Incidental Mutation 'R7765:Mprip'
ID 598194
Institutional Source Beutler Lab
Gene Symbol Mprip
Ensembl Gene ENSMUSG00000005417
Gene Name myosin phosphatase Rho interacting protein
Synonyms p116 Rho interacting protein, p116Rip, Gm34094, RIP3, Rhoip3
MMRRC Submission 045821-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.669) question?
Stock # R7765 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 59552973-59671686 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 59649047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 917 (T917M)
Ref Sequence ENSEMBL: ENSMUSP00000071081 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066330] [ENSMUST00000072031] [ENSMUST00000108751] [ENSMUST00000116371] [ENSMUST00000133861]
AlphaFold P97434
Predicted Effect possibly damaging
Transcript: ENSMUST00000066330
AA Change: T917M

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071081
Gene: ENSMUSG00000005417
AA Change: T917M

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 179 190 N/A INTRINSIC
low complexity region 221 234 N/A INTRINSIC
Blast:PH 249 320 1e-10 BLAST
PH 351 448 3.76e-18 SMART
low complexity region 492 501 N/A INTRINSIC
low complexity region 536 555 N/A INTRINSIC
coiled coil region 636 671 N/A INTRINSIC
Blast:PAC 806 848 2e-10 BLAST
low complexity region 1005 1023 N/A INTRINSIC
low complexity region 1047 1059 N/A INTRINSIC
low complexity region 1114 1128 N/A INTRINSIC
low complexity region 1183 1200 N/A INTRINSIC
coiled coil region 1267 1300 N/A INTRINSIC
coiled coil region 1617 1642 N/A INTRINSIC
coiled coil region 1729 1779 N/A INTRINSIC
coiled coil region 1899 1936 N/A INTRINSIC
coiled coil region 1960 2110 N/A INTRINSIC
coiled coil region 2132 2206 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072031
SMART Domains Protein: ENSMUSP00000071914
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 179 190 N/A INTRINSIC
low complexity region 221 234 N/A INTRINSIC
Blast:PH 254 320 1e-10 BLAST
PH 387 484 3.76e-18 SMART
low complexity region 528 537 N/A INTRINSIC
low complexity region 572 591 N/A INTRINSIC
coiled coil region 672 707 N/A INTRINSIC
coiled coil region 728 878 N/A INTRINSIC
coiled coil region 900 974 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108751
SMART Domains Protein: ENSMUSP00000104382
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 183 196 N/A INTRINSIC
Blast:PH 216 282 1e-10 BLAST
PH 349 446 3.76e-18 SMART
low complexity region 490 499 N/A INTRINSIC
low complexity region 534 553 N/A INTRINSIC
coiled coil region 634 669 N/A INTRINSIC
coiled coil region 690 840 N/A INTRINSIC
coiled coil region 862 936 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116371
SMART Domains Protein: ENSMUSP00000112072
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
PH 44 152 3.33e-10 SMART
low complexity region 179 190 N/A INTRINSIC
low complexity region 221 234 N/A INTRINSIC
Blast:PH 254 320 1e-10 BLAST
PH 387 484 3.76e-18 SMART
low complexity region 528 537 N/A INTRINSIC
low complexity region 572 591 N/A INTRINSIC
coiled coil region 672 707 N/A INTRINSIC
coiled coil region 728 878 N/A INTRINSIC
coiled coil region 900 974 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132620
SMART Domains Protein: ENSMUSP00000119422
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
low complexity region 68 81 N/A INTRINSIC
Blast:PH 101 167 9e-11 BLAST
PH 198 295 3.76e-18 SMART
low complexity region 339 348 N/A INTRINSIC
low complexity region 383 402 N/A INTRINSIC
coiled coil region 482 517 N/A INTRINSIC
coiled coil region 538 688 N/A INTRINSIC
coiled coil region 710 784 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133861
SMART Domains Protein: ENSMUSP00000119562
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
low complexity region 18 29 N/A INTRINSIC
low complexity region 47 58 N/A INTRINSIC
low complexity region 89 102 N/A INTRINSIC
low complexity region 152 162 N/A INTRINSIC
low complexity region 259 269 N/A INTRINSIC
PH 373 470 3.76e-18 SMART
low complexity region 514 523 N/A INTRINSIC
low complexity region 558 577 N/A INTRINSIC
coiled coil region 658 693 N/A INTRINSIC
coiled coil region 714 864 N/A INTRINSIC
coiled coil region 886 960 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156111
SMART Domains Protein: ENSMUSP00000114446
Gene: ENSMUSG00000005417

DomainStartEndE-ValueType
internal_repeat_1 5 38 1.61e-7 PROSPERO
internal_repeat_2 9 51 2.4e-6 PROSPERO
internal_repeat_1 59 92 1.61e-7 PROSPERO
internal_repeat_2 85 129 2.4e-6 PROSPERO
coiled coil region 140 177 N/A INTRINSIC
coiled coil region 201 351 N/A INTRINSIC
coiled coil region 373 447 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 T C 14: 66,297,345 (GRCm39) E187G probably damaging Het
Adam28 C T 14: 68,846,555 (GRCm39) probably null Het
Ap2a1 G A 7: 44,559,160 (GRCm39) T189M probably damaging Het
Apaf1 A G 10: 90,859,644 (GRCm39) Y845H probably benign Het
Asb14 G T 14: 26,619,718 (GRCm39) V55F probably benign Het
Brap A T 5: 121,800,192 (GRCm39) D71V probably damaging Het
Ccdc93 T G 1: 121,427,042 (GRCm39) F610V probably damaging Het
Cfap46 T G 7: 139,231,480 (GRCm39) D911A Het
Chn2 T C 6: 54,275,137 (GRCm39) probably null Het
Cib3 A G 8: 72,958,269 (GRCm39) F156S probably damaging Het
Csnk2a1-ps3 G A 1: 156,352,354 (GRCm39) G185D possibly damaging Het
Ctif A T 18: 75,738,715 (GRCm39) V164D probably damaging Het
Ddx27 T A 2: 166,869,879 (GRCm39) F405I probably damaging Het
Dnttip2 A G 3: 122,069,594 (GRCm39) T270A probably benign Het
Dst T A 1: 34,314,775 (GRCm39) S4455T probably damaging Het
Efcab8 A G 2: 153,685,110 (GRCm39) K47R Het
Efhd2 T C 4: 141,601,886 (GRCm39) E98G probably damaging Het
Fcmr T A 1: 130,802,025 (GRCm39) L93Q probably damaging Het
Fhdc1 T A 3: 84,351,906 (GRCm39) E1106D probably benign Het
Gcnt1 C T 19: 17,306,723 (GRCm39) G334D probably damaging Het
Hltf T C 3: 20,145,647 (GRCm39) F488L probably benign Het
Hmgxb4 C A 8: 75,727,436 (GRCm39) H140N probably damaging Het
Ifi214 A T 1: 173,352,402 (GRCm39) F342L probably damaging Het
Ip6k1 A G 9: 107,909,288 (GRCm39) D105G possibly damaging Het
Kank1 GCGAACG GCG 19: 25,388,569 (GRCm39) probably null Het
Kif18a G A 2: 109,137,285 (GRCm39) D506N probably benign Het
Klf17 T A 4: 117,617,812 (GRCm39) M182L probably benign Het
Kmt2d A G 15: 98,750,215 (GRCm39) F2493L unknown Het
Lefty1 A G 1: 180,764,112 (GRCm39) E84G probably damaging Het
Lyst T G 13: 13,884,117 (GRCm39) L2975R possibly damaging Het
Magea5 G A X: 153,837,174 (GRCm39) P73S possibly damaging Het
Mctp2 T C 7: 71,740,079 (GRCm39) probably null Het
Myh8 T A 11: 67,194,481 (GRCm39) I1564N probably benign Het
Npc1 A T 18: 12,328,105 (GRCm39) M1068K probably benign Het
Nr2e1 A G 10: 42,450,433 (GRCm39) C60R probably benign Het
Nrxn3 A G 12: 89,780,254 (GRCm39) I29V probably benign Het
Ntsr1 T A 2: 180,180,610 (GRCm39) H305Q probably damaging Het
Or2y1e A G 11: 49,218,571 (GRCm39) E111G probably damaging Het
Or8g35 A G 9: 39,381,612 (GRCm39) S137P probably benign Het
Or8h10 T A 2: 86,808,538 (GRCm39) I201F probably damaging Het
Pate2 A C 9: 35,581,197 (GRCm39) E22D probably benign Het
Pcdhb22 A G 18: 37,652,158 (GRCm39) T209A probably damaging Het
Pdss2 C T 10: 43,340,628 (GRCm39) S352F probably benign Het
Pfn3 T A 13: 55,562,900 (GRCm39) D27V probably damaging Het
Pigg T G 5: 108,461,920 (GRCm39) S84A probably benign Het
Prm3 CTCTTCTTCTTCTTC CTCTTCTTCTTC 16: 10,608,565 (GRCm39) probably benign Het
Prss22 C T 17: 24,213,592 (GRCm39) G233E probably damaging Het
Rad51b T C 12: 79,850,044 (GRCm39) probably null Het
Scn10a A G 9: 119,438,970 (GRCm39) V1632A possibly damaging Het
Serpinb3d T G 1: 107,007,512 (GRCm39) D158A probably damaging Het
Sh3yl1 T C 12: 31,008,868 (GRCm39) L266P probably damaging Het
Sidt2 A T 9: 45,852,873 (GRCm39) probably null Het
Stox1 C T 10: 62,501,778 (GRCm39) V261M probably benign Het
Taf7l2 T A 10: 115,949,158 (GRCm39) K123* probably null Het
Tll1 A G 8: 64,504,483 (GRCm39) Y638H probably damaging Het
Tst A T 15: 78,289,816 (GRCm39) M73K possibly damaging Het
Tuba4a C T 1: 75,193,003 (GRCm39) V232M probably benign Het
Unk T A 11: 115,943,908 (GRCm39) V343D probably benign Het
Usf3 T C 16: 44,039,426 (GRCm39) V1302A probably benign Het
Usp32 A T 11: 84,885,234 (GRCm39) L1271H probably damaging Het
Vwa5b2 C T 16: 20,413,361 (GRCm39) P192L probably benign Het
Zfp995 A G 17: 22,100,984 (GRCm39) Y38H probably damaging Het
Other mutations in Mprip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Mprip APN 11 59,639,417 (GRCm39) missense probably benign 0.07
IGL00563:Mprip APN 11 59,643,443 (GRCm39) missense probably damaging 1.00
IGL00905:Mprip APN 11 59,662,994 (GRCm39) missense possibly damaging 0.79
IGL00928:Mprip APN 11 59,635,578 (GRCm39) missense probably damaging 1.00
IGL01161:Mprip APN 11 59,622,399 (GRCm39) missense possibly damaging 0.93
IGL01991:Mprip APN 11 59,645,838 (GRCm39) missense probably damaging 0.99
IGL02491:Mprip APN 11 59,660,857 (GRCm39) missense probably benign 0.13
IGL03030:Mprip APN 11 59,631,941 (GRCm39) splice site probably null
IGL03056:Mprip APN 11 59,662,518 (GRCm39) missense probably damaging 1.00
IGL03293:Mprip APN 11 59,586,989 (GRCm39) missense probably damaging 1.00
R0049:Mprip UTSW 11 59,657,571 (GRCm39) missense probably damaging 0.99
R0097:Mprip UTSW 11 59,649,317 (GRCm39) missense possibly damaging 0.90
R0097:Mprip UTSW 11 59,649,317 (GRCm39) missense possibly damaging 0.90
R0147:Mprip UTSW 11 59,627,899 (GRCm39) missense possibly damaging 0.68
R0319:Mprip UTSW 11 59,587,864 (GRCm39) splice site probably benign
R0471:Mprip UTSW 11 59,650,561 (GRCm39) missense probably damaging 1.00
R0539:Mprip UTSW 11 59,631,943 (GRCm39) splice site probably benign
R0627:Mprip UTSW 11 59,660,798 (GRCm39) missense probably damaging 1.00
R0864:Mprip UTSW 11 59,649,587 (GRCm39) missense probably benign
R1218:Mprip UTSW 11 59,634,640 (GRCm39) missense probably damaging 1.00
R1469:Mprip UTSW 11 59,650,016 (GRCm39) missense probably damaging 1.00
R1469:Mprip UTSW 11 59,650,016 (GRCm39) missense probably damaging 1.00
R1695:Mprip UTSW 11 59,643,357 (GRCm39) missense probably damaging 0.99
R1698:Mprip UTSW 11 59,651,084 (GRCm39) missense possibly damaging 0.75
R1802:Mprip UTSW 11 59,645,867 (GRCm39) missense probably damaging 1.00
R1837:Mprip UTSW 11 59,657,571 (GRCm39) missense probably damaging 0.99
R1862:Mprip UTSW 11 59,649,047 (GRCm39) missense possibly damaging 0.90
R2094:Mprip UTSW 11 59,640,334 (GRCm39) splice site probably benign
R2107:Mprip UTSW 11 59,660,717 (GRCm39) missense probably damaging 1.00
R2108:Mprip UTSW 11 59,660,717 (GRCm39) missense probably damaging 1.00
R2510:Mprip UTSW 11 59,640,334 (GRCm39) splice site probably benign
R3003:Mprip UTSW 11 59,618,381 (GRCm39) missense possibly damaging 0.95
R3115:Mprip UTSW 11 59,656,229 (GRCm39) splice site probably null
R3941:Mprip UTSW 11 59,622,328 (GRCm39) splice site probably benign
R4347:Mprip UTSW 11 59,650,279 (GRCm39) missense possibly damaging 0.86
R4603:Mprip UTSW 11 59,622,399 (GRCm39) missense probably damaging 1.00
R4807:Mprip UTSW 11 59,648,846 (GRCm39) missense probably benign 0.00
R5011:Mprip UTSW 11 59,650,721 (GRCm39) missense possibly damaging 0.75
R5338:Mprip UTSW 11 59,651,399 (GRCm39) missense probably damaging 1.00
R5549:Mprip UTSW 11 59,651,644 (GRCm39) missense probably benign 0.00
R5569:Mprip UTSW 11 59,651,789 (GRCm39) missense probably damaging 1.00
R5604:Mprip UTSW 11 59,649,293 (GRCm39) missense probably benign
R5615:Mprip UTSW 11 59,649,313 (GRCm39) missense probably benign 0.08
R5846:Mprip UTSW 11 59,649,380 (GRCm39) missense probably damaging 1.00
R5970:Mprip UTSW 11 59,648,547 (GRCm39) missense probably damaging 0.96
R6054:Mprip UTSW 11 59,649,251 (GRCm39) missense probably benign
R6452:Mprip UTSW 11 59,643,609 (GRCm39) missense probably damaging 1.00
R6457:Mprip UTSW 11 59,649,815 (GRCm39) missense possibly damaging 0.69
R6544:Mprip UTSW 11 59,648,552 (GRCm39) missense probably benign 0.15
R6750:Mprip UTSW 11 59,586,957 (GRCm39) missense probably damaging 1.00
R6843:Mprip UTSW 11 59,650,554 (GRCm39) missense possibly damaging 0.54
R6851:Mprip UTSW 11 59,649,841 (GRCm39) missense probably damaging 0.99
R6867:Mprip UTSW 11 59,640,456 (GRCm39) critical splice donor site probably null
R7002:Mprip UTSW 11 59,652,016 (GRCm39) missense probably benign 0.22
R7023:Mprip UTSW 11 59,628,215 (GRCm39) missense probably damaging 1.00
R7764:Mprip UTSW 11 59,655,242 (GRCm39) missense probably damaging 0.99
R7828:Mprip UTSW 11 59,627,915 (GRCm39) missense probably damaging 1.00
R7866:Mprip UTSW 11 59,643,756 (GRCm39) missense possibly damaging 0.60
R7911:Mprip UTSW 11 59,651,681 (GRCm39) missense
R7979:Mprip UTSW 11 59,657,682 (GRCm39) missense probably damaging 1.00
R8292:Mprip UTSW 11 59,650,340 (GRCm39) missense probably benign 0.21
R8481:Mprip UTSW 11 59,648,982 (GRCm39) nonsense probably null
R8717:Mprip UTSW 11 59,650,526 (GRCm39) missense probably benign
R8810:Mprip UTSW 11 59,587,851 (GRCm39) critical splice donor site probably benign
R8981:Mprip UTSW 11 59,622,383 (GRCm39) missense probably damaging 1.00
R9214:Mprip UTSW 11 59,650,901 (GRCm39) missense possibly damaging 0.69
R9245:Mprip UTSW 11 59,628,403 (GRCm39) missense possibly damaging 0.68
R9748:Mprip UTSW 11 59,656,348 (GRCm39) missense probably damaging 1.00
Z1176:Mprip UTSW 11 59,650,310 (GRCm39) missense probably benign 0.05
Z1176:Mprip UTSW 11 59,628,230 (GRCm39) missense possibly damaging 0.83
Z1177:Mprip UTSW 11 59,648,463 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAATGCATTGCTGAGCTCAG -3'
(R):5'- TCTTGGAGCTCAGCCACATC -3'

Sequencing Primer
(F):5'- GTACCAGTGAGCAAGCCCAG -3'
(R):5'- TCCCCATCGGATGTGGC -3'
Posted On 2019-11-26