Incidental Mutation 'R7764:Fosb'
ID 598120
Institutional Source Beutler Lab
Gene Symbol Fosb
Ensembl Gene ENSMUSG00000003545
Gene Name FBJ osteosarcoma oncogene B
Synonyms
MMRRC Submission 045820-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7764 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 19036621-19043970 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19038971 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 271 (D271G)
Ref Sequence ENSEMBL: ENSMUSP00000003640 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003640] [ENSMUST00000207334] [ENSMUST00000207716] [ENSMUST00000208326] [ENSMUST00000208446] [ENSMUST00000208505]
AlphaFold P13346
Predicted Effect possibly damaging
Transcript: ENSMUST00000003640
AA Change: D271G

PolyPhen 2 Score 0.652 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000003640
Gene: ENSMUSG00000003545
AA Change: D271G

DomainStartEndE-ValueType
low complexity region 113 132 N/A INTRINSIC
BRLZ 153 217 5.58e-13 SMART
low complexity region 255 265 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000207334
AA Change: D235G

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably damaging
Transcript: ENSMUST00000207716
AA Change: D196G

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000208326
AA Change: D232G

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000208446
Predicted Effect probably benign
Transcript: ENSMUST00000208505
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show impaired nurturing behavior, altered behavioral tolerance to repeated motor seizures, reduced NMDA-mediated synaptic currents, and altered paradoxical sleep. Aging mice homozygous for another null allele may exhibit occasional tonic-clonic or generalized seizures. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 T G 16: 20,368,040 (GRCm39) L93V probably benign Het
Adss2 A C 1: 177,591,827 (GRCm39) M452R probably damaging Het
Aldh3b1 T A 19: 3,971,563 (GRCm39) K102* probably null Het
Ccdc162 A T 10: 41,566,109 (GRCm39) V78D possibly damaging Het
Ccr3 T C 9: 123,829,451 (GRCm39) V262A probably benign Het
Cdk13 A T 13: 17,895,890 (GRCm39) probably null Het
Cdyl A T 13: 36,000,126 (GRCm39) T136S possibly damaging Het
Chd2 T C 7: 73,121,567 (GRCm39) D1015G probably null Het
Cntn2 C A 1: 132,450,101 (GRCm39) A598S probably benign Het
Cxxc4 G T 3: 133,945,856 (GRCm39) G146C unknown Het
Dnah2 G A 11: 69,348,984 (GRCm39) T2501I probably benign Het
Dock8 T A 19: 25,074,899 (GRCm39) I471N probably benign Het
Eaf2 A G 16: 36,645,045 (GRCm39) V59A probably damaging Het
Egflam T A 15: 7,347,736 (GRCm39) I65F probably damaging Het
Exoc3l A G 8: 106,017,333 (GRCm39) V577A possibly damaging Het
Folh1 A T 7: 86,412,126 (GRCm39) M215K probably benign Het
Frmd4b A G 6: 97,272,891 (GRCm39) Y834H probably damaging Het
Fsip2 T C 2: 82,811,252 (GRCm39) S2524P possibly damaging Het
Gbp3 A G 3: 142,271,024 (GRCm39) T143A probably benign Het
Grk2 A T 19: 4,337,391 (GRCm39) L632Q probably damaging Het
Hars1 A T 18: 36,903,237 (GRCm39) D364E probably damaging Het
Hsd17b4 G T 18: 50,279,482 (GRCm39) G154* probably null Het
Kif5c T C 2: 49,617,973 (GRCm39) probably null Het
Kif5c T C 2: 49,639,339 (GRCm39) L800P probably damaging Het
Krt19 T C 11: 100,032,218 (GRCm39) N282S probably benign Het
Med23 T G 10: 24,785,818 (GRCm39) probably null Het
Meltf A G 16: 31,699,085 (GRCm39) Q65R probably benign Het
Mms22l T C 4: 24,598,842 (GRCm39) S1106P probably damaging Het
Mprip A G 11: 59,655,242 (GRCm39) T733A probably damaging Het
Mul1 G A 4: 138,162,080 (GRCm39) G4S possibly damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Mylk G T 16: 34,742,553 (GRCm39) V1022L probably benign Het
Ncald G T 15: 37,397,454 (GRCm39) N75K probably damaging Het
Nfib A G 4: 82,238,731 (GRCm39) S492P possibly damaging Het
Notch2 A T 3: 98,050,304 (GRCm39) I1860F probably damaging Het
Or9i14 A G 19: 13,792,111 (GRCm39) I281T probably benign Het
Oxr1 T C 15: 41,683,263 (GRCm39) S298P probably benign Het
Pcnt T C 10: 76,190,082 (GRCm39) D2818G probably benign Het
Pmpcb G A 5: 21,948,450 (GRCm39) A244T probably damaging Het
Poln A G 5: 34,274,151 (GRCm39) probably null Het
Polr1a G A 6: 71,930,054 (GRCm39) V914M probably damaging Het
Rab15 A C 12: 76,851,215 (GRCm39) probably null Het
Rasgrf1 G T 9: 89,876,747 (GRCm39) S704I possibly damaging Het
Rsf1 GGCGGCGG GGCGGCGGGCGCGGCGG 7: 97,229,134 (GRCm39) probably benign Het
Sart1 C A 19: 5,438,613 (GRCm39) G15W probably damaging Het
Scrib T C 15: 75,919,242 (GRCm39) *1666W probably null Het
Setd1b G C 5: 123,284,622 (GRCm39) R184P unknown Het
Sfxn2 A T 19: 46,574,179 (GRCm39) N123I probably damaging Het
Slc22a3 A G 17: 12,677,383 (GRCm39) W262R probably damaging Het
Slc38a10 A G 11: 119,995,905 (GRCm39) L1064P probably damaging Het
Sorcs2 A T 5: 36,181,416 (GRCm39) S1077R possibly damaging Het
Them7 G T 2: 105,128,171 (GRCm39) E51* probably null Het
Ubc A G 5: 125,465,133 (GRCm39) S65P possibly damaging Het
Ubqln3 A T 7: 103,790,443 (GRCm39) M549K possibly damaging Het
Vmn1r222 A G 13: 23,416,529 (GRCm39) L228P probably damaging Het
Vmn2r60 A G 7: 41,844,535 (GRCm39) T633A probably damaging Het
Zfp382 T C 7: 29,832,700 (GRCm39) V117A probably benign Het
Zic1 C T 9: 91,247,745 (GRCm39) probably benign Het
Zmym4 A T 4: 126,819,409 (GRCm39) F165I probably benign Het
Other mutations in Fosb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Fosb APN 7 19,041,039 (GRCm39) splice site probably null
R0183:Fosb UTSW 7 19,041,310 (GRCm39) missense probably damaging 0.99
R0374:Fosb UTSW 7 19,041,075 (GRCm39) missense probably damaging 0.99
R0555:Fosb UTSW 7 19,041,138 (GRCm39) missense possibly damaging 0.84
R2329:Fosb UTSW 7 19,041,110 (GRCm39) missense probably benign
R3498:Fosb UTSW 7 19,040,557 (GRCm39) missense probably damaging 1.00
R4064:Fosb UTSW 7 19,039,117 (GRCm39) nonsense probably null
R4790:Fosb UTSW 7 19,043,313 (GRCm39) missense probably damaging 1.00
R6327:Fosb UTSW 7 19,041,152 (GRCm39) missense probably benign
R6605:Fosb UTSW 7 19,043,283 (GRCm39) missense probably damaging 1.00
R7282:Fosb UTSW 7 19,039,113 (GRCm39) missense possibly damaging 0.62
R7444:Fosb UTSW 7 19,041,199 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- GAGTCAAAGGGTCCACACAC -3'
(R):5'- AGGAACGCCTGGAGTTTGTC -3'

Sequencing Primer
(F):5'- TGTTTGTCTAAAGAGTTTACAGAGC -3'
(R):5'- AGTTTGTCCTGGTGGCCCAC -3'
Posted On 2019-11-26