Incidental Mutation 'R7760:Or2t6'
ID 597816
Institutional Source Beutler Lab
Gene Symbol Or2t6
Ensembl Gene ENSMUSG00000052417
Gene Name olfactory receptor family 2 subfamily T member 6
Synonyms Olfr720, MOR274-2, GA_x6K02T2PLTE-6544896-6543946
MMRRC Submission 045816-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.286) question?
Stock # R7760 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 8293683-8294633 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 14175905 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 59 (Y59C)
Ref Sequence ENSEMBL: ENSMUSP00000146132 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035250] [ENSMUST00000206298] [ENSMUST00000216079] [ENSMUST00000217642]
AlphaFold Q8VF37
Predicted Effect probably damaging
Transcript: ENSMUST00000035250
AA Change: Y59C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046509
Gene: ENSMUSG00000052417
AA Change: Y59C

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 8.4e-49 PFAM
Pfam:7tm_1 40 289 8.9e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206298
AA Change: Y59C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216079
AA Change: Y59C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217642
AA Change: Y59C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.3237 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa11 C T 14: 25,873,251 (GRCm39) Q162* probably null Het
Arg1 T G 10: 24,803,361 (GRCm39) probably benign Het
Arl6 T C 16: 59,439,169 (GRCm39) D175G probably damaging Het
Capg A G 6: 72,534,769 (GRCm39) R199G probably damaging Het
Ceacam1 T A 7: 25,171,450 (GRCm39) E338V probably damaging Het
Clec4d A G 6: 123,247,300 (GRCm39) N148D probably benign Het
Ctr9 T G 7: 110,645,808 (GRCm39) I653R probably damaging Het
Dmwd C T 7: 18,814,660 (GRCm39) L437F probably damaging Het
Dnah7b T A 1: 46,240,413 (GRCm39) L1510Q probably damaging Het
Efcab5 T A 11: 77,042,752 (GRCm39) E136D probably benign Het
Elfn2 C T 15: 78,558,041 (GRCm39) A169T probably benign Het
Elp1 A G 4: 56,790,892 (GRCm39) V287A probably benign Het
Esrp2 T A 8: 106,860,102 (GRCm39) E326D probably benign Het
Fbrs T C 7: 127,088,572 (GRCm39) V718A probably damaging Het
Fbxl21 C T 13: 56,684,816 (GRCm39) R307C probably benign Het
Fbxl21 T C 13: 56,674,747 (GRCm39) S33P probably benign Het
Gatad2b C T 3: 90,261,776 (GRCm39) R461W probably damaging Het
Gm19410 T A 8: 36,269,491 (GRCm39) C1109S probably damaging Het
Gm6882 T A 7: 21,161,409 (GRCm39) D153V probably damaging Het
Golga3 A G 5: 110,353,716 (GRCm39) E918G probably benign Het
Greb1 T C 12: 16,773,417 (GRCm39) N219S probably benign Het
Grpel1 G T 5: 36,627,986 (GRCm39) R89L probably damaging Het
Ighv5-12 T A 12: 113,665,795 (GRCm39) Q101L probably benign Het
Ldb3 T A 14: 34,264,460 (GRCm39) N590I probably damaging Het
Man2c1 T C 9: 57,046,647 (GRCm39) V636A probably benign Het
Mblac2 G T 13: 81,859,996 (GRCm39) V117L probably benign Het
Muc6 T A 7: 141,237,322 (GRCm39) probably null Het
Nfatc3 A G 8: 106,834,973 (GRCm39) E773G possibly damaging Het
Ngef T C 1: 87,468,495 (GRCm39) D88G probably benign Het
Nipbl T C 15: 8,388,186 (GRCm39) E478G probably damaging Het
Pbx4 C A 8: 70,285,445 (GRCm39) D29E probably benign Het
Pcdhgb5 A G 18: 37,864,690 (GRCm39) I162V not run Het
Pdcd11 G A 19: 47,101,637 (GRCm39) V941M possibly damaging Het
Pigr A T 1: 130,774,368 (GRCm39) R449S possibly damaging Het
Plcb2 T C 2: 118,541,869 (GRCm39) T914A probably benign Het
Ppp5c A G 7: 16,740,274 (GRCm39) S387P probably damaging Het
Rnf7l T C 10: 63,257,316 (GRCm39) K68R probably damaging Het
Rtkn2 T G 10: 67,841,439 (GRCm39) S196A probably damaging Het
Sec31a A G 5: 100,540,487 (GRCm39) F400L probably damaging Het
Senp7 A T 16: 55,959,442 (GRCm39) M251L probably benign Het
Slc6a5 T C 7: 49,596,365 (GRCm39) F612L probably benign Het
Slc7a9 T C 7: 35,156,500 (GRCm39) I314T possibly damaging Het
Smc5 A C 19: 23,213,254 (GRCm39) S553A probably benign Het
Spaca3 T A 11: 80,755,389 (GRCm39) V133D probably damaging Het
Taco1 T A 11: 105,963,938 (GRCm39) D232E possibly damaging Het
Tarbp1 C T 8: 127,179,546 (GRCm39) R664H not run Het
Tlk2 T C 11: 105,169,993 (GRCm39) I674T probably damaging Het
Tnxb A T 17: 34,931,911 (GRCm39) E2148V probably damaging Het
Tom1l2 T C 11: 60,165,791 (GRCm39) S59G probably benign Het
Traj46 A T 14: 54,409,813 (GRCm39) H7L Het
Traj46 T G 14: 54,409,814 (GRCm39) H7Q Het
Trav6-4 T A 14: 53,692,103 (GRCm39) L70Q possibly damaging Het
Trmt1l C T 1: 151,318,425 (GRCm39) T245I possibly damaging Het
Wac T A 18: 7,921,913 (GRCm39) C601S probably benign Het
Wnt3 T A 11: 103,702,266 (GRCm39) H145Q probably benign Het
Zfp948 T C 17: 21,808,628 (GRCm39) C607R probably damaging Het
Other mutations in Or2t6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02658:Or2t6 APN 14 14,175,732 (GRCm38) missense possibly damaging 0.92
IGL02704:Or2t6 APN 14 14,175,483 (GRCm38) missense probably benign 0.00
IGL03308:Or2t6 APN 14 14,175,161 (GRCm38) missense probably benign
IGL03331:Or2t6 APN 14 14,176,017 (GRCm38) missense probably benign 0.16
R0008:Or2t6 UTSW 14 14,176,092 (GRCm38) start gained probably benign
R0131:Or2t6 UTSW 14 14,175,620 (GRCm38) missense probably benign 0.03
R0647:Or2t6 UTSW 14 14,175,858 (GRCm38) missense probably benign 0.35
R0747:Or2t6 UTSW 14 14,175,429 (GRCm38) missense probably benign 0.01
R1210:Or2t6 UTSW 14 14,176,029 (GRCm38) missense probably benign 0.00
R1225:Or2t6 UTSW 14 14,175,600 (GRCm38) missense possibly damaging 0.89
R1525:Or2t6 UTSW 14 14,175,725 (GRCm38) missense probably damaging 1.00
R1975:Or2t6 UTSW 14 14,175,446 (GRCm38) missense probably damaging 1.00
R1994:Or2t6 UTSW 14 14,175,854 (GRCm38) missense probably benign 0.16
R2310:Or2t6 UTSW 14 14,175,836 (GRCm38) missense probably benign 0.03
R3151:Or2t6 UTSW 14 14,175,203 (GRCm38) missense probably damaging 1.00
R4547:Or2t6 UTSW 14 14,175,854 (GRCm38) missense probably damaging 0.99
R4824:Or2t6 UTSW 14 14,175,885 (GRCm38) missense probably damaging 1.00
R5063:Or2t6 UTSW 14 14,175,593 (GRCm38) missense probably damaging 1.00
R5098:Or2t6 UTSW 14 14,175,683 (GRCm38) missense probably benign 0.03
R5430:Or2t6 UTSW 14 14,175,692 (GRCm38) missense probably benign 0.03
R5512:Or2t6 UTSW 14 14,175,633 (GRCm38) missense probably damaging 1.00
R5748:Or2t6 UTSW 14 14,175,314 (GRCm38) missense probably damaging 1.00
R7200:Or2t6 UTSW 14 14,175,477 (GRCm38) missense probably damaging 1.00
R7407:Or2t6 UTSW 14 14,175,402 (GRCm38) missense probably benign
R7666:Or2t6 UTSW 14 14,176,075 (GRCm38) missense probably benign
R8118:Or2t6 UTSW 14 14,175,863 (GRCm38) missense probably damaging 1.00
R8413:Or2t6 UTSW 14 14,175,416 (GRCm38) missense probably benign 0.00
R8873:Or2t6 UTSW 14 14,175,344 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATAGGCCATAAGTCCCAGCAG -3'
(R):5'- GCACTTGACAACAAAGGAGTC -3'

Sequencing Primer
(F):5'- TCCCAGCAGGAAGAACTCGG -3'
(R):5'- GACAACAAAGGAGTCTCATACATTTG -3'
Posted On 2019-11-26