Incidental Mutation 'R7765:Nrxn3'
| ID |
598200 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrxn3
|
| Ensembl Gene |
ENSMUSG00000066392 |
| Gene Name |
neurexin III |
| Synonyms |
4933401A11Rik, D12Bwg0831e, neurexin III alpha, neurexin III alpha, neurexin III beta, neurexin III beta, 9330112C09Rik |
| MMRRC Submission |
045821-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7765 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
88689646-90301709 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 89780254 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 29
(I29V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105757
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057634]
[ENSMUST00000110130]
[ENSMUST00000110133]
[ENSMUST00000163134]
[ENSMUST00000167103]
[ENSMUST00000167887]
[ENSMUST00000190626]
|
| AlphaFold |
Q6P9K9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057634
|
| SMART Domains |
Protein: ENSMUSP00000050075
Gene: ENSMUSG00000066392
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
94 |
246 |
3.28e-41 |
SMART |
|
EGF
|
273 |
307 |
4.1e-2 |
SMART |
|
LamG
|
332 |
470 |
4.87e-26 |
SMART |
|
LamG
|
518 |
654 |
7.08e-37 |
SMART |
|
EGF
|
688 |
722 |
1.99e1 |
SMART |
|
LamG
|
750 |
907 |
1.14e-17 |
SMART |
|
low complexity region
|
948 |
964 |
N/A |
INTRINSIC |
|
low complexity region
|
1028 |
1043 |
N/A |
INTRINSIC |
|
4.1m
|
1046 |
1064 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110130
AA Change: I29V
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000105757
Gene: ENSMUSG00000066392
AA Change: I29V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
35 |
N/A |
INTRINSIC |
|
LamG
|
107 |
264 |
1.14e-17 |
SMART |
|
Blast:LamG
|
294 |
410 |
6e-47 |
BLAST |
|
low complexity region
|
492 |
507 |
N/A |
INTRINSIC |
|
4.1m
|
510 |
528 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110133
AA Change: I29V
PolyPhen 2
Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000105760
Gene: ENSMUSG00000066392
AA Change: I29V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
35 |
N/A |
INTRINSIC |
|
LamG
|
107 |
234 |
1.8e-20 |
SMART |
|
Blast:LamG
|
264 |
330 |
1e-19 |
BLAST |
|
low complexity region
|
358 |
373 |
N/A |
INTRINSIC |
|
4.1m
|
376 |
394 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163134
|
| SMART Domains |
Protein: ENSMUSP00000129678
Gene: ENSMUSG00000066392
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
47 |
184 |
9.8e-31 |
SMART |
|
EGF
|
201 |
235 |
8.07e-1 |
SMART |
|
LamG
|
279 |
413 |
7.19e-38 |
SMART |
|
LamG
|
467 |
619 |
3.28e-41 |
SMART |
|
EGF
|
646 |
680 |
4.1e-2 |
SMART |
|
LamG
|
705 |
843 |
4.87e-26 |
SMART |
|
LamG
|
891 |
1027 |
7.08e-37 |
SMART |
|
EGF
|
1052 |
1086 |
1.99e1 |
SMART |
|
LamG
|
1114 |
1271 |
1.14e-17 |
SMART |
|
low complexity region
|
1312 |
1328 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1406 |
N/A |
INTRINSIC |
|
low complexity region
|
1499 |
1514 |
N/A |
INTRINSIC |
|
4.1m
|
1517 |
1535 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167103
|
| SMART Domains |
Protein: ENSMUSP00000127407
Gene: ENSMUSG00000066392
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
47 |
184 |
9.8e-31 |
SMART |
|
EGF
|
201 |
235 |
8.07e-1 |
SMART |
|
LamG
|
279 |
413 |
7.19e-38 |
SMART |
|
LamG
|
467 |
619 |
3.28e-41 |
SMART |
|
EGF
|
646 |
680 |
4.1e-2 |
SMART |
|
LamG
|
705 |
834 |
5.76e-28 |
SMART |
|
LamG
|
882 |
1018 |
7.08e-37 |
SMART |
|
EGF
|
1043 |
1077 |
1.99e1 |
SMART |
|
LamG
|
1105 |
1262 |
1.14e-17 |
SMART |
|
low complexity region
|
1303 |
1319 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167887
|
| SMART Domains |
Protein: ENSMUSP00000127926
Gene: ENSMUSG00000066392
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
94 |
246 |
3.28e-41 |
SMART |
|
EGF
|
273 |
307 |
4.1e-2 |
SMART |
|
LamG
|
332 |
470 |
4.87e-26 |
SMART |
|
LamG
|
518 |
654 |
7.08e-37 |
SMART |
|
EGF
|
688 |
722 |
1.99e1 |
SMART |
|
LamG
|
750 |
907 |
1.14e-17 |
SMART |
|
low complexity region
|
948 |
964 |
N/A |
INTRINSIC |
|
low complexity region
|
1028 |
1043 |
N/A |
INTRINSIC |
|
4.1m
|
1046 |
1064 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190626
|
| SMART Domains |
Protein: ENSMUSP00000139879
Gene: ENSMUSG00000066392
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
94 |
246 |
2.1e-43 |
SMART |
|
EGF
|
273 |
307 |
2e-4 |
SMART |
|
LamG
|
332 |
470 |
3.1e-28 |
SMART |
|
LamG
|
518 |
654 |
4.4e-39 |
SMART |
|
EGF
|
688 |
722 |
9.6e-2 |
SMART |
|
LamG
|
750 |
877 |
1.1e-22 |
SMART |
|
low complexity region
|
918 |
934 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
1000 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (62/62) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]
PHENOTYPE: Twenty percent of mice homozygous for a knock-out allele die postnatally prior to 20 days of age. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam2 |
T |
C |
14: 66,297,345 (GRCm39) |
E187G |
probably damaging |
Het |
| Adam28 |
C |
T |
14: 68,846,555 (GRCm39) |
|
probably null |
Het |
| Ap2a1 |
G |
A |
7: 44,559,160 (GRCm39) |
T189M |
probably damaging |
Het |
| Apaf1 |
A |
G |
10: 90,859,644 (GRCm39) |
Y845H |
probably benign |
Het |
| Asb14 |
G |
T |
14: 26,619,718 (GRCm39) |
V55F |
probably benign |
Het |
| Brap |
A |
T |
5: 121,800,192 (GRCm39) |
D71V |
probably damaging |
Het |
| Ccdc93 |
T |
G |
1: 121,427,042 (GRCm39) |
F610V |
probably damaging |
Het |
| Cfap46 |
T |
G |
7: 139,231,480 (GRCm39) |
D911A |
|
Het |
| Chn2 |
T |
C |
6: 54,275,137 (GRCm39) |
|
probably null |
Het |
| Cib3 |
A |
G |
8: 72,958,269 (GRCm39) |
F156S |
probably damaging |
Het |
| Csnk2a1-ps3 |
G |
A |
1: 156,352,354 (GRCm39) |
G185D |
possibly damaging |
Het |
| Ctif |
A |
T |
18: 75,738,715 (GRCm39) |
V164D |
probably damaging |
Het |
| Ddx27 |
T |
A |
2: 166,869,879 (GRCm39) |
F405I |
probably damaging |
Het |
| Dnttip2 |
A |
G |
3: 122,069,594 (GRCm39) |
T270A |
probably benign |
Het |
| Dst |
T |
A |
1: 34,314,775 (GRCm39) |
S4455T |
probably damaging |
Het |
| Efcab8 |
A |
G |
2: 153,685,110 (GRCm39) |
K47R |
|
Het |
| Efhd2 |
T |
C |
4: 141,601,886 (GRCm39) |
E98G |
probably damaging |
Het |
| Fcmr |
T |
A |
1: 130,802,025 (GRCm39) |
L93Q |
probably damaging |
Het |
| Fhdc1 |
T |
A |
3: 84,351,906 (GRCm39) |
E1106D |
probably benign |
Het |
| Gcnt1 |
C |
T |
19: 17,306,723 (GRCm39) |
G334D |
probably damaging |
Het |
| Hltf |
T |
C |
3: 20,145,647 (GRCm39) |
F488L |
probably benign |
Het |
| Hmgxb4 |
C |
A |
8: 75,727,436 (GRCm39) |
H140N |
probably damaging |
Het |
| Ifi214 |
A |
T |
1: 173,352,402 (GRCm39) |
F342L |
probably damaging |
Het |
| Ip6k1 |
A |
G |
9: 107,909,288 (GRCm39) |
D105G |
possibly damaging |
Het |
| Kank1 |
GCGAACG |
GCG |
19: 25,388,569 (GRCm39) |
|
probably null |
Het |
| Kif18a |
G |
A |
2: 109,137,285 (GRCm39) |
D506N |
probably benign |
Het |
| Klf17 |
T |
A |
4: 117,617,812 (GRCm39) |
M182L |
probably benign |
Het |
| Kmt2d |
A |
G |
15: 98,750,215 (GRCm39) |
F2493L |
unknown |
Het |
| Lefty1 |
A |
G |
1: 180,764,112 (GRCm39) |
E84G |
probably damaging |
Het |
| Lyst |
T |
G |
13: 13,884,117 (GRCm39) |
L2975R |
possibly damaging |
Het |
| Magea5 |
G |
A |
X: 153,837,174 (GRCm39) |
P73S |
possibly damaging |
Het |
| Mctp2 |
T |
C |
7: 71,740,079 (GRCm39) |
|
probably null |
Het |
| Mprip |
C |
T |
11: 59,649,047 (GRCm39) |
T917M |
possibly damaging |
Het |
| Myh8 |
T |
A |
11: 67,194,481 (GRCm39) |
I1564N |
probably benign |
Het |
| Npc1 |
A |
T |
18: 12,328,105 (GRCm39) |
M1068K |
probably benign |
Het |
| Nr2e1 |
A |
G |
10: 42,450,433 (GRCm39) |
C60R |
probably benign |
Het |
| Ntsr1 |
T |
A |
2: 180,180,610 (GRCm39) |
H305Q |
probably damaging |
Het |
| Or2y1e |
A |
G |
11: 49,218,571 (GRCm39) |
E111G |
probably damaging |
Het |
| Or8g35 |
A |
G |
9: 39,381,612 (GRCm39) |
S137P |
probably benign |
Het |
| Or8h10 |
T |
A |
2: 86,808,538 (GRCm39) |
I201F |
probably damaging |
Het |
| Pate2 |
A |
C |
9: 35,581,197 (GRCm39) |
E22D |
probably benign |
Het |
| Pcdhb22 |
A |
G |
18: 37,652,158 (GRCm39) |
T209A |
probably damaging |
Het |
| Pdss2 |
C |
T |
10: 43,340,628 (GRCm39) |
S352F |
probably benign |
Het |
| Pfn3 |
T |
A |
13: 55,562,900 (GRCm39) |
D27V |
probably damaging |
Het |
| Pigg |
T |
G |
5: 108,461,920 (GRCm39) |
S84A |
probably benign |
Het |
| Prm3 |
CTCTTCTTCTTCTTC |
CTCTTCTTCTTC |
16: 10,608,565 (GRCm39) |
|
probably benign |
Het |
| Prss22 |
C |
T |
17: 24,213,592 (GRCm39) |
G233E |
probably damaging |
Het |
| Rad51b |
T |
C |
12: 79,850,044 (GRCm39) |
|
probably null |
Het |
| Scn10a |
A |
G |
9: 119,438,970 (GRCm39) |
V1632A |
possibly damaging |
Het |
| Serpinb3d |
T |
G |
1: 107,007,512 (GRCm39) |
D158A |
probably damaging |
Het |
| Sh3yl1 |
T |
C |
12: 31,008,868 (GRCm39) |
L266P |
probably damaging |
Het |
| Sidt2 |
A |
T |
9: 45,852,873 (GRCm39) |
|
probably null |
Het |
| Stox1 |
C |
T |
10: 62,501,778 (GRCm39) |
V261M |
probably benign |
Het |
| Taf7l2 |
T |
A |
10: 115,949,158 (GRCm39) |
K123* |
probably null |
Het |
| Tll1 |
A |
G |
8: 64,504,483 (GRCm39) |
Y638H |
probably damaging |
Het |
| Tst |
A |
T |
15: 78,289,816 (GRCm39) |
M73K |
possibly damaging |
Het |
| Tuba4a |
C |
T |
1: 75,193,003 (GRCm39) |
V232M |
probably benign |
Het |
| Unk |
T |
A |
11: 115,943,908 (GRCm39) |
V343D |
probably benign |
Het |
| Usf3 |
T |
C |
16: 44,039,426 (GRCm39) |
V1302A |
probably benign |
Het |
| Usp32 |
A |
T |
11: 84,885,234 (GRCm39) |
L1271H |
probably damaging |
Het |
| Vwa5b2 |
C |
T |
16: 20,413,361 (GRCm39) |
P192L |
probably benign |
Het |
| Zfp995 |
A |
G |
17: 22,100,984 (GRCm39) |
Y38H |
probably damaging |
Het |
|
| Other mutations in Nrxn3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00911:Nrxn3
|
APN |
12 |
90,171,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Nrxn3
|
APN |
12 |
90,171,320 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01073:Nrxn3
|
APN |
12 |
89,221,510 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01338:Nrxn3
|
APN |
12 |
89,221,804 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01377:Nrxn3
|
APN |
12 |
89,499,782 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01409:Nrxn3
|
APN |
12 |
89,477,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Nrxn3
|
APN |
12 |
90,171,524 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02063:Nrxn3
|
APN |
12 |
88,762,565 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02171:Nrxn3
|
APN |
12 |
89,159,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Nrxn3
|
APN |
12 |
89,943,175 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02340:Nrxn3
|
APN |
12 |
90,171,402 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02343:Nrxn3
|
APN |
12 |
88,762,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02600:Nrxn3
|
APN |
12 |
89,478,682 (GRCm39) |
splice site |
probably benign |
|
|
IGL02735:Nrxn3
|
APN |
12 |
89,221,624 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03061:Nrxn3
|
APN |
12 |
89,478,698 (GRCm39) |
nonsense |
probably null |
|
|
IGL03206:Nrxn3
|
APN |
12 |
89,227,278 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03337:Nrxn3
|
APN |
12 |
89,221,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0098:Nrxn3
|
UTSW |
12 |
89,226,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0098:Nrxn3
|
UTSW |
12 |
89,226,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0144:Nrxn3
|
UTSW |
12 |
89,315,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0334:Nrxn3
|
UTSW |
12 |
89,780,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Nrxn3
|
UTSW |
12 |
88,762,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Nrxn3
|
UTSW |
12 |
90,298,567 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1324:Nrxn3
|
UTSW |
12 |
89,221,466 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1438:Nrxn3
|
UTSW |
12 |
90,298,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1484:Nrxn3
|
UTSW |
12 |
89,221,547 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1621:Nrxn3
|
UTSW |
12 |
88,762,480 (GRCm39) |
missense |
probably benign |
|
|
R1637:Nrxn3
|
UTSW |
12 |
89,321,238 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1659:Nrxn3
|
UTSW |
12 |
90,299,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Nrxn3
|
UTSW |
12 |
89,221,789 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1801:Nrxn3
|
UTSW |
12 |
90,250,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1912:Nrxn3
|
UTSW |
12 |
88,762,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1940:Nrxn3
|
UTSW |
12 |
89,227,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1993:Nrxn3
|
UTSW |
12 |
89,227,181 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R2002:Nrxn3
|
UTSW |
12 |
90,299,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Nrxn3
|
UTSW |
12 |
89,227,290 (GRCm39) |
splice site |
probably null |
|
|
R2179:Nrxn3
|
UTSW |
12 |
89,221,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2207:Nrxn3
|
UTSW |
12 |
89,315,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2284:Nrxn3
|
UTSW |
12 |
89,477,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2433:Nrxn3
|
UTSW |
12 |
89,943,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2969:Nrxn3
|
UTSW |
12 |
89,321,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3053:Nrxn3
|
UTSW |
12 |
89,221,871 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3076:Nrxn3
|
UTSW |
12 |
89,227,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3078:Nrxn3
|
UTSW |
12 |
89,227,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4033:Nrxn3
|
UTSW |
12 |
89,499,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Nrxn3
|
UTSW |
12 |
89,499,762 (GRCm39) |
nonsense |
probably null |
|
|
R4321:Nrxn3
|
UTSW |
12 |
90,166,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4470:Nrxn3
|
UTSW |
12 |
90,171,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4471:Nrxn3
|
UTSW |
12 |
90,171,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Nrxn3
|
UTSW |
12 |
90,171,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Nrxn3
|
UTSW |
12 |
89,477,421 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4776:Nrxn3
|
UTSW |
12 |
90,298,730 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4821:Nrxn3
|
UTSW |
12 |
90,171,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4869:Nrxn3
|
UTSW |
12 |
88,762,352 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4910:Nrxn3
|
UTSW |
12 |
89,227,130 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4960:Nrxn3
|
UTSW |
12 |
88,761,971 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4990:Nrxn3
|
UTSW |
12 |
89,227,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4991:Nrxn3
|
UTSW |
12 |
89,227,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Nrxn3
|
UTSW |
12 |
89,221,804 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5329:Nrxn3
|
UTSW |
12 |
89,780,354 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5888:Nrxn3
|
UTSW |
12 |
89,478,855 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6249:Nrxn3
|
UTSW |
12 |
89,221,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6264:Nrxn3
|
UTSW |
12 |
90,299,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6373:Nrxn3
|
UTSW |
12 |
89,943,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6401:Nrxn3
|
UTSW |
12 |
89,221,770 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6434:Nrxn3
|
UTSW |
12 |
88,762,285 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6528:Nrxn3
|
UTSW |
12 |
89,479,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Nrxn3
|
UTSW |
12 |
89,780,102 (GRCm39) |
intron |
probably benign |
|
|
R6632:Nrxn3
|
UTSW |
12 |
89,159,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6874:Nrxn3
|
UTSW |
12 |
90,298,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7122:Nrxn3
|
UTSW |
12 |
89,477,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7328:Nrxn3
|
UTSW |
12 |
88,762,345 (GRCm39) |
missense |
probably benign |
|
|
R7352:Nrxn3
|
UTSW |
12 |
88,817,063 (GRCm39) |
missense |
probably benign |
|
|
R7425:Nrxn3
|
UTSW |
12 |
89,479,870 (GRCm39) |
nonsense |
probably null |
|
|
R7444:Nrxn3
|
UTSW |
12 |
89,477,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Nrxn3
|
UTSW |
12 |
89,477,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Nrxn3
|
UTSW |
12 |
89,478,832 (GRCm39) |
missense |
probably benign |
|
|
R7738:Nrxn3
|
UTSW |
12 |
88,817,074 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8139:Nrxn3
|
UTSW |
12 |
90,171,438 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8192:Nrxn3
|
UTSW |
12 |
90,171,569 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8351:Nrxn3
|
UTSW |
12 |
89,477,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8368:Nrxn3
|
UTSW |
12 |
90,298,815 (GRCm39) |
nonsense |
probably null |
|
|
R8397:Nrxn3
|
UTSW |
12 |
90,298,583 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8426:Nrxn3
|
UTSW |
12 |
88,762,097 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8451:Nrxn3
|
UTSW |
12 |
89,477,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777:Nrxn3
|
UTSW |
12 |
89,227,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777-TAIL:Nrxn3
|
UTSW |
12 |
89,227,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8844:Nrxn3
|
UTSW |
12 |
89,153,920 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8870:Nrxn3
|
UTSW |
12 |
90,171,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9043:Nrxn3
|
UTSW |
12 |
89,227,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9102:Nrxn3
|
UTSW |
12 |
90,298,924 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9167:Nrxn3
|
UTSW |
12 |
89,154,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9445:Nrxn3
|
UTSW |
12 |
89,499,737 (GRCm39) |
nonsense |
probably null |
|
|
R9447:Nrxn3
|
UTSW |
12 |
89,221,678 (GRCm39) |
missense |
probably benign |
0.35 |
|
X0019:Nrxn3
|
UTSW |
12 |
90,165,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nrxn3
|
UTSW |
12 |
89,484,679 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
Z1176:Nrxn3
|
UTSW |
12 |
89,153,825 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Nrxn3
|
UTSW |
12 |
90,298,619 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1177:Nrxn3
|
UTSW |
12 |
89,227,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nrxn3
|
UTSW |
12 |
88,762,458 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Nrxn3
|
UTSW |
12 |
90,298,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCTCCTGCTATGATGGGC -3'
(R):5'- CTACCTGAAAGACAGTGGGTTAAAG -3'
Sequencing Primer
(F):5'- CCTCTGGGCATCATGAACTTCG -3'
(R):5'- GTGGGTTAAAGATTTGCAATGACCC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation