Incidental Mutation 'R7773:Or5b113'
ID 598736
Institutional Source Beutler Lab
Gene Symbol Or5b113
Ensembl Gene ENSMUSG00000049015
Gene Name olfactory receptor family 5 subfamily B member 113
Synonyms GA_x6K02T2RE5P-3695694-3696620, Olfr1467, MOR202-15
MMRRC Submission 045829-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R7773 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13341994-13342920 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13342598 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 202 (V202E)
Ref Sequence ENSEMBL: ENSMUSP00000149487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054687] [ENSMUST00000215096]
AlphaFold Q8VFW1
Predicted Effect probably benign
Transcript: ENSMUST00000054687
AA Change: V202E

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000061580
Gene: ENSMUSG00000049015
AA Change: V202E

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 6.6e-48 PFAM
Pfam:7tm_1 40 289 7.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215096
AA Change: V202E

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A G 3: 124,206,180 (GRCm39) I336T probably benign Het
4930519P11Rik T C 2: 154,455,107 (GRCm39) Y84C unknown Het
4930568D16Rik C T 2: 35,244,606 (GRCm39) G249S probably damaging Het
AAdacl4fm3 A T 4: 144,430,047 (GRCm39) L314Q probably damaging Het
Adprhl1 C T 8: 13,298,682 (GRCm39) V83I probably damaging Het
Agbl1 T A 7: 76,348,585 (GRCm39) V894E unknown Het
Amigo3 T C 9: 107,931,867 (GRCm39) L430P probably benign Het
Aoc1 A G 6: 48,883,146 (GRCm39) I341V probably benign Het
Bod1l A G 5: 41,990,055 (GRCm39) S223P probably benign Het
Cacnb3 T C 15: 98,537,819 (GRCm39) probably null Het
Ccdc63 G T 5: 122,247,335 (GRCm39) N503K probably damaging Het
Ccdc83 T A 7: 89,879,120 (GRCm39) I225F probably damaging Het
Cd200r1 A G 16: 44,610,050 (GRCm39) T90A possibly damaging Het
Cd8a A G 6: 71,350,799 (GRCm39) N88S probably benign Het
Cep170 A G 1: 176,567,642 (GRCm39) V152A Het
Chid1 T C 7: 141,109,518 (GRCm39) M123V probably benign Het
Cnnm4 T C 1: 36,538,603 (GRCm39) V595A probably benign Het
Coro7 A G 16: 4,449,870 (GRCm39) L630P probably damaging Het
Cpvl A G 6: 53,908,890 (GRCm39) probably null Het
Edem3 A T 1: 151,687,347 (GRCm39) K762* probably null Het
Elp6 T A 9: 110,141,627 (GRCm39) probably null Het
Emilin3 A T 2: 160,752,718 (GRCm39) Y77* probably null Het
Fam234b T A 6: 135,220,912 (GRCm39) I641N probably benign Het
Farsa T C 8: 85,590,781 (GRCm39) probably null Het
Foxf2 T C 13: 31,811,182 (GRCm39) S374P probably benign Het
Gm11596 A T 11: 99,683,667 (GRCm39) I151N unknown Het
Gm9817 C T 13: 45,232,427 (GRCm39) Q77* probably null Het
Gon4l A G 3: 88,803,102 (GRCm39) K1238E probably benign Het
H13 A G 2: 152,537,431 (GRCm39) Y292C probably damaging Het
Hip1r A G 5: 124,139,504 (GRCm39) N928S probably benign Het
Iqcf4 T C 9: 106,445,812 (GRCm39) N112D probably benign Het
Jak3 A C 8: 72,131,686 (GRCm39) T125P probably benign Het
Krt7 A C 15: 101,311,913 (GRCm39) K124Q possibly damaging Het
Ldc1 T C 4: 130,114,169 (GRCm39) N83D probably damaging Het
Lrrc66 G A 5: 73,764,664 (GRCm39) S793F probably damaging Het
Mycbp2 C T 14: 103,485,840 (GRCm39) V1074I probably damaging Het
Nckap5 T C 1: 125,954,581 (GRCm39) D657G probably benign Het
Nt5el A G 13: 105,218,793 (GRCm39) I42M probably damaging Het
Or8k21 T C 2: 86,145,034 (GRCm39) I199V probably benign Het
Osbpl7 A G 11: 96,941,548 (GRCm39) S24G probably benign Het
Pcm1 G T 8: 41,762,610 (GRCm39) E1385* probably null Het
Poc5 A G 13: 96,547,143 (GRCm39) T469A probably damaging Het
Ppp3ca A G 3: 136,596,222 (GRCm39) T296A probably benign Het
Prl6a1 T C 13: 27,502,125 (GRCm39) I164T probably damaging Het
Psmd6 GCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACC GCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACC 14: 14,119,882 (GRCm38) probably null Het
Rnf149 A C 1: 39,604,299 (GRCm39) M188R possibly damaging Het
Rpl10l T C 12: 66,331,041 (GRCm39) I31V probably benign Het
Serinc5 T C 13: 92,797,592 (GRCm39) S32P probably damaging Het
Sirt1 T A 10: 63,162,562 (GRCm39) K137M possibly damaging Het
Smc4 A G 3: 68,923,496 (GRCm39) Y251C probably damaging Het
Sod3 A C 5: 52,525,643 (GRCm39) E114A possibly damaging Het
Tgfbr3 A G 5: 107,288,368 (GRCm39) V431A probably benign Het
Tlr4 T C 4: 66,757,836 (GRCm39) S210P probably damaging Het
Trub2 G T 2: 29,676,520 (GRCm39) T70N probably benign Het
Tsga10 A T 1: 37,874,323 (GRCm39) C159S unknown Het
Vmn1r15 A T 6: 57,235,644 (GRCm39) I171F probably benign Het
Vmn2r50 T A 7: 9,771,562 (GRCm39) H713L possibly damaging Het
Zcchc14 T C 8: 122,378,514 (GRCm39) S43G unknown Het
Zfp638 T C 6: 83,956,196 (GRCm39) I1601T probably damaging Het
Other mutations in Or5b113
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00936:Or5b113 APN 19 13,341,988 (GRCm39) utr 5 prime probably benign
IGL01109:Or5b113 APN 19 13,342,063 (GRCm39) missense probably benign
IGL01939:Or5b113 APN 19 13,342,807 (GRCm39) missense probably benign 0.14
IGL02188:Or5b113 APN 19 13,342,643 (GRCm39) missense probably damaging 0.98
IGL02188:Or5b113 APN 19 13,342,396 (GRCm39) missense probably benign 0.39
IGL03223:Or5b113 APN 19 13,342,645 (GRCm39) missense probably benign
R0456:Or5b113 UTSW 19 13,342,102 (GRCm39) missense probably damaging 0.98
R1066:Or5b113 UTSW 19 13,342,451 (GRCm39) missense probably benign
R1189:Or5b113 UTSW 19 13,342,543 (GRCm39) missense probably benign 0.03
R1668:Or5b113 UTSW 19 13,342,234 (GRCm39) missense probably benign 0.00
R1754:Or5b113 UTSW 19 13,342,717 (GRCm39) missense probably damaging 1.00
R1860:Or5b113 UTSW 19 13,342,705 (GRCm39) missense possibly damaging 0.80
R1861:Or5b113 UTSW 19 13,342,705 (GRCm39) missense possibly damaging 0.80
R2181:Or5b113 UTSW 19 13,342,438 (GRCm39) missense probably benign 0.08
R2219:Or5b113 UTSW 19 13,342,901 (GRCm39) missense possibly damaging 0.88
R2516:Or5b113 UTSW 19 13,342,557 (GRCm39) nonsense probably null
R4757:Or5b113 UTSW 19 13,342,810 (GRCm39) missense probably benign 0.23
R5206:Or5b113 UTSW 19 13,342,429 (GRCm39) missense possibly damaging 0.91
R5376:Or5b113 UTSW 19 13,342,762 (GRCm39) missense possibly damaging 0.95
R5647:Or5b113 UTSW 19 13,342,541 (GRCm39) missense probably damaging 1.00
R5724:Or5b113 UTSW 19 13,342,515 (GRCm39) missense possibly damaging 0.62
R5741:Or5b113 UTSW 19 13,342,847 (GRCm39) missense probably damaging 0.97
R5906:Or5b113 UTSW 19 13,342,369 (GRCm39) missense probably damaging 1.00
R6636:Or5b113 UTSW 19 13,342,589 (GRCm39) missense probably benign 0.06
R6637:Or5b113 UTSW 19 13,342,589 (GRCm39) missense probably benign 0.06
R7000:Or5b113 UTSW 19 13,341,987 (GRCm39) start gained probably benign
R7254:Or5b113 UTSW 19 13,342,475 (GRCm39) missense probably benign 0.28
R7325:Or5b113 UTSW 19 13,342,001 (GRCm39) missense probably benign 0.00
R7828:Or5b113 UTSW 19 13,342,510 (GRCm39) missense probably benign 0.10
R9081:Or5b113 UTSW 19 13,342,019 (GRCm39) missense probably benign 0.12
R9135:Or5b113 UTSW 19 13,342,755 (GRCm39) missense possibly damaging 0.46
R9151:Or5b113 UTSW 19 13,342,222 (GRCm39) missense possibly damaging 0.95
R9470:Or5b113 UTSW 19 13,342,115 (GRCm39) missense probably damaging 1.00
R9792:Or5b113 UTSW 19 13,342,514 (GRCm39) missense probably damaging 0.99
R9793:Or5b113 UTSW 19 13,342,514 (GRCm39) missense probably damaging 0.99
Z1176:Or5b113 UTSW 19 13,342,280 (GRCm39) missense probably damaging 1.00
Z1176:Or5b113 UTSW 19 13,342,279 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACCACCATGACTACAAGTGTG -3'
(R):5'- AGTGATTGGAACTTGGCTGTAC -3'

Sequencing Primer
(F):5'- CACCATGACTACAAGTGTGTGTACG -3'
(R):5'- CAGGTGGATATAGCCTTGT -3'
Posted On 2019-11-26