Incidental Mutation 'R7788:Zswim3'
ID 599642
Institutional Source Beutler Lab
Gene Symbol Zswim3
Ensembl Gene ENSMUSG00000045822
Gene Name zinc finger SWIM-type containing 3
Synonyms 4921517A06Rik
MMRRC Submission 045844-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R7788 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 164647034-164664047 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 164661699 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 60 (C60R)
Ref Sequence ENSEMBL: ENSMUSP00000050970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017908] [ENSMUST00000052107] [ENSMUST00000132282]
AlphaFold Q8CFL8
Predicted Effect probably benign
Transcript: ENSMUST00000017908
SMART Domains Protein: ENSMUSP00000017908
Gene: ENSMUSG00000017764

DomainStartEndE-ValueType
Pfam:SWIM 342 375 2e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000052107
AA Change: C60R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050970
Gene: ENSMUSG00000045822
AA Change: C60R

DomainStartEndE-ValueType
low complexity region 436 453 N/A INTRINSIC
low complexity region 474 489 N/A INTRINSIC
ZnF_PMZ 546 573 2.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132282
Meta Mutation Damage Score 0.8164 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 99% (68/69)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam7 A T 14: 68,750,094 (GRCm39) V442E possibly damaging Het
Adgrv1 A T 13: 81,721,433 (GRCm39) V715D probably damaging Het
Aldh1l1 A C 6: 90,546,894 (GRCm39) D399A probably benign Het
Ankrd23 T C 1: 36,570,808 (GRCm39) N274S probably damaging Het
Aopep A T 13: 63,304,407 (GRCm39) H473L possibly damaging Het
Arid5b C T 10: 67,934,417 (GRCm39) G495E probably benign Het
Arpc4 A T 6: 113,362,565 (GRCm39) M149L probably benign Het
Bdp1 T C 13: 100,191,759 (GRCm39) T1407A possibly damaging Het
Calml3 A T 13: 3,854,121 (GRCm39) I28N probably damaging Het
Cdhr3 A G 12: 33,110,319 (GRCm39) S322P probably damaging Het
Cilk1 G C 9: 78,074,902 (GRCm39) V586L probably benign Het
Cntn5 A G 9: 9,704,934 (GRCm39) S622P probably benign Het
Col22a1 A G 15: 71,824,166 (GRCm39) probably null Het
Csf2rb2 A T 15: 78,177,041 (GRCm39) I143N probably benign Het
Cwh43 T C 5: 73,572,377 (GRCm39) L205P probably damaging Het
Dennd5b T C 6: 148,970,064 (GRCm39) T52A probably benign Het
Dhx40 A G 11: 86,666,502 (GRCm39) I597T possibly damaging Het
Dnajc21 A G 15: 10,460,133 (GRCm39) L268P probably damaging Het
Dzip1 A T 14: 119,120,805 (GRCm39) D717E probably benign Het
Elmo3 A G 8: 106,034,876 (GRCm39) N389D probably damaging Het
Evi2a T C 11: 79,418,768 (GRCm39) E14G unknown Het
Fam149a T A 8: 45,834,554 (GRCm39) R82W probably damaging Het
Farp1 A T 14: 121,513,665 (GRCm39) E820V probably benign Het
Fgd5 T A 6: 91,965,440 (GRCm39) S400T possibly damaging Het
Flnc G A 6: 29,456,443 (GRCm39) V2214I possibly damaging Het
Galnt4 C A 10: 98,944,975 (GRCm39) N233K possibly damaging Het
Gbp5 A G 3: 142,208,841 (GRCm39) Y128C probably damaging Het
Gm4871 G A 5: 144,969,420 (GRCm39) T33I probably benign Het
Gm5592 T C 7: 40,936,118 (GRCm39) S207P probably benign Het
Gtf2ird1 A T 5: 134,445,985 (GRCm39) C15* probably null Het
Ido2 T A 8: 25,037,242 (GRCm39) I155F probably damaging Het
Ifi27l2b A T 12: 103,423,268 (GRCm39) probably null Het
Il15ra C T 2: 11,728,404 (GRCm39) T49I probably damaging Het
Itpr3 T A 17: 27,337,571 (GRCm39) C2460* probably null Het
Kcnj11 T C 7: 45,749,179 (GRCm39) N48S probably damaging Het
Lmo7 A C 14: 102,136,012 (GRCm39) N695T possibly damaging Het
Mmp15 C A 8: 96,094,776 (GRCm39) H217N probably damaging Het
Mtcl2 C T 2: 156,869,504 (GRCm39) A1044T probably benign Het
Muc21 A T 17: 35,929,798 (GRCm39) S1463T unknown Het
Mug1 C A 6: 121,838,179 (GRCm39) H470N possibly damaging Het
Myo5c A T 9: 75,186,627 (GRCm39) D991V probably damaging Het
Nfkbid T A 7: 30,126,603 (GRCm39) N396K probably damaging Het
Oas1c A G 5: 120,939,107 (GRCm39) F361L probably benign Het
Or10aa1 A G 1: 173,869,650 (GRCm39) I45V probably benign Het
Or1e1b-ps1 A T 11: 73,845,948 (GRCm39) Y144F probably benign Het
Osbpl9 T C 4: 108,919,691 (GRCm39) K606E probably benign Het
Pkp2 C A 16: 16,043,272 (GRCm39) L111I probably benign Het
Pogz A G 3: 94,782,544 (GRCm39) Y635C probably damaging Het
Prdx2 A G 8: 85,698,303 (GRCm39) T165A probably benign Het
Ptcd3 T C 6: 71,862,541 (GRCm39) I465V probably benign Het
Ptprd G A 4: 75,916,841 (GRCm39) T770I probably damaging Het
Rapgef6 A G 11: 54,585,225 (GRCm39) Y1541C probably damaging Het
Rilpl1 A T 5: 124,634,200 (GRCm39) probably null Het
Rimbp3 T A 16: 17,030,568 (GRCm39) Y1331N probably benign Het
Sav1 T C 12: 70,030,995 (GRCm39) R176G probably damaging Het
Sirt5 A G 13: 43,536,623 (GRCm39) H219R probably benign Het
Skint5 T G 4: 113,403,715 (GRCm39) D1169A unknown Het
Slfn9 G T 11: 82,873,467 (GRCm39) Q479K possibly damaging Het
Spata31f1e A T 4: 42,793,546 (GRCm39) H195Q possibly damaging Het
Susd4 T C 1: 182,722,767 (GRCm39) I483T possibly damaging Het
Tmem156 C T 5: 65,232,912 (GRCm39) V217I possibly damaging Het
Tmem79 A G 3: 88,239,949 (GRCm39) Y254H probably benign Het
Tmprss2 T A 16: 97,377,429 (GRCm39) K223* probably null Het
Trav3-1 T C 14: 52,818,581 (GRCm39) V85A probably damaging Het
Ttn T C 2: 76,716,100 (GRCm39) probably null Het
Vmn2r22 T C 6: 123,614,559 (GRCm39) I344V not run Het
Vps13c A T 9: 67,847,765 (GRCm39) M2176L probably benign Het
Wdfy3 A T 5: 101,996,223 (GRCm39) V3213D probably damaging Het
Zbtb21 G A 16: 97,752,654 (GRCm39) T543M possibly damaging Het
Zc3hav1 A T 6: 38,309,691 (GRCm39) V377D probably benign Het
Other mutations in Zswim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Zswim3 APN 2 164,663,011 (GRCm39) missense probably damaging 1.00
IGL01345:Zswim3 APN 2 164,662,057 (GRCm39) missense probably damaging 1.00
IGL01608:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01621:Zswim3 APN 2 164,663,440 (GRCm39) missense probably damaging 1.00
IGL01634:Zswim3 APN 2 164,661,922 (GRCm39) missense probably damaging 0.99
IGL02165:Zswim3 APN 2 164,663,035 (GRCm39) missense possibly damaging 0.94
IGL02173:Zswim3 APN 2 164,662,759 (GRCm39) missense probably damaging 1.00
IGL02336:Zswim3 APN 2 164,662,297 (GRCm39) missense probably damaging 0.98
IGL02379:Zswim3 APN 2 164,662,602 (GRCm39) splice site probably null
R0321:Zswim3 UTSW 2 164,662,279 (GRCm39) missense possibly damaging 0.83
R1489:Zswim3 UTSW 2 164,661,901 (GRCm39) missense probably benign 0.00
R2126:Zswim3 UTSW 2 164,661,913 (GRCm39) missense probably benign 0.31
R2176:Zswim3 UTSW 2 164,662,614 (GRCm39) missense probably benign 0.08
R2859:Zswim3 UTSW 2 164,662,309 (GRCm39) missense probably damaging 1.00
R3853:Zswim3 UTSW 2 164,662,777 (GRCm39) missense possibly damaging 0.61
R4434:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4435:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4436:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4438:Zswim3 UTSW 2 164,662,563 (GRCm39) missense probably benign 0.00
R4805:Zswim3 UTSW 2 164,662,099 (GRCm39) missense possibly damaging 0.52
R5874:Zswim3 UTSW 2 164,662,032 (GRCm39) missense probably benign 0.06
R6417:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6420:Zswim3 UTSW 2 164,662,653 (GRCm39) missense probably damaging 0.97
R6722:Zswim3 UTSW 2 164,662,544 (GRCm39) splice site probably null
R6786:Zswim3 UTSW 2 164,662,771 (GRCm39) missense probably damaging 1.00
R7266:Zswim3 UTSW 2 164,662,402 (GRCm39) missense probably benign 0.41
R7467:Zswim3 UTSW 2 164,661,795 (GRCm39) missense possibly damaging 0.59
R7487:Zswim3 UTSW 2 164,662,135 (GRCm39) missense probably damaging 0.99
R8191:Zswim3 UTSW 2 164,662,128 (GRCm39) missense probably damaging 1.00
R8308:Zswim3 UTSW 2 164,663,566 (GRCm39) missense probably damaging 1.00
R8794:Zswim3 UTSW 2 164,662,687 (GRCm39) missense probably damaging 0.98
R9353:Zswim3 UTSW 2 164,662,261 (GRCm39) missense probably damaging 1.00
R9527:Zswim3 UTSW 2 164,662,285 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCGAAAGTGCTGTGACTAC -3'
(R):5'- TTTCCTGATGCTGAGCTGC -3'

Sequencing Primer
(F):5'- CAGAGTCACTGCACATTCTTCTC -3'
(R):5'- TTGTGTAGACATATTGCCTGAGGC -3'
Posted On 2019-11-26