|Institutional Source||Beutler Lab|
|Gene Name||serine/threonine kinase 24|
|Is this an essential gene?||Possibly non essential (E-score: 0.333)|
|Stock #||R7771 (G1)|
|Chromosomal Location||121286343-121380011 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 121337633 bp|
|Amino Acid Change||Glutamic Acid to Glycine at position 21 (E21G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000078746 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000079817]|
|Predicted Effect||probably damaging
AA Change: E21G
PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
AA Change: E21G
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
PHENOTYPE: A hypomorphic mutation increases degranulation of, and exocytosis by, neutrophils. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Stk24||
(F):5'- ACTGGCTCAGCACTGTGATC -3'
(R):5'- ACTCATGATACAGAGTCACAGC -3'
(F):5'- GGCTCAGCACTGTGATCTCTTG -3'
(R):5'- TGCTGTTGTCCCGCACG -3'