Incidental Mutation 'R7783:Try4'
ID 599372
Institutional Source Beutler Lab
Gene Symbol Try4
Ensembl Gene ENSMUSG00000054106
Gene Name trypsin 4
Synonyms 0910001B19Rik, Td
MMRRC Submission 045839-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7783 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 41302269-41305532 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41302295 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 4 (L4P)
Ref Sequence ENSEMBL: ENSMUSP00000031913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031913]
AlphaFold Q9R0T7
Predicted Effect possibly damaging
Transcript: ENSMUST00000031913
AA Change: L4P

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000031913
Gene: ENSMUSG00000054106
AA Change: L4P

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Tryp_SPc 23 239 9.72e-105 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb9 G T 5: 124,078,812 (GRCm38) Y447* probably null Het
Abl2 T C 1: 156,559,071 (GRCm38) V8A probably benign Het
Adam33 C T 2: 131,058,337 (GRCm38) R103K unknown Het
Adamts13 G T 2: 26,990,585 (GRCm38) A727S not run Het
Alpk2 A T 18: 65,306,254 (GRCm38) C689* probably null Het
Amt C T 9: 108,297,215 (GRCm38) Q60* probably null Het
Ankrd12 A G 17: 66,027,250 (GRCm38) probably null Het
Ankrd28 A T 14: 31,706,813 (GRCm38) N920K probably damaging Het
Ankrd36 T C 11: 5,635,359 (GRCm38) L390P probably damaging Het
Arvcf T G 16: 18,389,198 (GRCm38) H7Q probably benign Het
Asns A G 6: 7,677,978 (GRCm38) S367P probably damaging Het
BC005537 C T 13: 24,803,399 (GRCm38) R7W possibly damaging Het
C7 T A 15: 5,007,710 (GRCm38) H562L probably benign Het
Ccdc77 T C 6: 120,350,373 (GRCm38) D37G probably damaging Het
Cdc14a C T 3: 116,404,587 (GRCm38) A58T probably damaging Het
Cdc42bpb C T 12: 111,336,025 (GRCm38) probably null Het
Corin A T 5: 72,301,624 (GRCm38) F1068L probably benign Het
Epb42 T G 2: 121,034,435 (GRCm38) K58N probably benign Het
Ercc3 T A 18: 32,248,243 (GRCm38) S371T probably damaging Het
Fam193a A C 5: 34,431,180 (GRCm38) K358Q probably damaging Het
Fem1a G A 17: 56,257,522 (GRCm38) C205Y probably benign Het
Fh1 G A 1: 175,612,178 (GRCm38) T233M probably damaging Het
Ftsj3 CCTTCTTCTTCTTCTTCT CCTTCTTCTTCTTCT 11: 106,252,551 (GRCm38) probably benign Het
Gabra6 T C 11: 42,316,462 (GRCm38) N265S probably damaging Het
Gm10801 C CGTG 2: 98,663,807 (GRCm38) probably null Het
Gm996 A T 2: 25,577,808 (GRCm38) L697Q probably damaging Het
Grm6 T A 11: 50,863,082 (GRCm38) C738S probably damaging Het
Gtsf1 C T 15: 103,428,569 (GRCm38) probably benign Het
Hcrtr2 T A 9: 76,232,914 (GRCm38) Y364F probably damaging Het
Ick G T 9: 78,135,645 (GRCm38) V51F probably damaging Het
Ifit1bl1 T C 19: 34,593,936 (GRCm38) I374V probably benign Het
Il31ra A T 13: 112,541,251 (GRCm38) F250L probably benign Het
Iqgap1 A G 7: 80,809,059 (GRCm38) V37A probably benign Het
Izumo3 A T 4: 92,145,023 (GRCm38) I182K probably damaging Het
Kidins220 G A 12: 24,988,556 (GRCm38) A36T probably damaging Het
Lrrtm1 G T 6: 77,244,253 (GRCm38) R231L probably damaging Het
Micalcl A T 7: 112,412,976 (GRCm38) S678C probably damaging Het
Mme T G 3: 63,364,867 (GRCm38) F629C probably damaging Het
Muc5b T A 7: 141,857,341 (GRCm38) H1341Q unknown Het
Olfr1339 T A 4: 118,734,902 (GRCm38) D124E probably damaging Het
Olfr1391 A G 11: 49,328,202 (GRCm38) S264G probably benign Het
Olfr495 A G 7: 108,396,089 (GRCm38) H323R probably benign Het
Olfr513 A T 7: 108,755,569 (GRCm38) T238S probably damaging Het
Olfr61 A G 7: 140,637,724 (GRCm38) T8A possibly damaging Het
Parm1 A T 5: 91,593,865 (GRCm38) M31L probably benign Het
Pcdhb18 G A 18: 37,489,821 (GRCm38) C68Y probably benign Het
Pkn3 A T 2: 30,079,622 (GRCm38) E35V probably damaging Het
Pla2g4a A T 1: 149,872,744 (GRCm38) Y238N probably damaging Het
Pld6 T C 11: 59,787,271 (GRCm38) D122G probably damaging Het
Prag1 G T 8: 36,103,255 (GRCm38) A331S possibly damaging Het
Rbm44 A G 1: 91,168,829 (GRCm38) D970G probably benign Het
Rps6kc1 A G 1: 190,773,654 (GRCm38) V1037A probably benign Het
Slc12a7 T C 13: 73,805,469 (GRCm38) V766A probably benign Het
Spata18 A G 5: 73,668,610 (GRCm38) T87A Het
St3gal3 T C 4: 117,940,123 (GRCm38) M308V probably benign Het
Stx19 T C 16: 62,822,286 (GRCm38) L155S probably benign Het
Tespa1 A T 10: 130,356,883 (GRCm38) T145S probably damaging Het
Timm21 A C 18: 84,947,721 (GRCm38) F221V possibly damaging Het
Tlr1 A T 5: 64,924,921 (GRCm38) F771Y probably damaging Het
Tmem150a C A 6: 72,358,623 (GRCm38) L125I unknown Het
Txlna C T 4: 129,632,157 (GRCm38) R299H probably damaging Het
Txndc16 A T 14: 45,144,960 (GRCm38) N609K probably benign Het
Upf1 T C 8: 70,352,858 (GRCm38) T46A probably benign Het
Zfp266 T C 9: 20,500,330 (GRCm38) N184D probably benign Het
Zfp407 A G 18: 84,209,922 (GRCm38) V1854A possibly damaging Het
Zfp626 T A 7: 27,818,370 (GRCm38) C259S possibly damaging Het
Other mutations in Try4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Try4 APN 6 41,305,026 (GRCm38) missense probably damaging 1.00
IGL02216:Try4 APN 6 41,305,031 (GRCm38) missense probably benign
R0537:Try4 UTSW 6 41,304,362 (GRCm38) missense probably benign
R0731:Try4 UTSW 6 41,304,367 (GRCm38) missense probably benign 0.01
R1113:Try4 UTSW 6 41,305,374 (GRCm38) missense possibly damaging 0.90
R1833:Try4 UTSW 6 41,303,431 (GRCm38) missense probably damaging 0.98
R2246:Try4 UTSW 6 41,305,472 (GRCm38) missense possibly damaging 0.80
R4131:Try4 UTSW 6 41,305,401 (GRCm38) nonsense probably null
R4414:Try4 UTSW 6 41,304,971 (GRCm38) missense possibly damaging 0.84
R5457:Try4 UTSW 6 41,303,421 (GRCm38) missense probably damaging 1.00
R5707:Try4 UTSW 6 41,305,043 (GRCm38) missense possibly damaging 0.65
R6023:Try4 UTSW 6 41,303,421 (GRCm38) missense probably damaging 1.00
R7131:Try4 UTSW 6 41,304,403 (GRCm38) missense probably benign 0.03
R8051:Try4 UTSW 6 41,305,062 (GRCm38) missense probably damaging 0.99
R9320:Try4 UTSW 6 41,305,074 (GRCm38) critical splice donor site probably null
R9730:Try4 UTSW 6 41,305,062 (GRCm38) missense probably damaging 1.00
RF007:Try4 UTSW 6 41,305,363 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGCACCCGGAGTAAATTTCC -3'
(R):5'- TAGGCTTGCAGAGAAGCTTG -3'

Sequencing Primer
(F):5'- GCACCCGGAGTAAATTTCCTTATCAC -3'
(R):5'- CTTGCAGAGAAGCTTGAAAGATTG -3'
Posted On 2019-11-26