Incidental Mutation 'R7790:Dennd4c'
| ID |
599793 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
045846-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7790 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
86666792-86768840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 86717754 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 584
(T584A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045512
AA Change: T584A
PolyPhen 2
Score 0.725 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: T584A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082026
AA Change: T584A
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: T584A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142837
AA Change: T584A
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: T584A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (81/81) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700009N14Rik |
A |
T |
4: 39,451,201 (GRCm39) |
I136F |
possibly damaging |
Het |
| Abca13 |
A |
T |
11: 9,247,915 (GRCm39) |
K2554M |
probably damaging |
Het |
| Ankrd12 |
C |
T |
17: 66,291,225 (GRCm39) |
D1403N |
possibly damaging |
Het |
| Ankrd17 |
A |
G |
5: 90,408,011 (GRCm39) |
V1402A |
possibly damaging |
Het |
| Ankrd36 |
A |
T |
11: 5,585,176 (GRCm39) |
N329I |
possibly damaging |
Het |
| Atr |
A |
T |
9: 95,756,233 (GRCm39) |
D815V |
probably damaging |
Het |
| C9orf72 |
T |
C |
4: 35,192,997 (GRCm39) |
D444G |
unknown |
Het |
| Ceacam1 |
T |
C |
7: 25,173,375 (GRCm39) |
Y271C |
probably damaging |
Het |
| Cenpo |
T |
C |
12: 4,264,597 (GRCm39) |
H265R |
probably benign |
Het |
| Chd8 |
G |
A |
14: 52,463,539 (GRCm39) |
R702W |
probably damaging |
Het |
| Ckap5 |
A |
G |
2: 91,389,455 (GRCm39) |
N309S |
probably benign |
Het |
| Cxxc1 |
C |
T |
18: 74,350,855 (GRCm39) |
R83C |
probably damaging |
Het |
| Dcaf6 |
T |
C |
1: 165,227,284 (GRCm39) |
D281G |
probably damaging |
Het |
| Drgx |
T |
A |
14: 32,350,845 (GRCm39) |
L227Q |
probably damaging |
Het |
| Dync2h1 |
G |
T |
9: 7,114,914 (GRCm39) |
H2415N |
probably damaging |
Het |
| Dzip1l |
A |
G |
9: 99,543,015 (GRCm39) |
E490G |
possibly damaging |
Het |
| Fam124a |
T |
C |
14: 62,843,526 (GRCm39) |
S345P |
probably benign |
Het |
| Fam83b |
G |
A |
9: 76,399,330 (GRCm39) |
T591I |
probably benign |
Het |
| Frem1 |
T |
C |
4: 82,907,401 (GRCm39) |
S838G |
probably benign |
Het |
| Fsip2 |
G |
T |
2: 82,818,723 (GRCm39) |
D4819Y |
probably benign |
Het |
| Gm43302 |
T |
G |
5: 105,425,691 (GRCm39) |
K246T |
probably benign |
Het |
| Gml |
T |
C |
15: 74,685,462 (GRCm39) |
|
probably benign |
Het |
| Gpc1 |
A |
T |
1: 92,781,171 (GRCm39) |
H90L |
probably benign |
Het |
| Grik3 |
T |
C |
4: 125,579,812 (GRCm39) |
L519P |
probably damaging |
Het |
| Grwd1 |
A |
G |
7: 45,475,438 (GRCm39) |
V368A |
probably damaging |
Het |
| Gstm3 |
G |
A |
3: 107,876,555 (GRCm39) |
|
probably benign |
Het |
| Gtpbp6 |
A |
G |
5: 110,252,252 (GRCm39) |
S427P |
probably damaging |
Het |
| Heatr5b |
C |
T |
17: 79,126,252 (GRCm39) |
G560E |
probably damaging |
Het |
| Heatr9 |
A |
G |
11: 83,409,019 (GRCm39) |
V176A |
probably damaging |
Het |
| Hsf2bp |
A |
G |
17: 32,253,453 (GRCm39) |
V5A |
probably benign |
Het |
| Ints3 |
G |
T |
3: 90,307,720 (GRCm39) |
Q660K |
probably benign |
Het |
| Itpr2 |
A |
T |
6: 146,126,274 (GRCm39) |
L2048Q |
probably damaging |
Het |
| Kcnq1 |
G |
A |
7: 142,660,342 (GRCm39) |
|
probably null |
Het |
| Lsm12 |
A |
T |
11: 102,055,995 (GRCm39) |
|
probably null |
Het |
| Mcoln3 |
A |
G |
3: 145,845,247 (GRCm39) |
Y481C |
probably damaging |
Het |
| Meis3 |
A |
G |
7: 15,916,322 (GRCm39) |
N266D |
probably benign |
Het |
| Mgat5 |
G |
A |
1: 127,339,941 (GRCm39) |
E441K |
probably benign |
Het |
| Mroh6 |
C |
T |
15: 75,756,089 (GRCm39) |
R689H |
probably benign |
Het |
| Mtg1 |
T |
C |
7: 139,729,662 (GRCm39) |
Y251H |
probably damaging |
Het |
| Mtus2 |
A |
T |
5: 148,014,998 (GRCm39) |
Q597L |
probably benign |
Het |
| Myt1 |
A |
G |
2: 181,439,390 (GRCm39) |
E346G |
probably benign |
Het |
| Nat8f4 |
A |
G |
6: 85,877,873 (GRCm39) |
S217P |
probably benign |
Het |
| Ngf |
G |
A |
3: 102,417,140 (GRCm39) |
G17R |
unknown |
Het |
| Or7e171-ps1 |
A |
T |
9: 19,852,980 (GRCm39) |
M252K |
unknown |
Het |
| Pam |
T |
C |
1: 97,749,572 (GRCm39) |
Y968C |
probably damaging |
Het |
| Pcdhga7 |
T |
A |
18: 37,847,996 (GRCm39) |
M1K |
probably null |
Het |
| Pde8b |
G |
T |
13: 95,170,679 (GRCm39) |
D554E |
probably benign |
Het |
| Pdzd7 |
G |
A |
19: 45,033,962 (GRCm39) |
R41* |
probably null |
Het |
| Pkhd1l1 |
C |
T |
15: 44,441,977 (GRCm39) |
P3639S |
probably damaging |
Het |
| Plce1 |
A |
T |
19: 38,769,140 (GRCm39) |
E2280V |
probably damaging |
Het |
| Ryr1 |
T |
C |
7: 28,804,257 (GRCm39) |
I538V |
probably benign |
Het |
| Scaf11 |
A |
G |
15: 96,316,942 (GRCm39) |
L874P |
possibly damaging |
Het |
| Scpep1 |
G |
T |
11: 88,824,347 (GRCm39) |
D307E |
possibly damaging |
Het |
| Septin4 |
A |
G |
11: 87,480,065 (GRCm39) |
E327G |
probably damaging |
Het |
| Skint2 |
T |
G |
4: 112,473,751 (GRCm39) |
V11G |
possibly damaging |
Het |
| Slc26a4 |
T |
C |
12: 31,594,482 (GRCm39) |
N289D |
probably damaging |
Het |
| Slc35f3 |
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
8: 127,115,777 (GRCm39) |
|
probably benign |
Het |
| Slx4 |
T |
C |
16: 3,804,846 (GRCm39) |
E656G |
probably benign |
Het |
| Socs5 |
T |
C |
17: 87,441,791 (GRCm39) |
S244P |
probably benign |
Het |
| Spata31h1 |
C |
T |
10: 82,123,329 (GRCm39) |
C3227Y |
probably benign |
Het |
| Speer1e |
C |
A |
5: 11,234,185 (GRCm39) |
H30Q |
probably benign |
Het |
| Stt3b |
A |
C |
9: 115,105,887 (GRCm39) |
L196R |
probably damaging |
Het |
| Syne2 |
T |
A |
12: 75,975,877 (GRCm39) |
|
probably null |
Het |
| Tab2 |
T |
A |
10: 7,796,188 (GRCm39) |
N24I |
probably damaging |
Het |
| Taf4b |
T |
C |
18: 14,946,331 (GRCm39) |
S385P |
probably damaging |
Het |
| Tg |
T |
C |
15: 66,721,453 (GRCm39) |
Y2720H |
probably damaging |
Het |
| Tjap1 |
C |
T |
17: 46,569,616 (GRCm39) |
G448E |
probably benign |
Het |
| Tll1 |
A |
T |
8: 64,478,271 (GRCm39) |
C827* |
probably null |
Het |
| Tlr11 |
T |
A |
14: 50,599,382 (GRCm39) |
I456K |
probably benign |
Het |
| Tmem209 |
T |
C |
6: 30,497,854 (GRCm39) |
D305G |
probably damaging |
Het |
| Tmem82 |
A |
T |
4: 141,345,035 (GRCm39) |
|
probably null |
Het |
| Tnfrsf14 |
A |
G |
4: 155,007,750 (GRCm39) |
V207A |
probably benign |
Het |
| Tnks |
A |
T |
8: 35,328,694 (GRCm39) |
N625K |
probably benign |
Het |
| Tomm20 |
G |
A |
8: 127,666,700 (GRCm39) |
P58S |
possibly damaging |
Het |
| Ttc9b |
A |
G |
7: 27,353,761 (GRCm39) |
D137G |
probably benign |
Het |
| Ulk4 |
C |
T |
9: 121,092,734 (GRCm39) |
E168K |
possibly damaging |
Het |
| Usp9y |
T |
A |
Y: 1,444,573 (GRCm39) |
D122V |
probably damaging |
Het |
| Vps41 |
C |
A |
13: 19,026,438 (GRCm39) |
T512K |
possibly damaging |
Het |
| Wdr49 |
T |
A |
3: 75,182,335 (GRCm39) |
N698I |
probably benign |
Het |
| Zfp568 |
G |
A |
7: 29,722,150 (GRCm39) |
C365Y |
probably damaging |
Het |
| Zfp663 |
A |
T |
2: 165,194,453 (GRCm39) |
C589S |
probably damaging |
Het |
| Zfp971 |
A |
G |
2: 177,675,292 (GRCm39) |
K297R |
probably damaging |
Het |
| Zkscan16 |
G |
T |
4: 58,951,843 (GRCm39) |
E173* |
probably null |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,723,724 (GRCm39) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,717,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,721,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,732,036 (GRCm39) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,725,672 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,717,778 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,743,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,692,490 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,739,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,692,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,707,057 (GRCm39) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,696,140 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,696,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,696,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,725,663 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,717,701 (GRCm39) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,699,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,699,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,744,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,731,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,730,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,707,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,763,145 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,725,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,729,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,692,769 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,704,331 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,725,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Dennd4c
|
UTSW |
4 |
86,721,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,743,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,755,634 (GRCm39) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,729,764 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,699,881 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,743,557 (GRCm39) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,698,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,692,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,725,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,716,312 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,738,200 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,743,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4923:Dennd4c
|
UTSW |
4 |
86,725,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,699,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,713,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,729,693 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,713,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,729,690 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,744,223 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,709,589 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,743,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,723,828 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,743,686 (GRCm39) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,717,626 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,754,694 (GRCm39) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,717,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,730,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,725,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,721,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,747,975 (GRCm39) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,759,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7329:Dennd4c
|
UTSW |
4 |
86,698,111 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7466:Dennd4c
|
UTSW |
4 |
86,692,568 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,717,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,692,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Dennd4c
|
UTSW |
4 |
86,729,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,713,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,704,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,747,179 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,763,213 (GRCm39) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,744,109 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,759,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,744,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,754,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,739,702 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,743,349 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,755,637 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,738,170 (GRCm39) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,747,208 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,713,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,743,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,754,625 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCTTGTCAGTTCACCGAAAAC -3'
(R):5'- GTACACAACACATTGGACTCTTC -3'
Sequencing Primer
(F):5'- CCTCAAGAAAGTTCAGCAATTGAG -3'
(R):5'- GTAGGTTACAGGAAATGCAAATTCC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation