|
|Gene Name||dynein cytoplasmic 1 light intermediate chain 1|
|Synonyms||Dnclic1, 1110053F02Rik, LIC-1|
|Essential gene?||Probably essential (E-score: 0.782)|
|Stock #||R7757 (G1)|
|Chromosomal Location||114688790-114724302 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 114709277 bp (GRCm38)|
|Amino Acid Change||Histidine to Arginine at position 234 (H234R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000035366 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000047404]|
AA Change: H234R
PolyPhen 2 Score 0.650 (Sensitivity: 0.87; Specificity: 0.91)
AA Change: H234R
|Coding Region Coverage||
|Validation Efficiency||96% (70/73)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit increased anxiety-related response, increased dendrite length, increased neuron migration, and decreased lysosome trafficking. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dync1li1||
(F):5'- GGCTCACATGGTTCCATTTC -3'
(R):5'- AACACTTCAGCAGGGTGGTAG -3'
(F):5'- GGCTCACATGGTTCCATTTCTAAAC -3'
(R):5'- TGGTTCTACCATCCAGAGACCAG -3'