Incidental Mutation 'R7773:Lrrc66'
ID 598700
Institutional Source Beutler Lab
Gene Symbol Lrrc66
Ensembl Gene ENSMUSG00000067206
Gene Name leucine rich repeat containing 66
Synonyms
MMRRC Submission 045829-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R7773 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 73763985-73789771 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 73764664 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Phenylalanine at position 793 (S793F)
Ref Sequence ENSEMBL: ENSMUSP00000084423 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087177]
AlphaFold Q8K0B3
Predicted Effect probably damaging
Transcript: ENSMUST00000087177
AA Change: S793F

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000084423
Gene: ENSMUSG00000067206
AA Change: S793F

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRR 140 162 1.81e1 SMART
LRR_TYP 163 186 9.44e-2 SMART
LRR 187 210 1.26e2 SMART
LRR 211 234 4.84e1 SMART
low complexity region 298 309 N/A INTRINSIC
transmembrane domain 369 391 N/A INTRINSIC
low complexity region 434 445 N/A INTRINSIC
low complexity region 842 859 N/A INTRINSIC
Meta Mutation Damage Score 0.1043 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (55/56)
Allele List at MGI

All alleles(2) : Targeted, other(1) Gene trapped(1)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A G 3: 124,206,180 (GRCm39) I336T probably benign Het
4930519P11Rik T C 2: 154,455,107 (GRCm39) Y84C unknown Het
4930568D16Rik C T 2: 35,244,606 (GRCm39) G249S probably damaging Het
AAdacl4fm3 A T 4: 144,430,047 (GRCm39) L314Q probably damaging Het
Adprhl1 C T 8: 13,298,682 (GRCm39) V83I probably damaging Het
Agbl1 T A 7: 76,348,585 (GRCm39) V894E unknown Het
Amigo3 T C 9: 107,931,867 (GRCm39) L430P probably benign Het
Aoc1 A G 6: 48,883,146 (GRCm39) I341V probably benign Het
Bod1l A G 5: 41,990,055 (GRCm39) S223P probably benign Het
Cacnb3 T C 15: 98,537,819 (GRCm39) probably null Het
Ccdc63 G T 5: 122,247,335 (GRCm39) N503K probably damaging Het
Ccdc83 T A 7: 89,879,120 (GRCm39) I225F probably damaging Het
Cd200r1 A G 16: 44,610,050 (GRCm39) T90A possibly damaging Het
Cd8a A G 6: 71,350,799 (GRCm39) N88S probably benign Het
Cep170 A G 1: 176,567,642 (GRCm39) V152A Het
Chid1 T C 7: 141,109,518 (GRCm39) M123V probably benign Het
Cnnm4 T C 1: 36,538,603 (GRCm39) V595A probably benign Het
Coro7 A G 16: 4,449,870 (GRCm39) L630P probably damaging Het
Cpvl A G 6: 53,908,890 (GRCm39) probably null Het
Edem3 A T 1: 151,687,347 (GRCm39) K762* probably null Het
Elp6 T A 9: 110,141,627 (GRCm39) probably null Het
Emilin3 A T 2: 160,752,718 (GRCm39) Y77* probably null Het
Fam234b T A 6: 135,220,912 (GRCm39) I641N probably benign Het
Farsa T C 8: 85,590,781 (GRCm39) probably null Het
Foxf2 T C 13: 31,811,182 (GRCm39) S374P probably benign Het
Gm11596 A T 11: 99,683,667 (GRCm39) I151N unknown Het
Gm9817 C T 13: 45,232,427 (GRCm39) Q77* probably null Het
Gon4l A G 3: 88,803,102 (GRCm39) K1238E probably benign Het
H13 A G 2: 152,537,431 (GRCm39) Y292C probably damaging Het
Hip1r A G 5: 124,139,504 (GRCm39) N928S probably benign Het
Iqcf4 T C 9: 106,445,812 (GRCm39) N112D probably benign Het
Jak3 A C 8: 72,131,686 (GRCm39) T125P probably benign Het
Krt7 A C 15: 101,311,913 (GRCm39) K124Q possibly damaging Het
Ldc1 T C 4: 130,114,169 (GRCm39) N83D probably damaging Het
Mycbp2 C T 14: 103,485,840 (GRCm39) V1074I probably damaging Het
Nckap5 T C 1: 125,954,581 (GRCm39) D657G probably benign Het
Nt5el A G 13: 105,218,793 (GRCm39) I42M probably damaging Het
Or5b113 T A 19: 13,342,598 (GRCm39) V202E probably benign Het
Or8k21 T C 2: 86,145,034 (GRCm39) I199V probably benign Het
Osbpl7 A G 11: 96,941,548 (GRCm39) S24G probably benign Het
Pcm1 G T 8: 41,762,610 (GRCm39) E1385* probably null Het
Poc5 A G 13: 96,547,143 (GRCm39) T469A probably damaging Het
Ppp3ca A G 3: 136,596,222 (GRCm39) T296A probably benign Het
Prl6a1 T C 13: 27,502,125 (GRCm39) I164T probably damaging Het
Psmd6 GCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACC GCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACC 14: 14,119,882 (GRCm38) probably null Het
Rnf149 A C 1: 39,604,299 (GRCm39) M188R possibly damaging Het
Rpl10l T C 12: 66,331,041 (GRCm39) I31V probably benign Het
Serinc5 T C 13: 92,797,592 (GRCm39) S32P probably damaging Het
Sirt1 T A 10: 63,162,562 (GRCm39) K137M possibly damaging Het
Smc4 A G 3: 68,923,496 (GRCm39) Y251C probably damaging Het
Sod3 A C 5: 52,525,643 (GRCm39) E114A possibly damaging Het
Tgfbr3 A G 5: 107,288,368 (GRCm39) V431A probably benign Het
Tlr4 T C 4: 66,757,836 (GRCm39) S210P probably damaging Het
Trub2 G T 2: 29,676,520 (GRCm39) T70N probably benign Het
Tsga10 A T 1: 37,874,323 (GRCm39) C159S unknown Het
Vmn1r15 A T 6: 57,235,644 (GRCm39) I171F probably benign Het
Vmn2r50 T A 7: 9,771,562 (GRCm39) H713L possibly damaging Het
Zcchc14 T C 8: 122,378,514 (GRCm39) S43G unknown Het
Zfp638 T C 6: 83,956,196 (GRCm39) I1601T probably damaging Het
Other mutations in Lrrc66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Lrrc66 APN 5 73,764,457 (GRCm39) missense probably benign 0.10
IGL00913:Lrrc66 APN 5 73,765,499 (GRCm39) missense possibly damaging 0.76
IGL00954:Lrrc66 APN 5 73,765,741 (GRCm39) missense possibly damaging 0.94
IGL01061:Lrrc66 APN 5 73,772,842 (GRCm39) missense probably benign 0.01
IGL01343:Lrrc66 APN 5 73,765,806 (GRCm39) missense probably damaging 0.98
IGL01714:Lrrc66 APN 5 73,787,320 (GRCm39) missense probably benign 0.10
IGL01822:Lrrc66 APN 5 73,787,311 (GRCm39) missense probably benign 0.17
IGL02005:Lrrc66 APN 5 73,766,077 (GRCm39) missense possibly damaging 0.83
IGL02166:Lrrc66 APN 5 73,764,634 (GRCm39) missense probably damaging 0.99
IGL02380:Lrrc66 APN 5 73,787,009 (GRCm39) missense possibly damaging 0.55
IGL03162:Lrrc66 APN 5 73,764,725 (GRCm39) missense probably benign
BB002:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
BB012:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
D4043:Lrrc66 UTSW 5 73,764,869 (GRCm39) missense probably benign 0.03
R0126:Lrrc66 UTSW 5 73,764,431 (GRCm39) missense probably benign 0.10
R0437:Lrrc66 UTSW 5 73,765,030 (GRCm39) missense probably benign 0.23
R0638:Lrrc66 UTSW 5 73,772,816 (GRCm39) splice site probably benign
R0658:Lrrc66 UTSW 5 73,768,287 (GRCm39) missense probably benign 0.40
R0729:Lrrc66 UTSW 5 73,765,757 (GRCm39) missense probably benign
R1603:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1774:Lrrc66 UTSW 5 73,768,198 (GRCm39) missense probably benign 0.16
R1831:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1832:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1902:Lrrc66 UTSW 5 73,764,965 (GRCm39) missense probably damaging 0.99
R2858:Lrrc66 UTSW 5 73,764,646 (GRCm39) missense probably benign 0.08
R4097:Lrrc66 UTSW 5 73,765,047 (GRCm39) missense possibly damaging 0.94
R4164:Lrrc66 UTSW 5 73,787,119 (GRCm39) splice site probably null
R4582:Lrrc66 UTSW 5 73,765,580 (GRCm39) missense possibly damaging 0.94
R4708:Lrrc66 UTSW 5 73,787,005 (GRCm39) missense probably benign 0.06
R4856:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R4886:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R5074:Lrrc66 UTSW 5 73,765,354 (GRCm39) missense probably damaging 1.00
R5464:Lrrc66 UTSW 5 73,765,622 (GRCm39) missense probably benign 0.05
R5640:Lrrc66 UTSW 5 73,765,977 (GRCm39) missense probably benign 0.00
R5709:Lrrc66 UTSW 5 73,766,206 (GRCm39) missense probably benign
R5811:Lrrc66 UTSW 5 73,772,860 (GRCm39) missense possibly damaging 0.82
R6146:Lrrc66 UTSW 5 73,765,432 (GRCm39) missense probably benign 0.10
R7037:Lrrc66 UTSW 5 73,764,504 (GRCm39) missense probably benign 0.10
R7041:Lrrc66 UTSW 5 73,765,899 (GRCm39) missense possibly damaging 0.81
R7141:Lrrc66 UTSW 5 73,787,320 (GRCm39) missense probably benign 0.10
R7201:Lrrc66 UTSW 5 73,787,240 (GRCm39) missense probably benign 0.11
R7250:Lrrc66 UTSW 5 73,768,224 (GRCm39) missense probably benign 0.03
R7367:Lrrc66 UTSW 5 73,765,724 (GRCm39) missense probably benign 0.13
R7925:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
R8057:Lrrc66 UTSW 5 73,764,875 (GRCm39) nonsense probably null
R8167:Lrrc66 UTSW 5 73,786,952 (GRCm39) nonsense probably null
R8552:Lrrc66 UTSW 5 73,768,228 (GRCm39) missense probably benign 0.16
R8834:Lrrc66 UTSW 5 73,765,928 (GRCm39) missense possibly damaging 0.56
R8992:Lrrc66 UTSW 5 73,787,227 (GRCm39) missense probably benign 0.04
R9017:Lrrc66 UTSW 5 73,765,244 (GRCm39) missense possibly damaging 0.94
R9051:Lrrc66 UTSW 5 73,765,268 (GRCm39) missense probably benign 0.00
R9051:Lrrc66 UTSW 5 73,765,267 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TGATGGTGAACTATCTACATTTGGG -3'
(R):5'- ACACAAGGAGCTTGGCTGAG -3'

Sequencing Primer
(F):5'- GTGAACTATCTACATTTGGGGATTCC -3'
(R):5'- AATGATGGGACCAGCCAGCC -3'
Posted On 2019-11-26