Incidental Mutation 'R7798:Or4f6'
ID 600332
Institutional Source Beutler Lab
Gene Symbol Or4f6
Ensembl Gene ENSMUSG00000108827
Gene Name olfactory receptor family 4 subfamily F member 6
Synonyms Olfr1310, MOR245-3, GA_x6K02T2Q125-73056609-73055671
MMRRC Submission 045648-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R7798 (G1)
Quality Score 209.009
Status Not validated
Chromosome 2
Chromosomal Location 111838591-111839529 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111838617 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 305 (F305L)
Ref Sequence ENSEMBL: ENSMUSP00000149701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207169] [ENSMUST00000213559]
AlphaFold Q8VF85
Predicted Effect probably benign
Transcript: ENSMUST00000207169
AA Change: F305L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000213559
AA Change: F305L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700088E04Rik T A 15: 79,019,932 (GRCm39) N128I probably damaging Het
Abca13 A G 11: 9,241,664 (GRCm39) T1176A probably benign Het
Abca9 A G 11: 110,029,005 (GRCm39) V851A probably benign Het
Abcc6 C A 7: 45,626,277 (GRCm39) E1494* probably null Het
Adamts14 A T 10: 61,106,952 (GRCm39) V56E probably damaging Het
Adamts15 G A 9: 30,815,939 (GRCm39) T639M probably damaging Het
Albfm1 T C 5: 90,745,370 (GRCm39) S608P possibly damaging Het
Arhgap11a A C 2: 113,673,680 (GRCm39) V70G probably damaging Het
BC051665 A T 13: 60,932,249 (GRCm39) D113E probably benign Het
Best1 T C 19: 9,969,035 (GRCm39) Y227C probably damaging Het
Camk2b A G 11: 5,928,399 (GRCm39) S447P probably benign Het
Ccdc88a C A 11: 29,427,348 (GRCm39) Q1018K probably benign Het
Cdhr17 T C 5: 17,061,656 (GRCm39) F801L possibly damaging Het
Cfap74 T A 4: 155,507,079 (GRCm39) V180D Het
Clca3a1 T A 3: 144,463,723 (GRCm39) T185S probably damaging Het
Clca3b T C 3: 144,533,891 (GRCm39) S495G probably damaging Het
Cyb5r2 A T 7: 107,353,155 (GRCm39) Y96N possibly damaging Het
Cyp21a1 T C 17: 35,023,295 (GRCm39) K27E probably benign Het
Cyp2ab1 T C 16: 20,131,166 (GRCm39) E321G probably benign Het
Des T C 1: 75,339,003 (GRCm39) I228T probably damaging Het
Dis3l G T 9: 64,248,299 (GRCm39) P39T probably benign Het
Disp2 A C 2: 118,622,360 (GRCm39) I1031L probably benign Het
Ell3 TCTCCTC TCTC 2: 121,269,937 (GRCm39) probably benign Het
Etl4 G A 2: 20,786,757 (GRCm39) probably null Het
Fgf23 A T 6: 127,050,177 (GRCm39) D62V probably damaging Het
Galnt15 C T 14: 31,751,862 (GRCm39) T138I possibly damaging Het
Ggt6 A T 11: 72,326,367 (GRCm39) probably benign Het
Gpr180 T A 14: 118,391,098 (GRCm39) V209D probably damaging Het
Gzma A T 13: 113,232,858 (GRCm39) F78Y probably benign Het
Igkv8-30 A T 6: 70,094,355 (GRCm39) C19S probably benign Het
Il1r1 G A 1: 40,349,526 (GRCm39) V361I probably benign Het
Intu T C 3: 40,646,359 (GRCm39) V598A probably damaging Het
Itpr2 A G 6: 146,287,513 (GRCm39) F471L probably benign Het
Kntc1 T A 5: 123,924,357 (GRCm39) V1081E probably benign Het
Kntc1 T A 5: 123,957,180 (GRCm39) V2163E possibly damaging Het
Macf1 T C 4: 123,271,893 (GRCm39) K6552E probably damaging Het
Marf1 T C 16: 13,956,315 (GRCm39) H842R probably benign Het
Mgat4b A G 11: 50,116,497 (GRCm39) T10A possibly damaging Het
Muc21 C G 17: 35,932,146 (GRCm39) G680A unknown Het
Muc5ac T C 7: 141,347,778 (GRCm39) probably null Het
Nrk CGCAGCAGCAGCAGCAGCAGC CGCAGCAGCAGCAGCAGC X: 137,883,426 (GRCm39) probably benign Het
Nsun4 T G 4: 115,908,371 (GRCm39) S730R possibly damaging Het
Or12e1 A T 2: 87,022,636 (GRCm39) I202L probably benign Het
Or12k7 A T 2: 36,959,186 (GRCm39) S290C probably damaging Het
Or1n1 T C 2: 36,750,348 (GRCm39) E4G probably benign Het
Or4k15 A T 14: 50,364,895 (GRCm39) Y287F probably damaging Het
Padi3 C T 4: 140,513,750 (GRCm39) E653K probably benign Het
Pde4a A G 9: 21,109,959 (GRCm39) E280G possibly damaging Het
Phactr3 G A 2: 177,925,703 (GRCm39) R326H probably benign Het
Prob1 G A 18: 35,786,397 (GRCm39) P619L possibly damaging Het
Ptk2 G A 15: 73,167,224 (GRCm39) R368W probably damaging Het
Rgs6 A G 12: 83,116,293 (GRCm39) T240A probably benign Het
Rpa1 A T 11: 75,203,635 (GRCm39) Y356N probably damaging Het
Rxrb T A 17: 34,252,579 (GRCm39) D165E probably damaging Het
Sco1 A G 11: 66,944,628 (GRCm39) T84A possibly damaging Het
Sepsecs T C 5: 52,804,531 (GRCm39) I380V probably benign Het
Sfmbt1 T A 14: 30,538,759 (GRCm39) W793R probably damaging Het
Slco3a1 A G 7: 73,968,344 (GRCm39) S459P probably benign Het
Smg1 A T 7: 117,771,162 (GRCm39) S1503R possibly damaging Het
Sox2 G A 3: 34,704,791 (GRCm39) R76H probably damaging Het
Spty2d1 G A 7: 46,645,804 (GRCm39) S613F probably damaging Het
Stab2 A T 10: 86,793,776 (GRCm39) Y440N probably damaging Het
Syn3 A G 10: 85,916,117 (GRCm39) Y290H probably damaging Het
Tex15 C T 8: 34,071,875 (GRCm39) S2474F possibly damaging Het
Tgtp1 A G 11: 48,878,159 (GRCm39) F182S probably benign Het
Tmcc1 A T 6: 116,020,539 (GRCm39) S304R Het
Tmem130 T G 5: 144,680,580 (GRCm39) K275Q probably damaging Het
Tmem9 C A 1: 135,961,927 (GRCm39) T174K probably damaging Het
Ttyh3 C T 5: 140,620,538 (GRCm39) R233Q probably damaging Het
Tut7 A T 13: 59,963,389 (GRCm39) M323K possibly damaging Het
Twnk T C 19: 44,996,107 (GRCm39) M180T probably benign Het
Ube4a A G 9: 44,844,629 (GRCm39) V874A probably damaging Het
Ugt2a3 T C 5: 87,475,582 (GRCm39) N350S probably damaging Het
Vegfa C T 17: 46,342,761 (GRCm39) G19D probably damaging Het
Vmn2r2 C A 3: 64,041,518 (GRCm39) C399F possibly damaging Het
Vmn2r65 G T 7: 84,595,530 (GRCm39) P385T probably benign Het
Vmn2r65 A G 7: 84,596,192 (GRCm39) F164S probably damaging Het
Other mutations in Or4f6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01947:Or4f6 APN 2 111,839,361 (GRCm39) missense possibly damaging 0.86
IGL02700:Or4f6 APN 2 111,839,036 (GRCm39) missense probably benign 0.04
IGL03008:Or4f6 APN 2 111,838,868 (GRCm39) missense possibly damaging 0.95
IGL03121:Or4f6 APN 2 111,838,953 (GRCm39) missense probably benign 0.02
R0025:Or4f6 UTSW 2 111,839,365 (GRCm39) missense probably damaging 0.98
R1624:Or4f6 UTSW 2 111,838,877 (GRCm39) missense probably damaging 1.00
R1851:Or4f6 UTSW 2 111,839,036 (GRCm39) missense probably benign 0.04
R3872:Or4f6 UTSW 2 111,838,668 (GRCm39) missense possibly damaging 0.95
R3873:Or4f6 UTSW 2 111,838,668 (GRCm39) missense possibly damaging 0.95
R3874:Or4f6 UTSW 2 111,838,668 (GRCm39) missense possibly damaging 0.95
R4651:Or4f6 UTSW 2 111,838,595 (GRCm39) missense probably damaging 1.00
R4652:Or4f6 UTSW 2 111,838,595 (GRCm39) missense probably damaging 1.00
R4834:Or4f6 UTSW 2 111,839,276 (GRCm39) missense probably damaging 1.00
R5076:Or4f6 UTSW 2 111,838,937 (GRCm39) missense probably damaging 0.99
R7262:Or4f6 UTSW 2 111,838,902 (GRCm39) missense probably damaging 1.00
R7339:Or4f6 UTSW 2 111,838,820 (GRCm39) missense probably damaging 1.00
R7657:Or4f6 UTSW 2 111,839,093 (GRCm39) missense probably benign 0.02
R7875:Or4f6 UTSW 2 111,839,192 (GRCm39) missense probably benign 0.32
R8869:Or4f6 UTSW 2 111,838,596 (GRCm39) missense possibly damaging 0.88
R9689:Or4f6 UTSW 2 111,839,124 (GRCm39) missense probably benign 0.29
X0027:Or4f6 UTSW 2 111,839,169 (GRCm39) missense probably damaging 1.00
Z1176:Or4f6 UTSW 2 111,838,802 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTAGCTGGTAATTTCACTCTAG -3'
(R):5'- GGTAGTTTAGGTAAGGCCCTCTC -3'

Sequencing Primer
(F):5'- AGCTGGTAATTTCACTCTAGTTTTG -3'
(R):5'- AGGTAAGGCCCTCTCCACTTTG -3'
Posted On 2019-11-26