Incidental Mutation 'R7777:Pira2'
ID 598953
Institutional Source Beutler Lab
Gene Symbol Pira2
Ensembl Gene ENSMUSG00000089942
Gene Name paired-Ig-like receptor A2
Synonyms 6M23
MMRRC Submission 045833-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R7777 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 3839811-3848050 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3844696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 445 (F445Y)
Ref Sequence ENSEMBL: ENSMUSP00000104255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108615] [ENSMUST00000119469]
AlphaFold F8VQ94
Predicted Effect probably benign
Transcript: ENSMUST00000108615
AA Change: F445Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000104255
Gene: ENSMUSG00000089942
AA Change: F445Y

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG 34 118 2.39e-1 SMART
IG_like 129 220 1.94e1 SMART
IG 231 315 7.77e-1 SMART
IG 328 415 3.36e0 SMART
IG_like 435 502 3.18e0 SMART
IG 529 618 8.59e-3 SMART
low complexity region 654 663 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119469
AA Change: F445Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000113857
Gene: ENSMUSG00000089942
AA Change: F445Y

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG 34 118 2.39e-1 SMART
IG_like 129 220 1.94e1 SMART
IG 231 315 7.77e-1 SMART
IG 328 415 3.36e0 SMART
IG_like 435 502 3.18e0 SMART
IG 529 618 8.59e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b C T 12: 113,453,758 (GRCm39) P192S possibly damaging Het
Arhgef10 A G 8: 14,995,373 (GRCm39) T353A probably damaging Het
Cabyr A G 18: 12,877,828 (GRCm39) D55G probably damaging Het
Dcaf4 T C 12: 83,584,733 (GRCm39) V322A probably damaging Het
Ephb2 T A 4: 136,498,947 (GRCm39) E44V possibly damaging Het
Fam3c T C 6: 22,328,573 (GRCm39) I105V probably benign Het
Fras1 A G 5: 96,900,763 (GRCm39) D2994G probably damaging Het
Fryl C T 5: 73,228,641 (GRCm39) D1697N probably damaging Het
Gapdh A T 6: 125,139,911 (GRCm39) Y164* probably null Het
Gm4353 T G 7: 115,682,998 (GRCm39) Q194H possibly damaging Het
Ilvbl T A 10: 78,413,085 (GRCm39) probably null Het
Ism2 T A 12: 87,333,658 (GRCm39) probably null Het
Jak2 C T 19: 29,254,268 (GRCm39) T196I probably benign Het
Lcor T G 19: 41,547,234 (GRCm39) Y273D probably benign Het
Ldlrad4 G T 18: 68,368,740 (GRCm39) A66S possibly damaging Het
Lysmd4 T A 7: 66,873,446 (GRCm39) M27K possibly damaging Het
Muc17 G A 5: 137,175,564 (GRCm39) silent Het
Or11h4b A T 14: 50,918,261 (GRCm39) Y277N probably damaging Het
Or13a25 T A 7: 140,247,854 (GRCm39) I211N probably benign Het
Or5m10 A G 2: 85,717,951 (GRCm39) E269G possibly damaging Het
Oscp1 T C 4: 125,958,774 (GRCm39) probably null Het
Pkd2l2 C A 18: 34,549,913 (GRCm39) P186Q probably damaging Het
Plcb1 G A 2: 135,062,677 (GRCm39) G96R possibly damaging Het
Plcd3 G C 11: 102,965,481 (GRCm39) R535G probably benign Het
Plcg1 A G 2: 160,596,523 (GRCm39) M681V possibly damaging Het
Polr1b C A 2: 128,967,464 (GRCm39) F952L probably damaging Het
Polrmt A T 10: 79,575,022 (GRCm39) D836E probably benign Het
Pramel12 T C 4: 143,144,331 (GRCm39) Y226H possibly damaging Het
Prkag1 A T 15: 98,712,478 (GRCm39) I149N probably damaging Het
Prkci A T 3: 31,104,362 (GRCm39) Q575L possibly damaging Het
Prss40 C T 1: 34,591,846 (GRCm39) W276* probably null Het
Ptprn T C 1: 75,228,946 (GRCm39) D823G possibly damaging Het
Radil A C 5: 142,529,303 (GRCm39) F131C probably damaging Het
Rif1 A G 2: 52,006,368 (GRCm39) I550V probably benign Het
Rmnd1 T C 10: 4,361,713 (GRCm39) E320G probably damaging Het
Sec31b T A 19: 44,512,212 (GRCm39) K561* probably null Het
Spata31g1 C T 4: 42,970,171 (GRCm39) Q53* probably null Het
Spata31g1 T C 4: 42,971,095 (GRCm39) S143P probably benign Het
Tbx5 A C 5: 120,021,232 (GRCm39) T413P probably benign Het
Tmprss7 A G 16: 45,480,963 (GRCm39) probably null Het
Tnfaip8l2 T C 3: 95,047,307 (GRCm39) *185W probably null Het
Tpst2 A G 5: 112,457,560 (GRCm39) E296G possibly damaging Het
Ubn2 T A 6: 38,467,688 (GRCm39) S801T probably damaging Het
Usp34 A G 11: 23,332,638 (GRCm39) S1141G Het
Uts2r A G 11: 121,052,279 (GRCm39) N381S probably benign Het
Vmn2r44 G T 7: 8,381,314 (GRCm39) T193K possibly damaging Het
Wdr18 T A 10: 79,801,884 (GRCm39) M223K probably benign Het
Wdr64 T C 1: 175,617,564 (GRCm39) C715R possibly damaging Het
Zfp672 A G 11: 58,208,081 (GRCm39) F80S possibly damaging Het
Other mutations in Pira2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Pira2 APN 7 3,847,138 (GRCm39) missense probably damaging 1.00
IGL01810:Pira2 APN 7 3,847,611 (GRCm39) missense probably damaging 1.00
IGL03167:Pira2 APN 7 3,843,919 (GRCm39) missense probably damaging 0.98
IGL03171:Pira2 APN 7 3,845,604 (GRCm39) missense probably damaging 1.00
BB009:Pira2 UTSW 7 3,845,435 (GRCm39) critical splice donor site probably null
BB019:Pira2 UTSW 7 3,845,435 (GRCm39) critical splice donor site probably null
PIT4260001:Pira2 UTSW 7 3,845,173 (GRCm39) missense probably benign
PIT4260001:Pira2 UTSW 7 3,845,169 (GRCm39) missense probably benign
PIT4260001:Pira2 UTSW 7 3,845,172 (GRCm39) missense probably benign
R0517:Pira2 UTSW 7 3,847,196 (GRCm39) splice site probably benign
R1565:Pira2 UTSW 7 3,847,548 (GRCm39) missense probably damaging 1.00
R1870:Pira2 UTSW 7 3,847,452 (GRCm39) missense probably damaging 1.00
R2143:Pira2 UTSW 7 3,847,344 (GRCm39) missense probably damaging 1.00
R2144:Pira2 UTSW 7 3,847,344 (GRCm39) missense probably damaging 1.00
R2145:Pira2 UTSW 7 3,847,344 (GRCm39) missense probably damaging 1.00
R2149:Pira2 UTSW 7 3,847,170 (GRCm39) missense probably damaging 1.00
R2171:Pira2 UTSW 7 3,847,417 (GRCm39) missense probably benign 0.08
R3118:Pira2 UTSW 7 3,844,676 (GRCm39) nonsense probably null
R4658:Pira2 UTSW 7 3,843,933 (GRCm39) missense probably damaging 1.00
R5148:Pira2 UTSW 7 3,847,592 (GRCm39) missense possibly damaging 0.62
R5228:Pira2 UTSW 7 3,847,373 (GRCm39) missense probably benign 0.33
R5583:Pira2 UTSW 7 3,845,545 (GRCm39) missense probably benign 0.34
R5974:Pira2 UTSW 7 3,844,576 (GRCm39) missense probably benign 0.27
R6120:Pira2 UTSW 7 3,844,553 (GRCm39) missense probably damaging 1.00
R6122:Pira2 UTSW 7 3,845,445 (GRCm39) missense probably damaging 1.00
R6392:Pira2 UTSW 7 3,846,901 (GRCm39) missense possibly damaging 0.72
R6658:Pira2 UTSW 7 3,845,300 (GRCm39) missense probably benign 0.00
R6790:Pira2 UTSW 7 3,845,442 (GRCm39) missense probably damaging 1.00
R6990:Pira2 UTSW 7 3,844,067 (GRCm39) missense probably damaging 0.99
R7336:Pira2 UTSW 7 3,847,344 (GRCm39) missense probably damaging 1.00
R7597:Pira2 UTSW 7 3,845,460 (GRCm39) missense probably damaging 1.00
R7768:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R7861:Pira2 UTSW 7 3,847,543 (GRCm39) missense probably damaging 1.00
R7932:Pira2 UTSW 7 3,845,435 (GRCm39) critical splice donor site probably null
R7977:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R7984:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R7985:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R7987:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R8017:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R8017:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R8019:Pira2 UTSW 7 3,844,696 (GRCm39) missense probably benign
R8389:Pira2 UTSW 7 3,846,888 (GRCm39) missense probably damaging 1.00
R8972:Pira2 UTSW 7 3,845,070 (GRCm39) missense probably damaging 1.00
R8998:Pira2 UTSW 7 3,845,490 (GRCm39) missense probably damaging 1.00
R9350:Pira2 UTSW 7 3,844,030 (GRCm39) missense probably benign 0.04
R9766:Pira2 UTSW 7 3,845,517 (GRCm39) missense possibly damaging 0.80
Predicted Primers
Posted On 2019-11-26