Incidental Mutation 'R7793:Sez6'
| ID |
600066 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sez6
|
| Ensembl Gene |
ENSMUSG00000000632 |
| Gene Name |
seizure related gene 6 |
| Synonyms |
sez-6, D11Bhm177e |
| MMRRC Submission |
045849-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7793 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
77821626-77869874 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 77868426 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 929
(L929P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091532
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000646]
[ENSMUST00000093995]
|
| AlphaFold |
Q7TSK2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000000646
AA Change: L916P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000000646
Gene: ENSMUSG00000000632
AA Change: L916P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
72 |
85 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
235 |
N/A |
INTRINSIC |
|
CUB
|
241 |
350 |
9.36e-2 |
SMART |
|
CCP
|
354 |
409 |
1.23e-10 |
SMART |
|
CUB
|
413 |
524 |
1.41e-28 |
SMART |
|
CCP
|
529 |
586 |
5.43e-12 |
SMART |
|
CUB
|
590 |
701 |
7.49e-24 |
SMART |
|
CCP
|
707 |
762 |
3.09e-16 |
SMART |
|
CCP
|
768 |
827 |
3.5e-15 |
SMART |
|
CCP
|
835 |
892 |
1.42e-15 |
SMART |
|
transmembrane domain
|
910 |
932 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093995
AA Change: L929P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000091532
Gene: ENSMUSG00000000632
AA Change: L929P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
72 |
85 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
235 |
N/A |
INTRINSIC |
|
CUB
|
241 |
350 |
9.36e-2 |
SMART |
|
CCP
|
354 |
409 |
1.23e-10 |
SMART |
|
CUB
|
413 |
524 |
1.41e-28 |
SMART |
|
CCP
|
529 |
586 |
5.43e-12 |
SMART |
|
CUB
|
590 |
701 |
7.49e-24 |
SMART |
|
CCP
|
707 |
762 |
3.09e-16 |
SMART |
|
CCP
|
768 |
827 |
3.5e-15 |
SMART |
|
CCP
|
835 |
892 |
1.42e-15 |
SMART |
|
transmembrane domain
|
923 |
945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140630
|
| SMART Domains |
Protein: ENSMUSP00000115660
Gene: ENSMUSG00000000632
| Domain | Start | End | E-Value | Type |
|---|
|
CUB
|
29 |
140 |
9.8e-28 |
SMART |
|
CCP
|
157 |
214 |
5.43e-12 |
SMART |
|
Pfam:CUB
|
218 |
278 |
1.6e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151982
|
| SMART Domains |
Protein: ENSMUSP00000132041
Gene: ENSMUSG00000000632
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
|
CUB
|
75 |
184 |
9.36e-2 |
SMART |
|
CCP
|
188 |
243 |
1.23e-10 |
SMART |
|
CUB
|
247 |
358 |
8.08e-29 |
SMART |
|
low complexity region
|
379 |
394 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (94/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a null allele exhibit increased short dendrites, decreased excitatory synaptic signaling, resistance to pharmacologically induces seizures, decreased activity and impaired learning and coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2200002J24Rik |
T |
G |
7: 30,399,368 (GRCm39) |
I54S |
probably damaging |
Het |
| 2310002L09Rik |
C |
T |
4: 73,861,172 (GRCm39) |
V143M |
probably benign |
Het |
| Abca1 |
T |
C |
4: 53,042,367 (GRCm39) |
I1902V |
not run |
Het |
| Apob |
A |
C |
12: 8,058,124 (GRCm39) |
D2202A |
probably damaging |
Het |
| Arhgap44 |
T |
A |
11: 64,900,750 (GRCm39) |
S623C |
probably damaging |
Het |
| Arhgef7 |
T |
A |
8: 11,874,507 (GRCm39) |
W713R |
possibly damaging |
Het |
| Axdnd1 |
A |
C |
1: 156,166,313 (GRCm39) |
|
probably null |
Het |
| Bcl9l |
C |
A |
9: 44,420,994 (GRCm39) |
H1467N |
probably damaging |
Het |
| Bcl9l |
T |
C |
9: 44,420,263 (GRCm39) |
M1223T |
probably benign |
Het |
| Bltp2 |
C |
T |
11: 78,164,031 (GRCm39) |
P1124L |
possibly damaging |
Het |
| Brinp3 |
A |
G |
1: 146,622,306 (GRCm39) |
N236S |
probably benign |
Het |
| Cckbr |
T |
G |
7: 105,082,798 (GRCm39) |
L54V |
probably benign |
Het |
| Cd6 |
G |
A |
19: 10,775,722 (GRCm39) |
Q246* |
probably null |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Ces3a |
T |
A |
8: 105,782,293 (GRCm39) |
|
probably null |
Het |
| Cgnl1 |
T |
A |
9: 71,632,917 (GRCm39) |
N145Y |
probably damaging |
Het |
| Col6a5 |
T |
C |
9: 105,775,934 (GRCm39) |
D1707G |
probably damaging |
Het |
| Cyp2w1 |
A |
G |
5: 139,341,895 (GRCm39) |
T103A |
probably damaging |
Het |
| Dip2a |
A |
T |
10: 76,114,417 (GRCm39) |
I1021N |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,386,040 (GRCm39) |
T981A |
probably benign |
Het |
| Dnah8 |
A |
G |
17: 31,074,918 (GRCm39) |
I4546V |
probably benign |
Het |
| E2f8 |
A |
C |
7: 48,527,823 (GRCm39) |
F106L |
probably benign |
Het |
| Ecpas |
T |
C |
4: 58,853,150 (GRCm39) |
N395S |
probably damaging |
Het |
| Eif4g1 |
G |
A |
16: 20,507,364 (GRCm39) |
V1413I |
probably benign |
Het |
| Epha10 |
G |
A |
4: 124,808,246 (GRCm39) |
V688I |
probably benign |
Het |
| Exoc2 |
A |
T |
13: 31,095,161 (GRCm39) |
V245D |
probably benign |
Het |
| Eya4 |
T |
A |
10: 23,102,714 (GRCm39) |
E23D |
probably benign |
Het |
| Fbxw10 |
T |
A |
11: 62,738,213 (GRCm39) |
W36R |
possibly damaging |
Het |
| Gabbr1 |
G |
A |
17: 37,358,393 (GRCm39) |
G44S |
probably benign |
Het |
| Gabrg3 |
T |
A |
7: 56,829,328 (GRCm39) |
Q143L |
probably benign |
Het |
| Gm14412 |
A |
C |
2: 177,007,660 (GRCm39) |
I78M |
possibly damaging |
Het |
| Gm7298 |
T |
C |
6: 121,737,563 (GRCm39) |
|
probably null |
Het |
| Hpse2 |
A |
T |
19: 43,376,509 (GRCm39) |
L81Q |
probably damaging |
Het |
| Il18r1 |
A |
G |
1: 40,510,924 (GRCm39) |
H3R |
probably benign |
Het |
| Kansl1l |
T |
C |
1: 66,817,173 (GRCm39) |
K396E |
probably damaging |
Het |
| Kbtbd3 |
T |
A |
9: 4,331,221 (GRCm39) |
S532T |
probably damaging |
Het |
| Lrrtm4 |
T |
C |
6: 79,999,841 (GRCm39) |
Y418H |
probably damaging |
Het |
| Mfng |
G |
A |
15: 78,657,265 (GRCm39) |
R70C |
probably damaging |
Het |
| Mx2 |
T |
A |
16: 97,348,083 (GRCm39) |
I236K |
probably damaging |
Het |
| Mysm1 |
T |
C |
4: 94,853,369 (GRCm39) |
Q410R |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,294,030 (GRCm39) |
N100S |
probably benign |
Het |
| Nlrp4b |
T |
A |
7: 10,459,001 (GRCm39) |
H773Q |
probably benign |
Het |
| Nlrp5 |
T |
A |
7: 23,123,343 (GRCm39) |
S735T |
possibly damaging |
Het |
| Nt5c2 |
G |
A |
19: 46,880,020 (GRCm39) |
R363W |
probably benign |
Het |
| Or12k8 |
A |
G |
2: 36,974,933 (GRCm39) |
F276L |
possibly damaging |
Het |
| Or3a10 |
T |
A |
11: 73,935,614 (GRCm39) |
H162L |
possibly damaging |
Het |
| Otud7b |
A |
T |
3: 96,062,528 (GRCm39) |
Y589F |
probably benign |
Het |
| P2rx1 |
T |
A |
11: 72,900,079 (GRCm39) |
C165* |
probably null |
Het |
| Pax8 |
T |
C |
2: 24,319,609 (GRCm39) |
D354G |
possibly damaging |
Het |
| Pdcd11 |
G |
A |
19: 47,094,871 (GRCm39) |
V552I |
probably benign |
Het |
| Pde6c |
G |
T |
19: 38,148,201 (GRCm39) |
C485F |
possibly damaging |
Het |
| Pex5 |
T |
C |
6: 124,376,300 (GRCm39) |
Y434C |
probably benign |
Het |
| Ppargc1a |
T |
C |
5: 51,619,851 (GRCm39) |
|
probably null |
Het |
| Prss2 |
A |
T |
6: 41,501,886 (GRCm39) |
D224V |
possibly damaging |
Het |
| Psd2 |
A |
G |
18: 36,136,032 (GRCm39) |
N440S |
probably benign |
Het |
| Psmb3 |
T |
A |
11: 97,603,265 (GRCm39) |
D159E |
probably benign |
Het |
| Ptgr2 |
T |
G |
12: 84,354,575 (GRCm39) |
L252R |
probably damaging |
Het |
| Ptpro |
A |
T |
6: 137,393,818 (GRCm39) |
N829Y |
probably damaging |
Het |
| Rhobtb2 |
C |
A |
14: 70,034,280 (GRCm39) |
R315L |
probably benign |
Het |
| Rimbp2 |
A |
T |
5: 128,866,759 (GRCm39) |
V520D |
possibly damaging |
Het |
| Schip1 |
A |
T |
3: 68,401,911 (GRCm39) |
Y24F |
probably benign |
Het |
| Sdha |
A |
T |
13: 74,479,555 (GRCm39) |
V432E |
probably damaging |
Het |
| Shcbp1l |
A |
G |
1: 153,323,571 (GRCm39) |
I466V |
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,052,167 (GRCm39) |
S601G |
probably damaging |
Het |
| Slc6a7 |
A |
C |
18: 61,138,851 (GRCm39) |
L219R |
probably damaging |
Het |
| Smok2a |
T |
C |
17: 13,444,513 (GRCm39) |
M30T |
possibly damaging |
Het |
| Sp8 |
A |
G |
12: 118,813,144 (GRCm39) |
D333G |
probably damaging |
Het |
| Spp1 |
G |
A |
5: 104,588,200 (GRCm39) |
D201N |
probably damaging |
Het |
| Sstr3 |
A |
T |
15: 78,424,588 (GRCm39) |
L53Q |
probably damaging |
Het |
| Tacc2 |
T |
A |
7: 130,224,843 (GRCm39) |
N509K |
probably benign |
Het |
| Tdrd1 |
T |
C |
19: 56,852,809 (GRCm39) |
V1030A |
probably damaging |
Het |
| Tfrc |
A |
G |
16: 32,437,985 (GRCm39) |
K346R |
probably benign |
Het |
| Tgm3 |
G |
A |
2: 129,854,330 (GRCm39) |
|
probably null |
Het |
| Tomm5 |
C |
A |
4: 45,106,651 (GRCm39) |
L88F |
unknown |
Het |
| Trak1 |
T |
A |
9: 121,245,264 (GRCm39) |
C46* |
probably null |
Het |
| Trim8 |
A |
T |
19: 46,504,053 (GRCm39) |
D535V |
probably damaging |
Het |
| Trpm7 |
A |
T |
2: 126,665,995 (GRCm39) |
Y870* |
probably null |
Het |
| Tspoap1 |
T |
C |
11: 87,655,136 (GRCm39) |
L286P |
probably benign |
Het |
| Ttll3 |
AAGTA |
AAGTAGAGTA |
6: 113,376,120 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,562,389 (GRCm39) |
I28819F |
probably damaging |
Het |
| Twf2 |
T |
C |
9: 106,089,079 (GRCm39) |
S89P |
probably damaging |
Het |
| Ulk4 |
C |
T |
9: 121,092,734 (GRCm39) |
E168K |
possibly damaging |
Het |
| Unc13b |
T |
A |
4: 43,172,737 (GRCm39) |
N1188K |
unknown |
Het |
| Utp6 |
C |
T |
11: 79,828,556 (GRCm39) |
V528I |
probably benign |
Het |
| Vmn1r78 |
T |
C |
7: 11,887,241 (GRCm39) |
F284S |
probably benign |
Het |
| Vmn2r54 |
T |
A |
7: 12,366,196 (GRCm39) |
Q246L |
probably damaging |
Het |
| Vmn2r87 |
A |
G |
10: 130,313,413 (GRCm39) |
M451T |
probably benign |
Het |
| Vwf |
C |
T |
6: 125,663,483 (GRCm39) |
P2808L |
|
Het |
| Wdr97 |
T |
C |
15: 76,243,307 (GRCm39) |
L989P |
|
Het |
| Wwc1 |
T |
C |
11: 35,759,936 (GRCm39) |
Q693R |
probably benign |
Het |
| Zfp582 |
C |
T |
7: 6,356,886 (GRCm39) |
S233L |
probably damaging |
Het |
| Zfp658 |
T |
A |
7: 43,224,108 (GRCm39) |
H794Q |
possibly damaging |
Het |
| Zfp882 |
A |
G |
8: 72,666,985 (GRCm39) |
D8G |
probably damaging |
Het |
|
| Other mutations in Sez6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01125:Sez6
|
APN |
11 |
77,868,115 (GRCm39) |
splice site |
probably benign |
|
|
IGL01142:Sez6
|
APN |
11 |
77,864,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02252:Sez6
|
APN |
11 |
77,865,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02332:Sez6
|
APN |
11 |
77,845,568 (GRCm39) |
splice site |
probably benign |
|
|
IGL02366:Sez6
|
APN |
11 |
77,867,708 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02479:Sez6
|
APN |
11 |
77,868,852 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02963:Sez6
|
APN |
11 |
77,853,775 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
velum
|
UTSW |
11 |
77,865,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Sez6
|
UTSW |
11 |
77,844,699 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0054:Sez6
|
UTSW |
11 |
77,844,699 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0089:Sez6
|
UTSW |
11 |
77,865,170 (GRCm39) |
splice site |
probably benign |
|
|
R0485:Sez6
|
UTSW |
11 |
77,844,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0598:Sez6
|
UTSW |
11 |
77,868,647 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0729:Sez6
|
UTSW |
11 |
77,867,411 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1117:Sez6
|
UTSW |
11 |
77,865,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1199:Sez6
|
UTSW |
11 |
77,844,711 (GRCm39) |
missense |
probably benign |
|
|
R1534:Sez6
|
UTSW |
11 |
77,853,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Sez6
|
UTSW |
11 |
77,844,329 (GRCm39) |
missense |
probably benign |
|
|
R1840:Sez6
|
UTSW |
11 |
77,844,543 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1929:Sez6
|
UTSW |
11 |
77,863,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Sez6
|
UTSW |
11 |
77,844,894 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3156:Sez6
|
UTSW |
11 |
77,844,605 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3930:Sez6
|
UTSW |
11 |
77,867,708 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3931:Sez6
|
UTSW |
11 |
77,867,708 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4894:Sez6
|
UTSW |
11 |
77,866,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Sez6
|
UTSW |
11 |
77,866,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5026:Sez6
|
UTSW |
11 |
77,859,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5040:Sez6
|
UTSW |
11 |
77,859,915 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5057:Sez6
|
UTSW |
11 |
77,863,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Sez6
|
UTSW |
11 |
77,867,388 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5640:Sez6
|
UTSW |
11 |
77,864,585 (GRCm39) |
intron |
probably benign |
|
|
R6013:Sez6
|
UTSW |
11 |
77,864,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6126:Sez6
|
UTSW |
11 |
77,864,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Sez6
|
UTSW |
11 |
77,868,648 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6279:Sez6
|
UTSW |
11 |
77,867,367 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6300:Sez6
|
UTSW |
11 |
77,867,367 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6475:Sez6
|
UTSW |
11 |
77,864,670 (GRCm39) |
|
|
|
|
R6722:Sez6
|
UTSW |
11 |
77,844,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Sez6
|
UTSW |
11 |
77,844,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6910:Sez6
|
UTSW |
11 |
77,844,695 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7012:Sez6
|
UTSW |
11 |
77,868,621 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7233:Sez6
|
UTSW |
11 |
77,863,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7265:Sez6
|
UTSW |
11 |
77,853,691 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7289:Sez6
|
UTSW |
11 |
77,865,149 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7405:Sez6
|
UTSW |
11 |
77,853,717 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7408:Sez6
|
UTSW |
11 |
77,844,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7485:Sez6
|
UTSW |
11 |
77,864,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7592:Sez6
|
UTSW |
11 |
77,868,876 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7778:Sez6
|
UTSW |
11 |
77,865,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Sez6
|
UTSW |
11 |
77,867,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7824:Sez6
|
UTSW |
11 |
77,865,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Sez6
|
UTSW |
11 |
77,844,668 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8008:Sez6
|
UTSW |
11 |
77,864,082 (GRCm39) |
nonsense |
probably null |
|
|
R8840:Sez6
|
UTSW |
11 |
77,867,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8947:Sez6
|
UTSW |
11 |
77,844,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Sez6
|
UTSW |
11 |
77,865,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9040:Sez6
|
UTSW |
11 |
77,864,762 (GRCm39) |
missense |
probably benign |
|
|
R9081:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9082:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9092:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9094:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9095:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9097:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9169:Sez6
|
UTSW |
11 |
77,868,473 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9513:Sez6
|
UTSW |
11 |
77,865,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9630:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9632:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9646:Sez6
|
UTSW |
11 |
77,867,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9709:Sez6
|
UTSW |
11 |
77,865,121 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
X0013:Sez6
|
UTSW |
11 |
77,845,606 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0067:Sez6
|
UTSW |
11 |
77,865,264 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1088:Sez6
|
UTSW |
11 |
77,864,023 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTCTTGTCTACCATAGGCAGC -3'
(R):5'- TGCTGACTCTACCGTGATGC -3'
Sequencing Primer
(F):5'- CTTGTCTACCATAGGCAGCTAATGG -3'
(R):5'- ATGAGTTCGGGGAAGTTGCAG -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation