Incidental Mutation 'R7780:Wdr64'
ID 599137
Institutional Source Beutler Lab
Gene Symbol Wdr64
Ensembl Gene ENSMUSG00000026523
Gene Name WD repeat domain 64
Synonyms 4930415O10Rik, 4930511H01Rik
MMRRC Submission 045836-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7780 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 175526159-175643300 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 175556542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 263 (L263P)
Ref Sequence ENSEMBL: ENSMUSP00000128678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094288] [ENSMUST00000171939] [ENSMUST00000194087]
AlphaFold Q9D565
Predicted Effect probably damaging
Transcript: ENSMUST00000094288
AA Change: L273P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091846
Gene: ENSMUSG00000026523
AA Change: L273P

DomainStartEndE-ValueType
WD40 118 159 2.65e1 SMART
WD40 162 200 2.13e1 SMART
low complexity region 259 271 N/A INTRINSIC
Blast:WD40 277 316 5e-19 BLAST
WD40 323 361 2.4e-1 SMART
WD40 365 404 8.29e-1 SMART
WD40 407 449 1.7e2 SMART
WD40 457 493 1.19e1 SMART
WD40 497 538 4.55e-3 SMART
WD40 643 684 3.31e0 SMART
WD40 742 806 7.4e0 SMART
Blast:WD40 811 851 7e-17 BLAST
WD40 864 903 4.62e-4 SMART
Blast:XPGN 921 964 9e-19 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000171939
AA Change: L263P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128678
Gene: ENSMUSG00000026523
AA Change: L263P

DomainStartEndE-ValueType
WD40 151 190 5.73e0 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 306 4e-19 BLAST
WD40 313 351 2.4e-1 SMART
WD40 355 394 8.29e-1 SMART
WD40 397 439 1.7e2 SMART
WD40 447 483 1.19e1 SMART
WD40 487 528 4.55e-3 SMART
WD40 633 674 3.31e0 SMART
WD40 732 796 7.4e0 SMART
Blast:WD40 801 841 5e-17 BLAST
WD40 854 893 4.62e-4 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000194087
AA Change: L263P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141740
Gene: ENSMUSG00000026523
AA Change: L263P

DomainStartEndE-ValueType
WD40 151 190 3.6e-2 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 305 5e-19 BLAST
WD40 313 351 1.5e-3 SMART
WD40 355 394 5.2e-3 SMART
WD40 397 439 1.1e0 SMART
WD40 447 483 7.6e-2 SMART
WD40 487 528 2.9e-5 SMART
WD40 633 674 2.1e-2 SMART
WD40 732 796 4.7e-2 SMART
Blast:WD40 801 841 6e-17 BLAST
WD40 854 893 2.9e-6 SMART
Blast:XPGN 911 954 1e-18 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (77/77)
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 C T 8: 25,294,432 (GRCm39) R389K possibly damaging Het
Ahnak2 C T 12: 112,746,716 (GRCm39) V1205M Het
Ccr3 A G 9: 123,828,989 (GRCm39) Y108C probably benign Het
Cers5 T G 15: 99,637,589 (GRCm39) H220P probably damaging Het
Cfap61 A T 2: 145,995,692 (GRCm39) N1086Y possibly damaging Het
Cip2a T A 16: 48,822,023 (GRCm39) L217* probably null Het
Clstn3 T C 6: 124,439,161 (GRCm39) E32G probably damaging Het
Cox20 T C 1: 178,149,566 (GRCm39) C72R probably benign Het
Csf1 A T 3: 107,657,709 (GRCm39) N154K probably damaging Het
Cyp2j7 T A 4: 96,118,256 (GRCm39) K112N probably benign Het
Drosha A G 15: 12,848,172 (GRCm39) D488G probably benign Het
Edem1 A G 6: 108,818,589 (GRCm39) K199R probably benign Het
Esyt2 T C 12: 116,305,718 (GRCm39) I316T probably benign Het
Evpl C T 11: 116,125,000 (GRCm39) R154H not run Het
Fbn1 A G 2: 125,143,678 (GRCm39) L2817P probably benign Het
Fbxo42 T A 4: 140,921,131 (GRCm39) probably null Het
Fbxo43 T C 15: 36,162,358 (GRCm39) D283G probably damaging Het
Fdxr A T 11: 115,167,656 (GRCm39) S20T probably benign Het
Fkbp10 T C 11: 100,312,048 (GRCm39) Y203H probably damaging Het
Galntl6 C T 8: 58,880,733 (GRCm39) probably null Het
Gask1b G A 3: 79,848,711 (GRCm39) G486S probably damaging Het
Gm26657 C A 4: 56,741,056 (GRCm39) Y80* probably null Het
Gm973 T A 1: 59,597,289 (GRCm39) W440R probably damaging Het
Helz T A 11: 107,528,689 (GRCm39) F903Y probably damaging Het
Iqcf4 T A 9: 106,445,860 (GRCm39) I96F possibly damaging Het
Kcnq5 T A 1: 22,031,555 (GRCm39) Q84L probably benign Het
Krit1 G A 5: 3,862,772 (GRCm39) G254S probably damaging Het
Krtap6-2 A T 16: 89,216,510 (GRCm39) Y152* probably null Het
Loricrin A T 3: 91,988,460 (GRCm39) Y275* probably null Het
Map4 T C 9: 109,863,720 (GRCm39) I315T probably benign Het
Mcpt1 T A 14: 56,256,609 (GRCm39) probably null Het
Mdh1b C A 1: 63,759,133 (GRCm39) S153I possibly damaging Het
Mfsd12 C A 10: 81,193,718 (GRCm39) A96E probably benign Het
Mki67 T C 7: 135,315,697 (GRCm39) E55G probably benign Het
Mterf4 T C 1: 93,232,689 (GRCm39) E54G probably benign Het
Mucl3 A G 17: 35,947,874 (GRCm39) S452P possibly damaging Het
Nuggc T A 14: 65,882,490 (GRCm39) I745N probably damaging Het
Or6k6 T C 1: 173,945,115 (GRCm39) I156V probably benign Het
Or7g18 A G 9: 18,786,910 (GRCm39) T93A possibly damaging Het
Parg A T 14: 31,930,758 (GRCm39) N126I possibly damaging Het
Pcdh9 T C 14: 94,123,987 (GRCm39) I728V possibly damaging Het
Pcdha1 C G 18: 37,065,511 (GRCm39) P725R probably benign Het
Pcdha11 T A 18: 37,145,849 (GRCm39) L647M probably damaging Het
Phb2 T C 6: 124,692,995 (GRCm39) probably null Het
Plb1 A G 5: 32,483,610 (GRCm39) probably null Het
Pmch T A 10: 87,927,113 (GRCm39) F39I probably benign Het
Psmd7 A T 8: 108,307,920 (GRCm39) S188T possibly damaging Het
Pycr2 T A 1: 180,733,913 (GRCm39) D168E probably damaging Het
Rab43 A G 6: 87,771,692 (GRCm39) Y96H probably damaging Het
Ralgapa2 C T 2: 146,184,334 (GRCm39) G1511S probably benign Het
Rb1cc1 T A 1: 6,319,138 (GRCm39) C852* probably null Het
Rexo2 T C 9: 48,380,145 (GRCm39) N229S probably damaging Het
Sema4f A G 6: 82,890,941 (GRCm39) V622A possibly damaging Het
Serpina10 T C 12: 103,594,806 (GRCm39) S138G probably benign Het
Sptbn4 T A 7: 27,061,059 (GRCm39) T2415S possibly damaging Het
Tbc1d22b A G 17: 29,792,040 (GRCm39) N257D probably benign Het
Tbl3 A G 17: 24,921,205 (GRCm39) F529L probably damaging Het
Them6 A T 15: 74,593,427 (GRCm39) N95I probably benign Het
Thrb T C 14: 18,008,608 (GRCm38) S156P possibly damaging Het
Tmem186 G A 16: 8,453,731 (GRCm39) R177C probably benign Het
Ttn T A 2: 76,660,937 (GRCm39) probably null Het
Unc13a T A 8: 72,110,979 (GRCm39) I411F probably benign Het
Uqcc1 T C 2: 155,752,073 (GRCm39) probably null Het
Vmn1r56 T C 7: 5,199,516 (GRCm39) T34A possibly damaging Het
Vps39 A T 2: 120,155,680 (GRCm39) Y542* probably null Het
Wdr90 C T 17: 26,065,300 (GRCm39) R1652Q probably damaging Het
Wfdc16 A G 2: 164,477,785 (GRCm39) M88T probably benign Het
Wnk4 A G 11: 101,160,403 (GRCm39) D679G probably damaging Het
Ykt6 T C 11: 5,912,751 (GRCm39) I151T probably benign Het
Zbtb46 A G 2: 181,033,225 (GRCm39) C479R probably damaging Het
Zc3h7a A G 16: 10,967,115 (GRCm39) I559T probably benign Het
Zfhx3 A G 8: 109,678,283 (GRCm39) N3111S possibly damaging Het
Zfp619 T C 7: 39,184,432 (GRCm39) V154A possibly damaging Het
Zfp629 A T 7: 127,211,601 (GRCm39) D69E probably benign Het
Zfp882 T A 8: 72,668,073 (GRCm39) I300N possibly damaging Het
Zfp934 T C 13: 62,666,358 (GRCm39) H106R possibly damaging Het
Zfta T C 19: 7,399,737 (GRCm39) S495P probably damaging Het
Zfyve9 G A 4: 108,576,298 (GRCm39) T261I possibly damaging Het
Other mutations in Wdr64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00563:Wdr64 APN 1 175,526,366 (GRCm39) missense probably benign 0.00
IGL00902:Wdr64 APN 1 175,556,391 (GRCm39) missense probably damaging 1.00
IGL01347:Wdr64 APN 1 175,547,899 (GRCm39) missense probably benign 0.12
IGL01353:Wdr64 APN 1 175,559,151 (GRCm39) missense probably damaging 0.96
IGL01583:Wdr64 APN 1 175,594,722 (GRCm39) critical splice donor site probably null
IGL01643:Wdr64 APN 1 175,599,877 (GRCm39) missense probably damaging 1.00
IGL01673:Wdr64 APN 1 175,627,922 (GRCm39) missense possibly damaging 0.68
IGL01992:Wdr64 APN 1 175,533,637 (GRCm39) missense probably damaging 1.00
IGL02613:Wdr64 APN 1 175,594,613 (GRCm39) nonsense probably null
IGL02834:Wdr64 APN 1 175,633,415 (GRCm39) splice site probably benign
IGL03214:Wdr64 APN 1 175,571,201 (GRCm39) splice site probably benign
IGL03305:Wdr64 APN 1 175,583,152 (GRCm39) missense possibly damaging 0.94
IGL03308:Wdr64 APN 1 175,594,562 (GRCm39) unclassified probably benign
PIT4418001:Wdr64 UTSW 1 175,571,160 (GRCm39) nonsense probably null
R0036:Wdr64 UTSW 1 175,556,496 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0079:Wdr64 UTSW 1 175,622,668 (GRCm39) missense probably benign 0.02
R0380:Wdr64 UTSW 1 175,597,208 (GRCm39) splice site probably benign
R0486:Wdr64 UTSW 1 175,622,769 (GRCm39) splice site probably benign
R0520:Wdr64 UTSW 1 175,553,958 (GRCm39) missense probably damaging 1.00
R0598:Wdr64 UTSW 1 175,633,465 (GRCm39) missense probably damaging 1.00
R0711:Wdr64 UTSW 1 175,599,751 (GRCm39) missense probably benign 0.39
R0746:Wdr64 UTSW 1 175,620,539 (GRCm39) missense possibly damaging 0.92
R0927:Wdr64 UTSW 1 175,620,647 (GRCm39) missense probably damaging 0.97
R0947:Wdr64 UTSW 1 175,603,315 (GRCm39) missense probably benign
R1014:Wdr64 UTSW 1 175,583,192 (GRCm39) missense probably damaging 1.00
R1332:Wdr64 UTSW 1 175,622,706 (GRCm39) missense possibly damaging 0.82
R1416:Wdr64 UTSW 1 175,633,568 (GRCm39) missense probably benign 0.01
R1421:Wdr64 UTSW 1 175,594,716 (GRCm39) missense possibly damaging 0.85
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1796:Wdr64 UTSW 1 175,544,897 (GRCm39) missense probably damaging 1.00
R1797:Wdr64 UTSW 1 175,639,585 (GRCm39) missense probably damaging 1.00
R2145:Wdr64 UTSW 1 175,594,661 (GRCm39) missense probably benign 0.01
R2321:Wdr64 UTSW 1 175,622,653 (GRCm39) missense possibly damaging 0.57
R2449:Wdr64 UTSW 1 175,526,479 (GRCm39) missense probably benign
R4049:Wdr64 UTSW 1 175,633,422 (GRCm39) missense probably benign 0.21
R4155:Wdr64 UTSW 1 175,597,172 (GRCm39) missense probably benign 0.03
R4624:Wdr64 UTSW 1 175,599,829 (GRCm39) missense probably benign
R4661:Wdr64 UTSW 1 175,554,060 (GRCm39) missense probably damaging 1.00
R4711:Wdr64 UTSW 1 175,626,795 (GRCm39) missense probably damaging 1.00
R4891:Wdr64 UTSW 1 175,526,345 (GRCm39) unclassified probably benign
R4925:Wdr64 UTSW 1 175,552,268 (GRCm39) splice site probably null
R4943:Wdr64 UTSW 1 175,547,882 (GRCm39) missense probably benign 0.01
R5000:Wdr64 UTSW 1 175,553,941 (GRCm39) splice site probably null
R5001:Wdr64 UTSW 1 175,620,525 (GRCm39) critical splice acceptor site probably null
R5143:Wdr64 UTSW 1 175,553,979 (GRCm39) missense probably damaging 1.00
R5395:Wdr64 UTSW 1 175,583,164 (GRCm39) missense probably damaging 1.00
R5813:Wdr64 UTSW 1 175,639,623 (GRCm39) missense possibly damaging 0.89
R6014:Wdr64 UTSW 1 175,633,556 (GRCm39) missense possibly damaging 0.56
R6417:Wdr64 UTSW 1 175,553,956 (GRCm39) missense probably damaging 1.00
R6456:Wdr64 UTSW 1 175,613,175 (GRCm39) critical splice donor site probably null
R6555:Wdr64 UTSW 1 175,547,856 (GRCm39) missense probably damaging 1.00
R6576:Wdr64 UTSW 1 175,633,494 (GRCm39) missense possibly damaging 0.82
R6797:Wdr64 UTSW 1 175,638,176 (GRCm39) critical splice donor site probably null
R6891:Wdr64 UTSW 1 175,533,634 (GRCm39) missense probably damaging 1.00
R6959:Wdr64 UTSW 1 175,533,555 (GRCm39) missense probably damaging 1.00
R7205:Wdr64 UTSW 1 175,617,499 (GRCm39) missense probably benign 0.34
R7252:Wdr64 UTSW 1 175,603,240 (GRCm39) missense probably benign 0.00
R7552:Wdr64 UTSW 1 175,613,147 (GRCm39) missense possibly damaging 0.71
R7732:Wdr64 UTSW 1 175,617,495 (GRCm39) missense probably benign
R7777:Wdr64 UTSW 1 175,617,564 (GRCm39) missense possibly damaging 0.71
R7810:Wdr64 UTSW 1 175,559,092 (GRCm39) missense probably benign 0.01
R7833:Wdr64 UTSW 1 175,591,511 (GRCm39) missense probably damaging 1.00
R7843:Wdr64 UTSW 1 175,639,668 (GRCm39) missense probably benign 0.00
R7887:Wdr64 UTSW 1 175,613,111 (GRCm39) missense not run
R7991:Wdr64 UTSW 1 175,554,051 (GRCm39) missense probably benign 0.36
R8124:Wdr64 UTSW 1 175,626,844 (GRCm39) splice site probably null
R8129:Wdr64 UTSW 1 175,603,154 (GRCm39) missense probably damaging 0.96
R8673:Wdr64 UTSW 1 175,633,584 (GRCm39) missense probably damaging 1.00
R8728:Wdr64 UTSW 1 175,559,079 (GRCm39) missense probably benign 0.01
R8786:Wdr64 UTSW 1 175,636,327 (GRCm39) nonsense probably null
R8822:Wdr64 UTSW 1 175,544,920 (GRCm39) missense probably damaging 1.00
R8842:Wdr64 UTSW 1 175,599,893 (GRCm39) missense probably benign 0.02
R8887:Wdr64 UTSW 1 175,599,850 (GRCm39) missense probably benign 0.17
R9014:Wdr64 UTSW 1 175,526,395 (GRCm39) missense probably benign
R9330:Wdr64 UTSW 1 175,554,024 (GRCm39) missense possibly damaging 0.93
R9332:Wdr64 UTSW 1 175,599,871 (GRCm39) missense possibly damaging 0.71
R9465:Wdr64 UTSW 1 175,618,823 (GRCm39) missense possibly damaging 0.53
R9716:Wdr64 UTSW 1 175,622,658 (GRCm39) missense probably benign
R9717:Wdr64 UTSW 1 175,544,854 (GRCm39) missense probably damaging 1.00
Z1088:Wdr64 UTSW 1 175,533,551 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- ACTTTGTCATCAAGCCCATGGAC -3'
(R):5'- ATGCTTTCCTTATTATCTCGGGAG -3'

Sequencing Primer
(F):5'- ATGGACCACTGCCTGCTCTG -3'
(R):5'- CAAGCTGGCCTGGAATTCACTATG -3'
Posted On 2019-11-26