Incidental Mutation 'R7763:Plxna4'
| ID |
598010 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxna4
|
| Ensembl Gene |
ENSMUSG00000029765 |
| Gene Name |
plexin A4 |
| Synonyms |
Plxa4 |
| MMRRC Submission |
045819-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.600)
|
| Stock # |
R7763 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
32121478-32565127 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 32200915 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 753
(R753H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110748
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115096]
|
| AlphaFold |
Q80UG2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115096
AA Change: R753H
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000110748
Gene: ENSMUSG00000029765
AA Change: R753H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Sema
|
50 |
490 |
2.3e-131 |
SMART |
|
PSI
|
508 |
558 |
2.21e-14 |
SMART |
|
PSI
|
654 |
701 |
2.44e-7 |
SMART |
|
PSI
|
802 |
855 |
1.2e-6 |
SMART |
|
IPT
|
856 |
950 |
7.25e-16 |
SMART |
|
IPT
|
952 |
1036 |
4.1e-15 |
SMART |
|
IPT
|
1038 |
1138 |
2.86e-14 |
SMART |
|
IPT
|
1140 |
1229 |
6.88e-1 |
SMART |
|
transmembrane domain
|
1237 |
1259 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1310 |
1863 |
1.8e-264 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mice exhibit defective trajecotory and projection of peripheral sensory axons and sympathetic ganglion axons and the formation of the anterior commissure and the barrels. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Targeted, knock-out(2) |
| Other mutations in this stock |
Total: 111 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
T |
A |
7: 120,113,825 (GRCm39) |
W899R |
probably damaging |
Het |
| Abca5 |
A |
T |
11: 110,163,323 (GRCm39) |
W1631R |
possibly damaging |
Het |
| Actg2 |
T |
A |
6: 83,504,350 (GRCm39) |
D25V |
probably damaging |
Het |
| Akap10 |
G |
C |
11: 61,806,331 (GRCm39) |
D132E |
probably damaging |
Het |
| Angptl2 |
G |
T |
2: 33,132,394 (GRCm39) |
E334* |
probably null |
Het |
| Aprt |
T |
C |
8: 123,301,674 (GRCm39) |
R165G |
probably benign |
Het |
| Bmp1 |
A |
G |
14: 70,729,524 (GRCm39) |
F549S |
probably damaging |
Het |
| Capzb |
C |
T |
4: 139,007,864 (GRCm39) |
T215I |
probably benign |
Het |
| Car14 |
C |
T |
3: 95,811,684 (GRCm39) |
M1I |
probably null |
Het |
| Ccdc148 |
T |
A |
2: 58,713,648 (GRCm39) |
Q501L |
probably benign |
Het |
| Ccdc32 |
G |
A |
2: 118,857,828 (GRCm39) |
T12I |
probably damaging |
Het |
| Ccnf |
G |
A |
17: 24,443,986 (GRCm39) |
S594L |
probably damaging |
Het |
| Cdadc1 |
C |
T |
14: 59,811,283 (GRCm39) |
C409Y |
probably damaging |
Het |
| Cdh23 |
G |
T |
10: 60,148,356 (GRCm39) |
S2670R |
probably damaging |
Het |
| Cdh8 |
T |
A |
8: 100,006,306 (GRCm39) |
K94* |
probably null |
Het |
| Cdhr2 |
A |
T |
13: 54,865,505 (GRCm39) |
Y193F |
probably damaging |
Het |
| Cdon |
T |
A |
9: 35,365,711 (GRCm39) |
Y153* |
probably null |
Het |
| Chd1 |
G |
A |
17: 15,953,303 (GRCm39) |
G413R |
probably damaging |
Het |
| Cit |
A |
T |
5: 116,125,060 (GRCm39) |
T1582S |
probably benign |
Het |
| Clec4a3 |
T |
C |
6: 122,941,299 (GRCm39) |
L98P |
probably benign |
Het |
| Cpa4 |
T |
A |
6: 30,583,644 (GRCm39) |
D253E |
probably damaging |
Het |
| Cyp2c40 |
T |
A |
19: 39,795,612 (GRCm39) |
N189I |
possibly damaging |
Het |
| Daam2 |
G |
T |
17: 49,797,050 (GRCm39) |
A245E |
probably benign |
Het |
| Dennd5b |
A |
G |
6: 148,970,156 (GRCm39) |
F121S |
probably damaging |
Het |
| Dgkd |
A |
G |
1: 87,854,671 (GRCm39) |
T658A |
probably benign |
Het |
| Dmwd |
T |
A |
7: 18,814,265 (GRCm39) |
L305Q |
probably damaging |
Het |
| Dnah5 |
A |
T |
15: 28,314,001 (GRCm39) |
Y1939F |
probably damaging |
Het |
| Dock5 |
T |
C |
14: 68,058,776 (GRCm39) |
T512A |
probably damaging |
Het |
| Dop1b |
T |
A |
16: 93,552,402 (GRCm39) |
D398E |
probably benign |
Het |
| Eef1akmt4 |
A |
G |
16: 20,437,279 (GRCm39) |
H207R |
probably damaging |
Het |
| Egfr |
T |
C |
11: 16,841,266 (GRCm39) |
V719A |
probably damaging |
Het |
| Ep300 |
A |
T |
15: 81,470,784 (GRCm39) |
|
probably benign |
Het |
| Epha4 |
A |
G |
1: 77,366,668 (GRCm39) |
|
probably null |
Het |
| Erc2 |
T |
G |
14: 27,598,161 (GRCm39) |
|
probably null |
Het |
| Ergic1 |
A |
T |
17: 26,857,801 (GRCm39) |
Y209F |
possibly damaging |
Het |
| Fbxw28 |
A |
G |
9: 109,155,701 (GRCm39) |
I357T |
probably damaging |
Het |
| Flnb |
A |
T |
14: 7,926,478 (GRCm38) |
T1841S |
probably benign |
Het |
| Foxc1 |
G |
A |
13: 31,992,011 (GRCm39) |
S274N |
probably benign |
Het |
| Fto |
C |
T |
8: 92,136,071 (GRCm39) |
T115M |
probably damaging |
Het |
| Gm10228 |
C |
G |
16: 88,838,187 (GRCm39) |
C39S |
unknown |
Het |
| Gm7334 |
T |
C |
17: 51,005,743 (GRCm39) |
F10L |
possibly damaging |
Het |
| Hfm1 |
A |
G |
5: 107,029,727 (GRCm39) |
Y785H |
probably damaging |
Het |
| Hivep1 |
T |
A |
13: 42,312,937 (GRCm39) |
S1726T |
probably benign |
Het |
| Htt |
G |
T |
5: 35,009,534 (GRCm39) |
C1505F |
probably damaging |
Het |
| Hydin |
T |
C |
8: 111,232,475 (GRCm39) |
S1665P |
possibly damaging |
Het |
| Ifi209 |
T |
A |
1: 173,470,445 (GRCm39) |
N344K |
probably damaging |
Het |
| Ifnar2 |
T |
C |
16: 91,196,181 (GRCm39) |
M262T |
probably benign |
Het |
| Ighv7-3 |
T |
A |
12: 114,116,827 (GRCm39) |
S112C |
probably damaging |
Het |
| Igkv4-86 |
A |
G |
6: 68,887,563 (GRCm39) |
S59P |
probably benign |
Het |
| Iglv1 |
A |
G |
16: 18,904,239 (GRCm39) |
|
probably benign |
Het |
| Ipo7 |
T |
A |
7: 109,652,006 (GRCm39) |
D928E |
possibly damaging |
Het |
| Itgae |
G |
T |
11: 73,014,095 (GRCm39) |
|
probably null |
Het |
| Kbtbd12 |
T |
A |
6: 88,595,179 (GRCm39) |
Q217L |
probably benign |
Het |
| Kcnma1 |
T |
A |
14: 23,350,074 (GRCm39) |
Y1155F |
possibly damaging |
Het |
| Kif14 |
A |
G |
1: 136,444,121 (GRCm39) |
E1371G |
probably benign |
Het |
| Lilrb4a |
A |
T |
10: 51,367,142 (GRCm39) |
Y10F |
probably benign |
Het |
| Lrp2 |
A |
T |
2: 69,333,732 (GRCm39) |
V1503E |
probably damaging |
Het |
| Mfsd6 |
A |
T |
1: 52,747,799 (GRCm39) |
D355E |
probably benign |
Het |
| Mri1 |
T |
C |
8: 84,977,657 (GRCm39) |
H226R |
|
Het |
| Mroh4 |
C |
T |
15: 74,496,554 (GRCm39) |
E278K |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,574,739 (GRCm39) |
L1063H |
probably benign |
Het |
| Mzf1 |
A |
T |
7: 12,778,018 (GRCm39) |
I541N |
probably damaging |
Het |
| Nasp |
T |
A |
4: 116,469,230 (GRCm39) |
E116D |
probably benign |
Het |
| Nlrp10 |
T |
A |
7: 108,525,033 (GRCm39) |
E149V |
probably damaging |
Het |
| Notch4 |
G |
A |
17: 34,801,392 (GRCm39) |
C1080Y |
probably damaging |
Het |
| Nova1 |
T |
G |
12: 46,767,481 (GRCm39) |
I147L |
unknown |
Het |
| Ogdh |
A |
G |
11: 6,288,558 (GRCm39) |
M223V |
probably benign |
Het |
| Or2a56 |
T |
C |
6: 42,932,723 (GRCm39) |
I97T |
probably benign |
Het |
| Or2y1e |
G |
T |
11: 49,218,498 (GRCm39) |
A87S |
probably benign |
Het |
| Or4n4 |
A |
T |
14: 50,518,945 (GRCm39) |
I255N |
probably damaging |
Het |
| Or6c66b |
G |
T |
10: 129,377,324 (GRCm39) |
R306L |
probably benign |
Het |
| P3h3 |
T |
C |
6: 124,831,395 (GRCm39) |
Q330R |
probably benign |
Het |
| Pcdhb10 |
A |
G |
18: 37,544,935 (GRCm39) |
T4A |
not run |
Het |
| Pkd2l2 |
A |
T |
18: 34,566,340 (GRCm39) |
|
probably null |
Het |
| Plekhb1 |
C |
T |
7: 100,294,870 (GRCm39) |
V168I |
probably benign |
Het |
| Pramel17 |
T |
C |
4: 101,694,338 (GRCm39) |
I182V |
possibly damaging |
Het |
| Prex1 |
G |
C |
2: 166,555,629 (GRCm39) |
P4A |
unknown |
Het |
| Ptgdr |
A |
G |
14: 45,096,535 (GRCm39) |
V59A |
probably damaging |
Het |
| Ralgapa1 |
T |
A |
12: 55,804,740 (GRCm39) |
I519F |
probably benign |
Het |
| Rbpms |
A |
G |
8: 34,279,481 (GRCm39) |
I170T |
probably benign |
Het |
| Sec31b |
T |
A |
19: 44,512,274 (GRCm39) |
|
probably null |
Het |
| Skint11 |
A |
T |
4: 114,084,905 (GRCm39) |
Y138F |
probably benign |
Het |
| Slain2 |
A |
G |
5: 73,105,953 (GRCm39) |
Y196C |
probably damaging |
Het |
| Slco1b2 |
T |
A |
6: 141,621,950 (GRCm39) |
C503* |
probably null |
Het |
| Slfn3 |
A |
T |
11: 83,105,614 (GRCm39) |
Y537F |
possibly damaging |
Het |
| Slu7 |
T |
C |
11: 43,335,592 (GRCm39) |
Y443H |
probably damaging |
Het |
| Sorl1 |
T |
A |
9: 41,955,205 (GRCm39) |
E683D |
probably damaging |
Het |
| Sos1 |
T |
A |
17: 80,721,142 (GRCm39) |
I893L |
probably benign |
Het |
| St8sia2 |
T |
A |
7: 73,593,069 (GRCm39) |
Y329F |
probably damaging |
Het |
| Stra6l |
C |
A |
4: 45,869,570 (GRCm39) |
S212* |
probably null |
Het |
| Syne3 |
C |
T |
12: 104,963,754 (GRCm39) |
|
probably benign |
Het |
| Tenm4 |
T |
A |
7: 96,544,899 (GRCm39) |
I2342N |
probably benign |
Het |
| Tescl |
T |
A |
7: 24,032,688 (GRCm39) |
E212D |
probably benign |
Het |
| Trip11 |
A |
G |
12: 101,811,114 (GRCm39) |
S1879P |
probably benign |
Het |
| Ube2c |
A |
T |
2: 164,613,211 (GRCm39) |
|
probably null |
Het |
| Umodl1 |
T |
A |
17: 31,205,430 (GRCm39) |
I675N |
probably benign |
Het |
| Vipr2 |
T |
C |
12: 116,086,338 (GRCm39) |
F121S |
probably damaging |
Het |
| Vmn1r206 |
A |
T |
13: 22,804,839 (GRCm39) |
S123T |
possibly damaging |
Het |
| Vmn1r58 |
A |
G |
7: 5,413,912 (GRCm39) |
V106A |
probably damaging |
Het |
| Vmn2r112 |
A |
G |
17: 22,822,099 (GRCm39) |
Y259C |
probably damaging |
Het |
| Vmn2r66 |
T |
C |
7: 84,654,909 (GRCm39) |
K467E |
probably benign |
Het |
| Vmn2r98 |
T |
C |
17: 19,300,797 (GRCm39) |
F600L |
probably benign |
Het |
| Vps13a |
T |
A |
19: 16,723,364 (GRCm39) |
N278I |
possibly damaging |
Het |
| Vwa5a |
A |
C |
9: 38,652,458 (GRCm39) |
D747A |
possibly damaging |
Het |
| Xdh |
G |
A |
17: 74,241,829 (GRCm39) |
P157S |
possibly damaging |
Het |
| Xrn1 |
G |
A |
9: 95,880,401 (GRCm39) |
|
probably null |
Het |
| Zfp362 |
T |
A |
4: 128,680,824 (GRCm39) |
H180L |
probably benign |
Het |
| Zfp560 |
A |
T |
9: 20,258,619 (GRCm39) |
W748R |
possibly damaging |
Het |
| Zfp808 |
A |
T |
13: 62,320,478 (GRCm39) |
Q569L |
probably benign |
Het |
| Zfp93 |
T |
A |
7: 23,974,643 (GRCm39) |
D209E |
possibly damaging |
Het |
| Zftraf1 |
A |
T |
15: 76,542,747 (GRCm39) |
Y138N |
probably damaging |
Het |
|
| Other mutations in Plxna4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Plxna4
|
APN |
6 |
32,139,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01395:Plxna4
|
APN |
6 |
32,216,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01506:Plxna4
|
APN |
6 |
32,493,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01606:Plxna4
|
APN |
6 |
32,134,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Plxna4
|
APN |
6 |
32,287,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01767:Plxna4
|
APN |
6 |
32,214,613 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01968:Plxna4
|
APN |
6 |
32,192,139 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02109:Plxna4
|
APN |
6 |
32,192,576 (GRCm39) |
missense |
probably benign |
|
|
IGL02299:Plxna4
|
APN |
6 |
32,142,091 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02306:Plxna4
|
APN |
6 |
32,183,059 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02312:Plxna4
|
APN |
6 |
32,142,052 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02326:Plxna4
|
APN |
6 |
32,129,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02658:Plxna4
|
APN |
6 |
32,162,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02683:Plxna4
|
APN |
6 |
32,494,541 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02701:Plxna4
|
APN |
6 |
32,494,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02995:Plxna4
|
APN |
6 |
32,493,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03030:Plxna4
|
APN |
6 |
32,179,160 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03264:Plxna4
|
APN |
6 |
32,155,337 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03304:Plxna4
|
APN |
6 |
32,141,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL03382:Plxna4
|
APN |
6 |
32,179,129 (GRCm39) |
missense |
probably benign |
0.23 |
|
corona
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Disposed
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
inclined
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
Slope
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
G4846:Plxna4
|
UTSW |
6 |
32,169,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0133:Plxna4
|
UTSW |
6 |
32,174,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0200:Plxna4
|
UTSW |
6 |
32,174,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0308:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0468:Plxna4
|
UTSW |
6 |
32,192,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Plxna4
|
UTSW |
6 |
32,179,054 (GRCm39) |
missense |
probably benign |
|
|
R0542:Plxna4
|
UTSW |
6 |
32,169,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0548:Plxna4
|
UTSW |
6 |
32,134,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Plxna4
|
UTSW |
6 |
32,162,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1144:Plxna4
|
UTSW |
6 |
32,174,091 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1190:Plxna4
|
UTSW |
6 |
32,228,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1228:Plxna4
|
UTSW |
6 |
32,201,087 (GRCm39) |
splice site |
probably null |
|
|
R1569:Plxna4
|
UTSW |
6 |
32,162,410 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1803:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1832:Plxna4
|
UTSW |
6 |
32,174,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2068:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2157:Plxna4
|
UTSW |
6 |
32,493,909 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2842:Plxna4
|
UTSW |
6 |
32,192,566 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2849:Plxna4
|
UTSW |
6 |
32,162,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2892:Plxna4
|
UTSW |
6 |
32,493,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Plxna4
|
UTSW |
6 |
32,142,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Plxna4
|
UTSW |
6 |
32,192,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Plxna4
|
UTSW |
6 |
32,213,300 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Plxna4
|
UTSW |
6 |
32,177,883 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4307:Plxna4
|
UTSW |
6 |
32,140,444 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4331:Plxna4
|
UTSW |
6 |
32,127,480 (GRCm39) |
nonsense |
probably null |
|
|
R4478:Plxna4
|
UTSW |
6 |
32,173,068 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4529:Plxna4
|
UTSW |
6 |
32,473,831 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4566:Plxna4
|
UTSW |
6 |
32,494,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4568:Plxna4
|
UTSW |
6 |
32,129,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4685:Plxna4
|
UTSW |
6 |
32,142,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Plxna4
|
UTSW |
6 |
32,493,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4939:Plxna4
|
UTSW |
6 |
32,142,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Plxna4
|
UTSW |
6 |
32,201,094 (GRCm39) |
splice site |
probably null |
|
|
R5181:Plxna4
|
UTSW |
6 |
32,493,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Plxna4
|
UTSW |
6 |
32,228,007 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5259:Plxna4
|
UTSW |
6 |
32,493,956 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5306:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5487:Plxna4
|
UTSW |
6 |
32,494,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Plxna4
|
UTSW |
6 |
32,155,293 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5542:Plxna4
|
UTSW |
6 |
32,183,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5567:Plxna4
|
UTSW |
6 |
32,134,915 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5634:Plxna4
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
R5653:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5665:Plxna4
|
UTSW |
6 |
32,192,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5845:Plxna4
|
UTSW |
6 |
32,214,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Plxna4
|
UTSW |
6 |
32,494,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5938:Plxna4
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5973:Plxna4
|
UTSW |
6 |
32,228,000 (GRCm39) |
splice site |
probably null |
|
|
R6433:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6482:Plxna4
|
UTSW |
6 |
32,493,672 (GRCm39) |
missense |
probably benign |
|
|
R6560:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6721:Plxna4
|
UTSW |
6 |
32,177,794 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6810:Plxna4
|
UTSW |
6 |
32,287,457 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6985:Plxna4
|
UTSW |
6 |
32,214,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7024:Plxna4
|
UTSW |
6 |
32,169,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7046:Plxna4
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7137:Plxna4
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Plxna4
|
UTSW |
6 |
32,473,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7199:Plxna4
|
UTSW |
6 |
32,192,113 (GRCm39) |
nonsense |
probably null |
|
|
R7248:Plxna4
|
UTSW |
6 |
32,139,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7260:Plxna4
|
UTSW |
6 |
32,216,455 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7361:Plxna4
|
UTSW |
6 |
32,173,057 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7383:Plxna4
|
UTSW |
6 |
32,129,734 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7405:Plxna4
|
UTSW |
6 |
32,173,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7635:Plxna4
|
UTSW |
6 |
32,473,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7754:Plxna4
|
UTSW |
6 |
32,129,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7789:Plxna4
|
UTSW |
6 |
32,183,168 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8167:Plxna4
|
UTSW |
6 |
32,493,981 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8191:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8225:Plxna4
|
UTSW |
6 |
32,139,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8284:Plxna4
|
UTSW |
6 |
32,129,789 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8305:Plxna4
|
UTSW |
6 |
32,188,000 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8438:Plxna4
|
UTSW |
6 |
32,179,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8493:Plxna4
|
UTSW |
6 |
32,192,647 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8714:Plxna4
|
UTSW |
6 |
32,140,379 (GRCm39) |
nonsense |
probably null |
|
|
R8759:Plxna4
|
UTSW |
6 |
32,169,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8822:Plxna4
|
UTSW |
6 |
32,127,431 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8844:Plxna4
|
UTSW |
6 |
32,174,026 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8974:Plxna4
|
UTSW |
6 |
32,216,447 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9020:Plxna4
|
UTSW |
6 |
32,211,497 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9144:Plxna4
|
UTSW |
6 |
32,162,496 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9206:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9208:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9257:Plxna4
|
UTSW |
6 |
32,139,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9269:Plxna4
|
UTSW |
6 |
32,155,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Plxna4
|
UTSW |
6 |
32,159,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9469:Plxna4
|
UTSW |
6 |
32,494,526 (GRCm39) |
missense |
probably benign |
|
|
R9583:Plxna4
|
UTSW |
6 |
32,192,169 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9647:Plxna4
|
UTSW |
6 |
32,228,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9695:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9801:Plxna4
|
UTSW |
6 |
32,140,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
V1024:Plxna4
|
UTSW |
6 |
32,211,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Plxna4
|
UTSW |
6 |
32,493,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAATGGCTACAATCAGAGTTCACAG -3'
(R):5'- AAGCTGAGCCATGCCTTCTG -3'
Sequencing Primer
(F):5'- CTACAATCAGAGTTCACAGCTAGTAG -3'
(R):5'- ATGCCTTCTGTCCCCAGG -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation