Incidental Mutation 'R7793:Tacc2'
| ID |
600044 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tacc2
|
| Ensembl Gene |
ENSMUSG00000030852 |
| Gene Name |
transforming, acidic coiled-coil containing protein 2 |
| Synonyms |
|
| MMRRC Submission |
045849-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7793 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
130179168-130366515 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 130224843 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 509
(N509K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081561
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059145]
[ENSMUST00000084513]
[ENSMUST00000124096]
[ENSMUST00000207789]
[ENSMUST00000207918]
[ENSMUST00000208722]
[ENSMUST00000215492]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059145
|
| SMART Domains |
Protein: ENSMUSP00000061242
Gene: ENSMUSG00000030852
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
173 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
291 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
345 |
356 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
483 |
566 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
571 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
603 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
662 |
N/A |
INTRINSIC |
|
coiled coil region
|
873 |
900 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
939 |
1145 |
4e-85 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084513
AA Change: N509K
PolyPhen 2
Score 0.336 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000081561
Gene: ENSMUSG00000030852
AA Change: N509K
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
19 |
346 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
398 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
431 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
778 |
1068 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
1397 |
1415 |
N/A |
INTRINSIC |
|
low complexity region
|
1723 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1794 |
1809 |
N/A |
INTRINSIC |
|
low complexity region
|
1854 |
1880 |
N/A |
INTRINSIC |
|
low complexity region
|
2052 |
2063 |
N/A |
INTRINSIC |
|
low complexity region
|
2278 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2310 |
2321 |
N/A |
INTRINSIC |
|
low complexity region
|
2355 |
2369 |
N/A |
INTRINSIC |
|
coiled coil region
|
2606 |
2633 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
2673 |
2873 |
6.1e-87 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207789
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000207918
AA Change: N509K
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000208722
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000215492
AA Change: N528K
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (94/94) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2200002J24Rik |
T |
G |
7: 30,399,368 (GRCm39) |
I54S |
probably damaging |
Het |
| 2310002L09Rik |
C |
T |
4: 73,861,172 (GRCm39) |
V143M |
probably benign |
Het |
| Abca1 |
T |
C |
4: 53,042,367 (GRCm39) |
I1902V |
not run |
Het |
| Apob |
A |
C |
12: 8,058,124 (GRCm39) |
D2202A |
probably damaging |
Het |
| Arhgap44 |
T |
A |
11: 64,900,750 (GRCm39) |
S623C |
probably damaging |
Het |
| Arhgef7 |
T |
A |
8: 11,874,507 (GRCm39) |
W713R |
possibly damaging |
Het |
| Axdnd1 |
A |
C |
1: 156,166,313 (GRCm39) |
|
probably null |
Het |
| Bcl9l |
C |
A |
9: 44,420,994 (GRCm39) |
H1467N |
probably damaging |
Het |
| Bcl9l |
T |
C |
9: 44,420,263 (GRCm39) |
M1223T |
probably benign |
Het |
| Bltp2 |
C |
T |
11: 78,164,031 (GRCm39) |
P1124L |
possibly damaging |
Het |
| Brinp3 |
A |
G |
1: 146,622,306 (GRCm39) |
N236S |
probably benign |
Het |
| Cckbr |
T |
G |
7: 105,082,798 (GRCm39) |
L54V |
probably benign |
Het |
| Cd6 |
G |
A |
19: 10,775,722 (GRCm39) |
Q246* |
probably null |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Ces3a |
T |
A |
8: 105,782,293 (GRCm39) |
|
probably null |
Het |
| Cgnl1 |
T |
A |
9: 71,632,917 (GRCm39) |
N145Y |
probably damaging |
Het |
| Col6a5 |
T |
C |
9: 105,775,934 (GRCm39) |
D1707G |
probably damaging |
Het |
| Cyp2w1 |
A |
G |
5: 139,341,895 (GRCm39) |
T103A |
probably damaging |
Het |
| Dip2a |
A |
T |
10: 76,114,417 (GRCm39) |
I1021N |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,386,040 (GRCm39) |
T981A |
probably benign |
Het |
| Dnah8 |
A |
G |
17: 31,074,918 (GRCm39) |
I4546V |
probably benign |
Het |
| E2f8 |
A |
C |
7: 48,527,823 (GRCm39) |
F106L |
probably benign |
Het |
| Ecpas |
T |
C |
4: 58,853,150 (GRCm39) |
N395S |
probably damaging |
Het |
| Eif4g1 |
G |
A |
16: 20,507,364 (GRCm39) |
V1413I |
probably benign |
Het |
| Epha10 |
G |
A |
4: 124,808,246 (GRCm39) |
V688I |
probably benign |
Het |
| Exoc2 |
A |
T |
13: 31,095,161 (GRCm39) |
V245D |
probably benign |
Het |
| Eya4 |
T |
A |
10: 23,102,714 (GRCm39) |
E23D |
probably benign |
Het |
| Fbxw10 |
T |
A |
11: 62,738,213 (GRCm39) |
W36R |
possibly damaging |
Het |
| Gabbr1 |
G |
A |
17: 37,358,393 (GRCm39) |
G44S |
probably benign |
Het |
| Gabrg3 |
T |
A |
7: 56,829,328 (GRCm39) |
Q143L |
probably benign |
Het |
| Gm14412 |
A |
C |
2: 177,007,660 (GRCm39) |
I78M |
possibly damaging |
Het |
| Gm7298 |
T |
C |
6: 121,737,563 (GRCm39) |
|
probably null |
Het |
| Hpse2 |
A |
T |
19: 43,376,509 (GRCm39) |
L81Q |
probably damaging |
Het |
| Il18r1 |
A |
G |
1: 40,510,924 (GRCm39) |
H3R |
probably benign |
Het |
| Kansl1l |
T |
C |
1: 66,817,173 (GRCm39) |
K396E |
probably damaging |
Het |
| Kbtbd3 |
T |
A |
9: 4,331,221 (GRCm39) |
S532T |
probably damaging |
Het |
| Lrrtm4 |
T |
C |
6: 79,999,841 (GRCm39) |
Y418H |
probably damaging |
Het |
| Mfng |
G |
A |
15: 78,657,265 (GRCm39) |
R70C |
probably damaging |
Het |
| Mx2 |
T |
A |
16: 97,348,083 (GRCm39) |
I236K |
probably damaging |
Het |
| Mysm1 |
T |
C |
4: 94,853,369 (GRCm39) |
Q410R |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,294,030 (GRCm39) |
N100S |
probably benign |
Het |
| Nlrp4b |
T |
A |
7: 10,459,001 (GRCm39) |
H773Q |
probably benign |
Het |
| Nlrp5 |
T |
A |
7: 23,123,343 (GRCm39) |
S735T |
possibly damaging |
Het |
| Nt5c2 |
G |
A |
19: 46,880,020 (GRCm39) |
R363W |
probably benign |
Het |
| Or12k8 |
A |
G |
2: 36,974,933 (GRCm39) |
F276L |
possibly damaging |
Het |
| Or3a10 |
T |
A |
11: 73,935,614 (GRCm39) |
H162L |
possibly damaging |
Het |
| Otud7b |
A |
T |
3: 96,062,528 (GRCm39) |
Y589F |
probably benign |
Het |
| P2rx1 |
T |
A |
11: 72,900,079 (GRCm39) |
C165* |
probably null |
Het |
| Pax8 |
T |
C |
2: 24,319,609 (GRCm39) |
D354G |
possibly damaging |
Het |
| Pdcd11 |
G |
A |
19: 47,094,871 (GRCm39) |
V552I |
probably benign |
Het |
| Pde6c |
G |
T |
19: 38,148,201 (GRCm39) |
C485F |
possibly damaging |
Het |
| Pex5 |
T |
C |
6: 124,376,300 (GRCm39) |
Y434C |
probably benign |
Het |
| Ppargc1a |
T |
C |
5: 51,619,851 (GRCm39) |
|
probably null |
Het |
| Prss2 |
A |
T |
6: 41,501,886 (GRCm39) |
D224V |
possibly damaging |
Het |
| Psd2 |
A |
G |
18: 36,136,032 (GRCm39) |
N440S |
probably benign |
Het |
| Psmb3 |
T |
A |
11: 97,603,265 (GRCm39) |
D159E |
probably benign |
Het |
| Ptgr2 |
T |
G |
12: 84,354,575 (GRCm39) |
L252R |
probably damaging |
Het |
| Ptpro |
A |
T |
6: 137,393,818 (GRCm39) |
N829Y |
probably damaging |
Het |
| Rhobtb2 |
C |
A |
14: 70,034,280 (GRCm39) |
R315L |
probably benign |
Het |
| Rimbp2 |
A |
T |
5: 128,866,759 (GRCm39) |
V520D |
possibly damaging |
Het |
| Schip1 |
A |
T |
3: 68,401,911 (GRCm39) |
Y24F |
probably benign |
Het |
| Sdha |
A |
T |
13: 74,479,555 (GRCm39) |
V432E |
probably damaging |
Het |
| Sez6 |
T |
C |
11: 77,868,426 (GRCm39) |
L929P |
probably damaging |
Het |
| Shcbp1l |
A |
G |
1: 153,323,571 (GRCm39) |
I466V |
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,052,167 (GRCm39) |
S601G |
probably damaging |
Het |
| Slc6a7 |
A |
C |
18: 61,138,851 (GRCm39) |
L219R |
probably damaging |
Het |
| Smok2a |
T |
C |
17: 13,444,513 (GRCm39) |
M30T |
possibly damaging |
Het |
| Sp8 |
A |
G |
12: 118,813,144 (GRCm39) |
D333G |
probably damaging |
Het |
| Spp1 |
G |
A |
5: 104,588,200 (GRCm39) |
D201N |
probably damaging |
Het |
| Sstr3 |
A |
T |
15: 78,424,588 (GRCm39) |
L53Q |
probably damaging |
Het |
| Tdrd1 |
T |
C |
19: 56,852,809 (GRCm39) |
V1030A |
probably damaging |
Het |
| Tfrc |
A |
G |
16: 32,437,985 (GRCm39) |
K346R |
probably benign |
Het |
| Tgm3 |
G |
A |
2: 129,854,330 (GRCm39) |
|
probably null |
Het |
| Tomm5 |
C |
A |
4: 45,106,651 (GRCm39) |
L88F |
unknown |
Het |
| Trak1 |
T |
A |
9: 121,245,264 (GRCm39) |
C46* |
probably null |
Het |
| Trim8 |
A |
T |
19: 46,504,053 (GRCm39) |
D535V |
probably damaging |
Het |
| Trpm7 |
A |
T |
2: 126,665,995 (GRCm39) |
Y870* |
probably null |
Het |
| Tspoap1 |
T |
C |
11: 87,655,136 (GRCm39) |
L286P |
probably benign |
Het |
| Ttll3 |
AAGTA |
AAGTAGAGTA |
6: 113,376,120 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,562,389 (GRCm39) |
I28819F |
probably damaging |
Het |
| Twf2 |
T |
C |
9: 106,089,079 (GRCm39) |
S89P |
probably damaging |
Het |
| Ulk4 |
C |
T |
9: 121,092,734 (GRCm39) |
E168K |
possibly damaging |
Het |
| Unc13b |
T |
A |
4: 43,172,737 (GRCm39) |
N1188K |
unknown |
Het |
| Utp6 |
C |
T |
11: 79,828,556 (GRCm39) |
V528I |
probably benign |
Het |
| Vmn1r78 |
T |
C |
7: 11,887,241 (GRCm39) |
F284S |
probably benign |
Het |
| Vmn2r54 |
T |
A |
7: 12,366,196 (GRCm39) |
Q246L |
probably damaging |
Het |
| Vmn2r87 |
A |
G |
10: 130,313,413 (GRCm39) |
M451T |
probably benign |
Het |
| Vwf |
C |
T |
6: 125,663,483 (GRCm39) |
P2808L |
|
Het |
| Wdr97 |
T |
C |
15: 76,243,307 (GRCm39) |
L989P |
|
Het |
| Wwc1 |
T |
C |
11: 35,759,936 (GRCm39) |
Q693R |
probably benign |
Het |
| Zfp582 |
C |
T |
7: 6,356,886 (GRCm39) |
S233L |
probably damaging |
Het |
| Zfp658 |
T |
A |
7: 43,224,108 (GRCm39) |
H794Q |
possibly damaging |
Het |
| Zfp882 |
A |
G |
8: 72,666,985 (GRCm39) |
D8G |
probably damaging |
Het |
|
| Other mutations in Tacc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00836:Tacc2
|
APN |
7 |
130,360,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Tacc2
|
APN |
7 |
130,360,919 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01621:Tacc2
|
APN |
7 |
130,331,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02000:Tacc2
|
APN |
7 |
130,330,898 (GRCm39) |
splice site |
probably null |
|
|
IGL02075:Tacc2
|
APN |
7 |
130,330,582 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02201:Tacc2
|
APN |
7 |
130,227,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02205:Tacc2
|
APN |
7 |
130,228,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Tacc2
|
APN |
7 |
130,225,129 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02456:Tacc2
|
APN |
7 |
130,227,991 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02559:Tacc2
|
APN |
7 |
130,360,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02734:Tacc2
|
APN |
7 |
130,227,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02800:Tacc2
|
APN |
7 |
130,225,809 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02938:Tacc2
|
APN |
7 |
130,330,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tacc2
|
APN |
7 |
130,225,585 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03278:Tacc2
|
APN |
7 |
130,335,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03283:Tacc2
|
APN |
7 |
130,343,996 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL03371:Tacc2
|
APN |
7 |
130,227,791 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
aces
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Jacks
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
kings
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0002:Tacc2
|
UTSW |
7 |
130,223,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0119:Tacc2
|
UTSW |
7 |
130,223,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0244:Tacc2
|
UTSW |
7 |
130,353,555 (GRCm39) |
splice site |
probably benign |
|
|
R0619:Tacc2
|
UTSW |
7 |
130,318,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Tacc2
|
UTSW |
7 |
130,179,239 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0632:Tacc2
|
UTSW |
7 |
130,227,325 (GRCm39) |
nonsense |
probably null |
|
|
R1015:Tacc2
|
UTSW |
7 |
130,225,795 (GRCm39) |
missense |
probably benign |
|
|
R1081:Tacc2
|
UTSW |
7 |
130,330,304 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1086:Tacc2
|
UTSW |
7 |
130,228,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1351:Tacc2
|
UTSW |
7 |
130,264,733 (GRCm39) |
intron |
probably benign |
|
|
R1538:Tacc2
|
UTSW |
7 |
130,227,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1743:Tacc2
|
UTSW |
7 |
130,228,328 (GRCm39) |
nonsense |
probably null |
|
|
R1771:Tacc2
|
UTSW |
7 |
130,343,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1876:Tacc2
|
UTSW |
7 |
130,225,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1893:Tacc2
|
UTSW |
7 |
130,227,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Tacc2
|
UTSW |
7 |
130,225,932 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2005:Tacc2
|
UTSW |
7 |
130,333,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Tacc2
|
UTSW |
7 |
130,223,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2338:Tacc2
|
UTSW |
7 |
130,335,299 (GRCm39) |
splice site |
probably null |
|
|
R2407:Tacc2
|
UTSW |
7 |
130,223,770 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3051:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3052:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3053:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3116:Tacc2
|
UTSW |
7 |
130,360,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Tacc2
|
UTSW |
7 |
130,336,724 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3683:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3685:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3872:Tacc2
|
UTSW |
7 |
130,224,152 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4063:Tacc2
|
UTSW |
7 |
130,330,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4410:Tacc2
|
UTSW |
7 |
130,343,941 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4434:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4438:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4618:Tacc2
|
UTSW |
7 |
130,227,946 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4674:Tacc2
|
UTSW |
7 |
130,226,591 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4742:Tacc2
|
UTSW |
7 |
130,227,697 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4934:Tacc2
|
UTSW |
7 |
130,330,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4947:Tacc2
|
UTSW |
7 |
130,227,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4964:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Tacc2
|
UTSW |
7 |
130,225,678 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5052:Tacc2
|
UTSW |
7 |
130,336,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Tacc2
|
UTSW |
7 |
130,331,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Tacc2
|
UTSW |
7 |
130,224,990 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5556:Tacc2
|
UTSW |
7 |
130,276,336 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5645:Tacc2
|
UTSW |
7 |
130,225,781 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5886:Tacc2
|
UTSW |
7 |
130,330,850 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5996:Tacc2
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6074:Tacc2
|
UTSW |
7 |
130,227,165 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6127:Tacc2
|
UTSW |
7 |
130,227,845 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6156:Tacc2
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6298:Tacc2
|
UTSW |
7 |
130,228,255 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6444:Tacc2
|
UTSW |
7 |
130,225,142 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6533:Tacc2
|
UTSW |
7 |
130,224,567 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6724:Tacc2
|
UTSW |
7 |
130,330,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Tacc2
|
UTSW |
7 |
130,330,618 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7150:Tacc2
|
UTSW |
7 |
130,330,807 (GRCm39) |
missense |
probably benign |
|
|
R7290:Tacc2
|
UTSW |
7 |
130,331,103 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7404:Tacc2
|
UTSW |
7 |
130,225,066 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7460:Tacc2
|
UTSW |
7 |
130,226,363 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7651:Tacc2
|
UTSW |
7 |
130,224,884 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7666:Tacc2
|
UTSW |
7 |
130,318,544 (GRCm39) |
start gained |
probably benign |
|
|
R7695:Tacc2
|
UTSW |
7 |
130,330,633 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7766:Tacc2
|
UTSW |
7 |
130,345,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7861:Tacc2
|
UTSW |
7 |
130,227,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8204:Tacc2
|
UTSW |
7 |
130,226,159 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8244:Tacc2
|
UTSW |
7 |
130,330,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tacc2
|
UTSW |
7 |
130,331,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Tacc2
|
UTSW |
7 |
130,227,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8348:Tacc2
|
UTSW |
7 |
130,225,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8369:Tacc2
|
UTSW |
7 |
130,223,888 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8381:Tacc2
|
UTSW |
7 |
130,225,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8804:Tacc2
|
UTSW |
7 |
130,294,693 (GRCm39) |
missense |
probably benign |
|
|
R8809:Tacc2
|
UTSW |
7 |
130,276,421 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8835:Tacc2
|
UTSW |
7 |
130,228,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8880:Tacc2
|
UTSW |
7 |
130,318,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8918:Tacc2
|
UTSW |
7 |
130,227,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8936:Tacc2
|
UTSW |
7 |
130,228,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8953:Tacc2
|
UTSW |
7 |
130,227,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9026:Tacc2
|
UTSW |
7 |
130,225,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Tacc2
|
UTSW |
7 |
130,228,304 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,058 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9222:Tacc2
|
UTSW |
7 |
130,227,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9264:Tacc2
|
UTSW |
7 |
130,228,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Tacc2
|
UTSW |
7 |
130,223,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Tacc2
|
UTSW |
7 |
130,226,771 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9515:Tacc2
|
UTSW |
7 |
130,366,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:Tacc2
|
UTSW |
7 |
130,361,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tacc2
|
UTSW |
7 |
130,336,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,346,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,226,000 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,225,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,336,679 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,227,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,226,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCTGCCACAGAACAGATG -3'
(R):5'- ACTGTGTGCCTTTGAAACCTC -3'
Sequencing Primer
(F):5'- CGGAAGCCAACATCAGATCTTAG -3'
(R):5'- CACCTTTCTTGGTCTCCAGATGGG -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation