Mutagenetix > Incidental Mutation

Incidental Mutation 'R7763:Vmn2r98'

598084

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

045819-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

R7763 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19080535 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 600 (F600L)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: F600L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: F600L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 111 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	A	7: 120,514,602 (GRCm38)	W899R	probably damaging	Het
Abca5	A	T	11: 110,272,497 (GRCm38)	W1631R	possibly damaging	Het
Actg2	T	A	6: 83,527,368 (GRCm38)	D25V	probably damaging	Het
Akap10	G	C	11: 61,915,505 (GRCm38)	D132E	probably damaging	Het
Angptl2	G	T	2: 33,242,382 (GRCm38)	E334*	probably null	Het
Aprt	T	C	8: 122,574,935 (GRCm38)	R165G	probably benign	Het
B020004J07Rik	T	C	4: 101,837,141 (GRCm38)	I182V	possibly damaging	Het
Bmp1	A	G	14: 70,492,084 (GRCm38)	F549S	probably damaging	Het
Capzb	C	T	4: 139,280,553 (GRCm38)	T215I	probably benign	Het
Car14	C	T	3: 95,904,372 (GRCm38)	M1I	probably null	Het
Ccdc148	T	A	2: 58,823,636 (GRCm38)	Q501L	probably benign	Het
Ccdc32	G	A	2: 119,027,347 (GRCm38)	T12I	probably damaging	Het
Ccnf	G	A	17: 24,225,012 (GRCm38)	S594L	probably damaging	Het
Cdadc1	C	T	14: 59,573,834 (GRCm38)	C409Y	probably damaging	Het
Cdh23	G	T	10: 60,312,577 (GRCm38)	S2670R	probably damaging	Het
Cdh8	T	A	8: 99,279,674 (GRCm38)	K94*	probably null	Het
Cdhr2	A	T	13: 54,717,692 (GRCm38)	Y193F	probably damaging	Het
Cdon	T	A	9: 35,454,415 (GRCm38)	Y153*	probably null	Het
Chd1	G	A	17: 15,733,041 (GRCm38)	G413R	probably damaging	Het
Cit	A	T	5: 115,987,001 (GRCm38)	T1582S	probably benign	Het
Clec4a3	T	C	6: 122,964,340 (GRCm38)	L98P	probably benign	Het
Cpa4	T	A	6: 30,583,645 (GRCm38)	D253E	probably damaging	Het
Cyhr1	A	T	15: 76,658,547 (GRCm38)	Y138N	probably damaging	Het
Cyp2c40	T	A	19: 39,807,168 (GRCm38)	N189I	possibly damaging	Het
Daam2	G	T	17: 49,490,022 (GRCm38)	A245E	probably benign	Het
Dennd5b	A	G	6: 149,068,658 (GRCm38)	F121S	probably damaging	Het
Dgkd	A	G	1: 87,926,949 (GRCm38)	T658A	probably benign	Het
Dmwd	T	A	7: 19,080,340 (GRCm38)	L305Q	probably damaging	Het
Dnah5	A	T	15: 28,313,855 (GRCm38)	Y1939F	probably damaging	Het
Dock5	T	C	14: 67,821,327 (GRCm38)	T512A	probably damaging	Het
Dopey2	T	A	16: 93,755,514 (GRCm38)	D398E	probably benign	Het
Eef1akmt4	A	G	16: 20,618,529 (GRCm38)	H207R	probably damaging	Het
Egfr	T	C	11: 16,891,266 (GRCm38)	V719A	probably damaging	Het
Ep300	A	T	15: 81,586,583 (GRCm38)		probably benign	Het
Epha4	A	G	1: 77,390,031 (GRCm38)		probably null	Het
Erc2	T	G	14: 27,876,204 (GRCm38)		probably null	Het
Ergic1	A	T	17: 26,638,827 (GRCm38)	Y209F	possibly damaging	Het
Fbxw28	A	G	9: 109,326,633 (GRCm38)	I357T	probably damaging	Het
Flnb	A	T	14: 7,926,478 (GRCm38)	T1841S	probably benign	Het
Foxc1	G	A	13: 31,808,028 (GRCm38)	S274N	probably benign	Het
Fto	C	T	8: 91,409,443 (GRCm38)	T115M	probably damaging	Het
Gm10228	C	G	16: 89,041,299 (GRCm38)	C39S	unknown	Het
Gm7334	T	C	17: 50,698,715 (GRCm38)	F10L	possibly damaging	Het
Hfm1	A	G	5: 106,881,861 (GRCm38)	Y785H	probably damaging	Het
Hivep1	T	A	13: 42,159,461 (GRCm38)	S1726T	probably benign	Het
Htt	G	T	5: 34,852,190 (GRCm38)	C1505F	probably damaging	Het
Hydin	T	C	8: 110,505,843 (GRCm38)	S1665P	possibly damaging	Het
Ifi209	T	A	1: 173,642,879 (GRCm38)	N344K	probably damaging	Het
Ifnar2	T	C	16: 91,399,293 (GRCm38)	M262T	probably benign	Het
Ighv7-3	T	A	12: 114,153,207 (GRCm38)	S112C	probably damaging	Het
Igkv4-86	A	G	6: 68,910,579 (GRCm38)	S59P	probably benign	Het
Iglv1	A	G	16: 19,085,489 (GRCm38)		probably benign	Het
Ipo7	T	A	7: 110,052,799 (GRCm38)	D928E	possibly damaging	Het
Itgae	G	T	11: 73,123,269 (GRCm38)		probably null	Het
Kbtbd12	T	A	6: 88,618,197 (GRCm38)	Q217L	probably benign	Het
Kcnma1	T	A	14: 23,300,006 (GRCm38)	Y1155F	possibly damaging	Het
Kif14	A	G	1: 136,516,383 (GRCm38)	E1371G	probably benign	Het
Lilrb4a	A	T	10: 51,491,046 (GRCm38)	Y10F	probably benign	Het
Lrp2	A	T	2: 69,503,388 (GRCm38)	V1503E	probably damaging	Het
Mfsd6	A	T	1: 52,708,640 (GRCm38)	D355E	probably benign	Het
Mri1	T	C	8: 84,251,028 (GRCm38)	H226R		Het
Mroh4	C	T	15: 74,624,705 (GRCm38)	E278K	probably damaging	Het
Muc4	T	A	16: 32,753,311 (GRCm38)	L1063H	probably benign	Het
Mzf1	A	T	7: 13,044,091 (GRCm38)	I541N	probably damaging	Het
Nasp	T	A	4: 116,612,033 (GRCm38)	E116D	probably benign	Het
Nlrp10	T	A	7: 108,925,826 (GRCm38)	E149V	probably damaging	Het
Notch4	G	A	17: 34,582,418 (GRCm38)	C1080Y	probably damaging	Het
Nova1	T	G	12: 46,720,698 (GRCm38)	I147L	unknown	Het
Ogdh	A	G	11: 6,338,558 (GRCm38)	M223V	probably benign	Het
Olfr1391	G	T	11: 49,327,671 (GRCm38)	A87S	probably benign	Het
Olfr444	T	C	6: 42,955,789 (GRCm38)	I97T	probably benign	Het
Olfr732	A	T	14: 50,281,488 (GRCm38)	I255N	probably damaging	Het
Olfr792	G	T	10: 129,541,455 (GRCm38)	R306L	probably benign	Het
P3h3	T	C	6: 124,854,432 (GRCm38)	Q330R	probably benign	Het
Pcdhb10	A	G	18: 37,411,882 (GRCm38)	T4A	not run	Het
Pkd2l2	A	T	18: 34,433,287 (GRCm38)		probably null	Het
Plekhb1	C	T	7: 100,645,663 (GRCm38)	V168I	probably benign	Het
Plxna4	C	T	6: 32,223,980 (GRCm38)	R753H	probably damaging	Het
Prex1	G	C	2: 166,713,709 (GRCm38)	P4A	unknown	Het
Ptgdr	A	G	14: 44,859,078 (GRCm38)	V59A	probably damaging	Het
Ralgapa1	T	A	12: 55,757,955 (GRCm38)	I519F	probably benign	Het
Rbpms	A	G	8: 33,789,453 (GRCm38)	I170T	probably benign	Het
Sec31b	T	A	19: 44,523,835 (GRCm38)		probably null	Het
Skint11	A	T	4: 114,227,708 (GRCm38)	Y138F	probably benign	Het
Slain2	A	G	5: 72,948,610 (GRCm38)	Y196C	probably damaging	Het
Slco1b2	T	A	6: 141,676,224 (GRCm38)	C503*	probably null	Het
Slfn3	A	T	11: 83,214,788 (GRCm38)	Y537F	possibly damaging	Het
Slu7	T	C	11: 43,444,765 (GRCm38)	Y443H	probably damaging	Het
Sorl1	T	A	9: 42,043,909 (GRCm38)	E683D	probably damaging	Het
Sos1	T	A	17: 80,413,713 (GRCm38)	I893L	probably benign	Het
St8sia2	T	A	7: 73,943,321 (GRCm38)	Y329F	probably damaging	Het
Stra6l	C	A	4: 45,869,570 (GRCm38)	S212*	probably null	Het
Syne3	C	T	12: 104,997,495 (GRCm38)		probably benign	Het
Tenm4	T	A	7: 96,895,692 (GRCm38)	I2342N	probably benign	Het
Tescl	T	A	7: 24,333,263 (GRCm38)	E212D	probably benign	Het
Trip11	A	G	12: 101,844,855 (GRCm38)	S1879P	probably benign	Het
Ube2c	A	T	2: 164,771,291 (GRCm38)		probably null	Het
Umodl1	T	A	17: 30,986,456 (GRCm38)	I675N	probably benign	Het
Vipr2	T	C	12: 116,122,718 (GRCm38)	F121S	probably damaging	Het
Vmn1r206	A	T	13: 22,620,669 (GRCm38)	S123T	possibly damaging	Het
Vmn1r58	A	G	7: 5,410,913 (GRCm38)	V106A	probably damaging	Het
Vmn2r112	A	G	17: 22,603,118 (GRCm38)	Y259C	probably damaging	Het
Vmn2r66	T	C	7: 85,005,701 (GRCm38)	K467E	probably benign	Het
Vps13a	T	A	19: 16,746,000 (GRCm38)	N278I	possibly damaging	Het
Vwa5a	A	C	9: 38,741,162 (GRCm38)	D747A	possibly damaging	Het
Xdh	G	A	17: 73,934,834 (GRCm38)	P157S	possibly damaging	Het
Xrn1	G	A	9: 95,998,348 (GRCm38)		probably null	Het
Zfp362	T	A	4: 128,787,031 (GRCm38)	H180L	probably benign	Het
Zfp560	A	T	9: 20,347,323 (GRCm38)	W748R	possibly damaging	Het
Zfp808	A	T	13: 62,172,664 (GRCm38)	Q569L	probably benign	Het
Zfp93	T	A	7: 24,275,218 (GRCm38)	D209E	possibly damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,065,745 (GRCm38)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,065,185 (GRCm38)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,065,758 (GRCm38)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,065,259 (GRCm38)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,066,451 (GRCm38)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,066,440 (GRCm38)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,066,440 (GRCm38)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,066,286 (GRCm38)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,080,679 (GRCm38)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,065,851 (GRCm38)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,065,821 (GRCm38)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,080,961 (GRCm38)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,065,259 (GRCm38)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,066,013 (GRCm38)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,081,021 (GRCm38)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,065,980 (GRCm38)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,069,845 (GRCm38)	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19,080,961 (GRCm38)	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19,066,400 (GRCm38)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,066,347 (GRCm38)	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19,066,347 (GRCm38)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,065,827 (GRCm38)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,053,613 (GRCm38)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,080,497 (GRCm38)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,080,520 (GRCm38)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,080,749 (GRCm38)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,065,948 (GRCm38)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,065,178 (GRCm38)	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19,067,383 (GRCm38)	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19,080,908 (GRCm38)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,066,440 (GRCm38)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,066,418 (GRCm38)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,065,333 (GRCm38)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,081,291 (GRCm38)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,065,951 (GRCm38)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,080,436 (GRCm38)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,065,819 (GRCm38)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,081,177 (GRCm38)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,067,402 (GRCm38)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,065,863 (GRCm38)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,065,863 (GRCm38)	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19,065,863 (GRCm38)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,080,625 (GRCm38)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,066,092 (GRCm38)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,069,745 (GRCm38)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,066,340 (GRCm38)	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19,066,157 (GRCm38)	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19,066,044 (GRCm38)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,053,553 (GRCm38)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,080,719 (GRCm38)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,069,754 (GRCm38)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,069,753 (GRCm38)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,067,383 (GRCm38)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,080,899 (GRCm38)	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19,065,998 (GRCm38)	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19,066,074 (GRCm38)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,065,881 (GRCm38)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,065,801 (GRCm38)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,065,248 (GRCm38)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,066,268 (GRCm38)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,080,922 (GRCm38)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,065,313 (GRCm38)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,067,308 (GRCm38)	missense	possibly damaging	0.95
R7771:Vmn2r98	UTSW	17	19,067,198 (GRCm38)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,067,231 (GRCm38)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,053,650 (GRCm38)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,081,163 (GRCm38)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,080,769 (GRCm38)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,066,270 (GRCm38)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,065,269 (GRCm38)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,066,121 (GRCm38)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,066,121 (GRCm38)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,081,219 (GRCm38)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,066,515 (GRCm38)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,067,255 (GRCm38)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,081,234 (GRCm38)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,065,403 (GRCm38)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,067,423 (GRCm38)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,065,136 (GRCm38)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- TGAACTCCTGATCTCGATAACC -3'
(R):5'- AGCTTTGGCCAACACAGTACC -3'

Sequencing Primer
(F):5'- GTGTGTGAAATGTCCTGAG -3'
(R):5'- GTGAAAGCAACTGCAAATGTTGTCTG -3'

Posted On

2019-11-26