Incidental Mutation 'R7789:Vmn2r17'
ID 599724
Institutional Source Beutler Lab
Gene Symbol Vmn2r17
Ensembl Gene ENSMUSG00000091879
Gene Name vomeronasal 2, receptor 17
Synonyms EG384221
MMRRC Submission 045845-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R7789 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 109567879-109601253 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109600831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 710 (C710S)
Ref Sequence ENSEMBL: ENSMUSP00000131450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171841]
AlphaFold E9PYF5
Predicted Effect possibly damaging
Transcript: ENSMUST00000171841
AA Change: C710S

PolyPhen 2 Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: C710S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 465 7e-26 PFAM
Pfam:NCD3G 508 562 3.5e-18 PFAM
Pfam:7tm_3 593 830 4.8e-55 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 99% (77/78)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik G A 16: 4,682,175 (GRCm39) E163K probably benign Het
Adam34 T A 8: 44,105,488 (GRCm39) R52S probably benign Het
Adcy8 A T 15: 64,743,623 (GRCm39) C328* probably null Het
Ankrd26 G T 6: 118,504,760 (GRCm39) S716R possibly damaging Het
Ankrd26 G T 6: 118,504,759 (GRCm39) H717N probably damaging Het
Ankrd40 C A 11: 94,225,535 (GRCm39) P189T probably damaging Het
Anln A G 9: 22,263,333 (GRCm39) S113P Het
Arid5b C T 10: 67,934,417 (GRCm39) G495E probably benign Het
Asxl1 C T 2: 153,241,943 (GRCm39) T832I probably benign Het
Bicd2 C T 13: 49,533,135 (GRCm39) R574C probably damaging Het
Boll T C 1: 55,399,826 (GRCm39) probably null Het
Casr A G 16: 36,315,653 (GRCm39) F806L probably damaging Het
Casz1 C A 4: 149,013,863 (GRCm39) N142K probably benign Het
Cbl C T 9: 44,074,764 (GRCm39) D433N probably damaging Het
Ceacam14 T A 7: 17,548,096 (GRCm39) V62D probably damaging Het
Chst10 T C 1: 38,923,532 (GRCm39) N18S probably benign Het
Cyp2j6 C T 4: 96,433,953 (GRCm39) R119H probably benign Het
Cyp4a14 C G 4: 115,352,107 (GRCm39) V102L probably benign Het
Dnajb3 A T 1: 88,133,399 (GRCm39) M1K probably null Het
Dnajc6 A T 4: 101,475,729 (GRCm39) K534M possibly damaging Het
Dnase2a T C 8: 85,635,505 (GRCm39) probably null Het
Dock10 A G 1: 80,536,930 (GRCm39) I985T possibly damaging Het
Emsy G T 7: 98,270,696 (GRCm39) P436Q probably damaging Het
Enpp1 A T 10: 24,529,981 (GRCm39) probably null Het
Erc1 T A 6: 119,750,670 (GRCm39) R353* probably null Het
Fbn2 T A 18: 58,172,385 (GRCm39) D2140V probably benign Het
Fgfr1 T A 8: 26,052,329 (GRCm39) Y218* probably null Het
Fhod1 C T 8: 106,056,740 (GRCm39) R1045H probably damaging Het
Focad G T 4: 88,147,643 (GRCm39) L427F unknown Het
Gbf1 T A 19: 46,242,441 (GRCm39) L144M probably damaging Het
Glmn T G 5: 107,696,941 (GRCm39) N592T probably benign Het
Golgb1 C G 16: 36,695,761 (GRCm39) P87A unknown Het
H2bw2 G A X: 135,828,471 (GRCm39) R120K unknown Het
Insyn2b T A 11: 34,352,537 (GRCm39) M193K probably benign Het
Itga9 T G 9: 118,487,564 (GRCm39) F216V possibly damaging Het
Klhl18 T C 9: 110,268,076 (GRCm39) D149G unknown Het
Lcat C T 8: 106,668,857 (GRCm39) V114M probably benign Het
Lrrc8c C A 5: 105,755,066 (GRCm39) N280K probably damaging Het
Mettl8 T C 2: 70,796,806 (GRCm39) Y283C probably damaging Het
Mgat4a A T 1: 37,529,360 (GRCm39) I173K probably damaging Het
Mmp1a T C 9: 7,475,266 (GRCm39) V345A possibly damaging Het
Mok T A 12: 110,778,261 (GRCm39) H215L probably damaging Het
Mphosph9 C G 5: 124,453,650 (GRCm39) E221Q probably damaging Het
Muc4 C G 16: 32,575,221 (GRCm39) Q1269E probably benign Het
Mug1 C A 6: 121,838,179 (GRCm39) H470N possibly damaging Het
Myom1 A G 17: 71,424,431 (GRCm39) T1525A probably benign Het
Nap1l1 C T 10: 111,326,317 (GRCm39) S143L probably benign Het
Or1af1 C T 2: 37,109,672 (GRCm39) T57I probably benign Het
Or2j6 A T 7: 139,980,610 (GRCm39) Y116* probably null Het
Or52d1 T A 7: 103,756,195 (GRCm39) S236R probably damaging Het
Or7g29 G T 9: 19,286,361 (GRCm39) T272K probably benign Het
Plbd2 T C 5: 120,623,819 (GRCm39) S568G probably damaging Het
Plxna4 T A 6: 32,183,168 (GRCm39) probably null Het
Plxnc1 T A 10: 94,630,339 (GRCm39) E1520V probably damaging Het
Ppil3 G A 1: 58,473,538 (GRCm39) T104I possibly damaging Het
Ptprm A T 17: 67,402,534 (GRCm39) V118E probably damaging Het
Rimbp2 T C 5: 128,851,399 (GRCm39) D849G probably damaging Het
Rnf213 T C 11: 119,361,045 (GRCm39) probably null Het
Sema3f T A 9: 107,582,631 (GRCm39) K37N probably benign Het
Sh3glb1 G T 3: 144,397,892 (GRCm39) probably null Het
Sh3rf3 A G 10: 58,922,637 (GRCm39) D571G probably benign Het
Sipa1l3 T C 7: 29,077,150 (GRCm39) Y874C probably damaging Het
Smchd1 G A 17: 71,782,296 (GRCm39) probably benign Het
Snrnp70 A T 7: 45,026,045 (GRCm39) Y441* probably null Het
Ssrp1 C T 2: 84,871,525 (GRCm39) R316W probably damaging Het
Syt10 A T 15: 89,711,101 (GRCm39) V144E probably damaging Het
Tdrd12 A G 7: 35,188,117 (GRCm39) L562P Het
Trim68 T C 7: 102,333,676 (GRCm39) D2G possibly damaging Het
Trub2 T A 2: 29,667,920 (GRCm39) H240L probably damaging Het
Tssc4 A G 7: 142,623,515 (GRCm39) probably null Het
Usp7 T A 16: 8,516,675 (GRCm39) Q539L probably benign Het
Vmn2r99 G T 17: 19,614,079 (GRCm39) V600F possibly damaging Het
Vps13d C T 4: 144,826,635 (GRCm39) V2879M Het
Vrtn T A 12: 84,697,080 (GRCm39) M610K probably benign Het
Xpo4 T C 14: 57,850,806 (GRCm39) E366G probably benign Het
Zyg11a G A 4: 108,040,845 (GRCm39) P703S probably damaging Het
Other mutations in Vmn2r17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Vmn2r17 APN 5 109,575,858 (GRCm39) missense probably benign 0.15
IGL01457:Vmn2r17 APN 5 109,600,898 (GRCm39) missense probably benign 0.00
IGL01527:Vmn2r17 APN 5 109,601,006 (GRCm39) missense probably damaging 1.00
IGL01693:Vmn2r17 APN 5 109,600,384 (GRCm39) missense probably damaging 1.00
IGL01738:Vmn2r17 APN 5 109,577,364 (GRCm39) missense probably damaging 1.00
IGL01767:Vmn2r17 APN 5 109,567,903 (GRCm39) missense probably benign 0.01
IGL01932:Vmn2r17 APN 5 109,574,916 (GRCm39) missense probably benign 0.00
IGL01970:Vmn2r17 APN 5 109,575,813 (GRCm39) missense probably damaging 0.97
IGL02009:Vmn2r17 APN 5 109,600,714 (GRCm39) missense possibly damaging 0.67
IGL02365:Vmn2r17 APN 5 109,601,175 (GRCm39) missense probably damaging 1.00
IGL02385:Vmn2r17 APN 5 109,582,247 (GRCm39) missense probably damaging 1.00
IGL02457:Vmn2r17 APN 5 109,601,012 (GRCm39) missense probably damaging 1.00
IGL02646:Vmn2r17 APN 5 109,600,946 (GRCm39) missense probably damaging 1.00
IGL02741:Vmn2r17 APN 5 109,568,077 (GRCm39) missense probably benign
IGL03213:Vmn2r17 APN 5 109,582,256 (GRCm39) critical splice donor site probably null
IGL03216:Vmn2r17 APN 5 109,600,756 (GRCm39) missense probably damaging 1.00
IGL03342:Vmn2r17 APN 5 109,575,782 (GRCm39) missense probably damaging 1.00
IGL03408:Vmn2r17 APN 5 109,577,238 (GRCm39) splice site probably benign
R0349:Vmn2r17 UTSW 5 109,576,202 (GRCm39) missense probably damaging 1.00
R0418:Vmn2r17 UTSW 5 109,600,747 (GRCm39) missense probably damaging 1.00
R0800:Vmn2r17 UTSW 5 109,575,192 (GRCm39) splice site probably benign
R0836:Vmn2r17 UTSW 5 109,575,822 (GRCm39) missense possibly damaging 0.89
R1715:Vmn2r17 UTSW 5 109,576,110 (GRCm39) missense probably benign 0.00
R1738:Vmn2r17 UTSW 5 109,576,377 (GRCm39) missense probably benign 0.10
R1801:Vmn2r17 UTSW 5 109,576,344 (GRCm39) missense probably damaging 1.00
R2054:Vmn2r17 UTSW 5 109,600,352 (GRCm39) missense probably damaging 0.98
R2060:Vmn2r17 UTSW 5 109,575,075 (GRCm39) missense probably benign 0.00
R2192:Vmn2r17 UTSW 5 109,582,144 (GRCm39) missense possibly damaging 0.81
R2315:Vmn2r17 UTSW 5 109,575,897 (GRCm39) missense probably damaging 1.00
R2374:Vmn2r17 UTSW 5 109,575,104 (GRCm39) missense probably benign
R3612:Vmn2r17 UTSW 5 109,577,463 (GRCm39) missense probably benign 0.00
R3832:Vmn2r17 UTSW 5 109,576,262 (GRCm39) missense probably damaging 1.00
R4273:Vmn2r17 UTSW 5 109,600,832 (GRCm39) missense probably benign 0.44
R4494:Vmn2r17 UTSW 5 109,576,335 (GRCm39) missense probably damaging 1.00
R4597:Vmn2r17 UTSW 5 109,577,428 (GRCm39) missense probably benign 0.01
R4675:Vmn2r17 UTSW 5 109,575,049 (GRCm39) missense probably benign 0.00
R4701:Vmn2r17 UTSW 5 109,575,849 (GRCm39) missense probably damaging 0.99
R4754:Vmn2r17 UTSW 5 109,600,715 (GRCm39) missense probably damaging 0.99
R4841:Vmn2r17 UTSW 5 109,582,246 (GRCm39) missense probably damaging 1.00
R4842:Vmn2r17 UTSW 5 109,582,246 (GRCm39) missense probably damaging 1.00
R4865:Vmn2r17 UTSW 5 109,574,985 (GRCm39) missense probably damaging 1.00
R4902:Vmn2r17 UTSW 5 109,601,220 (GRCm39) missense probably benign 0.14
R4989:Vmn2r17 UTSW 5 109,575,739 (GRCm39) missense probably benign 0.07
R5101:Vmn2r17 UTSW 5 109,576,217 (GRCm39) missense probably damaging 0.99
R5109:Vmn2r17 UTSW 5 109,577,342 (GRCm39) missense probably benign 0.06
R5123:Vmn2r17 UTSW 5 109,575,774 (GRCm39) missense possibly damaging 0.90
R5474:Vmn2r17 UTSW 5 109,582,150 (GRCm39) missense probably damaging 1.00
R5485:Vmn2r17 UTSW 5 109,567,972 (GRCm39) missense probably benign 0.06
R5611:Vmn2r17 UTSW 5 109,576,030 (GRCm39) missense probably damaging 0.97
R5652:Vmn2r17 UTSW 5 109,577,430 (GRCm39) missense probably benign 0.10
R5717:Vmn2r17 UTSW 5 109,575,140 (GRCm39) missense possibly damaging 0.94
R5735:Vmn2r17 UTSW 5 109,600,716 (GRCm39) missense possibly damaging 0.67
R5766:Vmn2r17 UTSW 5 109,575,139 (GRCm39) missense possibly damaging 0.46
R6645:Vmn2r17 UTSW 5 109,576,247 (GRCm39) missense probably damaging 1.00
R6786:Vmn2r17 UTSW 5 109,575,695 (GRCm39) missense probably benign 0.30
R6821:Vmn2r17 UTSW 5 109,577,331 (GRCm39) missense probably damaging 1.00
R6979:Vmn2r17 UTSW 5 109,576,265 (GRCm39) missense possibly damaging 0.46
R6984:Vmn2r17 UTSW 5 109,600,533 (GRCm39) missense probably benign 0.10
R7269:Vmn2r17 UTSW 5 109,576,337 (GRCm39) missense possibly damaging 0.88
R7509:Vmn2r17 UTSW 5 109,575,695 (GRCm39) missense probably benign 0.30
R7736:Vmn2r17 UTSW 5 109,600,757 (GRCm39) missense probably benign 0.05
R7814:Vmn2r17 UTSW 5 109,575,739 (GRCm39) missense probably benign 0.07
R7847:Vmn2r17 UTSW 5 109,568,063 (GRCm39) missense probably damaging 1.00
R7863:Vmn2r17 UTSW 5 109,568,035 (GRCm39) missense probably benign
R7893:Vmn2r17 UTSW 5 109,575,944 (GRCm39) missense probably benign 0.05
R8234:Vmn2r17 UTSW 5 109,601,235 (GRCm39) missense probably benign 0.01
R8382:Vmn2r17 UTSW 5 109,576,387 (GRCm39) missense probably benign 0.01
R8435:Vmn2r17 UTSW 5 109,576,172 (GRCm39) missense probably benign 0.01
R8465:Vmn2r17 UTSW 5 109,600,691 (GRCm39) missense probably damaging 0.99
R8555:Vmn2r17 UTSW 5 109,600,810 (GRCm39) missense probably damaging 0.99
R8900:Vmn2r17 UTSW 5 109,575,863 (GRCm39) missense probably benign 0.25
R9293:Vmn2r17 UTSW 5 109,600,712 (GRCm39) missense probably damaging 1.00
R9308:Vmn2r17 UTSW 5 109,600,505 (GRCm39) missense probably damaging 0.98
R9378:Vmn2r17 UTSW 5 109,575,732 (GRCm39) missense possibly damaging 0.94
R9597:Vmn2r17 UTSW 5 109,575,669 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCCTACAGCAGACCACATTTG -3'
(R):5'- TGCTGAACGTTAGGAACTTGGC -3'

Sequencing Primer
(F):5'- CATTTGGAGTATTTTTCACAGTAGCC -3'
(R):5'- GCTTCATTGAATCTGTCAGGAAG -3'
Posted On 2019-11-26