Incidental Mutation 'R7782:Or7c70'
ID 599315
Institutional Source Beutler Lab
Gene Symbol Or7c70
Ensembl Gene ENSMUSG00000051190
Gene Name olfactory receptor family 7 subfamily C member 70
Synonyms MOR142-2_p, Olfr1356, MOR142-1, GA_x6K02T2QGN0-2962025-2962987
MMRRC Submission 045838-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.236) question?
Stock # R7782 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 78682785-78683747 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78683447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 101 (I101V)
Ref Sequence ENSEMBL: ENSMUSP00000144815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061289] [ENSMUST00000205100]
AlphaFold Q7TQU8
Predicted Effect probably benign
Transcript: ENSMUST00000061289
AA Change: I101V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000054345
Gene: ENSMUSG00000051190
AA Change: I101V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.6e-58 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.4e-5 PFAM
Pfam:7tm_1 41 290 6.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205100
AA Change: I101V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000144815
Gene: ENSMUSG00000051190
AA Change: I101V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.6e-58 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.4e-5 PFAM
Pfam:7tm_1 41 290 6.5e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (80/80)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933415A04Rik GTGTGTGTATGTGTGT GTGTGTGT 11: 43,478,239 (GRCm39) probably null Het
Adamts16 A G 13: 70,984,265 (GRCm39) S133P probably damaging Het
Adamts17 T C 7: 66,774,802 (GRCm39) W1001R probably damaging Het
Aox4 T A 1: 58,270,251 (GRCm39) probably null Het
B4galnt4 C T 7: 140,644,988 (GRCm39) P221S probably damaging Het
BC005537 C T 13: 24,987,382 (GRCm39) R7W possibly damaging Het
BC034090 T C 1: 155,108,410 (GRCm39) probably benign Het
Best2 T A 8: 85,736,143 (GRCm39) D312V probably damaging Het
Bod1l A T 5: 41,975,286 (GRCm39) D2009E probably benign Het
Ccdc158 A C 5: 92,793,373 (GRCm39) S672A probably benign Het
Ccdc43 A T 11: 102,588,443 (GRCm39) L31Q probably damaging Het
Cdcp3 G A 7: 130,904,466 (GRCm39) probably null Het
Chaf1a T G 17: 56,369,291 (GRCm39) H507Q probably benign Het
Clptm1l A G 13: 73,752,439 (GRCm39) Y28C probably damaging Het
Cp G A 3: 20,029,223 (GRCm39) probably null Het
Crocc C T 4: 140,752,597 (GRCm39) A1432T probably benign Het
Crybg2 A G 4: 133,801,137 (GRCm39) T457A probably benign Het
Csnk2a1-ps3 C T 1: 156,352,552 (GRCm39) T251I probably damaging Het
Dennd4a A G 9: 64,814,202 (GRCm39) D1473G probably damaging Het
Diaph3 A G 14: 87,274,940 (GRCm39) F172S probably benign Het
Dnajc5b A G 3: 19,629,006 (GRCm39) N100S probably benign Het
Dusp13b G A 14: 21,791,404 (GRCm39) T16I possibly damaging Het
Epb42 T G 2: 120,864,916 (GRCm39) K58N probably benign Het
Fat1 A G 8: 45,403,948 (GRCm39) Y233C probably damaging Het
Fcgbp T A 7: 27,784,460 (GRCm39) Y173* probably null Het
Fign T A 2: 63,809,506 (GRCm39) D588V probably damaging Het
Fignl2 C T 15: 100,951,188 (GRCm39) V365M unknown Het
Fnip2 A C 3: 79,415,430 (GRCm39) Y203D probably benign Het
Ftsj3 CCTTCTTCTTCTTCTTCT CCTTCTTCTTCTTCT 11: 106,143,377 (GRCm39) probably benign Het
Gfral C A 9: 76,100,572 (GRCm39) V289L probably benign Het
H2bc21 T A 3: 96,128,487 (GRCm39) probably null Het
Heatr5b G T 17: 79,103,370 (GRCm39) T1161K probably damaging Het
Hectd4 A T 5: 121,443,784 (GRCm39) I1335F possibly damaging Het
Htt T A 5: 35,040,336 (GRCm39) V2166D probably benign Het
Ipo5 G C 14: 121,170,537 (GRCm39) K436N possibly damaging Het
Iqca1l A G 5: 24,749,224 (GRCm39) L758P probably damaging Het
Itga6 A G 2: 71,671,879 (GRCm39) E794G probably damaging Het
Itga9 G A 9: 118,672,712 (GRCm39) C148Y Het
Kcnip2 A C 19: 45,785,524 (GRCm39) probably null Het
Kcnk6 T C 7: 28,925,269 (GRCm39) T116A possibly damaging Het
Kctd21 A G 7: 96,997,297 (GRCm39) I257V probably benign Het
Kif19a G A 11: 114,672,748 (GRCm39) R299Q probably damaging Het
Kifc2 G A 15: 76,548,328 (GRCm39) G391R probably benign Het
Klrg2 A G 6: 38,604,562 (GRCm39) V381A possibly damaging Het
Mob1b A G 5: 88,897,542 (GRCm39) probably null Het
Or13p8 T C 4: 118,584,106 (GRCm39) Y221H probably damaging Het
Or6c69 T G 10: 129,747,392 (GRCm39) S252R probably damaging Het
Or6c75 T C 10: 129,337,020 (GRCm39) V81A probably benign Het
Oxsm C A 14: 16,240,925 (GRCm38) A375S possibly damaging Het
Pcdha3 T C 18: 37,081,193 (GRCm39) V645A probably damaging Het
Pcdhb15 T A 18: 37,607,788 (GRCm39) V340E possibly damaging Het
Pced1a G A 2: 130,264,435 (GRCm39) P132S probably damaging Het
Pla2r1 C T 2: 60,334,531 (GRCm39) V414M probably benign Het
Plekhg4 A C 8: 106,104,399 (GRCm39) I493L probably benign Het
Plekhj1 T A 10: 80,634,179 (GRCm39) probably benign Het
Pmfbp1 G T 8: 110,254,412 (GRCm39) K482N probably damaging Het
Ppil3 T C 1: 58,473,574 (GRCm39) N92S probably benign Het
Ppt2 A G 17: 34,844,686 (GRCm39) S156P probably benign Het
Prss41 A T 17: 24,056,087 (GRCm39) D255E probably benign Het
Psg25 T A 7: 18,255,227 (GRCm39) M430L probably benign Het
Rffl A T 11: 82,703,595 (GRCm39) C109* probably null Het
Rock2 A G 12: 17,021,111 (GRCm39) E991G probably benign Het
Rpap2 A G 5: 107,768,058 (GRCm39) I299V probably benign Het
Rras T C 7: 44,670,529 (GRCm39) S158P probably benign Het
Serpinb10 G A 1: 107,463,196 (GRCm39) probably benign Het
Smyd3 A T 1: 178,799,859 (GRCm39) I360N possibly damaging Het
Synm A G 7: 67,384,714 (GRCm39) S541P probably damaging Het
Tasor A G 14: 27,193,901 (GRCm39) T1034A probably benign Het
Tbc1d31 C A 15: 57,821,764 (GRCm39) T813K possibly damaging Het
Trav7n-4 A G 14: 53,329,103 (GRCm39) M38V probably benign Het
Tulp3 A C 6: 128,301,943 (GRCm39) N359K possibly damaging Het
Twf1 T C 15: 94,480,654 (GRCm39) K196E probably benign Het
Usp24 A T 4: 106,173,771 (GRCm39) N35Y probably damaging Het
Usp46 T A 5: 74,162,772 (GRCm39) E342D probably benign Het
Vps50 T A 6: 3,532,202 (GRCm39) probably null Het
Vps8 T A 16: 21,330,308 (GRCm39) I727N possibly damaging Het
Wdr90 C T 17: 26,065,300 (GRCm39) R1652Q probably damaging Het
Zfp11 A T 5: 129,734,027 (GRCm39) V478E possibly damaging Het
Zfp493 A G 13: 67,935,123 (GRCm39) K359E probably benign Het
Zfp536 T C 7: 37,268,126 (GRCm39) Y430C probably damaging Het
Zfpm1 A G 8: 123,063,689 (GRCm39) D916G unknown Het
Other mutations in Or7c70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00904:Or7c70 APN 10 78,683,597 (GRCm39) missense probably damaging 1.00
IGL01343:Or7c70 APN 10 78,683,431 (GRCm39) missense probably damaging 0.97
IGL01576:Or7c70 APN 10 78,683,207 (GRCm39) missense possibly damaging 0.94
IGL02314:Or7c70 APN 10 78,683,099 (GRCm39) missense probably damaging 1.00
IGL02474:Or7c70 APN 10 78,682,897 (GRCm39) missense probably damaging 1.00
IGL02960:Or7c70 APN 10 78,683,371 (GRCm39) missense probably damaging 1.00
IGL03049:Or7c70 APN 10 78,683,356 (GRCm39) missense possibly damaging 0.81
IGL03328:Or7c70 APN 10 78,683,201 (GRCm39) missense probably benign 0.39
R1602:Or7c70 UTSW 10 78,682,802 (GRCm39) missense probably benign
R1722:Or7c70 UTSW 10 78,682,805 (GRCm39) missense probably benign
R2178:Or7c70 UTSW 10 78,683,612 (GRCm39) missense probably damaging 0.96
R3903:Or7c70 UTSW 10 78,683,132 (GRCm39) missense probably benign 0.00
R3904:Or7c70 UTSW 10 78,683,132 (GRCm39) missense probably benign 0.00
R4241:Or7c70 UTSW 10 78,683,739 (GRCm39) missense probably benign 0.00
R4833:Or7c70 UTSW 10 78,683,409 (GRCm39) missense probably damaging 1.00
R5465:Or7c70 UTSW 10 78,682,852 (GRCm39) missense probably benign 0.00
R5527:Or7c70 UTSW 10 78,683,609 (GRCm39) missense probably benign 0.02
R5606:Or7c70 UTSW 10 78,683,395 (GRCm39) missense probably benign 0.19
R5977:Or7c70 UTSW 10 78,683,572 (GRCm39) missense possibly damaging 0.95
R6219:Or7c70 UTSW 10 78,683,093 (GRCm39) missense possibly damaging 0.88
R6996:Or7c70 UTSW 10 78,683,351 (GRCm39) missense probably benign 0.00
R7136:Or7c70 UTSW 10 78,683,615 (GRCm39) missense probably benign 0.43
R7996:Or7c70 UTSW 10 78,683,155 (GRCm39) missense probably damaging 1.00
R8955:Or7c70 UTSW 10 78,683,576 (GRCm39) missense probably damaging 1.00
R9330:Or7c70 UTSW 10 78,683,153 (GRCm39) missense probably benign 0.00
R9427:Or7c70 UTSW 10 78,682,906 (GRCm39) missense probably damaging 0.99
R9474:Or7c70 UTSW 10 78,682,891 (GRCm39) missense probably damaging 0.99
Z1176:Or7c70 UTSW 10 78,682,855 (GRCm39) missense possibly damaging 0.73
Z1177:Or7c70 UTSW 10 78,683,290 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGGTAGGGAACTCATGACGC -3'
(R):5'- AAGACTCTGACCTGCAGTCC -3'

Sequencing Primer
(F):5'- TAGGGAACTCATGACGCTGACTATC -3'
(R):5'- TATGTACCTGGTCACCATCACAGG -3'
Posted On 2019-11-26