Mutagenetix > Incidental Mutation

Incidental Mutation 'R7788:Ptprd'

599647

Institutional Source

Beutler Lab

Gene Symbol

Ptprd

Ensembl Gene

ENSMUSG00000028399

Gene Name

protein tyrosine phosphatase receptor type D

Synonyms

1110002J03Rik, B230219D21Rik, 3000002J10Rik

MMRRC Submission

045844-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7788 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

75859475-78130198 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 75916841 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 770 (T770I)

Ref Sequence

ENSEMBL: ENSMUSP00000099898 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050757] [ENSMUST00000098005] [ENSMUST00000102834] [ENSMUST00000107289] [ENSMUST00000173376] [ENSMUST00000174023] [ENSMUST00000174180] [ENSMUST00000174531] [ENSMUST00000174831]

AlphaFold

Q64487

Predicted Effect

probably damaging
Transcript: ENSMUST00000050757
AA Change: T1021I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058466
Gene: ENSMUSG00000028399
AA Change: T1021I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	208	1.38e-15	SMART
IGc2	238	299	8.13e-4	SMART
FN3	313	392	7.92e-14	SMART
FN3	408	491	5.73e-11	SMART
IG_like	499	593	8.34e1	SMART
FN3	506	584	9.1e-14	SMART
FN3	597	674	1.21e0	SMART
transmembrane domain	847	869	N/A	INTRINSIC
low complexity region	870	882	N/A	INTRINSIC
PTPc	949	1207	6.38e-134	SMART
PTPc	1236	1498	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000098005
AA Change: T1022I

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000095614
Gene: ENSMUSG00000028399
AA Change: T1022I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	607	684	1.21e0	SMART
transmembrane domain	857	879	N/A	INTRINSIC
low complexity region	886	897	N/A	INTRINSIC
PTPc	950	1208	6.38e-134	SMART
PTPc	1237	1499	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000102834
AA Change: T770I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000099898
Gene: ENSMUSG00000028399
AA Change: T770I

Domain	Start	End	E-Value	Type
IGc2	1	62	8.13e-4	SMART
FN3	76	155	7.92e-14	SMART
FN3	171	254	5.73e-11	SMART
IG_like	262	356	8.34e1	SMART
FN3	269	347	9.1e-14	SMART
FN3	360	437	1.21e0	SMART
transmembrane domain	610	632	N/A	INTRINSIC
low complexity region	633	645	N/A	INTRINSIC
PTPc	698	956	6.38e-134	SMART
PTPc	985	1247	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000107289
AA Change: T1428I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000102910
Gene: ENSMUSG00000028399
AA Change: T1428I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	609	696	2.72e-12	SMART
FN3	712	809	2.87e-11	SMART
FN3	824	904	4.96e-6	SMART
FN3	919	1003	4.12e-12	SMART
FN3	1018	1095	1.95e0	SMART
transmembrane domain	1268	1290	N/A	INTRINSIC
low complexity region	1291	1303	N/A	INTRINSIC
PTPc	1356	1614	6.38e-134	SMART
PTPc	1643	1905	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000173376
AA Change: T1024I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133468
Gene: ENSMUSG00000028399
AA Change: T1024I

Domain	Start	End	E-Value	Type
IGc2	43	112	8.57e-12	SMART
IGc2	145	221	8.5e-16	SMART
low complexity region	232	244	N/A	INTRINSIC
IGc2	255	316	8.13e-4	SMART
FN3	330	409	7.92e-14	SMART
FN3	425	508	5.73e-11	SMART
IG_like	516	610	8.34e1	SMART
FN3	523	601	9.1e-14	SMART
FN3	614	691	1.21e0	SMART
transmembrane domain	864	886	N/A	INTRINSIC
low complexity region	887	899	N/A	INTRINSIC
PTPc	952	1210	6.38e-134	SMART
PTPc	1239	1501	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174023
AA Change: T1018I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133562
Gene: ENSMUSG00000028399
AA Change: T1018I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	211	4.88e-16	SMART
low complexity region	222	234	N/A	INTRINSIC
IGc2	245	306	8.13e-4	SMART
FN3	320	399	7.92e-14	SMART
FN3	415	498	5.73e-11	SMART
IG_like	506	600	8.34e1	SMART
FN3	513	591	9.1e-14	SMART
FN3	604	681	1.21e0	SMART
transmembrane domain	853	875	N/A	INTRINSIC
low complexity region	882	893	N/A	INTRINSIC
PTPc	946	1204	6.38e-134	SMART
PTPc	1233	1495	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174180
AA Change: T1406I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133973
Gene: ENSMUSG00000028399
AA Change: T1406I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	205	2.09e-15	SMART
IGc2	235	296	8.13e-4	SMART
FN3	310	389	7.92e-14	SMART
FN3	405	488	5.73e-11	SMART
IG_like	496	590	8.34e1	SMART
FN3	503	581	9.1e-14	SMART
FN3	596	683	2.72e-12	SMART
FN3	699	787	6.15e-11	SMART
FN3	802	882	4.96e-6	SMART
FN3	897	981	4.12e-12	SMART
FN3	996	1073	1.95e0	SMART
transmembrane domain	1246	1268	N/A	INTRINSIC
low complexity region	1269	1281	N/A	INTRINSIC
PTPc	1334	1592	6.38e-134	SMART
PTPc	1621	1883	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174531
AA Change: T1011I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000134229
Gene: ENSMUSG00000028399
AA Change: T1011I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	208	1.38e-15	SMART
low complexity region	219	231	N/A	INTRINSIC
IGc2	242	303	8.13e-4	SMART
FN3	317	396	7.92e-14	SMART
FN3	412	495	5.73e-11	SMART
IG_like	503	597	8.34e1	SMART
FN3	510	588	9.1e-14	SMART
FN3	601	678	1.21e0	SMART
transmembrane domain	851	873	N/A	INTRINSIC
low complexity region	874	886	N/A	INTRINSIC
PTPc	939	1197	6.38e-134	SMART
PTPc	1226	1488	9.17e-135	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000174831
AA Change: T1021I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133328
Gene: ENSMUSG00000028399
AA Change: T1021I

Domain	Start	End	E-Value	Type
IGc2	36	105	8.57e-12	SMART
IGc2	138	214	8.5e-16	SMART
low complexity region	225	237	N/A	INTRINSIC
IGc2	248	309	8.13e-4	SMART
FN3	323	402	7.92e-14	SMART
FN3	418	501	5.73e-11	SMART
IG_like	509	603	8.34e1	SMART
FN3	516	594	9.1e-14	SMART
FN3	607	684	1.21e0	SMART
transmembrane domain	856	878	N/A	INTRINSIC
low complexity region	885	896	N/A	INTRINSIC
PTPc	949	1207	6.38e-134	SMART
PTPc	1236	1498	9.17e-135	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

99% (68/69)

MGI Phenotype

PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired learning of spatial tasks, enhanced long-term potentiation at hippocampal synapses, and high mortality associated with reduced food intake. [provided by MGI curators]

Allele List at MGI

All alleles(9) : Targeted(4) Gene trapped(5)

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam7	A	T	14: 68,750,094 (GRCm39)	V442E	possibly damaging	Het
Adgrv1	A	T	13: 81,721,433 (GRCm39)	V715D	probably damaging	Het
Aldh1l1	A	C	6: 90,546,894 (GRCm39)	D399A	probably benign	Het
Ankrd23	T	C	1: 36,570,808 (GRCm39)	N274S	probably damaging	Het
Aopep	A	T	13: 63,304,407 (GRCm39)	H473L	possibly damaging	Het
Arid5b	C	T	10: 67,934,417 (GRCm39)	G495E	probably benign	Het
Arpc4	A	T	6: 113,362,565 (GRCm39)	M149L	probably benign	Het
Bdp1	T	C	13: 100,191,759 (GRCm39)	T1407A	possibly damaging	Het
Calml3	A	T	13: 3,854,121 (GRCm39)	I28N	probably damaging	Het
Cdhr3	A	G	12: 33,110,319 (GRCm39)	S322P	probably damaging	Het
Cilk1	G	C	9: 78,074,902 (GRCm39)	V586L	probably benign	Het
Cntn5	A	G	9: 9,704,934 (GRCm39)	S622P	probably benign	Het
Col22a1	A	G	15: 71,824,166 (GRCm39)		probably null	Het
Csf2rb2	A	T	15: 78,177,041 (GRCm39)	I143N	probably benign	Het
Cwh43	T	C	5: 73,572,377 (GRCm39)	L205P	probably damaging	Het
Dennd5b	T	C	6: 148,970,064 (GRCm39)	T52A	probably benign	Het
Dhx40	A	G	11: 86,666,502 (GRCm39)	I597T	possibly damaging	Het
Dnajc21	A	G	15: 10,460,133 (GRCm39)	L268P	probably damaging	Het
Dzip1	A	T	14: 119,120,805 (GRCm39)	D717E	probably benign	Het
Elmo3	A	G	8: 106,034,876 (GRCm39)	N389D	probably damaging	Het
Evi2a	T	C	11: 79,418,768 (GRCm39)	E14G	unknown	Het
Fam149a	T	A	8: 45,834,554 (GRCm39)	R82W	probably damaging	Het
Farp1	A	T	14: 121,513,665 (GRCm39)	E820V	probably benign	Het
Fgd5	T	A	6: 91,965,440 (GRCm39)	S400T	possibly damaging	Het
Flnc	G	A	6: 29,456,443 (GRCm39)	V2214I	possibly damaging	Het
Galnt4	C	A	10: 98,944,975 (GRCm39)	N233K	possibly damaging	Het
Gbp5	A	G	3: 142,208,841 (GRCm39)	Y128C	probably damaging	Het
Gm4871	G	A	5: 144,969,420 (GRCm39)	T33I	probably benign	Het
Gm5592	T	C	7: 40,936,118 (GRCm39)	S207P	probably benign	Het
Gtf2ird1	A	T	5: 134,445,985 (GRCm39)	C15*	probably null	Het
Ido2	T	A	8: 25,037,242 (GRCm39)	I155F	probably damaging	Het
Ifi27l2b	A	T	12: 103,423,268 (GRCm39)		probably null	Het
Il15ra	C	T	2: 11,728,404 (GRCm39)	T49I	probably damaging	Het
Itpr3	T	A	17: 27,337,571 (GRCm39)	C2460*	probably null	Het
Kcnj11	T	C	7: 45,749,179 (GRCm39)	N48S	probably damaging	Het
Lmo7	A	C	14: 102,136,012 (GRCm39)	N695T	possibly damaging	Het
Mmp15	C	A	8: 96,094,776 (GRCm39)	H217N	probably damaging	Het
Mtcl2	C	T	2: 156,869,504 (GRCm39)	A1044T	probably benign	Het
Muc21	A	T	17: 35,929,798 (GRCm39)	S1463T	unknown	Het
Mug1	C	A	6: 121,838,179 (GRCm39)	H470N	possibly damaging	Het
Myo5c	A	T	9: 75,186,627 (GRCm39)	D991V	probably damaging	Het
Nfkbid	T	A	7: 30,126,603 (GRCm39)	N396K	probably damaging	Het
Oas1c	A	G	5: 120,939,107 (GRCm39)	F361L	probably benign	Het
Or10aa1	A	G	1: 173,869,650 (GRCm39)	I45V	probably benign	Het
Or1e1b-ps1	A	T	11: 73,845,948 (GRCm39)	Y144F	probably benign	Het
Osbpl9	T	C	4: 108,919,691 (GRCm39)	K606E	probably benign	Het
Pkp2	C	A	16: 16,043,272 (GRCm39)	L111I	probably benign	Het
Pogz	A	G	3: 94,782,544 (GRCm39)	Y635C	probably damaging	Het
Prdx2	A	G	8: 85,698,303 (GRCm39)	T165A	probably benign	Het
Ptcd3	T	C	6: 71,862,541 (GRCm39)	I465V	probably benign	Het
Rapgef6	A	G	11: 54,585,225 (GRCm39)	Y1541C	probably damaging	Het
Rilpl1	A	T	5: 124,634,200 (GRCm39)		probably null	Het
Rimbp3	T	A	16: 17,030,568 (GRCm39)	Y1331N	probably benign	Het
Sav1	T	C	12: 70,030,995 (GRCm39)	R176G	probably damaging	Het
Sirt5	A	G	13: 43,536,623 (GRCm39)	H219R	probably benign	Het
Skint5	T	G	4: 113,403,715 (GRCm39)	D1169A	unknown	Het
Slfn9	G	T	11: 82,873,467 (GRCm39)	Q479K	possibly damaging	Het
Spata31f1e	A	T	4: 42,793,546 (GRCm39)	H195Q	possibly damaging	Het
Susd4	T	C	1: 182,722,767 (GRCm39)	I483T	possibly damaging	Het
Tmem156	C	T	5: 65,232,912 (GRCm39)	V217I	possibly damaging	Het
Tmem79	A	G	3: 88,239,949 (GRCm39)	Y254H	probably benign	Het
Tmprss2	T	A	16: 97,377,429 (GRCm39)	K223*	probably null	Het
Trav3-1	T	C	14: 52,818,581 (GRCm39)	V85A	probably damaging	Het
Ttn	T	C	2: 76,716,100 (GRCm39)		probably null	Het
Vmn2r22	T	C	6: 123,614,559 (GRCm39)	I344V	not run	Het
Vps13c	A	T	9: 67,847,765 (GRCm39)	M2176L	probably benign	Het
Wdfy3	A	T	5: 101,996,223 (GRCm39)	V3213D	probably damaging	Het
Zbtb21	G	A	16: 97,752,654 (GRCm39)	T543M	possibly damaging	Het
Zc3hav1	A	T	6: 38,309,691 (GRCm39)	V377D	probably benign	Het
Zswim3	T	C	2: 164,661,699 (GRCm39)	C60R	probably damaging	Het

Other mutations in Ptprd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00964:Ptprd	APN	4	75,916,793 (GRCm39)	nonsense	probably null
IGL01067:Ptprd	APN	4	75,977,922 (GRCm39)	missense	probably damaging	1.00
IGL01121:Ptprd	APN	4	75,872,438 (GRCm39)	splice site	probably benign
IGL01531:Ptprd	APN	4	76,003,757 (GRCm39)	missense	probably damaging	0.98
IGL01661:Ptprd	APN	4	75,872,320 (GRCm39)	missense	probably damaging	1.00
IGL01723:Ptprd	APN	4	76,161,910 (GRCm39)	missense	probably damaging	1.00
IGL01735:Ptprd	APN	4	76,055,057 (GRCm39)	splice site	probably null
IGL01810:Ptprd	APN	4	76,058,744 (GRCm39)	splice site	probably benign
IGL01834:Ptprd	APN	4	76,046,832 (GRCm39)	missense	probably damaging	1.00
IGL01835:Ptprd	APN	4	76,165,058 (GRCm39)	missense	probably benign	0.02
IGL01867:Ptprd	APN	4	76,161,884 (GRCm39)	missense	probably damaging	1.00
IGL02582:Ptprd	APN	4	75,865,361 (GRCm39)	missense	probably damaging	1.00
IGL02591:Ptprd	APN	4	75,900,287 (GRCm39)	missense	probably damaging	1.00
IGL02741:Ptprd	APN	4	76,051,521 (GRCm39)	missense	probably damaging	1.00
IGL02866:Ptprd	APN	4	75,968,674 (GRCm39)	missense	probably damaging	1.00
IGL02960:Ptprd	APN	4	76,047,105 (GRCm39)	missense	probably damaging	1.00
IGL03155:Ptprd	APN	4	75,984,456 (GRCm39)	missense	possibly damaging	0.95
IGL03230:Ptprd	APN	4	75,968,654 (GRCm39)	nonsense	probably null
IGL03343:Ptprd	APN	4	75,977,966 (GRCm39)	missense	probably damaging	1.00
unhurried	UTSW	4	76,018,870 (GRCm39)	nonsense	probably null
ANU22:Ptprd	UTSW	4	76,018,693 (GRCm39)	missense	probably damaging	0.99
F5493:Ptprd	UTSW	4	76,002,645 (GRCm39)	missense	probably damaging	1.00
P0033:Ptprd	UTSW	4	76,047,091 (GRCm39)	nonsense	probably null
R0044:Ptprd	UTSW	4	76,004,566 (GRCm39)	missense	probably benign	0.08
R0044:Ptprd	UTSW	4	76,004,566 (GRCm39)	missense	probably benign	0.08
R0076:Ptprd	UTSW	4	75,865,276 (GRCm39)	splice site	probably benign
R0137:Ptprd	UTSW	4	76,055,140 (GRCm39)	missense	probably benign	0.24
R0358:Ptprd	UTSW	4	75,863,226 (GRCm39)	missense	probably damaging	1.00
R0365:Ptprd	UTSW	4	76,055,083 (GRCm39)	missense	probably damaging	1.00
R0385:Ptprd	UTSW	4	76,046,902 (GRCm39)	missense	probably damaging	1.00
R0601:Ptprd	UTSW	4	76,018,711 (GRCm39)	missense	probably benign
R0646:Ptprd	UTSW	4	76,002,640 (GRCm39)	missense	probably damaging	0.99
R0667:Ptprd	UTSW	4	75,875,583 (GRCm39)	missense	probably damaging	1.00
R0707:Ptprd	UTSW	4	75,875,476 (GRCm39)	missense	probably damaging	1.00
R0734:Ptprd	UTSW	4	76,058,834 (GRCm39)	missense	probably damaging	1.00
R0827:Ptprd	UTSW	4	76,047,152 (GRCm39)	missense	probably damaging	0.98
R0932:Ptprd	UTSW	4	76,055,122 (GRCm39)	missense	probably damaging	1.00
R1069:Ptprd	UTSW	4	76,018,870 (GRCm39)	nonsense	probably null
R1069:Ptprd	UTSW	4	75,916,724 (GRCm39)	splice site	probably benign
R1086:Ptprd	UTSW	4	76,051,495 (GRCm39)	missense	probably damaging	1.00
R1439:Ptprd	UTSW	4	75,984,437 (GRCm39)	missense	probably damaging	1.00
R1440:Ptprd	UTSW	4	76,002,789 (GRCm39)	missense	probably damaging	0.98
R1688:Ptprd	UTSW	4	75,900,921 (GRCm39)	missense	probably damaging	1.00
R1858:Ptprd	UTSW	4	75,865,384 (GRCm39)	missense	probably damaging	1.00
R2001:Ptprd	UTSW	4	75,872,359 (GRCm39)	missense	probably damaging	1.00
R2020:Ptprd	UTSW	4	76,051,398 (GRCm39)	missense	probably damaging	1.00
R2023:Ptprd	UTSW	4	75,875,341 (GRCm39)	missense	probably damaging	1.00
R2413:Ptprd	UTSW	4	76,051,437 (GRCm39)	missense	probably damaging	1.00
R2510:Ptprd	UTSW	4	76,004,248 (GRCm39)	critical splice donor site	probably null
R2914:Ptprd	UTSW	4	75,865,338 (GRCm39)	missense	probably damaging	1.00
R2971:Ptprd	UTSW	4	76,025,561 (GRCm39)	missense	probably benign	0.10
R3051:Ptprd	UTSW	4	76,018,867 (GRCm39)	missense	probably damaging	1.00
R3433:Ptprd	UTSW	4	76,004,248 (GRCm39)	critical splice donor site	probably null
R3964:Ptprd	UTSW	4	75,978,073 (GRCm39)	splice site	probably benign
R4009:Ptprd	UTSW	4	75,874,634 (GRCm39)	missense	possibly damaging	0.94
R4394:Ptprd	UTSW	4	76,046,922 (GRCm39)	missense	probably damaging	1.00
R4420:Ptprd	UTSW	4	75,957,614 (GRCm39)	missense	possibly damaging	0.92
R4424:Ptprd	UTSW	4	76,021,200 (GRCm39)	missense	probably benign	0.22
R4575:Ptprd	UTSW	4	76,162,023 (GRCm39)	missense	possibly damaging	0.55
R4578:Ptprd	UTSW	4	76,162,023 (GRCm39)	missense	possibly damaging	0.55
R4715:Ptprd	UTSW	4	76,025,570 (GRCm39)	missense	probably benign	0.03
R4782:Ptprd	UTSW	4	76,009,769 (GRCm39)	missense	probably benign	0.01
R4785:Ptprd	UTSW	4	76,058,790 (GRCm39)	missense	probably benign	0.05
R4799:Ptprd	UTSW	4	76,009,769 (GRCm39)	missense	probably benign	0.01
R4944:Ptprd	UTSW	4	76,047,136 (GRCm39)	missense	probably damaging	1.00
R4950:Ptprd	UTSW	4	76,058,752 (GRCm39)	splice site	probably null
R4969:Ptprd	UTSW	4	76,051,542 (GRCm39)	missense	probably damaging	1.00
R5153:Ptprd	UTSW	4	75,930,339 (GRCm39)	missense	probably damaging	1.00
R5164:Ptprd	UTSW	4	76,018,995 (GRCm39)	splice site	probably null
R5287:Ptprd	UTSW	4	75,872,405 (GRCm39)	nonsense	probably null
R5305:Ptprd	UTSW	4	75,900,863 (GRCm39)	missense	probably damaging	1.00
R5362:Ptprd	UTSW	4	76,047,050 (GRCm39)	missense	probably damaging	1.00
R5403:Ptprd	UTSW	4	75,872,405 (GRCm39)	nonsense	probably null
R5531:Ptprd	UTSW	4	75,977,904 (GRCm39)	critical splice donor site	probably null
R5543:Ptprd	UTSW	4	75,977,990 (GRCm39)	missense	probably damaging	1.00
R5634:Ptprd	UTSW	4	75,990,255 (GRCm39)	missense	probably benign	0.01
R5719:Ptprd	UTSW	4	75,972,839 (GRCm39)	critical splice acceptor site	probably null
R5884:Ptprd	UTSW	4	75,900,927 (GRCm39)	missense	probably damaging	1.00
R6247:Ptprd	UTSW	4	75,984,528 (GRCm39)	missense	probably benign	0.06
R6250:Ptprd	UTSW	4	76,047,232 (GRCm39)	missense	probably damaging	1.00
R6335:Ptprd	UTSW	4	75,872,420 (GRCm39)	missense	probably damaging	1.00
R6352:Ptprd	UTSW	4	76,009,789 (GRCm39)	splice site	probably null
R6533:Ptprd	UTSW	4	76,046,765 (GRCm39)	missense	probably damaging	1.00
R6756:Ptprd	UTSW	4	75,873,536 (GRCm39)	missense	probably damaging	1.00
R6782:Ptprd	UTSW	4	76,243,377 (GRCm39)	splice site	probably null
R7131:Ptprd	UTSW	4	75,984,577 (GRCm39)	missense	probably damaging	1.00
R7170:Ptprd	UTSW	4	75,990,199 (GRCm39)	missense	probably benign	0.06
R7233:Ptprd	UTSW	4	75,978,020 (GRCm39)	missense	probably benign	0.00
R7246:Ptprd	UTSW	4	76,046,913 (GRCm39)	missense	probably damaging	1.00
R7413:Ptprd	UTSW	4	76,165,076 (GRCm39)	missense	probably benign	0.00
R7428:Ptprd	UTSW	4	76,004,705 (GRCm39)	missense	probably benign	0.03
R7442:Ptprd	UTSW	4	75,978,058 (GRCm39)	nonsense	probably null
R7491:Ptprd	UTSW	4	76,051,392 (GRCm39)	missense	probably benign	0.23
R7526:Ptprd	UTSW	4	75,984,564 (GRCm39)	missense	probably benign	0.00
R7609:Ptprd	UTSW	4	75,990,240 (GRCm39)	missense	probably benign	0.03
R7612:Ptprd	UTSW	4	76,004,696 (GRCm39)	missense	probably benign	0.45
R7659:Ptprd	UTSW	4	76,047,153 (GRCm39)	missense	probably benign	0.03
R7743:Ptprd	UTSW	4	76,004,326 (GRCm39)	missense	probably damaging	1.00
R7748:Ptprd	UTSW	4	76,017,741 (GRCm39)	missense	probably null	0.39
R7836:Ptprd	UTSW	4	75,900,881 (GRCm39)	missense	probably damaging	0.99
R7937:Ptprd	UTSW	4	76,013,772 (GRCm39)	missense	probably benign	0.00
R8000:Ptprd	UTSW	4	75,984,479 (GRCm39)	missense	possibly damaging	0.95
R8018:Ptprd	UTSW	4	76,003,757 (GRCm39)	missense	probably damaging	0.98
R8072:Ptprd	UTSW	4	76,004,273 (GRCm39)	missense	probably benign	0.01
R8119:Ptprd	UTSW	4	76,047,263 (GRCm39)	missense	probably benign	0.00
R8350:Ptprd	UTSW	4	75,868,898 (GRCm39)	missense	probably damaging	1.00
R8387:Ptprd	UTSW	4	75,873,526 (GRCm39)	missense	probably damaging	1.00
R8458:Ptprd	UTSW	4	75,984,496 (GRCm39)	missense	probably benign	0.00
R8529:Ptprd	UTSW	4	76,047,262 (GRCm39)	missense	probably damaging	1.00
R8699:Ptprd	UTSW	4	75,959,629 (GRCm39)	missense	probably benign
R8924:Ptprd	UTSW	4	75,916,736 (GRCm39)	critical splice donor site	probably null
R8984:Ptprd	UTSW	4	75,863,251 (GRCm39)	missense	probably damaging	1.00
R9024:Ptprd	UTSW	4	75,874,567 (GRCm39)	missense	probably damaging	1.00
R9204:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9206:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9259:Ptprd	UTSW	4	75,990,200 (GRCm39)	missense	probably damaging	0.99
R9311:Ptprd	UTSW	4	76,051,320 (GRCm39)	missense	probably benign	0.25
R9417:Ptprd	UTSW	4	75,865,335 (GRCm39)	missense	probably damaging	0.99
R9427:Ptprd	UTSW	4	76,051,440 (GRCm39)	missense	probably benign	0.01
R9579:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9580:Ptprd	UTSW	4	75,872,315 (GRCm39)	missense	possibly damaging	0.46
R9701:Ptprd	UTSW	4	75,916,896 (GRCm39)	missense	probably damaging	1.00
RF016:Ptprd	UTSW	4	76,046,892 (GRCm39)	missense	probably benign	0.01
RF023:Ptprd	UTSW	4	76,046,802 (GRCm39)	missense	probably damaging	0.98
Z1176:Ptprd	UTSW	4	76,051,451 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GACATCCATTTCCAAGGACTGAC -3'
(R):5'- GGCTATGGAATAAAGTAGAACCTTG -3'

Sequencing Primer
(F):5'- CTGTTAAAAAGTGCTACCCTGGG -3'
(R):5'- CTTGCTGTTAAACCAGATCCAGACTG -3'

Posted On

2019-11-26