Mutagenetix > Incidental Mutation

Incidental Mutation 'R7776:Nynrin'

598917

Institutional Source

Beutler Lab

Gene Symbol

Nynrin

Ensembl Gene

ENSMUSG00000075592

Gene Name

NYN domain and retroviral integrase containing

Synonyms

MMRRC Submission

045832-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7776 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

56091572-56112193 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 56103420 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Serine at position 755 (G755S)

Ref Sequence

ENSEMBL: ENSMUSP00000098098 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479] [ENSMUST00000227465]

AlphaFold

Q5DTZ0

Predicted Effect

probably damaging
Transcript: ENSMUST00000100529
AA Change: G755S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: G755S

Domain	Start	End	E-Value	Type
low complexity region	581	606	N/A	INTRINSIC
Pfam:RNase_Zc3h12a	739	890	1.6e-54	PFAM
low complexity region	938	952	N/A	INTRINSIC
low complexity region	1212	1228	N/A	INTRINSIC
low complexity region	1390	1397	N/A	INTRINSIC
PDB:3S3O\|B	1478	1706	6e-8	PDB
SCOP:d1cxqa_	1552	1646	2e-12	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000168479
AA Change: G755S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: G755S

Domain	Start	End	E-Value	Type
low complexity region	581	606	N/A	INTRINSIC
Pfam:RNase_Zc3h12a	739	890	5.5e-54	PFAM
low complexity region	938	952	N/A	INTRINSIC
low complexity region	1212	1228	N/A	INTRINSIC
low complexity region	1390	1397	N/A	INTRINSIC
PDB:3S3O\|B	1478	1706	6e-8	PDB
SCOP:d1cxqa_	1552	1646	2e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000227465

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	T	C	7: 119,832,214 (GRCm39)		probably null	Het
Abca3	T	A	17: 24,605,250 (GRCm39)	V716D	possibly damaging	Het
Adprhl1	C	T	8: 13,298,682 (GRCm39)	V83I	probably damaging	Het
Alkbh1	A	G	12: 87,478,215 (GRCm39)	V232A	probably damaging	Het
Arhgef10l	T	A	4: 140,302,642 (GRCm39)	I271F	probably damaging	Het
Aspm	T	A	1: 139,407,584 (GRCm39)	M2157K	possibly damaging	Het
Capn13	G	A	17: 73,629,049 (GRCm39)	S586L	probably benign	Het
Cd3g	A	T	9: 44,885,459 (GRCm39)		probably null	Het
Cfap54	A	T	10: 92,704,603 (GRCm39)	Y2826N	unknown	Het
Cmas	T	C	6: 142,710,283 (GRCm39)	V134A	probably damaging	Het
Cnp	A	G	11: 100,469,814 (GRCm39)	H250R	probably damaging	Het
Dact1	G	A	12: 71,364,688 (GRCm39)	A453T	probably benign	Het
Dcaf6	T	A	1: 165,179,623 (GRCm39)	R506*	probably null	Het
Dph1	A	G	11: 75,081,272 (GRCm39)	V5A	probably benign	Het
Entpd3	A	G	9: 120,387,568 (GRCm39)	Y255C	probably damaging	Het
Etl4	A	T	2: 20,811,957 (GRCm39)	T1715S	probably damaging	Het
Exd2	T	A	12: 80,539,334 (GRCm39)	H466Q	probably damaging	Het
Fbln2	A	G	6: 91,246,181 (GRCm39)	N1056S	probably damaging	Het
Fcrl5	A	T	3: 87,351,502 (GRCm39)	Q250L	possibly damaging	Het
Fignl2	A	G	15: 100,951,301 (GRCm39)	V327A	unknown	Het
Gm10226	T	A	17: 21,910,866 (GRCm39)	C34S	possibly damaging	Het
H2bc6	A	T	13: 23,769,938 (GRCm39)	M1K	probably null	Het
Kdm6b	A	G	11: 69,296,960 (GRCm39)	S436P	possibly damaging	Het
Lmnb2	G	T	10: 80,753,991 (GRCm39)	A21E	possibly damaging	Het
Mcf2l	A	T	8: 12,930,127 (GRCm39)	E49V	probably benign	Het
Muc2	A	G	7: 141,290,942 (GRCm39)	E76G		Het
Naa60	T	C	16: 3,718,573 (GRCm39)	I135T	probably benign	Het
Neb	T	C	2: 52,097,713 (GRCm39)	Y4924C	possibly damaging	Het
Nlrp10	T	A	7: 108,524,656 (GRCm39)	I275F	probably damaging	Het
Nr3c2	T	C	8: 77,636,174 (GRCm39)	V425A	possibly damaging	Het
Nucb2	T	A	7: 116,128,248 (GRCm39)	D286E	probably damaging	Het
Or5d41	T	C	2: 88,054,429 (GRCm39)	T316A	probably damaging	Het
Padi2	T	A	4: 140,651,656 (GRCm39)	D135E	probably benign	Het
Pcdha6	T	A	18: 37,103,034 (GRCm39)	S742R	probably benign	Het
Pcdhgb5	T	A	18: 37,866,007 (GRCm39)	S601T	probably damaging	Het
Pira13	T	C	7: 3,826,246 (GRCm39)	N249S	unknown	Het
Polr1b	C	A	2: 128,967,464 (GRCm39)	F952L	probably damaging	Het
Prr15l	T	C	11: 96,825,390 (GRCm39)	W7R	possibly damaging	Het
Ptpn23	G	A	9: 110,215,368 (GRCm39)	H1431Y	possibly damaging	Het
Rnf20	C	T	4: 49,644,592 (GRCm39)	Q286*	probably null	Het
Rptor	T	C	11: 119,783,453 (GRCm39)	I1149T	probably benign	Het
Sfrp2	A	G	3: 83,674,086 (GRCm39)	I80V	probably benign	Het
Slc38a2	T	C	15: 96,588,033 (GRCm39)	D497G	probably benign	Het
Slc43a1	T	A	2: 84,671,197 (GRCm39)	M44K	probably damaging	Het
Stil	T	A	4: 114,890,035 (GRCm39)	V841E	possibly damaging	Het
Stip1	T	A	19: 6,999,141 (GRCm39)	H479L	probably benign	Het
Supt6	A	G	11: 78,100,355 (GRCm39)	Y1486H	probably damaging	Het
Taf6	T	C	5: 138,180,282 (GRCm39)	D324G	probably damaging	Het
Tgif1	T	A	17: 71,158,452 (GRCm39)		probably benign	Het
Tmprss11f	T	C	5: 86,681,605 (GRCm39)	E216G	probably benign	Het
Tmprss7	C	A	16: 45,488,014 (GRCm39)	A472S	probably benign	Het
Trpm1	T	A	7: 63,897,939 (GRCm39)	F1191I	probably benign	Het
Tspan12	T	A	6: 21,836,442 (GRCm39)	N40I	probably damaging	Het
Ttll3	AAGTA	AAGTACAGTA	6: 113,376,120 (GRCm39)		probably null	Het
Unc13c	A	T	9: 73,602,232 (GRCm39)	I1338N	probably damaging	Het
Vegfc	T	A	8: 54,530,835 (GRCm39)	S8T	unknown	Het
Vmn1r59	T	A	7: 5,457,634 (GRCm39)	Q42L	probably damaging	Het
Vmn2r-ps117	A	T	17: 19,043,934 (GRCm39)	I337F	probably damaging	Het
Xylb	G	A	9: 119,209,766 (GRCm39)		probably null	Het
Zfp551	T	A	7: 12,152,569 (GRCm39)	I55F	probably damaging	Het
Zfp972	T	C	2: 177,563,532 (GRCm39)	N27S	probably benign	Het

Other mutations in Nynrin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Nynrin	APN	14	56,105,905 (GRCm39)	missense	probably benign	0.38
IGL01131:Nynrin	APN	14	56,110,142 (GRCm39)	missense	probably damaging	1.00
IGL01357:Nynrin	APN	14	56,107,874 (GRCm39)	missense	probably benign
IGL01537:Nynrin	APN	14	56,109,502 (GRCm39)	missense	possibly damaging	0.87
IGL01583:Nynrin	APN	14	56,107,968 (GRCm39)	missense	probably damaging	1.00
IGL01726:Nynrin	APN	14	56,101,611 (GRCm39)	missense	probably benign
IGL02161:Nynrin	APN	14	56,101,441 (GRCm39)	missense	probably damaging	1.00
IGL02167:Nynrin	APN	14	56,100,792 (GRCm39)	missense	probably damaging	1.00
IGL02247:Nynrin	APN	14	56,109,167 (GRCm39)	nonsense	probably null
IGL02302:Nynrin	APN	14	56,105,962 (GRCm39)	missense	probably benign	0.43
IGL02524:Nynrin	APN	14	56,108,931 (GRCm39)	missense	possibly damaging	0.73
IGL02600:Nynrin	APN	14	56,101,449 (GRCm39)	missense	probably benign	0.38
IGL02639:Nynrin	APN	14	56,108,112 (GRCm39)	missense	probably damaging	1.00
IGL02654:Nynrin	APN	14	56,100,716 (GRCm39)	missense	possibly damaging	0.95
IGL02659:Nynrin	APN	14	56,103,554 (GRCm39)	unclassified	probably benign
IGL02736:Nynrin	APN	14	56,108,366 (GRCm39)	missense	probably damaging	1.00
IGL02949:Nynrin	APN	14	56,109,837 (GRCm39)	missense	probably damaging	0.99
PIT4458001:Nynrin	UTSW	14	56,101,425 (GRCm39)	missense	probably benign	0.39
R0017:Nynrin	UTSW	14	56,109,852 (GRCm39)	missense	probably damaging	1.00
R0078:Nynrin	UTSW	14	56,100,789 (GRCm39)	missense	probably damaging	1.00
R0211:Nynrin	UTSW	14	56,109,255 (GRCm39)	missense	probably benign	0.08
R0211:Nynrin	UTSW	14	56,109,255 (GRCm39)	missense	probably benign	0.08
R0413:Nynrin	UTSW	14	56,109,648 (GRCm39)	missense	possibly damaging	0.90
R0609:Nynrin	UTSW	14	56,110,218 (GRCm39)	missense	probably damaging	1.00
R0626:Nynrin	UTSW	14	56,105,492 (GRCm39)	missense	probably damaging	1.00
R1205:Nynrin	UTSW	14	56,091,646 (GRCm39)	intron	probably benign
R1222:Nynrin	UTSW	14	56,100,998 (GRCm39)	missense	probably benign	0.02
R1385:Nynrin	UTSW	14	56,102,356 (GRCm39)	missense	probably benign	0.00
R1820:Nynrin	UTSW	14	56,107,835 (GRCm39)	missense	possibly damaging	0.95
R1829:Nynrin	UTSW	14	56,110,404 (GRCm39)	missense	possibly damaging	0.50
R1874:Nynrin	UTSW	14	56,100,950 (GRCm39)	missense	probably benign	0.04
R1927:Nynrin	UTSW	14	56,101,049 (GRCm39)	missense	probably benign	0.00
R2233:Nynrin	UTSW	14	56,109,524 (GRCm39)	missense	possibly damaging	0.83
R3018:Nynrin	UTSW	14	56,100,867 (GRCm39)	missense	probably benign	0.00
R3154:Nynrin	UTSW	14	56,101,044 (GRCm39)	missense	possibly damaging	0.46
R3853:Nynrin	UTSW	14	56,101,562 (GRCm39)	missense	probably benign	0.24
R4648:Nynrin	UTSW	14	56,110,351 (GRCm39)	nonsense	probably null
R4722:Nynrin	UTSW	14	56,091,852 (GRCm39)	missense	probably damaging	0.97
R4735:Nynrin	UTSW	14	56,107,625 (GRCm39)	missense	probably benign	0.03
R4736:Nynrin	UTSW	14	56,101,454 (GRCm39)	missense	probably damaging	1.00
R4780:Nynrin	UTSW	14	56,100,720 (GRCm39)	missense	probably damaging	1.00
R4804:Nynrin	UTSW	14	56,102,326 (GRCm39)	missense	probably benign
R4816:Nynrin	UTSW	14	56,109,458 (GRCm39)	missense	probably damaging	1.00
R5307:Nynrin	UTSW	14	56,101,263 (GRCm39)	missense	probably damaging	1.00
R5372:Nynrin	UTSW	14	56,105,948 (GRCm39)	missense	probably benign	0.01
R5432:Nynrin	UTSW	14	56,101,923 (GRCm39)	missense	possibly damaging	0.80
R5800:Nynrin	UTSW	14	56,108,088 (GRCm39)	missense	probably damaging	1.00
R5825:Nynrin	UTSW	14	56,101,683 (GRCm39)	missense	probably benign	0.00
R6149:Nynrin	UTSW	14	56,091,780 (GRCm39)	missense	possibly damaging	0.83
R6244:Nynrin	UTSW	14	56,105,485 (GRCm39)	missense	probably damaging	1.00
R6350:Nynrin	UTSW	14	56,105,533 (GRCm39)	missense	probably benign	0.19
R6379:Nynrin	UTSW	14	56,107,848 (GRCm39)	missense	probably damaging	1.00
R6437:Nynrin	UTSW	14	56,109,227 (GRCm39)	missense	probably benign	0.00
R6501:Nynrin	UTSW	14	56,100,989 (GRCm39)	missense	probably benign
R6702:Nynrin	UTSW	14	56,101,935 (GRCm39)	missense	possibly damaging	0.80
R6703:Nynrin	UTSW	14	56,101,935 (GRCm39)	missense	possibly damaging	0.80
R6907:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6908:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6928:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6934:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R6935:Nynrin	UTSW	14	56,101,335 (GRCm39)	missense	probably benign	0.20
R7197:Nynrin	UTSW	14	56,109,380 (GRCm39)	missense	probably benign	0.00
R7204:Nynrin	UTSW	14	56,110,190 (GRCm39)	missense	probably damaging	1.00
R7272:Nynrin	UTSW	14	56,107,872 (GRCm39)	missense	probably damaging	1.00
R7335:Nynrin	UTSW	14	56,101,371 (GRCm39)	missense	probably benign
R7361:Nynrin	UTSW	14	56,107,857 (GRCm39)	missense	possibly damaging	0.71
R7368:Nynrin	UTSW	14	56,107,968 (GRCm39)	missense	probably damaging	1.00
R7443:Nynrin	UTSW	14	56,108,873 (GRCm39)	missense	probably benign	0.18
R7584:Nynrin	UTSW	14	56,109,041 (GRCm39)	missense	probably damaging	1.00
R7677:Nynrin	UTSW	14	56,107,693 (GRCm39)	missense	probably benign
R7723:Nynrin	UTSW	14	56,109,502 (GRCm39)	missense	possibly damaging	0.87
R7787:Nynrin	UTSW	14	56,107,980 (GRCm39)	missense	probably benign
R7842:Nynrin	UTSW	14	56,102,553 (GRCm39)	missense	probably damaging	1.00
R7852:Nynrin	UTSW	14	56,108,886 (GRCm39)	missense	probably damaging	0.96
R8040:Nynrin	UTSW	14	56,108,982 (GRCm39)	missense	probably benign	0.01
R8159:Nynrin	UTSW	14	56,102,517 (GRCm39)	missense	probably benign
R8159:Nynrin	UTSW	14	56,100,587 (GRCm39)	missense	probably damaging	0.99
R8258:Nynrin	UTSW	14	56,100,815 (GRCm39)	missense	possibly damaging	0.95
R8259:Nynrin	UTSW	14	56,100,815 (GRCm39)	missense	possibly damaging	0.95
R8343:Nynrin	UTSW	14	56,101,248 (GRCm39)	missense	probably benign
R8504:Nynrin	UTSW	14	56,107,703 (GRCm39)	missense	probably benign	0.01
R8671:Nynrin	UTSW	14	56,107,899 (GRCm39)	missense	possibly damaging	0.52
R8691:Nynrin	UTSW	14	56,110,106 (GRCm39)	missense	probably damaging	1.00
R8777:Nynrin	UTSW	14	56,109,120 (GRCm39)	missense	probably benign
R8777-TAIL:Nynrin	UTSW	14	56,109,120 (GRCm39)	missense	probably benign
R9041:Nynrin	UTSW	14	56,108,753 (GRCm39)	missense	possibly damaging	0.83
R9346:Nynrin	UTSW	14	56,100,495 (GRCm39)	missense	probably benign	0.01
R9366:Nynrin	UTSW	14	56,100,587 (GRCm39)	missense	probably damaging	0.99
R9690:Nynrin	UTSW	14	56,108,204 (GRCm39)	missense	probably benign	0.00
RF007:Nynrin	UTSW	14	56,103,658 (GRCm39)	splice site	probably null

Predicted Primers

PCR Primer
(F):5'- ATCAGGCTCTTGGCACACAG -3'
(R):5'- AGTGGCTCTCTGAGGATGAC -3'

Sequencing Primer
(F):5'- GACCAGCCTTGTCTACGTAGTAAG -3'
(R):5'- TGGCTCTCTGAGGATGACACAAC -3'

Posted On

2019-11-26