Incidental Mutation 'R7772:Wdr90'
ID |
598673 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Wdr90
|
Ensembl Gene |
ENSMUSG00000073434 |
Gene Name |
WD repeat domain 90 |
Synonyms |
3230401M21Rik |
MMRRC Submission |
045828-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.101)
|
Stock # |
R7772 (G1)
|
Quality Score |
105.008 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
26063745-26080475 bp(-) (GRCm39) |
Type of Mutation |
start gained |
DNA Base Change (assembly) |
T to A
at 26080465 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135420
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026828]
[ENSMUST00000079461]
[ENSMUST00000176923]
|
AlphaFold |
Q6ZPG2 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000026828
|
SMART Domains |
Protein: ENSMUSP00000026828 Gene: ENSMUSG00000025732
Domain | Start | End | E-Value | Type |
Pfam:FAM195
|
59 |
158 |
8.3e-33 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000079461
|
SMART Domains |
Protein: ENSMUSP00000078426 Gene: ENSMUSG00000073434
Domain | Start | End | E-Value | Type |
low complexity region
|
32 |
53 |
N/A |
INTRINSIC |
Pfam:DUF667
|
60 |
183 |
5e-26 |
PFAM |
Pfam:DUF667
|
210 |
271 |
3.7e-9 |
PFAM |
low complexity region
|
381 |
396 |
N/A |
INTRINSIC |
WD40
|
478 |
519 |
5.94e0 |
SMART |
WD40
|
522 |
565 |
3.2e0 |
SMART |
WD40
|
572 |
612 |
3.3e1 |
SMART |
WD40
|
687 |
725 |
1.15e1 |
SMART |
WD40
|
728 |
766 |
5.75e-1 |
SMART |
WD40
|
768 |
808 |
9.24e-4 |
SMART |
WD40
|
811 |
850 |
4.13e0 |
SMART |
WD40
|
853 |
892 |
4.62e-1 |
SMART |
WD40
|
950 |
993 |
1.07e1 |
SMART |
WD40
|
996 |
1035 |
5.75e-1 |
SMART |
WD40
|
1040 |
1077 |
1.58e-2 |
SMART |
WD40
|
1290 |
1334 |
5.23e-3 |
SMART |
WD40
|
1337 |
1378 |
1.27e-1 |
SMART |
WD40
|
1384 |
1419 |
1.83e2 |
SMART |
WD40
|
1422 |
1469 |
3.08e0 |
SMART |
WD40
|
1472 |
1509 |
9.9e0 |
SMART |
WD40
|
1568 |
1607 |
9.02e-7 |
SMART |
WD40
|
1610 |
1655 |
5.75e-1 |
SMART |
WD40
|
1659 |
1697 |
2.98e-1 |
SMART |
WD40
|
1700 |
1749 |
6.14e1 |
SMART |
WD40
|
1850 |
1888 |
1.92e-1 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176678
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176923
|
SMART Domains |
Protein: ENSMUSP00000135420 Gene: ENSMUSG00000073434
Domain | Start | End | E-Value | Type |
low complexity region
|
32 |
53 |
N/A |
INTRINSIC |
Pfam:DUF667
|
60 |
252 |
5.1e-14 |
PFAM |
low complexity region
|
363 |
378 |
N/A |
INTRINSIC |
WD40
|
460 |
501 |
5.94e0 |
SMART |
WD40
|
504 |
547 |
3.2e0 |
SMART |
WD40
|
554 |
594 |
3.3e1 |
SMART |
WD40
|
669 |
707 |
1.15e1 |
SMART |
WD40
|
710 |
748 |
5.75e-1 |
SMART |
WD40
|
750 |
790 |
9.24e-4 |
SMART |
WD40
|
793 |
832 |
4.13e0 |
SMART |
WD40
|
835 |
874 |
4.62e-1 |
SMART |
WD40
|
932 |
975 |
1.07e1 |
SMART |
WD40
|
978 |
1017 |
5.75e-1 |
SMART |
WD40
|
1022 |
1059 |
1.58e-2 |
SMART |
WD40
|
1272 |
1316 |
5.23e-3 |
SMART |
WD40
|
1319 |
1360 |
1.27e-1 |
SMART |
WD40
|
1366 |
1401 |
1.83e2 |
SMART |
WD40
|
1404 |
1451 |
3.08e0 |
SMART |
WD40
|
1454 |
1491 |
9.9e0 |
SMART |
WD40
|
1550 |
1589 |
9.02e-7 |
SMART |
WD40
|
1592 |
1637 |
5.75e-1 |
SMART |
WD40
|
1641 |
1679 |
2.98e-1 |
SMART |
WD40
|
1682 |
1731 |
6.14e1 |
SMART |
WD40
|
1832 |
1870 |
1.92e-1 |
SMART |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
99% (68/69) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 72 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4921536K21Rik |
T |
A |
11: 3,839,784 (GRCm39) |
|
probably null |
Het |
Adora3 |
T |
C |
3: 105,815,039 (GRCm39) |
V263A |
probably benign |
Het |
Adprhl1 |
C |
T |
8: 13,298,682 (GRCm39) |
V83I |
probably damaging |
Het |
Arfgef1 |
A |
G |
1: 10,227,235 (GRCm39) |
V1368A |
possibly damaging |
Het |
Arid4a |
A |
T |
12: 71,108,363 (GRCm39) |
N56I |
possibly damaging |
Het |
Art3 |
A |
T |
5: 92,551,472 (GRCm39) |
Y277F |
probably damaging |
Het |
Atp2a1 |
A |
T |
7: 126,047,707 (GRCm39) |
|
probably null |
Het |
Banf1 |
T |
C |
19: 5,415,150 (GRCm39) |
K54E |
possibly damaging |
Het |
Bckdk |
A |
G |
7: 127,505,073 (GRCm39) |
Y151C |
probably damaging |
Het |
C1qtnf3 |
C |
A |
15: 10,958,130 (GRCm39) |
P58T |
possibly damaging |
Het |
Cadps2 |
T |
C |
6: 23,390,445 (GRCm39) |
R744G |
probably benign |
Het |
Cdc25b |
A |
G |
2: 131,031,029 (GRCm39) |
D118G |
probably damaging |
Het |
Cnot9 |
G |
A |
1: 74,566,151 (GRCm39) |
V181I |
probably damaging |
Het |
Cobl |
C |
T |
11: 12,204,488 (GRCm39) |
G738D |
probably benign |
Het |
Col18a1 |
T |
A |
10: 76,904,220 (GRCm39) |
|
probably null |
Het |
Crnkl1 |
A |
G |
2: 145,772,564 (GRCm39) |
V171A |
probably benign |
Het |
Dhx57 |
C |
T |
17: 80,580,507 (GRCm39) |
D482N |
possibly damaging |
Het |
Dpysl2 |
A |
T |
14: 67,066,425 (GRCm39) |
|
probably null |
Het |
Drd3 |
G |
T |
16: 43,582,758 (GRCm39) |
A52S |
probably benign |
Het |
Dst |
T |
C |
1: 34,220,469 (GRCm39) |
V2091A |
possibly damaging |
Het |
Evpl |
T |
C |
11: 116,112,261 (GRCm39) |
T1810A |
probably benign |
Het |
Fbxo2 |
T |
A |
4: 148,248,783 (GRCm39) |
W92R |
probably damaging |
Het |
Gas2l2 |
T |
A |
11: 83,320,103 (GRCm39) |
D51V |
possibly damaging |
Het |
Gm11232 |
A |
T |
4: 71,674,818 (GRCm39) |
V228E |
possibly damaging |
Het |
Gm14305 |
C |
T |
2: 176,412,764 (GRCm39) |
Q219* |
probably null |
Het |
Gpr137b |
T |
C |
13: 13,533,991 (GRCm39) |
Y355C |
|
Het |
Gpr39 |
G |
T |
1: 125,605,334 (GRCm39) |
M87I |
possibly damaging |
Het |
Heatr1 |
T |
C |
13: 12,432,522 (GRCm39) |
M1089T |
probably benign |
Het |
Ifi206 |
A |
T |
1: 173,308,640 (GRCm39) |
M452K |
|
Het |
Ints8 |
A |
T |
4: 11,227,190 (GRCm39) |
I561N |
probably damaging |
Het |
Itgb2 |
A |
T |
10: 77,396,946 (GRCm39) |
K660N |
probably benign |
Het |
Jun |
A |
C |
4: 94,939,081 (GRCm39) |
V143G |
probably benign |
Het |
Kalrn |
A |
G |
16: 33,851,952 (GRCm39) |
M2076T |
probably benign |
Het |
Krt10 |
G |
T |
11: 99,279,913 (GRCm39) |
S82R |
unknown |
Het |
Lipm |
T |
A |
19: 34,095,291 (GRCm39) |
H295Q |
probably damaging |
Het |
Mybpc2 |
A |
C |
7: 44,165,348 (GRCm39) |
|
probably null |
Het |
Nedd4 |
T |
C |
9: 72,584,608 (GRCm39) |
V103A |
possibly damaging |
Het |
Nol10 |
T |
C |
12: 17,398,586 (GRCm39) |
I11T |
probably damaging |
Het |
Nup210l |
A |
G |
3: 90,067,233 (GRCm39) |
S758G |
probably damaging |
Het |
Or13d1 |
T |
A |
4: 52,970,713 (GRCm39) |
C31S |
probably damaging |
Het |
Or52r1c |
T |
G |
7: 102,735,388 (GRCm39) |
I216S |
probably benign |
Het |
Or8d4 |
T |
C |
9: 40,038,661 (GRCm39) |
I199V |
probably benign |
Het |
Osbpl9 |
T |
C |
4: 108,923,384 (GRCm39) |
H425R |
probably damaging |
Het |
Parp1 |
G |
T |
1: 180,416,963 (GRCm39) |
R582S |
possibly damaging |
Het |
Piwil1 |
A |
T |
5: 128,816,527 (GRCm39) |
R36S |
probably benign |
Het |
Pjvk |
T |
C |
2: 76,487,877 (GRCm39) |
|
probably null |
Het |
Plekha6 |
G |
T |
1: 133,097,760 (GRCm39) |
E31D |
possibly damaging |
Het |
Polr1b |
C |
A |
2: 128,967,464 (GRCm39) |
F952L |
probably damaging |
Het |
Prm3 |
CTCTTCTTCTTCTTC |
CTCTTCTTCTTC |
16: 10,608,565 (GRCm39) |
|
probably benign |
Het |
Psmc6 |
T |
A |
14: 45,581,107 (GRCm39) |
I301N |
probably damaging |
Het |
Rfpl4 |
C |
A |
7: 5,118,543 (GRCm39) |
S9I |
probably benign |
Het |
Rnf14 |
G |
T |
18: 38,442,629 (GRCm39) |
C310F |
probably damaging |
Het |
Rnf17 |
T |
A |
14: 56,715,144 (GRCm39) |
F845L |
probably benign |
Het |
Robo2 |
T |
C |
16: 73,758,777 (GRCm39) |
I665V |
probably benign |
Het |
Rtl1 |
T |
A |
12: 109,559,619 (GRCm39) |
H740L |
probably damaging |
Het |
Ryr2 |
A |
G |
13: 11,765,897 (GRCm39) |
S1280P |
probably benign |
Het |
Slc12a8 |
G |
A |
16: 33,371,335 (GRCm39) |
R126H |
probably damaging |
Het |
Slc9a1 |
T |
C |
4: 133,139,276 (GRCm39) |
F165L |
probably damaging |
Het |
Snx19 |
T |
C |
9: 30,340,221 (GRCm39) |
I453T |
probably damaging |
Het |
Spag17 |
T |
C |
3: 99,987,434 (GRCm39) |
Y1575H |
probably damaging |
Het |
Spef2 |
T |
C |
15: 9,704,567 (GRCm39) |
I415M |
probably damaging |
Het |
Ssx2ip |
T |
G |
3: 146,138,885 (GRCm39) |
I459S |
probably damaging |
Het |
Stfa1 |
A |
G |
16: 36,097,363 (GRCm39) |
|
probably null |
Het |
Tmem156 |
A |
T |
5: 65,237,517 (GRCm39) |
S48T |
probably damaging |
Het |
Tmx3 |
T |
A |
18: 90,545,918 (GRCm39) |
|
probably null |
Het |
Unc93a |
A |
T |
17: 13,328,639 (GRCm39) |
F405I |
possibly damaging |
Het |
Vmn1r209 |
T |
A |
13: 22,990,664 (GRCm39) |
I9F |
possibly damaging |
Het |
Vmn2r93 |
A |
G |
17: 18,533,482 (GRCm39) |
D462G |
probably damaging |
Het |
Zfp551 |
T |
C |
7: 12,152,535 (GRCm39) |
D66G |
probably damaging |
Het |
Znrf4 |
A |
C |
17: 56,819,247 (GRCm39) |
V20G |
possibly damaging |
Het |
Zscan4d |
T |
C |
7: 10,896,770 (GRCm39) |
E200G |
probably benign |
Het |
Zup1 |
A |
T |
10: 33,797,698 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Wdr90 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00418:Wdr90
|
APN |
17 |
26,068,338 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01118:Wdr90
|
APN |
17 |
26,073,661 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01964:Wdr90
|
APN |
17 |
26,067,383 (GRCm39) |
missense |
probably benign |
|
IGL02116:Wdr90
|
APN |
17 |
26,078,466 (GRCm39) |
missense |
probably benign |
0.12 |
IGL02172:Wdr90
|
APN |
17 |
26,069,408 (GRCm39) |
missense |
probably benign |
0.22 |
IGL02716:Wdr90
|
APN |
17 |
26,076,194 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02961:Wdr90
|
APN |
17 |
26,067,649 (GRCm39) |
nonsense |
probably null |
|
IGL03229:Wdr90
|
APN |
17 |
26,064,437 (GRCm39) |
splice site |
probably benign |
|
IGL03367:Wdr90
|
APN |
17 |
26,066,765 (GRCm39) |
splice site |
probably benign |
|
IGL03098:Wdr90
|
UTSW |
17 |
26,078,961 (GRCm39) |
intron |
probably benign |
|
R0111:Wdr90
|
UTSW |
17 |
26,067,418 (GRCm39) |
splice site |
probably benign |
|
R0454:Wdr90
|
UTSW |
17 |
26,079,023 (GRCm39) |
missense |
probably damaging |
0.96 |
R0457:Wdr90
|
UTSW |
17 |
26,079,459 (GRCm39) |
missense |
probably benign |
0.00 |
R0488:Wdr90
|
UTSW |
17 |
26,067,591 (GRCm39) |
missense |
probably damaging |
1.00 |
R0622:Wdr90
|
UTSW |
17 |
26,074,632 (GRCm39) |
missense |
probably damaging |
1.00 |
R0671:Wdr90
|
UTSW |
17 |
26,065,367 (GRCm39) |
missense |
probably benign |
0.04 |
R0799:Wdr90
|
UTSW |
17 |
26,079,104 (GRCm39) |
missense |
probably benign |
0.38 |
R1177:Wdr90
|
UTSW |
17 |
26,065,028 (GRCm39) |
missense |
possibly damaging |
0.85 |
R1460:Wdr90
|
UTSW |
17 |
26,079,422 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1468:Wdr90
|
UTSW |
17 |
26,073,027 (GRCm39) |
missense |
probably damaging |
1.00 |
R1468:Wdr90
|
UTSW |
17 |
26,073,027 (GRCm39) |
missense |
probably damaging |
1.00 |
R1544:Wdr90
|
UTSW |
17 |
26,068,284 (GRCm39) |
missense |
possibly damaging |
0.69 |
R2057:Wdr90
|
UTSW |
17 |
26,074,173 (GRCm39) |
missense |
probably benign |
0.05 |
R2087:Wdr90
|
UTSW |
17 |
26,065,577 (GRCm39) |
missense |
probably damaging |
1.00 |
R2159:Wdr90
|
UTSW |
17 |
26,070,715 (GRCm39) |
missense |
probably benign |
|
R2208:Wdr90
|
UTSW |
17 |
26,079,362 (GRCm39) |
missense |
probably damaging |
1.00 |
R2345:Wdr90
|
UTSW |
17 |
26,078,136 (GRCm39) |
missense |
probably benign |
0.05 |
R2391:Wdr90
|
UTSW |
17 |
26,070,429 (GRCm39) |
missense |
probably damaging |
1.00 |
R2394:Wdr90
|
UTSW |
17 |
26,070,429 (GRCm39) |
missense |
probably damaging |
1.00 |
R2520:Wdr90
|
UTSW |
17 |
26,074,326 (GRCm39) |
missense |
probably damaging |
1.00 |
R3798:Wdr90
|
UTSW |
17 |
26,069,472 (GRCm39) |
missense |
probably benign |
0.01 |
R3979:Wdr90
|
UTSW |
17 |
26,078,252 (GRCm39) |
missense |
probably benign |
0.00 |
R4111:Wdr90
|
UTSW |
17 |
26,068,342 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4326:Wdr90
|
UTSW |
17 |
26,072,705 (GRCm39) |
missense |
probably benign |
0.25 |
R4459:Wdr90
|
UTSW |
17 |
26,079,976 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4697:Wdr90
|
UTSW |
17 |
26,074,337 (GRCm39) |
missense |
probably benign |
0.03 |
R4735:Wdr90
|
UTSW |
17 |
26,078,424 (GRCm39) |
missense |
probably benign |
|
R4907:Wdr90
|
UTSW |
17 |
26,079,624 (GRCm39) |
intron |
probably benign |
|
R5070:Wdr90
|
UTSW |
17 |
26,065,307 (GRCm39) |
missense |
probably damaging |
1.00 |
R5230:Wdr90
|
UTSW |
17 |
26,074,277 (GRCm39) |
missense |
probably benign |
0.01 |
R5268:Wdr90
|
UTSW |
17 |
26,069,819 (GRCm39) |
missense |
probably damaging |
1.00 |
R5287:Wdr90
|
UTSW |
17 |
26,080,441 (GRCm39) |
utr 5 prime |
probably benign |
|
R5382:Wdr90
|
UTSW |
17 |
26,064,572 (GRCm39) |
missense |
probably damaging |
1.00 |
R5511:Wdr90
|
UTSW |
17 |
26,063,995 (GRCm39) |
unclassified |
probably benign |
|
R5545:Wdr90
|
UTSW |
17 |
26,064,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R5707:Wdr90
|
UTSW |
17 |
26,076,166 (GRCm39) |
missense |
probably benign |
0.00 |
R5973:Wdr90
|
UTSW |
17 |
26,065,381 (GRCm39) |
missense |
probably damaging |
1.00 |
R5973:Wdr90
|
UTSW |
17 |
26,064,107 (GRCm39) |
missense |
probably damaging |
0.99 |
R6385:Wdr90
|
UTSW |
17 |
26,067,504 (GRCm39) |
missense |
probably damaging |
1.00 |
R6481:Wdr90
|
UTSW |
17 |
26,064,885 (GRCm39) |
missense |
probably damaging |
0.99 |
R7078:Wdr90
|
UTSW |
17 |
26,068,623 (GRCm39) |
missense |
probably damaging |
1.00 |
R7214:Wdr90
|
UTSW |
17 |
26,064,367 (GRCm39) |
missense |
probably benign |
0.00 |
R7288:Wdr90
|
UTSW |
17 |
26,065,286 (GRCm39) |
missense |
probably benign |
0.03 |
R7304:Wdr90
|
UTSW |
17 |
26,070,480 (GRCm39) |
missense |
probably benign |
0.10 |
R7309:Wdr90
|
UTSW |
17 |
26,079,676 (GRCm39) |
missense |
probably benign |
0.02 |
R7391:Wdr90
|
UTSW |
17 |
26,065,502 (GRCm39) |
missense |
probably benign |
0.08 |
R7622:Wdr90
|
UTSW |
17 |
26,073,083 (GRCm39) |
missense |
probably benign |
0.00 |
R7646:Wdr90
|
UTSW |
17 |
26,079,104 (GRCm39) |
missense |
probably benign |
0.38 |
R7779:Wdr90
|
UTSW |
17 |
26,065,300 (GRCm39) |
missense |
probably damaging |
1.00 |
R7780:Wdr90
|
UTSW |
17 |
26,065,300 (GRCm39) |
missense |
probably damaging |
1.00 |
R7781:Wdr90
|
UTSW |
17 |
26,065,300 (GRCm39) |
missense |
probably damaging |
1.00 |
R7782:Wdr90
|
UTSW |
17 |
26,065,300 (GRCm39) |
missense |
probably damaging |
1.00 |
R7812:Wdr90
|
UTSW |
17 |
26,071,532 (GRCm39) |
missense |
probably damaging |
1.00 |
R7870:Wdr90
|
UTSW |
17 |
26,079,513 (GRCm39) |
missense |
probably damaging |
0.96 |
R7911:Wdr90
|
UTSW |
17 |
26,069,723 (GRCm39) |
missense |
probably benign |
0.00 |
R8126:Wdr90
|
UTSW |
17 |
26,067,951 (GRCm39) |
missense |
possibly damaging |
0.48 |
R8260:Wdr90
|
UTSW |
17 |
26,064,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R8315:Wdr90
|
UTSW |
17 |
26,064,399 (GRCm39) |
missense |
probably benign |
0.21 |
R8919:Wdr90
|
UTSW |
17 |
26,076,146 (GRCm39) |
missense |
|
|
R8938:Wdr90
|
UTSW |
17 |
26,076,146 (GRCm39) |
missense |
|
|
R8940:Wdr90
|
UTSW |
17 |
26,076,146 (GRCm39) |
missense |
|
|
R9038:Wdr90
|
UTSW |
17 |
26,076,200 (GRCm39) |
missense |
|
|
R9079:Wdr90
|
UTSW |
17 |
26,076,403 (GRCm39) |
missense |
|
|
R9401:Wdr90
|
UTSW |
17 |
26,064,750 (GRCm39) |
small insertion |
probably benign |
|
R9471:Wdr90
|
UTSW |
17 |
26,080,015 (GRCm39) |
missense |
possibly damaging |
0.72 |
R9642:Wdr90
|
UTSW |
17 |
26,072,694 (GRCm39) |
critical splice donor site |
probably null |
|
X0064:Wdr90
|
UTSW |
17 |
26,067,537 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Wdr90
|
UTSW |
17 |
26,079,470 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CATTGAGGAAAGGGTGCTGC -3'
(R):5'- CTTAGCACAGTTCCCTGCACAG -3'
Sequencing Primer
(F):5'- AAAGGGTGCTGCCAGGC -3'
(R):5'- AGTTCCCTGCACAGTGCTGAG -3'
|
Posted On |
2019-11-26 |