Incidental Mutation 'R7759:Itgb4'
ID 597747
Institutional Source Beutler Lab
Gene Symbol Itgb4
Ensembl Gene ENSMUSG00000020758
Gene Name integrin beta 4
Synonyms CD104
MMRRC Submission 045815-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7759 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 115865556-115899238 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115894536 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 1364 (R1364G)
Ref Sequence ENSEMBL: ENSMUSP00000102066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021107] [ENSMUST00000021114] [ENSMUST00000068981] [ENSMUST00000106458] [ENSMUST00000106460] [ENSMUST00000106461] [ENSMUST00000169928]
AlphaFold A2A863
Predicted Effect probably damaging
Transcript: ENSMUST00000021107
AA Change: R1360G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000021107
Gene: ENSMUSG00000020758
AA Change: R1360G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 712 1.32e-28 SMART
low complexity region 715 732 N/A INTRINSIC
transmembrane domain 737 756 N/A INTRINSIC
Calx_beta 980 1085 3.13e-35 SMART
FN3 1125 1203 3.15e-8 SMART
FN3 1218 1305 6.29e-8 SMART
low complexity region 1324 1332 N/A INTRINSIC
FN3 1508 1589 1.79e-12 SMART
FN3 1621 1705 1.7e-13 SMART
low complexity region 1738 1751 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000021114
SMART Domains Protein: ENSMUSP00000021114
Gene: ENSMUSG00000020766

DomainStartEndE-ValueType
Pfam:GalKase_gal_bdg 18 67 2.6e-24 PFAM
Pfam:GHMP_kinases_N 126 194 7.3e-14 PFAM
Pfam:GHMP_kinases_C 289 374 1.6e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000068981
AA Change: R1364G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000070811
Gene: ENSMUSG00000020758
AA Change: R1364G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
FN3 1459 1540 1.79e-12 SMART
FN3 1572 1656 1.7e-13 SMART
low complexity region 1689 1702 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000106458
AA Change: R1364G

PolyPhen 2 Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000102066
Gene: ENSMUSG00000020758
AA Change: R1364G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
low complexity region 1413 1425 N/A INTRINSIC
FN3 1524 1605 1.79e-12 SMART
FN3 1637 1721 1.7e-13 SMART
low complexity region 1754 1767 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000106460
AA Change: R1364G

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000102068
Gene: ENSMUSG00000020758
AA Change: R1364G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
FN3 1512 1593 1.79e-12 SMART
FN3 1625 1709 1.7e-13 SMART
low complexity region 1742 1755 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000106461
AA Change: R1364G

PolyPhen 2 Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000102069
Gene: ENSMUSG00000020758
AA Change: R1364G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 713 7.06e-29 SMART
low complexity region 716 733 N/A INTRINSIC
transmembrane domain 738 757 N/A INTRINSIC
Calx_beta 981 1086 3.13e-35 SMART
FN3 1129 1207 3.15e-8 SMART
FN3 1222 1309 6.29e-8 SMART
low complexity region 1328 1336 N/A INTRINSIC
low complexity region 1413 1425 N/A INTRINSIC
FN3 1524 1605 1.79e-12 SMART
FN3 1637 1721 1.7e-13 SMART
low complexity region 1754 1767 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000169928
AA Change: R1360G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127604
Gene: ENSMUSG00000020758
AA Change: R1360G

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
PSI 30 74 3.89e-1 SMART
INB 38 457 4.23e-213 SMART
VWA 130 361 8.29e-1 SMART
EGF_like 544 576 3.23e1 SMART
Integrin_B_tail 628 712 1.32e-28 SMART
low complexity region 715 732 N/A INTRINSIC
transmembrane domain 737 756 N/A INTRINSIC
Calx_beta 980 1085 3.13e-35 SMART
FN3 1125 1203 3.15e-8 SMART
FN3 1218 1305 6.29e-8 SMART
low complexity region 1324 1332 N/A INTRINSIC
FN3 1508 1589 1.79e-12 SMART
FN3 1621 1705 1.7e-13 SMART
low complexity region 1738 1751 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations die shortly after birth with extensive detachment of the epidermis and other squamus epithelia. Stratified tissues lack hemidesmosomes and simple epithelia are also defective in adherence. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik G T 16: 4,682,514 (GRCm39) G215V probably benign Het
Adamts1 C A 16: 85,594,683 (GRCm39) G652C probably damaging Het
Adck1 G A 12: 88,368,887 (GRCm39) A122T possibly damaging Het
Akap1 A C 11: 88,736,659 (GRCm39) M34R probably damaging Het
Apc2 C T 10: 80,147,030 (GRCm39) R695C probably damaging Het
Apon T A 10: 128,090,384 (GRCm39) W21R probably benign Het
Arhgef16 T C 4: 154,371,432 (GRCm39) T254A probably benign Het
Arid5b T A 10: 67,933,632 (GRCm39) S757C probably damaging Het
B020004C17Rik A C 14: 57,254,242 (GRCm39) I122L possibly damaging Het
Bckdhb T G 9: 83,892,379 (GRCm39) V270G probably damaging Het
Cacna1d A G 14: 29,821,145 (GRCm39) Y1146H probably benign Het
Carmil2 A G 8: 106,423,668 (GRCm39) D1214G possibly damaging Het
Ccdc142 T C 6: 83,084,912 (GRCm39) V636A probably benign Het
Chd9 T C 8: 91,704,178 (GRCm39) probably null Het
Csmd3 A G 15: 47,561,569 (GRCm39) S1336P Het
Cubn A G 2: 13,352,961 (GRCm39) Y1926H probably damaging Het
Dock4 A T 12: 40,867,735 (GRCm39) D1437V probably damaging Het
Eme1 A T 11: 94,536,666 (GRCm39) Y504* probably null Het
Enah G A 1: 181,746,009 (GRCm39) A687V unknown Het
Endou A C 15: 97,611,747 (GRCm39) V339G probably damaging Het
Ephb6 G A 6: 41,591,539 (GRCm39) R232H probably benign Het
Ephx2 G A 14: 66,326,968 (GRCm39) A409V possibly damaging Het
Esd T A 14: 74,983,007 (GRCm39) C219* probably null Het
Fscb A T 12: 64,520,866 (GRCm39) M200K probably benign Het
Gabra6 A T 11: 42,208,508 (GRCm39) V108D probably damaging Het
Gm11555 A G 11: 99,540,568 (GRCm39) V137A unknown Het
Gpld1 A G 13: 25,146,383 (GRCm39) D209G probably damaging Het
Ikzf1 T A 11: 11,719,256 (GRCm39) I408N probably damaging Het
Kif26b A C 1: 178,506,509 (GRCm39) K195T probably damaging Het
Mfsd12 T C 10: 81,199,427 (GRCm39) W440R probably benign Het
Mtrr C T 13: 68,718,146 (GRCm39) E373K probably damaging Het
Mug2 T A 6: 122,058,317 (GRCm39) V1293E probably damaging Het
Myof C A 19: 37,928,346 (GRCm39) A1068S probably benign Het
Ncam2 A G 16: 81,412,672 (GRCm39) D720G probably damaging Het
Nova2 G T 7: 18,692,176 (GRCm39) G435V Het
Oacyl T A 18: 65,843,631 (GRCm39) D109E probably damaging Het
Or2y1g A T 11: 49,171,463 (GRCm39) M163L probably benign Het
Or56a4 G A 7: 104,806,232 (GRCm39) S219F probably damaging Het
Pdcd11 G A 19: 47,101,637 (GRCm39) V941M possibly damaging Het
Pdzd8 C A 19: 59,288,358 (GRCm39) R1014L probably damaging Het
Ppm1h T G 10: 122,740,018 (GRCm39) D364E probably benign Het
Rigi C A 4: 40,225,104 (GRCm39) A298S probably damaging Het
Rp1 T C 1: 4,415,107 (GRCm39) N2002D probably benign Het
Sall1 C T 8: 89,768,979 (GRCm39) probably null Het
Scn10a C T 9: 119,477,198 (GRCm39) W728* probably null Het
Setdb2 G T 14: 59,656,813 (GRCm39) T168K probably damaging Het
Sgms1 T C 19: 32,137,276 (GRCm39) I97V probably benign Het
Slc8a3 A T 12: 81,361,325 (GRCm39) M498K probably benign Het
Smpd4 A T 16: 17,456,497 (GRCm39) E362D probably damaging Het
Ssc5d A T 7: 4,940,529 (GRCm39) K881* probably null Het
Strn4 A G 7: 16,564,309 (GRCm39) E313G probably damaging Het
Tas2r113 A T 6: 132,870,890 (GRCm39) N306I possibly damaging Het
Tdrd6 G T 17: 43,935,730 (GRCm39) R1773S probably benign Het
Thbs2 T C 17: 14,897,321 (GRCm39) E729G probably damaging Het
Tnfrsf23 G A 7: 143,224,572 (GRCm39) T135I probably damaging Het
Tollip A G 7: 141,438,276 (GRCm39) M218T probably benign Het
Tyk2 A T 9: 21,031,554 (GRCm39) probably null Het
Ubr2 G A 17: 47,296,974 (GRCm39) R269C probably damaging Het
Uggt1 A T 1: 36,185,806 (GRCm39) M1459K possibly damaging Het
Upf1 A G 8: 70,786,730 (GRCm39) V929A probably benign Het
Usp48 T C 4: 137,321,763 (GRCm39) S24P probably benign Het
Vmn1r214 G A 13: 23,218,631 (GRCm39) E42K not run Het
Vmn1r83 G T 7: 12,055,360 (GRCm39) D232E probably benign Het
Vmn2r25 C T 6: 123,800,339 (GRCm39) V668I probably damaging Het
Vmn2r6 A G 3: 64,463,991 (GRCm39) I281T probably damaging Het
Ywhag A T 5: 135,940,043 (GRCm39) Y184N probably damaging Het
Zdbf2 A C 1: 63,347,535 (GRCm39) E1971D possibly damaging Het
Zfp568 G A 7: 29,722,839 (GRCm39) A595T possibly damaging Het
Zfy2 T C Y: 2,117,083 (GRCm39) D248G probably benign Het
Other mutations in Itgb4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01360:Itgb4 APN 11 115,881,766 (GRCm39) missense probably damaging 1.00
IGL01391:Itgb4 APN 11 115,881,746 (GRCm39) missense probably damaging 1.00
IGL01431:Itgb4 APN 11 115,897,283 (GRCm39) splice site probably benign
IGL01750:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01752:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01756:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01766:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL01769:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02188:Itgb4 APN 11 115,894,213 (GRCm39) missense probably benign 0.08
IGL02262:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02293:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02318:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02319:Itgb4 APN 11 115,879,752 (GRCm39) missense probably damaging 0.99
IGL02338:Itgb4 APN 11 115,898,795 (GRCm39) missense probably damaging 1.00
IGL02734:Itgb4 APN 11 115,896,792 (GRCm39) missense probably benign
IGL02879:Itgb4 APN 11 115,885,178 (GRCm39) missense probably benign 0.05
IGL02889:Itgb4 APN 11 115,879,731 (GRCm39) missense probably damaging 1.00
IGL03183:Itgb4 APN 11 115,879,550 (GRCm39) missense probably damaging 1.00
IGL03054:Itgb4 UTSW 11 115,891,166 (GRCm39) nonsense probably null
R0021:Itgb4 UTSW 11 115,870,453 (GRCm39) missense possibly damaging 0.95
R0092:Itgb4 UTSW 11 115,869,950 (GRCm39) missense probably damaging 1.00
R0305:Itgb4 UTSW 11 115,870,238 (GRCm39) missense probably damaging 1.00
R0408:Itgb4 UTSW 11 115,898,428 (GRCm39) missense probably damaging 0.99
R0465:Itgb4 UTSW 11 115,870,582 (GRCm39) missense probably damaging 1.00
R0499:Itgb4 UTSW 11 115,870,521 (GRCm39) missense probably benign 0.00
R0535:Itgb4 UTSW 11 115,881,835 (GRCm39) missense possibly damaging 0.86
R0571:Itgb4 UTSW 11 115,870,594 (GRCm39) missense possibly damaging 0.94
R0613:Itgb4 UTSW 11 115,884,168 (GRCm39) missense probably damaging 0.98
R0838:Itgb4 UTSW 11 115,888,988 (GRCm39) intron probably benign
R1381:Itgb4 UTSW 11 115,885,163 (GRCm39) missense probably benign 0.00
R1451:Itgb4 UTSW 11 115,881,710 (GRCm39) missense probably damaging 1.00
R1459:Itgb4 UTSW 11 115,869,937 (GRCm39) missense probably benign 0.42
R1460:Itgb4 UTSW 11 115,874,990 (GRCm39) missense probably damaging 0.96
R1473:Itgb4 UTSW 11 115,874,873 (GRCm39) missense probably benign 0.01
R1484:Itgb4 UTSW 11 115,890,625 (GRCm39) missense probably benign 0.01
R1593:Itgb4 UTSW 11 115,871,817 (GRCm39) missense probably damaging 1.00
R1623:Itgb4 UTSW 11 115,882,142 (GRCm39) nonsense probably null
R1633:Itgb4 UTSW 11 115,898,586 (GRCm39) missense probably damaging 1.00
R1642:Itgb4 UTSW 11 115,898,183 (GRCm39) missense probably damaging 1.00
R1669:Itgb4 UTSW 11 115,882,156 (GRCm39) missense probably benign 0.07
R1713:Itgb4 UTSW 11 115,894,315 (GRCm39) missense probably damaging 1.00
R1732:Itgb4 UTSW 11 115,879,744 (GRCm39) missense probably damaging 1.00
R1791:Itgb4 UTSW 11 115,879,346 (GRCm39) missense probably damaging 1.00
R1847:Itgb4 UTSW 11 115,874,590 (GRCm39) missense probably benign 0.31
R1902:Itgb4 UTSW 11 115,871,564 (GRCm39) missense probably damaging 0.98
R1945:Itgb4 UTSW 11 115,884,279 (GRCm39) nonsense probably null
R2102:Itgb4 UTSW 11 115,896,561 (GRCm39) missense probably benign 0.23
R2184:Itgb4 UTSW 11 115,870,450 (GRCm39) missense probably damaging 0.96
R2334:Itgb4 UTSW 11 115,884,261 (GRCm39) missense probably damaging 1.00
R2401:Itgb4 UTSW 11 115,897,389 (GRCm39) missense possibly damaging 0.67
R3743:Itgb4 UTSW 11 115,894,496 (GRCm39) missense probably damaging 1.00
R3938:Itgb4 UTSW 11 115,896,752 (GRCm39) missense possibly damaging 0.92
R4134:Itgb4 UTSW 11 115,897,296 (GRCm39) missense probably benign 0.03
R4280:Itgb4 UTSW 11 115,881,761 (GRCm39) missense probably damaging 1.00
R4342:Itgb4 UTSW 11 115,879,555 (GRCm39) missense probably benign 0.01
R4434:Itgb4 UTSW 11 115,890,640 (GRCm39) missense probably benign 0.10
R4505:Itgb4 UTSW 11 115,874,087 (GRCm39) splice site silent
R4585:Itgb4 UTSW 11 115,884,151 (GRCm39) missense probably damaging 1.00
R4586:Itgb4 UTSW 11 115,884,151 (GRCm39) missense probably damaging 1.00
R4601:Itgb4 UTSW 11 115,896,548 (GRCm39) missense probably damaging 1.00
R4921:Itgb4 UTSW 11 115,897,431 (GRCm39) missense probably benign 0.12
R4962:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5027:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5029:Itgb4 UTSW 11 115,879,417 (GRCm39) intron probably benign
R5084:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5085:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5124:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5125:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5150:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5175:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5176:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5179:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5207:Itgb4 UTSW 11 115,897,365 (GRCm39) missense probably damaging 1.00
R5263:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5264:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5334:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5337:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5344:Itgb4 UTSW 11 115,880,575 (GRCm39) missense probably null 0.92
R5391:Itgb4 UTSW 11 115,875,894 (GRCm39) missense probably benign 0.05
R5437:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5440:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5653:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5654:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5655:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5772:Itgb4 UTSW 11 115,879,258 (GRCm39) intron probably benign
R5812:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5813:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5814:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5863:Itgb4 UTSW 11 115,881,748 (GRCm39) missense probably damaging 1.00
R5864:Itgb4 UTSW 11 115,881,748 (GRCm39) missense probably damaging 1.00
R5865:Itgb4 UTSW 11 115,881,748 (GRCm39) missense probably damaging 1.00
R5951:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5954:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R5982:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6043:Itgb4 UTSW 11 115,870,212 (GRCm39) missense probably benign 0.30
R6133:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6134:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6135:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6169:Itgb4 UTSW 11 115,885,102 (GRCm39) missense probably damaging 0.98
R6172:Itgb4 UTSW 11 115,891,237 (GRCm39) missense probably benign 0.23
R6255:Itgb4 UTSW 11 115,888,963 (GRCm39) missense possibly damaging 0.83
R6258:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6259:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6260:Itgb4 UTSW 11 115,874,983 (GRCm39) missense probably benign 0.00
R6612:Itgb4 UTSW 11 115,874,897 (GRCm39) missense probably benign 0.00
R7037:Itgb4 UTSW 11 115,896,391 (GRCm39) nonsense probably null
R7371:Itgb4 UTSW 11 115,888,906 (GRCm39) missense probably benign 0.29
R7605:Itgb4 UTSW 11 115,897,302 (GRCm39) missense probably benign 0.01
R7659:Itgb4 UTSW 11 115,870,557 (GRCm39) missense probably damaging 1.00
R7804:Itgb4 UTSW 11 115,894,510 (GRCm39) missense probably damaging 1.00
R7832:Itgb4 UTSW 11 115,891,087 (GRCm39) missense probably damaging 1.00
R7842:Itgb4 UTSW 11 115,873,531 (GRCm39) missense probably benign 0.18
R7923:Itgb4 UTSW 11 115,873,525 (GRCm39) critical splice acceptor site probably null
R8004:Itgb4 UTSW 11 115,873,531 (GRCm39) missense probably benign 0.00
R8143:Itgb4 UTSW 11 115,884,255 (GRCm39) missense probably damaging 1.00
R8427:Itgb4 UTSW 11 115,882,544 (GRCm39) critical splice donor site probably null
R8857:Itgb4 UTSW 11 115,871,853 (GRCm39) missense probably benign 0.04
R8863:Itgb4 UTSW 11 115,875,898 (GRCm39) nonsense probably null
R8932:Itgb4 UTSW 11 115,879,295 (GRCm39) missense probably benign 0.01
R9153:Itgb4 UTSW 11 115,874,879 (GRCm39) missense probably benign 0.00
R9207:Itgb4 UTSW 11 115,897,923 (GRCm39) missense probably damaging 1.00
R9239:Itgb4 UTSW 11 115,898,130 (GRCm39) missense probably damaging 1.00
R9267:Itgb4 UTSW 11 115,870,465 (GRCm39) missense probably benign
R9289:Itgb4 UTSW 11 115,885,187 (GRCm39) missense probably benign 0.01
R9328:Itgb4 UTSW 11 115,880,625 (GRCm39) missense probably benign 0.00
R9435:Itgb4 UTSW 11 115,895,855 (GRCm39) missense probably benign 0.01
R9450:Itgb4 UTSW 11 115,874,097 (GRCm39) missense probably damaging 1.00
R9649:Itgb4 UTSW 11 115,885,171 (GRCm39) missense possibly damaging 0.78
R9779:Itgb4 UTSW 11 115,882,485 (GRCm39) missense probably damaging 1.00
X0062:Itgb4 UTSW 11 115,884,278 (GRCm39) missense probably damaging 1.00
Z1176:Itgb4 UTSW 11 115,897,346 (GRCm39) missense probably damaging 1.00
Z1177:Itgb4 UTSW 11 115,888,884 (GRCm39) missense probably benign 0.00
Z1177:Itgb4 UTSW 11 115,877,637 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GAGGCTATCATCAACCTGGC -3'
(R):5'- AGCAGTTTTGTCCCTTCAGAAC -3'

Sequencing Primer
(F):5'- CCATGTCCAGTGAGTGACAG -3'
(R):5'- TTGTCCCTTCAGAACCATGAGAAGG -3'
Posted On 2019-11-26