Incidental Mutation 'R7773:Olfr1467'
ID598736
Institutional Source Beutler Lab
Gene Symbol Olfr1467
Ensembl Gene ENSMUSG00000049015
Gene Nameolfactory receptor 1467
SynonymsMOR202-15, GA_x6K02T2RE5P-3695694-3696620
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #R7773 (G1)
Quality Score225.009
Status Validated
Chromosome19
Chromosomal Location13362236-13368054 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 13365234 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 202 (V202E)
Ref Sequence ENSEMBL: ENSMUSP00000149487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054687] [ENSMUST00000215096]
Predicted Effect probably benign
Transcript: ENSMUST00000054687
AA Change: V202E

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000061580
Gene: ENSMUSG00000049015
AA Change: V202E

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 6.6e-48 PFAM
Pfam:7tm_1 40 289 7.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215096
AA Change: V202E

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A G 3: 124,412,531 I336T probably benign Het
4930519P11Rik T C 2: 154,613,187 Y84C unknown Het
4930568D16Rik C T 2: 35,354,594 G249S probably damaging Het
4933425L06Rik A G 13: 105,082,285 I42M probably damaging Het
Adprhl1 C T 8: 13,248,682 V83I probably damaging Het
Agbl1 T A 7: 76,698,837 V894E unknown Het
Amigo3 T C 9: 108,054,668 L430P probably benign Het
Aoc1 A G 6: 48,906,212 I341V probably benign Het
Bod1l A G 5: 41,832,712 S223P probably benign Het
Cacnb3 T C 15: 98,639,938 probably null Het
Ccdc63 G T 5: 122,109,272 N503K probably damaging Het
Ccdc83 T A 7: 90,229,912 I225F probably damaging Het
Cd200r1 A G 16: 44,789,687 T90A possibly damaging Het
Cd8a A G 6: 71,373,815 N88S probably benign Het
Cep170 A G 1: 176,740,076 V152A Het
Chid1 T C 7: 141,529,605 M123V probably benign Het
Cnnm4 T C 1: 36,499,522 V595A probably benign Het
Coro7 A G 16: 4,632,006 L630P probably damaging Het
Cpvl A G 6: 53,931,905 probably null Het
Edem3 A T 1: 151,811,596 K762* probably null Het
Elp6 T A 9: 110,312,559 probably null Het
Emilin3 A T 2: 160,910,798 Y77* probably null Het
Fam234b T A 6: 135,243,914 I641N probably benign Het
Farsa T C 8: 84,864,152 probably null Het
Foxf2 T C 13: 31,627,199 S374P probably benign Het
Gm11596 A T 11: 99,792,841 I151N unknown Het
Gm13178 A T 4: 144,703,477 L314Q probably damaging Het
Gm853 T C 4: 130,220,376 N83D probably damaging Het
Gm9817 C T 13: 45,078,951 Q77* probably null Het
Gon4l A G 3: 88,895,795 K1238E probably benign Het
H13 A G 2: 152,695,511 Y292C probably damaging Het
Hip1r A G 5: 124,001,441 N928S probably benign Het
Iqcf4 T C 9: 106,568,613 N112D probably benign Het
Jak3 A C 8: 71,679,042 T125P probably benign Het
Krt7 A C 15: 101,414,032 K124Q possibly damaging Het
Lrrc66 G A 5: 73,607,321 S793F probably damaging Het
Mycbp2 C T 14: 103,248,404 V1074I probably damaging Het
Nckap5 T C 1: 126,026,844 D657G probably benign Het
Olfr1053 T C 2: 86,314,690 I199V probably benign Het
Osbpl7 A G 11: 97,050,722 S24G probably benign Het
Pcm1 G T 8: 41,309,573 E1385* probably null Het
Poc5 A G 13: 96,410,635 T469A probably damaging Het
Ppp3ca A G 3: 136,890,461 T296A probably benign Het
Prl6a1 T C 13: 27,318,142 I164T probably damaging Het
Psmd6 GCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACC GCAGAGCGGGCAGGGCATCTCACTGACCCTGTCACCTACCCAGAGCGGGCAGGGCATCTCACTGACC 14: 14,119,882 probably null Het
Rnf149 A C 1: 39,565,218 M188R possibly damaging Het
Rpl10l T C 12: 66,284,267 I31V probably benign Het
Serinc5 T C 13: 92,661,084 S32P probably damaging Het
Sirt1 T A 10: 63,326,783 K137M possibly damaging Het
Smc4 A G 3: 69,016,163 Y251C probably damaging Het
Sod3 A C 5: 52,368,301 E114A possibly damaging Het
Tgfbr3 A G 5: 107,140,502 V431A probably benign Het
Tlr4 T C 4: 66,839,599 S210P probably damaging Het
Trub2 G T 2: 29,786,508 T70N probably benign Het
Tsga10 A T 1: 37,835,242 C159S unknown Het
Vmn1r15 A T 6: 57,258,659 I171F probably benign Het
Vmn2r50 T A 7: 10,037,635 H713L possibly damaging Het
Zcchc14 T C 8: 121,651,775 S43G unknown Het
Zfp638 T C 6: 83,979,214 I1601T probably damaging Het
Other mutations in Olfr1467
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00936:Olfr1467 APN 19 13364624 utr 5 prime probably benign
IGL01109:Olfr1467 APN 19 13364699 missense probably benign
IGL01939:Olfr1467 APN 19 13365443 missense probably benign 0.14
IGL02188:Olfr1467 APN 19 13365032 missense probably benign 0.39
IGL02188:Olfr1467 APN 19 13365279 missense probably damaging 0.98
IGL03223:Olfr1467 APN 19 13365281 missense probably benign
R0456:Olfr1467 UTSW 19 13364738 missense probably damaging 0.98
R1066:Olfr1467 UTSW 19 13365087 missense probably benign
R1189:Olfr1467 UTSW 19 13365179 missense probably benign 0.03
R1668:Olfr1467 UTSW 19 13364870 missense probably benign 0.00
R1754:Olfr1467 UTSW 19 13365353 missense probably damaging 1.00
R1860:Olfr1467 UTSW 19 13365341 missense possibly damaging 0.80
R1861:Olfr1467 UTSW 19 13365341 missense possibly damaging 0.80
R2181:Olfr1467 UTSW 19 13365074 missense probably benign 0.08
R2219:Olfr1467 UTSW 19 13365537 missense possibly damaging 0.88
R2516:Olfr1467 UTSW 19 13365193 nonsense probably null
R4757:Olfr1467 UTSW 19 13365446 missense probably benign 0.23
R5206:Olfr1467 UTSW 19 13365065 missense possibly damaging 0.91
R5376:Olfr1467 UTSW 19 13365398 missense possibly damaging 0.95
R5647:Olfr1467 UTSW 19 13365177 missense probably damaging 1.00
R5724:Olfr1467 UTSW 19 13365151 missense possibly damaging 0.62
R5741:Olfr1467 UTSW 19 13365483 missense probably damaging 0.97
R5906:Olfr1467 UTSW 19 13365005 missense probably damaging 1.00
R6636:Olfr1467 UTSW 19 13365225 missense probably benign 0.06
R6637:Olfr1467 UTSW 19 13365225 missense probably benign 0.06
R7000:Olfr1467 UTSW 19 13364623 start gained probably benign
R7254:Olfr1467 UTSW 19 13365111 missense probably benign 0.28
R7325:Olfr1467 UTSW 19 13364637 missense probably benign 0.00
R7828:Olfr1467 UTSW 19 13365146 missense probably benign 0.10
Z1176:Olfr1467 UTSW 19 13364915 missense probably damaging 1.00
Z1176:Olfr1467 UTSW 19 13364916 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACCACCATGACTACAAGTGTG -3'
(R):5'- AGTGATTGGAACTTGGCTGTAC -3'

Sequencing Primer
(F):5'- CACCATGACTACAAGTGTGTGTACG -3'
(R):5'- CAGGTGGATATAGCCTTGT -3'
Posted On2019-11-26