Incidental Mutation 'R7797:Naa15'
ID 600264
Institutional Source Beutler Lab
Gene Symbol Naa15
Ensembl Gene ENSMUSG00000063273
Gene Name N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms Narg1, 5730450D16Rik, ASTBDN, Tbdn-1, tubedown, mNAT1
MMRRC Submission 045853-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R7797 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 51323437-51383406 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 51356031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 322 (C322Y)
Ref Sequence ENSEMBL: ENSMUSP00000029303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029303] [ENSMUST00000193266]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000029303
AA Change: C322Y

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000029303
Gene: ENSMUSG00000063273
AA Change: C322Y

DomainStartEndE-ValueType
TPR 46 79 6.24e1 SMART
TPR 80 113 1.01e0 SMART
Blast:TPR 224 257 3e-12 BLAST
TPR 374 407 1.87e1 SMART
TPR 408 441 5.06e1 SMART
low complexity region 603 641 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000192197
Predicted Effect probably damaging
Transcript: ENSMUST00000193266
AA Change: C272Y

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000141433
Gene: ENSMUSG00000063273
AA Change: C272Y

DomainStartEndE-ValueType
Blast:TPR 1 29 3e-10 BLAST
TPR 30 63 4.9e-3 SMART
Blast:TPR 174 207 3e-12 BLAST
TPR 324 357 8.9e-2 SMART
TPR 358 391 2.4e-1 SMART
coiled coil region 533 585 N/A INTRINSIC
Blast:TPR 622 655 7e-10 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (68/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A G 11: 109,862,509 (GRCm39) probably null Het
Adam3 T G 8: 25,184,660 (GRCm39) N535T probably damaging Het
Adam34l T A 8: 44,079,411 (GRCm39) E271V probably benign Het
Adamts4 A G 1: 171,085,387 (GRCm39) K679E probably damaging Het
Arnt G A 3: 95,387,572 (GRCm39) probably null Het
Asah2 A G 19: 31,999,761 (GRCm39) F321L probably damaging Het
Asb15 T C 6: 24,562,505 (GRCm39) S156P probably damaging Het
Baiap2l1 A C 5: 144,255,760 (GRCm39) S65A probably damaging Het
Bend7 T G 2: 4,754,455 (GRCm39) M186R probably damaging Het
Blnk T C 19: 40,948,232 (GRCm39) K146E possibly damaging Het
Cd19 A G 7: 126,012,680 (GRCm39) W238R probably damaging Het
Cd44 T A 2: 102,679,079 (GRCm39) N241I probably benign Het
Cdh23 T C 10: 60,220,973 (GRCm39) E1257G probably benign Het
Cfap300 G T 9: 8,027,130 (GRCm39) P136Q possibly damaging Het
Cntnap5c T C 17: 58,666,270 (GRCm39) V1100A probably benign Het
Cul7 T C 17: 46,969,568 (GRCm39) V945A possibly damaging Het
Dock2 C T 11: 34,232,652 (GRCm39) C1116Y probably damaging Het
Ehbp1 T C 11: 22,046,109 (GRCm39) M547V possibly damaging Het
Fam50b G A 13: 34,931,084 (GRCm39) E187K possibly damaging Het
Grhl3 C G 4: 135,286,416 (GRCm39) K88N possibly damaging Het
Hbb-y T A 7: 103,501,088 (GRCm39) Y146F probably damaging Het
Hivep2 T C 10: 14,005,847 (GRCm39) V815A probably benign Het
Hoxa7 T A 6: 52,192,870 (GRCm39) I173F probably damaging Het
Igkv1-110 T G 6: 68,247,977 (GRCm39) S29A probably benign Het
Jade2 A G 11: 51,708,126 (GRCm39) S696P probably benign Het
Kif1b T A 4: 149,321,844 (GRCm39) Q1025L probably benign Het
Kif2c A T 4: 117,028,940 (GRCm39) C241S probably benign Het
Kmt2d G T 15: 98,762,287 (GRCm39) H400N probably benign Het
Krt35 T A 11: 99,985,713 (GRCm39) N174Y probably damaging Het
Ldlrad1 G A 4: 107,066,688 (GRCm39) A8T probably benign Het
Magi3 A G 3: 103,958,618 (GRCm39) V489A probably damaging Het
Mapk7 T C 11: 61,380,241 (GRCm39) E739G possibly damaging Het
Mcidas G A 13: 113,135,521 (GRCm39) G315S probably damaging Het
Mdga1 C T 17: 30,061,814 (GRCm39) probably null Het
Megf8 G A 7: 25,034,022 (GRCm39) R607H probably damaging Het
Met T A 6: 17,533,952 (GRCm39) N634K probably damaging Het
Miip C T 4: 147,947,375 (GRCm39) G236S probably benign Het
Mmp11 G T 10: 75,759,314 (GRCm39) T107K Het
Mroh2b A C 15: 4,978,587 (GRCm39) N1378H probably benign Het
Naip1 T A 13: 100,580,986 (GRCm39) Y87F probably damaging Het
Ngrn A G 7: 79,914,185 (GRCm39) D112G probably benign Het
Osbpl1a C A 18: 13,015,321 (GRCm39) C369F probably damaging Het
Pcnx2 G C 8: 126,512,087 (GRCm39) D1406E possibly damaging Het
Phf8-ps T C 17: 33,286,664 (GRCm39) D46G probably damaging Het
Pold1 G A 7: 44,191,213 (GRCm39) P206L probably benign Het
Psen1 A G 12: 83,746,396 (GRCm39) S20G probably benign Het
Ptpn23 C T 9: 110,222,875 (GRCm39) D61N possibly damaging Het
Rbfox3 A T 11: 118,387,310 (GRCm39) L268Q possibly damaging Het
Rbm22 A G 18: 60,694,344 (GRCm39) T26A probably damaging Het
Rpgrip1 G A 14: 52,371,277 (GRCm39) R332Q possibly damaging Het
Rrm2b A T 15: 37,927,505 (GRCm39) L347* probably null Het
Rsf1 A T 7: 97,310,692 (GRCm39) D474V Het
Ryr2 C T 13: 11,816,066 (GRCm39) R640Q probably damaging Het
Sec16b A G 1: 157,389,245 (GRCm39) E691G unknown Het
Septin1 A T 7: 126,813,937 (GRCm39) V365E unknown Het
Tlk2 A G 11: 105,101,444 (GRCm39) H114R probably benign Het
Tmem200a A G 10: 25,869,864 (GRCm39) I135T possibly damaging Het
Tpst2 T A 5: 112,455,782 (GRCm39) V107E probably damaging Het
Trim30a A T 7: 104,060,407 (GRCm39) D456E possibly damaging Het
Ttll3 T C 6: 113,371,738 (GRCm39) V45A possibly damaging Het
Ulk2 A G 11: 61,672,928 (GRCm39) Y889H probably benign Het
Umodl1 A G 17: 31,178,125 (GRCm39) S34G probably benign Het
Vmn1r67 A G 7: 10,180,903 (GRCm39) I56V probably benign Het
Vmn2r120 C T 17: 57,815,874 (GRCm39) G827E probably damaging Het
Zc3h6 T C 2: 128,857,555 (GRCm39) probably null Het
Other mutations in Naa15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Naa15 APN 3 51,345,826 (GRCm39) missense probably damaging 1.00
IGL01753:Naa15 APN 3 51,350,274 (GRCm39) missense probably damaging 1.00
IGL01837:Naa15 APN 3 51,351,369 (GRCm39) nonsense probably null
IGL02619:Naa15 APN 3 51,367,552 (GRCm39) missense probably benign 0.03
IGL02691:Naa15 APN 3 51,358,747 (GRCm39) missense probably damaging 0.97
IGL02974:Naa15 APN 3 51,368,628 (GRCm39) missense possibly damaging 0.95
R0009:Naa15 UTSW 3 51,377,640 (GRCm39) missense probably damaging 1.00
R0010:Naa15 UTSW 3 51,343,634 (GRCm39) critical splice acceptor site probably null
R0114:Naa15 UTSW 3 51,355,859 (GRCm39) critical splice donor site probably null
R0411:Naa15 UTSW 3 51,373,060 (GRCm39) missense possibly damaging 0.81
R1348:Naa15 UTSW 3 51,373,091 (GRCm39) missense probably damaging 1.00
R1941:Naa15 UTSW 3 51,363,355 (GRCm39) nonsense probably null
R3082:Naa15 UTSW 3 51,367,471 (GRCm39) missense probably damaging 1.00
R4377:Naa15 UTSW 3 51,355,786 (GRCm39) missense possibly damaging 0.91
R4591:Naa15 UTSW 3 51,349,345 (GRCm39) missense probably damaging 1.00
R4980:Naa15 UTSW 3 51,366,173 (GRCm39) critical splice donor site probably null
R5087:Naa15 UTSW 3 51,364,706 (GRCm39) splice site probably null
R5139:Naa15 UTSW 3 51,351,261 (GRCm39) missense probably damaging 1.00
R5289:Naa15 UTSW 3 51,363,315 (GRCm39) missense probably damaging 1.00
R5527:Naa15 UTSW 3 51,349,368 (GRCm39) missense probably damaging 1.00
R5776:Naa15 UTSW 3 51,367,447 (GRCm39) missense probably damaging 0.96
R5909:Naa15 UTSW 3 51,367,485 (GRCm39) missense probably damaging 1.00
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6034:Naa15 UTSW 3 51,350,242 (GRCm39) missense probably damaging 0.98
R6194:Naa15 UTSW 3 51,370,721 (GRCm39) missense probably benign 0.00
R6291:Naa15 UTSW 3 51,350,212 (GRCm39) missense probably damaging 1.00
R6522:Naa15 UTSW 3 51,378,935 (GRCm39) missense probably damaging 1.00
R6731:Naa15 UTSW 3 51,363,294 (GRCm39) missense probably damaging 1.00
R6984:Naa15 UTSW 3 51,380,021 (GRCm39) missense probably benign 0.10
R7040:Naa15 UTSW 3 51,380,205 (GRCm39) missense possibly damaging 0.89
R7091:Naa15 UTSW 3 51,366,177 (GRCm39) splice site probably null
R7380:Naa15 UTSW 3 51,367,268 (GRCm39) splice site probably null
R7685:Naa15 UTSW 3 51,377,395 (GRCm39) splice site probably null
R7781:Naa15 UTSW 3 51,378,904 (GRCm39) critical splice acceptor site probably null
R7836:Naa15 UTSW 3 51,370,688 (GRCm39) nonsense probably null
R7981:Naa15 UTSW 3 51,366,092 (GRCm39) missense probably damaging 0.96
R8513:Naa15 UTSW 3 51,367,444 (GRCm39) missense probably damaging 0.99
R8923:Naa15 UTSW 3 51,367,443 (GRCm39) missense probably damaging 1.00
R9159:Naa15 UTSW 3 51,358,802 (GRCm39) missense probably benign 0.01
R9701:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
R9802:Naa15 UTSW 3 51,349,370 (GRCm39) nonsense probably null
X0020:Naa15 UTSW 3 51,377,553 (GRCm39) missense probably benign 0.00
X0061:Naa15 UTSW 3 51,356,022 (GRCm39) missense probably benign 0.11
X0061:Naa15 UTSW 3 51,356,021 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCTGGACTAAATACCCCAG -3'
(R):5'- TCAGTAAAGCACCGAAGAGC -3'

Sequencing Primer
(F):5'- AGGCTGCCCTTAAACTTTTTATCTGG -3'
(R):5'- CAGACTACAAATGGAAAAGGGTACAC -3'
Posted On 2019-11-26