Mutagenetix > Incidental Mutation

Incidental Mutation 'R7780:Zfhx3'

599169

Institutional Source

Beutler Lab

Gene Symbol

Zfhx3

Ensembl Gene

ENSMUSG00000038872

Gene Name

zinc finger homeobox 3

Synonyms

Sci, A230102L03Rik, WBP9, Atbf1

MMRRC Submission

045836-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.923) question?

Stock #

R7780 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

109005975-109688268 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 109678283 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 3111 (N3111S)

Ref Sequence

ENSEMBL: ENSMUSP00000044612 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043896] [ENSMUST00000220518]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000043896
AA Change: N3111S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000044612
Gene: ENSMUSG00000038872
AA Change: N3111S

Domain	Start	End	E-Value	Type
ZnF_C2H2	79	103	7.89e0	SMART
low complexity region	110	127	N/A	INTRINSIC
low complexity region	148	165	N/A	INTRINSIC
ZnF_C2H2	282	305	1.36e1	SMART
low complexity region	393	411	N/A	INTRINSIC
coiled coil region	453	496	N/A	INTRINSIC
low complexity region	500	523	N/A	INTRINSIC
ZnF_C2H2	641	664	3.47e0	SMART
ZnF_C2H2	672	695	6.78e-3	SMART
ZnF_U1	724	758	5.71e-1	SMART
ZnF_C2H2	727	751	4.87e-4	SMART
low complexity region	771	785	N/A	INTRINSIC
low complexity region	796	804	N/A	INTRINSIC
ZnF_C2H2	805	829	6.67e-2	SMART
ZnF_U1	982	1016	2.35e0	SMART
ZnF_C2H2	985	1009	4.57e0	SMART
ZnF_C2H2	1041	1065	3.99e0	SMART
ZnF_U1	1086	1120	1.36e0	SMART
ZnF_C2H2	1089	1113	1.33e-1	SMART
ZnF_C2H2	1233	1256	4.11e-2	SMART
ZnF_C2H2	1262	1285	4.34e-1	SMART
ZnF_C2H2	1370	1395	1.08e-1	SMART
ZnF_C2H2	1411	1433	3.34e-2	SMART
ZnF_C2H2	1439	1462	8.09e-1	SMART
low complexity region	1500	1512	N/A	INTRINSIC
ZnF_U1	1552	1586	1.05e0	SMART
ZnF_C2H2	1555	1579	8.22e-2	SMART
ZnF_U1	1603	1637	4.19e0	SMART
ZnF_C2H2	1606	1630	1.16e-1	SMART
low complexity region	1643	1669	N/A	INTRINSIC
low complexity region	1734	1776	N/A	INTRINSIC
low complexity region	1792	1802	N/A	INTRINSIC
low complexity region	1842	1878	N/A	INTRINSIC
low complexity region	1881	1894	N/A	INTRINSIC
low complexity region	1967	1985	N/A	INTRINSIC
ZnF_C2H2	1990	2013	1.62e0	SMART
low complexity region	2041	2088	N/A	INTRINSIC
low complexity region	2110	2125	N/A	INTRINSIC
HOX	2152	2214	1.13e-16	SMART
HOX	2249	2311	2.41e-20	SMART
ZnF_C2H2	2335	2355	1.72e1	SMART
low complexity region	2383	2414	N/A	INTRINSIC
low complexity region	2458	2473	N/A	INTRINSIC
low complexity region	2476	2521	N/A	INTRINSIC
ZnF_C2H2	2539	2561	1.79e-2	SMART
low complexity region	2606	2619	N/A	INTRINSIC
HOX	2650	2712	2.97e-20	SMART
ZnF_C2H2	2720	2743	7.67e-2	SMART
low complexity region	2929	2950	N/A	INTRINSIC
HOX	2954	3016	1.07e-17	SMART
ZnF_U1	3029	3063	1.8e-1	SMART
ZnF_C2H2	3032	3056	8.31e0	SMART
low complexity region	3130	3144	N/A	INTRINSIC
low complexity region	3181	3235	N/A	INTRINSIC
low complexity region	3237	3256	N/A	INTRINSIC
low complexity region	3268	3282	N/A	INTRINSIC
low complexity region	3290	3299	N/A	INTRINSIC
coiled coil region	3362	3417	N/A	INTRINSIC
low complexity region	3452	3476	N/A	INTRINSIC
ZnF_C2H2	3489	3509	1.45e2	SMART
ZnF_U1	3546	3580	1.36e0	SMART
ZnF_C2H2	3549	3573	1.77e1	SMART
low complexity region	3602	3633	N/A	INTRINSIC
low complexity region	3642	3674	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000220518
AA Change: N3111S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (77/77)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time. [provided by MGI curators]

Allele List at MGI

All alleles(18) : Gene trapped(18)

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	C	T	8: 25,294,432 (GRCm39)	R389K	possibly damaging	Het
Ahnak2	C	T	12: 112,746,716 (GRCm39)	V1205M		Het
Ccr3	A	G	9: 123,828,989 (GRCm39)	Y108C	probably benign	Het
Cers5	T	G	15: 99,637,589 (GRCm39)	H220P	probably damaging	Het
Cfap61	A	T	2: 145,995,692 (GRCm39)	N1086Y	possibly damaging	Het
Cip2a	T	A	16: 48,822,023 (GRCm39)	L217*	probably null	Het
Clstn3	T	C	6: 124,439,161 (GRCm39)	E32G	probably damaging	Het
Cox20	T	C	1: 178,149,566 (GRCm39)	C72R	probably benign	Het
Csf1	A	T	3: 107,657,709 (GRCm39)	N154K	probably damaging	Het
Cyp2j7	T	A	4: 96,118,256 (GRCm39)	K112N	probably benign	Het
Drosha	A	G	15: 12,848,172 (GRCm39)	D488G	probably benign	Het
Edem1	A	G	6: 108,818,589 (GRCm39)	K199R	probably benign	Het
Esyt2	T	C	12: 116,305,718 (GRCm39)	I316T	probably benign	Het
Evpl	C	T	11: 116,125,000 (GRCm39)	R154H	not run	Het
Fbn1	A	G	2: 125,143,678 (GRCm39)	L2817P	probably benign	Het
Fbxo42	T	A	4: 140,921,131 (GRCm39)		probably null	Het
Fbxo43	T	C	15: 36,162,358 (GRCm39)	D283G	probably damaging	Het
Fdxr	A	T	11: 115,167,656 (GRCm39)	S20T	probably benign	Het
Fkbp10	T	C	11: 100,312,048 (GRCm39)	Y203H	probably damaging	Het
Galntl6	C	T	8: 58,880,733 (GRCm39)		probably null	Het
Gask1b	G	A	3: 79,848,711 (GRCm39)	G486S	probably damaging	Het
Gm26657	C	A	4: 56,741,056 (GRCm39)	Y80*	probably null	Het
Gm973	T	A	1: 59,597,289 (GRCm39)	W440R	probably damaging	Het
Helz	T	A	11: 107,528,689 (GRCm39)	F903Y	probably damaging	Het
Iqcf4	T	A	9: 106,445,860 (GRCm39)	I96F	possibly damaging	Het
Kcnq5	T	A	1: 22,031,555 (GRCm39)	Q84L	probably benign	Het
Krit1	G	A	5: 3,862,772 (GRCm39)	G254S	probably damaging	Het
Krtap6-2	A	T	16: 89,216,510 (GRCm39)	Y152*	probably null	Het
Loricrin	A	T	3: 91,988,460 (GRCm39)	Y275*	probably null	Het
Map4	T	C	9: 109,863,720 (GRCm39)	I315T	probably benign	Het
Mcpt1	T	A	14: 56,256,609 (GRCm39)		probably null	Het
Mdh1b	C	A	1: 63,759,133 (GRCm39)	S153I	possibly damaging	Het
Mfsd12	C	A	10: 81,193,718 (GRCm39)	A96E	probably benign	Het
Mki67	T	C	7: 135,315,697 (GRCm39)	E55G	probably benign	Het
Mterf4	T	C	1: 93,232,689 (GRCm39)	E54G	probably benign	Het
Mucl3	A	G	17: 35,947,874 (GRCm39)	S452P	possibly damaging	Het
Nuggc	T	A	14: 65,882,490 (GRCm39)	I745N	probably damaging	Het
Or6k6	T	C	1: 173,945,115 (GRCm39)	I156V	probably benign	Het
Or7g18	A	G	9: 18,786,910 (GRCm39)	T93A	possibly damaging	Het
Parg	A	T	14: 31,930,758 (GRCm39)	N126I	possibly damaging	Het
Pcdh9	T	C	14: 94,123,987 (GRCm39)	I728V	possibly damaging	Het
Pcdha1	C	G	18: 37,065,511 (GRCm39)	P725R	probably benign	Het
Pcdha11	T	A	18: 37,145,849 (GRCm39)	L647M	probably damaging	Het
Phb2	T	C	6: 124,692,995 (GRCm39)		probably null	Het
Plb1	A	G	5: 32,483,610 (GRCm39)		probably null	Het
Pmch	T	A	10: 87,927,113 (GRCm39)	F39I	probably benign	Het
Psmd7	A	T	8: 108,307,920 (GRCm39)	S188T	possibly damaging	Het
Pycr2	T	A	1: 180,733,913 (GRCm39)	D168E	probably damaging	Het
Rab43	A	G	6: 87,771,692 (GRCm39)	Y96H	probably damaging	Het
Ralgapa2	C	T	2: 146,184,334 (GRCm39)	G1511S	probably benign	Het
Rb1cc1	T	A	1: 6,319,138 (GRCm39)	C852*	probably null	Het
Rexo2	T	C	9: 48,380,145 (GRCm39)	N229S	probably damaging	Het
Sema4f	A	G	6: 82,890,941 (GRCm39)	V622A	possibly damaging	Het
Serpina10	T	C	12: 103,594,806 (GRCm39)	S138G	probably benign	Het
Sptbn4	T	A	7: 27,061,059 (GRCm39)	T2415S	possibly damaging	Het
Tbc1d22b	A	G	17: 29,792,040 (GRCm39)	N257D	probably benign	Het
Tbl3	A	G	17: 24,921,205 (GRCm39)	F529L	probably damaging	Het
Them6	A	T	15: 74,593,427 (GRCm39)	N95I	probably benign	Het
Thrb	T	C	14: 18,008,608 (GRCm38)	S156P	possibly damaging	Het
Tmem186	G	A	16: 8,453,731 (GRCm39)	R177C	probably benign	Het
Ttn	T	A	2: 76,660,937 (GRCm39)		probably null	Het
Unc13a	T	A	8: 72,110,979 (GRCm39)	I411F	probably benign	Het
Uqcc1	T	C	2: 155,752,073 (GRCm39)		probably null	Het
Vmn1r56	T	C	7: 5,199,516 (GRCm39)	T34A	possibly damaging	Het
Vps39	A	T	2: 120,155,680 (GRCm39)	Y542*	probably null	Het
Wdr64	T	C	1: 175,556,542 (GRCm39)	L263P	probably damaging	Het
Wdr90	C	T	17: 26,065,300 (GRCm39)	R1652Q	probably damaging	Het
Wfdc16	A	G	2: 164,477,785 (GRCm39)	M88T	probably benign	Het
Wnk4	A	G	11: 101,160,403 (GRCm39)	D679G	probably damaging	Het
Ykt6	T	C	11: 5,912,751 (GRCm39)	I151T	probably benign	Het
Zbtb46	A	G	2: 181,033,225 (GRCm39)	C479R	probably damaging	Het
Zc3h7a	A	G	16: 10,967,115 (GRCm39)	I559T	probably benign	Het
Zfp619	T	C	7: 39,184,432 (GRCm39)	V154A	possibly damaging	Het
Zfp629	A	T	7: 127,211,601 (GRCm39)	D69E	probably benign	Het
Zfp882	T	A	8: 72,668,073 (GRCm39)	I300N	possibly damaging	Het
Zfp934	T	C	13: 62,666,358 (GRCm39)	H106R	possibly damaging	Het
Zfta	T	C	19: 7,399,737 (GRCm39)	S495P	probably damaging	Het
Zfyve9	G	A	4: 108,576,298 (GRCm39)	T261I	possibly damaging	Het

Other mutations in Zfhx3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01011:Zfhx3	APN	8	109,520,226 (GRCm39)	missense	probably benign	0.00
IGL01946:Zfhx3	APN	8	109,660,561 (GRCm39)	missense	probably damaging	0.98
IGL01973:Zfhx3	APN	8	109,673,825 (GRCm39)	missense	probably damaging	1.00
IGL01983:Zfhx3	APN	8	109,673,866 (GRCm39)	missense	probably damaging	1.00
IGL02151:Zfhx3	APN	8	109,520,515 (GRCm39)	missense	probably damaging	1.00
IGL02405:Zfhx3	APN	8	109,682,374 (GRCm39)	missense	unknown
IGL02406:Zfhx3	APN	8	109,682,374 (GRCm39)	missense	unknown
IGL02408:Zfhx3	APN	8	109,682,004 (GRCm39)	splice site	probably benign
IGL02549:Zfhx3	APN	8	109,527,141 (GRCm39)	missense	probably damaging	1.00
IGL02601:Zfhx3	APN	8	109,583,462 (GRCm39)	missense	probably damaging	1.00
IGL02649:Zfhx3	APN	8	109,520,167 (GRCm39)	missense	possibly damaging	0.94
IGL03027:Zfhx3	APN	8	109,519,820 (GRCm39)	missense	probably damaging	0.98
IGL03053:Zfhx3	APN	8	109,673,132 (GRCm39)	missense	probably damaging	0.99
IGL03168:Zfhx3	APN	8	109,673,132 (GRCm39)	missense	probably damaging	0.99
IGL03194:Zfhx3	APN	8	109,521,359 (GRCm39)	missense	probably damaging	0.97
IGL03248:Zfhx3	APN	8	109,673,182 (GRCm39)	missense	probably damaging	1.00
FR4449:Zfhx3	UTSW	8	109,682,726 (GRCm39)	small insertion	probably benign
FR4589:Zfhx3	UTSW	8	109,682,733 (GRCm39)	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	109,682,735 (GRCm39)	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	109,682,734 (GRCm39)	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	109,682,720 (GRCm39)	small insertion	probably benign
G5030:Zfhx3	UTSW	8	109,678,091 (GRCm39)	missense	possibly damaging	0.86
R0016:Zfhx3	UTSW	8	109,676,810 (GRCm39)	missense	probably benign	0.02
R0090:Zfhx3	UTSW	8	109,676,689 (GRCm39)	missense	possibly damaging	0.85
R0330:Zfhx3	UTSW	8	109,675,589 (GRCm39)	missense	probably damaging	1.00
R0332:Zfhx3	UTSW	8	109,673,255 (GRCm39)	missense	probably damaging	1.00
R0398:Zfhx3	UTSW	8	109,677,878 (GRCm39)	missense	probably damaging	0.98
R0539:Zfhx3	UTSW	8	109,527,141 (GRCm39)	missense	probably damaging	1.00
R0546:Zfhx3	UTSW	8	109,520,819 (GRCm39)	missense	probably damaging	1.00
R0614:Zfhx3	UTSW	8	109,675,599 (GRCm39)	nonsense	probably null
R0614:Zfhx3	UTSW	8	109,675,171 (GRCm39)	missense	probably benign	0.03
R0653:Zfhx3	UTSW	8	109,673,440 (GRCm39)	missense	possibly damaging	0.95
R0718:Zfhx3	UTSW	8	109,682,282 (GRCm39)	missense	unknown
R0825:Zfhx3	UTSW	8	109,675,840 (GRCm39)	missense	probably damaging	0.99
R1143:Zfhx3	UTSW	8	109,521,043 (GRCm39)	missense	probably damaging	1.00
R1319:Zfhx3	UTSW	8	109,660,465 (GRCm39)	missense	probably damaging	0.99
R1347:Zfhx3	UTSW	8	109,527,330 (GRCm39)	splice site	probably benign
R1412:Zfhx3	UTSW	8	109,641,199 (GRCm39)	missense	possibly damaging	0.88
R1447:Zfhx3	UTSW	8	109,675,076 (GRCm39)	missense	probably benign	0.03
R1530:Zfhx3	UTSW	8	109,675,121 (GRCm39)	missense	probably damaging	1.00
R1745:Zfhx3	UTSW	8	109,682,494 (GRCm39)	missense	unknown
R1764:Zfhx3	UTSW	8	109,678,276 (GRCm39)	missense	probably benign	0.18
R1781:Zfhx3	UTSW	8	109,520,167 (GRCm39)	missense	probably benign	0.01
R1917:Zfhx3	UTSW	8	109,682,880 (GRCm39)	missense	unknown
R1956:Zfhx3	UTSW	8	109,520,774 (GRCm39)	missense	probably benign	0.02
R2049:Zfhx3	UTSW	8	109,671,809 (GRCm39)	missense	probably benign	0.01
R2196:Zfhx3	UTSW	8	109,526,885 (GRCm39)	missense	probably damaging	1.00
R3085:Zfhx3	UTSW	8	109,682,664 (GRCm39)	missense	unknown
R3765:Zfhx3	UTSW	8	109,519,394 (GRCm39)	missense	probably damaging	0.97
R4162:Zfhx3	UTSW	8	109,683,619 (GRCm39)	missense	unknown
R4243:Zfhx3	UTSW	8	109,518,952 (GRCm39)	missense	probably damaging	0.97
R4380:Zfhx3	UTSW	8	109,683,022 (GRCm39)	missense	unknown
R4433:Zfhx3	UTSW	8	109,682,269 (GRCm39)	missense	unknown
R4509:Zfhx3	UTSW	8	109,520,411 (GRCm39)	missense	probably benign	0.01
R4731:Zfhx3	UTSW	8	109,682,716 (GRCm39)	missense	unknown
R4788:Zfhx3	UTSW	8	109,520,842 (GRCm39)	missense	probably damaging	1.00
R4812:Zfhx3	UTSW	8	109,674,593 (GRCm39)	missense	possibly damaging	0.83
R4893:Zfhx3	UTSW	8	109,683,639 (GRCm39)	missense	unknown
R4907:Zfhx3	UTSW	8	109,519,986 (GRCm39)	missense	probably damaging	0.99
R4935:Zfhx3	UTSW	8	109,674,482 (GRCm39)	missense	possibly damaging	0.92
R4943:Zfhx3	UTSW	8	109,674,949 (GRCm39)	missense	probably damaging	0.98
R5154:Zfhx3	UTSW	8	109,527,207 (GRCm39)	missense	probably damaging	1.00
R5377:Zfhx3	UTSW	8	109,677,817 (GRCm39)	missense	possibly damaging	0.95
R5388:Zfhx3	UTSW	8	109,673,446 (GRCm39)	missense	possibly damaging	0.88
R5434:Zfhx3	UTSW	8	109,519,031 (GRCm39)	missense	probably damaging	0.99
R5445:Zfhx3	UTSW	8	109,682,842 (GRCm39)	missense	unknown
R5541:Zfhx3	UTSW	8	109,675,583 (GRCm39)	missense	probably damaging	0.99
R5571:Zfhx3	UTSW	8	109,682,623 (GRCm39)	missense	unknown
R5700:Zfhx3	UTSW	8	109,660,499 (GRCm39)	missense	probably damaging	1.00
R5754:Zfhx3	UTSW	8	109,526,964 (GRCm39)	missense	probably damaging	0.99
R5867:Zfhx3	UTSW	8	109,520,078 (GRCm39)	missense	probably damaging	1.00
R5905:Zfhx3	UTSW	8	109,520,135 (GRCm39)	missense	probably damaging	1.00
R5922:Zfhx3	UTSW	8	109,673,330 (GRCm39)	missense	probably damaging	1.00
R5972:Zfhx3	UTSW	8	109,677,483 (GRCm39)	missense	possibly damaging	0.91
R6020:Zfhx3	UTSW	8	109,519,159 (GRCm39)	missense	probably damaging	1.00
R6028:Zfhx3	UTSW	8	109,520,135 (GRCm39)	missense	probably damaging	1.00
R6113:Zfhx3	UTSW	8	109,674,053 (GRCm39)	missense	probably benign	0.04
R6253:Zfhx3	UTSW	8	109,682,020 (GRCm39)	missense	possibly damaging	0.96
R6356:Zfhx3	UTSW	8	109,673,251 (GRCm39)	missense	probably damaging	1.00
R6800:Zfhx3	UTSW	8	109,676,149 (GRCm39)	missense	probably benign	0.20
R6829:Zfhx3	UTSW	8	109,676,915 (GRCm39)	missense	probably damaging	0.98
R6872:Zfhx3	UTSW	8	109,527,273 (GRCm39)	missense	probably damaging	1.00
R6873:Zfhx3	UTSW	8	109,527,273 (GRCm39)	missense	probably damaging	1.00
R6919:Zfhx3	UTSW	8	109,527,160 (GRCm39)	missense	probably damaging	1.00
R6921:Zfhx3	UTSW	8	109,678,024 (GRCm39)	missense	possibly damaging	0.53
R6925:Zfhx3	UTSW	8	109,683,453 (GRCm39)	missense	unknown
R6927:Zfhx3	UTSW	8	109,683,453 (GRCm39)	missense	unknown
R7152:Zfhx3	UTSW	8	109,674,839 (GRCm39)	missense	possibly damaging	0.94
R7169:Zfhx3	UTSW	8	109,678,030 (GRCm39)	missense	possibly damaging	0.86
R7214:Zfhx3	UTSW	8	109,675,493 (GRCm39)	missense	probably damaging	0.98
R7378:Zfhx3	UTSW	8	109,519,880 (GRCm39)	missense	probably damaging	0.99
R7391:Zfhx3	UTSW	8	109,674,475 (GRCm39)	missense	probably damaging	0.96
R7442:Zfhx3	UTSW	8	109,519,468 (GRCm39)	missense	probably damaging	0.97
R7636:Zfhx3	UTSW	8	109,673,441 (GRCm39)	missense	probably benign	0.25
R7649:Zfhx3	UTSW	8	109,678,276 (GRCm39)	missense	probably benign	0.18
R7699:Zfhx3	UTSW	8	109,677,754 (GRCm39)	missense	probably benign	0.18
R7728:Zfhx3	UTSW	8	109,678,201 (GRCm39)	missense	probably benign	0.01
R7904:Zfhx3	UTSW	8	109,677,695 (GRCm39)	missense	probably damaging	0.98
R8032:Zfhx3	UTSW	8	109,677,854 (GRCm39)	missense	possibly damaging	0.51
R8158:Zfhx3	UTSW	8	109,675,353 (GRCm39)	missense	possibly damaging	0.82
R8163:Zfhx3	UTSW	8	109,675,925 (GRCm39)	missense	probably damaging	1.00
R8215:Zfhx3	UTSW	8	109,677,349 (GRCm39)	missense	probably benign
R8217:Zfhx3	UTSW	8	109,677,349 (GRCm39)	missense	probably benign
R8218:Zfhx3	UTSW	8	109,677,349 (GRCm39)	missense	probably benign
R8369:Zfhx3	UTSW	8	109,583,448 (GRCm39)	missense	possibly damaging	0.82
R8424:Zfhx3	UTSW	8	109,583,385 (GRCm39)	missense	probably damaging	0.98
R8482:Zfhx3	UTSW	8	109,674,511 (GRCm39)	missense	probably benign	0.02
R8504:Zfhx3	UTSW	8	109,583,549 (GRCm39)	missense	possibly damaging	0.95
R8871:Zfhx3	UTSW	8	109,676,867 (GRCm39)	missense	possibly damaging	0.85
R9144:Zfhx3	UTSW	8	109,676,794 (GRCm39)	missense	possibly damaging	0.53
R9202:Zfhx3	UTSW	8	109,677,920 (GRCm39)	missense	possibly damaging	0.92
R9213:Zfhx3	UTSW	8	109,676,756 (GRCm39)	missense	probably benign	0.18
R9218:Zfhx3	UTSW	8	109,520,501 (GRCm39)	missense	probably benign	0.17
R9370:Zfhx3	UTSW	8	109,521,340 (GRCm39)	missense	probably damaging	1.00
R9422:Zfhx3	UTSW	8	109,430,850 (GRCm39)	start gained	probably benign
R9530:Zfhx3	UTSW	8	109,527,010 (GRCm39)	missense	probably damaging	1.00
RF027:Zfhx3	UTSW	8	109,682,730 (GRCm39)	small insertion	probably benign
RF028:Zfhx3	UTSW	8	109,682,728 (GRCm39)	small insertion	probably benign
RF029:Zfhx3	UTSW	8	109,682,724 (GRCm39)	small insertion	probably benign
RF031:Zfhx3	UTSW	8	109,682,730 (GRCm39)	small insertion	probably benign
RF032:Zfhx3	UTSW	8	109,682,724 (GRCm39)	small insertion	probably benign
RF037:Zfhx3	UTSW	8	109,682,730 (GRCm39)	nonsense	probably null
RF038:Zfhx3	UTSW	8	109,682,733 (GRCm39)	small insertion	probably benign
RF040:Zfhx3	UTSW	8	109,682,733 (GRCm39)	small insertion	probably benign
RF042:Zfhx3	UTSW	8	109,682,730 (GRCm39)	small insertion	probably benign
RF042:Zfhx3	UTSW	8	109,682,720 (GRCm39)	small insertion	probably benign
RF054:Zfhx3	UTSW	8	109,682,728 (GRCm39)	small insertion	probably benign
RF060:Zfhx3	UTSW	8	109,682,720 (GRCm39)	small insertion	probably benign
X0019:Zfhx3	UTSW	8	109,678,285 (GRCm39)	missense	probably benign	0.00
X0026:Zfhx3	UTSW	8	109,675,777 (GRCm39)	missense	probably damaging	1.00
Z1088:Zfhx3	UTSW	8	109,677,989 (GRCm39)	missense	possibly damaging	0.72
Z1176:Zfhx3	UTSW	8	109,527,081 (GRCm39)	missense	probably damaging	1.00
Z1176:Zfhx3	UTSW	8	109,520,555 (GRCm39)	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- TGCACTTTGTGTGGCATCAAG -3'
(R):5'- AAAACGAGCTTCTACTGAACTCTG -3'

Sequencing Primer
(F):5'- CACTTTGTGTGGCATCAAGTACAGC -3'
(R):5'- GAGCTTCTACTGAACTCTGAAAGC -3'

Posted On

2019-11-26