Incidental Mutation 'R7759:Ncam2'
ID 597764
Institutional Source Beutler Lab
Gene Symbol Ncam2
Ensembl Gene ENSMUSG00000022762
Gene Name neural cell adhesion molecule 2
Synonyms Ncam-2, RNCAM, R4B12 antigen, Ocam
MMRRC Submission 045815-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7759 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 80997585-81423716 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 81412672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 720 (D720G)
Ref Sequence ENSEMBL: ENSMUSP00000063468 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067602]
AlphaFold O35136
Predicted Effect probably damaging
Transcript: ENSMUST00000067602
AA Change: D720G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063468
Gene: ENSMUSG00000022762
AA Change: D720G

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IGc2 33 100 3.18e-6 SMART
IGc2 127 193 1.13e-11 SMART
IGc2 223 288 2.03e-13 SMART
IGc2 313 387 1.12e-15 SMART
IGc2 413 482 9.93e-8 SMART
FN3 496 578 5.91e-13 SMART
FN3 594 675 2.87e-2 SMART
transmembrane domain 696 718 N/A INTRINSIC
low complexity region 741 757 N/A INTRINSIC
low complexity region 789 812 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
PHENOTYPE: A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit exhibit increased proliferation rate and clonogenic frequency in spinal cord-derived neurospheres. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik G T 16: 4,682,514 (GRCm39) G215V probably benign Het
Adamts1 C A 16: 85,594,683 (GRCm39) G652C probably damaging Het
Adck1 G A 12: 88,368,887 (GRCm39) A122T possibly damaging Het
Akap1 A C 11: 88,736,659 (GRCm39) M34R probably damaging Het
Apc2 C T 10: 80,147,030 (GRCm39) R695C probably damaging Het
Apon T A 10: 128,090,384 (GRCm39) W21R probably benign Het
Arhgef16 T C 4: 154,371,432 (GRCm39) T254A probably benign Het
Arid5b T A 10: 67,933,632 (GRCm39) S757C probably damaging Het
B020004C17Rik A C 14: 57,254,242 (GRCm39) I122L possibly damaging Het
Bckdhb T G 9: 83,892,379 (GRCm39) V270G probably damaging Het
Cacna1d A G 14: 29,821,145 (GRCm39) Y1146H probably benign Het
Carmil2 A G 8: 106,423,668 (GRCm39) D1214G possibly damaging Het
Ccdc142 T C 6: 83,084,912 (GRCm39) V636A probably benign Het
Chd9 T C 8: 91,704,178 (GRCm39) probably null Het
Csmd3 A G 15: 47,561,569 (GRCm39) S1336P Het
Cubn A G 2: 13,352,961 (GRCm39) Y1926H probably damaging Het
Dock4 A T 12: 40,867,735 (GRCm39) D1437V probably damaging Het
Eme1 A T 11: 94,536,666 (GRCm39) Y504* probably null Het
Enah G A 1: 181,746,009 (GRCm39) A687V unknown Het
Endou A C 15: 97,611,747 (GRCm39) V339G probably damaging Het
Ephb6 G A 6: 41,591,539 (GRCm39) R232H probably benign Het
Ephx2 G A 14: 66,326,968 (GRCm39) A409V possibly damaging Het
Esd T A 14: 74,983,007 (GRCm39) C219* probably null Het
Fscb A T 12: 64,520,866 (GRCm39) M200K probably benign Het
Gabra6 A T 11: 42,208,508 (GRCm39) V108D probably damaging Het
Gm11555 A G 11: 99,540,568 (GRCm39) V137A unknown Het
Gpld1 A G 13: 25,146,383 (GRCm39) D209G probably damaging Het
Ikzf1 T A 11: 11,719,256 (GRCm39) I408N probably damaging Het
Itgb4 A G 11: 115,894,536 (GRCm39) R1364G possibly damaging Het
Kif26b A C 1: 178,506,509 (GRCm39) K195T probably damaging Het
Mfsd12 T C 10: 81,199,427 (GRCm39) W440R probably benign Het
Mtrr C T 13: 68,718,146 (GRCm39) E373K probably damaging Het
Mug2 T A 6: 122,058,317 (GRCm39) V1293E probably damaging Het
Myof C A 19: 37,928,346 (GRCm39) A1068S probably benign Het
Nova2 G T 7: 18,692,176 (GRCm39) G435V Het
Oacyl T A 18: 65,843,631 (GRCm39) D109E probably damaging Het
Or2y1g A T 11: 49,171,463 (GRCm39) M163L probably benign Het
Or56a4 G A 7: 104,806,232 (GRCm39) S219F probably damaging Het
Pdcd11 G A 19: 47,101,637 (GRCm39) V941M possibly damaging Het
Pdzd8 C A 19: 59,288,358 (GRCm39) R1014L probably damaging Het
Ppm1h T G 10: 122,740,018 (GRCm39) D364E probably benign Het
Rigi C A 4: 40,225,104 (GRCm39) A298S probably damaging Het
Rp1 T C 1: 4,415,107 (GRCm39) N2002D probably benign Het
Sall1 C T 8: 89,768,979 (GRCm39) probably null Het
Scn10a C T 9: 119,477,198 (GRCm39) W728* probably null Het
Setdb2 G T 14: 59,656,813 (GRCm39) T168K probably damaging Het
Sgms1 T C 19: 32,137,276 (GRCm39) I97V probably benign Het
Slc8a3 A T 12: 81,361,325 (GRCm39) M498K probably benign Het
Smpd4 A T 16: 17,456,497 (GRCm39) E362D probably damaging Het
Ssc5d A T 7: 4,940,529 (GRCm39) K881* probably null Het
Strn4 A G 7: 16,564,309 (GRCm39) E313G probably damaging Het
Tas2r113 A T 6: 132,870,890 (GRCm39) N306I possibly damaging Het
Tdrd6 G T 17: 43,935,730 (GRCm39) R1773S probably benign Het
Thbs2 T C 17: 14,897,321 (GRCm39) E729G probably damaging Het
Tnfrsf23 G A 7: 143,224,572 (GRCm39) T135I probably damaging Het
Tollip A G 7: 141,438,276 (GRCm39) M218T probably benign Het
Tyk2 A T 9: 21,031,554 (GRCm39) probably null Het
Ubr2 G A 17: 47,296,974 (GRCm39) R269C probably damaging Het
Uggt1 A T 1: 36,185,806 (GRCm39) M1459K possibly damaging Het
Upf1 A G 8: 70,786,730 (GRCm39) V929A probably benign Het
Usp48 T C 4: 137,321,763 (GRCm39) S24P probably benign Het
Vmn1r214 G A 13: 23,218,631 (GRCm39) E42K not run Het
Vmn1r83 G T 7: 12,055,360 (GRCm39) D232E probably benign Het
Vmn2r25 C T 6: 123,800,339 (GRCm39) V668I probably damaging Het
Vmn2r6 A G 3: 64,463,991 (GRCm39) I281T probably damaging Het
Ywhag A T 5: 135,940,043 (GRCm39) Y184N probably damaging Het
Zdbf2 A C 1: 63,347,535 (GRCm39) E1971D possibly damaging Het
Zfp568 G A 7: 29,722,839 (GRCm39) A595T possibly damaging Het
Zfy2 T C Y: 2,117,083 (GRCm39) D248G probably benign Het
Other mutations in Ncam2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01138:Ncam2 APN 16 81,314,467 (GRCm39) missense probably damaging 1.00
IGL01369:Ncam2 APN 16 81,258,459 (GRCm39) missense probably benign 0.09
IGL01554:Ncam2 APN 16 81,309,823 (GRCm39) missense possibly damaging 0.88
IGL01892:Ncam2 APN 16 81,386,587 (GRCm39) missense possibly damaging 0.71
IGL02320:Ncam2 APN 16 81,231,725 (GRCm39) missense probably damaging 0.99
IGL02669:Ncam2 APN 16 81,314,429 (GRCm39) missense probably benign 0.18
IGL03073:Ncam2 APN 16 81,418,235 (GRCm39) missense possibly damaging 0.70
IGL03353:Ncam2 APN 16 81,231,788 (GRCm39) missense probably benign 0.04
BB009:Ncam2 UTSW 16 81,412,708 (GRCm39) missense probably damaging 0.99
BB019:Ncam2 UTSW 16 81,412,708 (GRCm39) missense probably damaging 0.99
R0087:Ncam2 UTSW 16 81,231,789 (GRCm39) missense probably benign 0.11
R0097:Ncam2 UTSW 16 81,314,425 (GRCm39) missense probably damaging 1.00
R0276:Ncam2 UTSW 16 81,314,517 (GRCm39) splice site probably benign
R0279:Ncam2 UTSW 16 81,420,225 (GRCm39) splice site probably benign
R0471:Ncam2 UTSW 16 80,997,772 (GRCm39) start gained probably benign
R0523:Ncam2 UTSW 16 81,258,531 (GRCm39) missense probably damaging 0.99
R1353:Ncam2 UTSW 16 80,997,803 (GRCm39) start codon destroyed probably null
R1646:Ncam2 UTSW 16 81,262,594 (GRCm39) critical splice donor site probably benign
R1884:Ncam2 UTSW 16 81,234,571 (GRCm39) missense probably damaging 1.00
R2002:Ncam2 UTSW 16 81,386,586 (GRCm39) missense possibly damaging 0.70
R2157:Ncam2 UTSW 16 81,287,277 (GRCm39) missense probably damaging 1.00
R2330:Ncam2 UTSW 16 81,309,809 (GRCm39) missense probably benign 0.17
R2404:Ncam2 UTSW 16 81,287,128 (GRCm39) splice site probably benign
R2434:Ncam2 UTSW 16 81,392,113 (GRCm39) missense probably benign 0.01
R3104:Ncam2 UTSW 16 81,262,598 (GRCm39) splice site probably benign
R3842:Ncam2 UTSW 16 81,231,698 (GRCm39) missense probably damaging 1.00
R3954:Ncam2 UTSW 16 81,386,612 (GRCm39) missense probably damaging 1.00
R4039:Ncam2 UTSW 16 81,287,211 (GRCm39) missense probably benign 0.02
R4210:Ncam2 UTSW 16 81,323,991 (GRCm39) missense probably benign 0.02
R4514:Ncam2 UTSW 16 81,309,884 (GRCm39) missense probably benign 0.13
R4583:Ncam2 UTSW 16 81,314,445 (GRCm39) missense probably damaging 1.00
R4586:Ncam2 UTSW 16 81,262,457 (GRCm39) missense probably benign 0.06
R4710:Ncam2 UTSW 16 81,262,594 (GRCm39) critical splice donor site probably null
R4732:Ncam2 UTSW 16 81,231,772 (GRCm39) missense possibly damaging 0.63
R4733:Ncam2 UTSW 16 81,231,772 (GRCm39) missense possibly damaging 0.63
R4876:Ncam2 UTSW 16 81,287,234 (GRCm39) missense probably benign 0.27
R4923:Ncam2 UTSW 16 81,386,679 (GRCm39) missense possibly damaging 0.48
R5131:Ncam2 UTSW 16 81,234,550 (GRCm39) missense probably benign 0.44
R5329:Ncam2 UTSW 16 81,231,707 (GRCm39) missense probably damaging 1.00
R5478:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5479:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5481:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5519:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5522:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5523:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5524:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5526:Ncam2 UTSW 16 81,231,766 (GRCm39) nonsense probably null
R5718:Ncam2 UTSW 16 81,386,702 (GRCm39) splice site probably null
R5793:Ncam2 UTSW 16 81,372,991 (GRCm39) missense possibly damaging 0.95
R6050:Ncam2 UTSW 16 81,240,054 (GRCm39) nonsense probably null
R6212:Ncam2 UTSW 16 81,229,650 (GRCm39) missense probably damaging 1.00
R6847:Ncam2 UTSW 16 81,229,606 (GRCm39) missense probably damaging 1.00
R6935:Ncam2 UTSW 16 81,323,879 (GRCm39) missense probably benign 0.24
R7159:Ncam2 UTSW 16 81,287,262 (GRCm39) missense probably damaging 1.00
R7193:Ncam2 UTSW 16 81,386,683 (GRCm39) missense probably damaging 1.00
R7232:Ncam2 UTSW 16 81,309,759 (GRCm39) missense probably damaging 1.00
R7346:Ncam2 UTSW 16 81,420,256 (GRCm39) missense probably damaging 1.00
R7568:Ncam2 UTSW 16 81,386,689 (GRCm39) missense probably benign 0.19
R7686:Ncam2 UTSW 16 81,418,342 (GRCm39) missense probably damaging 0.99
R7848:Ncam2 UTSW 16 81,287,267 (GRCm39) missense probably benign
R7932:Ncam2 UTSW 16 81,412,708 (GRCm39) missense probably damaging 0.99
R8078:Ncam2 UTSW 16 81,240,136 (GRCm39) missense possibly damaging 0.60
R8287:Ncam2 UTSW 16 81,323,883 (GRCm39) missense probably benign 0.07
R8354:Ncam2 UTSW 16 81,309,847 (GRCm39) missense probably benign 0.00
R8429:Ncam2 UTSW 16 81,386,523 (GRCm39) missense probably damaging 1.00
R8507:Ncam2 UTSW 16 81,309,867 (GRCm39) missense possibly damaging 0.63
R8546:Ncam2 UTSW 16 81,314,419 (GRCm39) missense probably benign 0.21
R8775:Ncam2 UTSW 16 81,314,429 (GRCm39) missense probably benign 0.18
R8775-TAIL:Ncam2 UTSW 16 81,314,429 (GRCm39) missense probably benign 0.18
R9082:Ncam2 UTSW 16 81,412,660 (GRCm39) missense probably damaging 1.00
R9346:Ncam2 UTSW 16 81,252,204 (GRCm39) missense probably benign 0.07
R9386:Ncam2 UTSW 16 81,252,252 (GRCm39) missense probably damaging 1.00
R9498:Ncam2 UTSW 16 81,309,887 (GRCm39) missense probably benign 0.03
R9510:Ncam2 UTSW 16 81,420,341 (GRCm39) makesense probably null
R9587:Ncam2 UTSW 16 81,262,501 (GRCm39) missense probably benign 0.00
R9616:Ncam2 UTSW 16 81,240,142 (GRCm39) missense probably damaging 1.00
R9642:Ncam2 UTSW 16 81,418,251 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGGATTAAGTTGCCACTCACTAC -3'
(R):5'- AAGTTGTACTTGTGCTCCACTC -3'

Sequencing Primer
(F):5'- GTTGCCACTCACTACTCCATATTTTC -3'
(R):5'- CCACTCATGGGAGGTGGTG -3'
Posted On 2019-11-26