Incidental Mutation 'R7772:Cdc25b'
ID 598621
Institutional Source Beutler Lab
Gene Symbol Cdc25b
Ensembl Gene ENSMUSG00000027330
Gene Name cell division cycle 25B
Synonyms
MMRRC Submission 045828-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7772 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 131028869-131040417 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 131031029 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 118 (D118G)
Ref Sequence ENSEMBL: ENSMUSP00000028804 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028801] [ENSMUST00000028804] [ENSMUST00000079857]
AlphaFold P30306
Predicted Effect probably benign
Transcript: ENSMUST00000028801
SMART Domains Protein: ENSMUSP00000028801
Gene: ENSMUSG00000027329

DomainStartEndE-ValueType
Pfam:CH_2 13 109 9.3e-36 PFAM
Pfam:CAMSAP_CH 14 96 7.9e-24 PFAM
coiled coil region 182 234 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000028804
AA Change: D118G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028804
Gene: ENSMUSG00000027330
AA Change: D118G

DomainStartEndE-ValueType
low complexity region 86 105 N/A INTRINSIC
Pfam:M-inducer_phosp 111 379 3.3e-103 PFAM
RHOD 417 531 4.29e-26 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000079857
AA Change: D118G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078784
Gene: ENSMUSG00000027330
AA Change: D118G

DomainStartEndE-ValueType
low complexity region 86 105 N/A INTRINSIC
Pfam:M-inducer_phosp 111 354 2.4e-78 PFAM
RHOD 391 505 4.29e-26 SMART
Meta Mutation Damage Score 0.7113 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
PHENOTYPE: The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921536K21Rik T A 11: 3,839,784 (GRCm39) probably null Het
Adora3 T C 3: 105,815,039 (GRCm39) V263A probably benign Het
Adprhl1 C T 8: 13,298,682 (GRCm39) V83I probably damaging Het
Arfgef1 A G 1: 10,227,235 (GRCm39) V1368A possibly damaging Het
Arid4a A T 12: 71,108,363 (GRCm39) N56I possibly damaging Het
Art3 A T 5: 92,551,472 (GRCm39) Y277F probably damaging Het
Atp2a1 A T 7: 126,047,707 (GRCm39) probably null Het
Banf1 T C 19: 5,415,150 (GRCm39) K54E possibly damaging Het
Bckdk A G 7: 127,505,073 (GRCm39) Y151C probably damaging Het
C1qtnf3 C A 15: 10,958,130 (GRCm39) P58T possibly damaging Het
Cadps2 T C 6: 23,390,445 (GRCm39) R744G probably benign Het
Cnot9 G A 1: 74,566,151 (GRCm39) V181I probably damaging Het
Cobl C T 11: 12,204,488 (GRCm39) G738D probably benign Het
Col18a1 T A 10: 76,904,220 (GRCm39) probably null Het
Crnkl1 A G 2: 145,772,564 (GRCm39) V171A probably benign Het
Dhx57 C T 17: 80,580,507 (GRCm39) D482N possibly damaging Het
Dpysl2 A T 14: 67,066,425 (GRCm39) probably null Het
Drd3 G T 16: 43,582,758 (GRCm39) A52S probably benign Het
Dst T C 1: 34,220,469 (GRCm39) V2091A possibly damaging Het
Evpl T C 11: 116,112,261 (GRCm39) T1810A probably benign Het
Fbxo2 T A 4: 148,248,783 (GRCm39) W92R probably damaging Het
Gas2l2 T A 11: 83,320,103 (GRCm39) D51V possibly damaging Het
Gm11232 A T 4: 71,674,818 (GRCm39) V228E possibly damaging Het
Gm14305 C T 2: 176,412,764 (GRCm39) Q219* probably null Het
Gpr137b T C 13: 13,533,991 (GRCm39) Y355C Het
Gpr39 G T 1: 125,605,334 (GRCm39) M87I possibly damaging Het
Heatr1 T C 13: 12,432,522 (GRCm39) M1089T probably benign Het
Ifi206 A T 1: 173,308,640 (GRCm39) M452K Het
Ints8 A T 4: 11,227,190 (GRCm39) I561N probably damaging Het
Itgb2 A T 10: 77,396,946 (GRCm39) K660N probably benign Het
Jun A C 4: 94,939,081 (GRCm39) V143G probably benign Het
Kalrn A G 16: 33,851,952 (GRCm39) M2076T probably benign Het
Krt10 G T 11: 99,279,913 (GRCm39) S82R unknown Het
Lipm T A 19: 34,095,291 (GRCm39) H295Q probably damaging Het
Mybpc2 A C 7: 44,165,348 (GRCm39) probably null Het
Nedd4 T C 9: 72,584,608 (GRCm39) V103A possibly damaging Het
Nol10 T C 12: 17,398,586 (GRCm39) I11T probably damaging Het
Nup210l A G 3: 90,067,233 (GRCm39) S758G probably damaging Het
Or13d1 T A 4: 52,970,713 (GRCm39) C31S probably damaging Het
Or52r1c T G 7: 102,735,388 (GRCm39) I216S probably benign Het
Or8d4 T C 9: 40,038,661 (GRCm39) I199V probably benign Het
Osbpl9 T C 4: 108,923,384 (GRCm39) H425R probably damaging Het
Parp1 G T 1: 180,416,963 (GRCm39) R582S possibly damaging Het
Piwil1 A T 5: 128,816,527 (GRCm39) R36S probably benign Het
Pjvk T C 2: 76,487,877 (GRCm39) probably null Het
Plekha6 G T 1: 133,097,760 (GRCm39) E31D possibly damaging Het
Polr1b C A 2: 128,967,464 (GRCm39) F952L probably damaging Het
Prm3 CTCTTCTTCTTCTTC CTCTTCTTCTTC 16: 10,608,565 (GRCm39) probably benign Het
Psmc6 T A 14: 45,581,107 (GRCm39) I301N probably damaging Het
Rfpl4 C A 7: 5,118,543 (GRCm39) S9I probably benign Het
Rnf14 G T 18: 38,442,629 (GRCm39) C310F probably damaging Het
Rnf17 T A 14: 56,715,144 (GRCm39) F845L probably benign Het
Robo2 T C 16: 73,758,777 (GRCm39) I665V probably benign Het
Rtl1 T A 12: 109,559,619 (GRCm39) H740L probably damaging Het
Ryr2 A G 13: 11,765,897 (GRCm39) S1280P probably benign Het
Slc12a8 G A 16: 33,371,335 (GRCm39) R126H probably damaging Het
Slc9a1 T C 4: 133,139,276 (GRCm39) F165L probably damaging Het
Snx19 T C 9: 30,340,221 (GRCm39) I453T probably damaging Het
Spag17 T C 3: 99,987,434 (GRCm39) Y1575H probably damaging Het
Spef2 T C 15: 9,704,567 (GRCm39) I415M probably damaging Het
Ssx2ip T G 3: 146,138,885 (GRCm39) I459S probably damaging Het
Stfa1 A G 16: 36,097,363 (GRCm39) probably null Het
Tmem156 A T 5: 65,237,517 (GRCm39) S48T probably damaging Het
Tmx3 T A 18: 90,545,918 (GRCm39) probably null Het
Unc93a A T 17: 13,328,639 (GRCm39) F405I possibly damaging Het
Vmn1r209 T A 13: 22,990,664 (GRCm39) I9F possibly damaging Het
Vmn2r93 A G 17: 18,533,482 (GRCm39) D462G probably damaging Het
Wdr90 T A 17: 26,080,465 (GRCm39) probably benign Het
Zfp551 T C 7: 12,152,535 (GRCm39) D66G probably damaging Het
Znrf4 A C 17: 56,819,247 (GRCm39) V20G possibly damaging Het
Zscan4d T C 7: 10,896,770 (GRCm39) E200G probably benign Het
Zup1 A T 10: 33,797,698 (GRCm39) probably null Het
Other mutations in Cdc25b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03230:Cdc25b APN 2 131,030,060 (GRCm39) missense probably benign 0.00
R0471:Cdc25b UTSW 2 131,039,204 (GRCm39) missense probably damaging 0.99
R0639:Cdc25b UTSW 2 131,039,182 (GRCm39) missense probably benign 0.00
R0645:Cdc25b UTSW 2 131,033,533 (GRCm39) missense probably benign 0.06
R0673:Cdc25b UTSW 2 131,039,182 (GRCm39) missense probably benign 0.00
R1574:Cdc25b UTSW 2 131,033,057 (GRCm39) splice site probably benign
R4094:Cdc25b UTSW 2 131,031,037 (GRCm39) missense probably benign
R4433:Cdc25b UTSW 2 131,033,618 (GRCm39) missense probably benign 0.02
R4722:Cdc25b UTSW 2 131,035,271 (GRCm39) missense probably damaging 1.00
R4817:Cdc25b UTSW 2 131,035,223 (GRCm39) missense probably damaging 1.00
R4957:Cdc25b UTSW 2 131,035,525 (GRCm39) missense possibly damaging 0.80
R5345:Cdc25b UTSW 2 131,034,516 (GRCm39) missense probably benign 0.18
R5407:Cdc25b UTSW 2 131,035,567 (GRCm39) missense probably damaging 1.00
R5562:Cdc25b UTSW 2 131,036,678 (GRCm39) missense probably damaging 1.00
R5594:Cdc25b UTSW 2 131,033,538 (GRCm39) missense probably damaging 1.00
R5792:Cdc25b UTSW 2 131,033,679 (GRCm39) missense probably damaging 1.00
R5831:Cdc25b UTSW 2 131,029,301 (GRCm39) critical splice donor site probably null
R7204:Cdc25b UTSW 2 131,033,552 (GRCm39) missense probably damaging 1.00
R7292:Cdc25b UTSW 2 131,033,093 (GRCm39) missense probably damaging 1.00
R7399:Cdc25b UTSW 2 131,036,574 (GRCm39) missense probably damaging 1.00
R7501:Cdc25b UTSW 2 131,036,080 (GRCm39) missense probably damaging 1.00
R8186:Cdc25b UTSW 2 131,031,050 (GRCm39) missense probably benign 0.05
R8783:Cdc25b UTSW 2 131,033,772 (GRCm39) missense probably benign 0.05
R8985:Cdc25b UTSW 2 131,035,180 (GRCm39) missense probably damaging 1.00
R9141:Cdc25b UTSW 2 131,033,857 (GRCm39) critical splice donor site probably null
R9153:Cdc25b UTSW 2 131,034,564 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GTCCCATGCTTAGGGTTCATAAG -3'
(R):5'- GCTTCCCTGTAAGAAAGCAGG -3'

Sequencing Primer
(F):5'- GCTTAGGGTTCATAAGTAGGTTTTG -3'
(R):5'- TGCAGAGATCTGAGTTCAGTACCC -3'
Posted On 2019-11-26