Incidental Mutation 'R7799:Vmn2r24'
| ID |
600432 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r24
|
| Ensembl Gene |
ENSMUSG00000072780 |
| Gene Name |
vomeronasal 2, receptor 24 |
| Synonyms |
EG243628 |
| MMRRC Submission |
045854-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R7799 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 123757422 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Tyrosine
at position 97
(H97Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
| AlphaFold |
D3YUI0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075095
AA Change: H97Y
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: H97Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
98% (50/51) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
C |
3: 137,775,362 (GRCm39) |
V1517A |
probably benign |
Het |
| Adam17 |
C |
A |
12: 21,390,493 (GRCm39) |
G410C |
probably damaging |
Het |
| Adcy3 |
A |
G |
12: 4,254,762 (GRCm39) |
D698G |
probably damaging |
Het |
| Afap1 |
T |
A |
5: 36,131,742 (GRCm39) |
N356K |
possibly damaging |
Het |
| Afm |
A |
G |
5: 90,671,713 (GRCm39) |
N132D |
probably benign |
Het |
| Bsdc1 |
T |
A |
4: 129,359,141 (GRCm39) |
|
probably null |
Het |
| Ccdc121rt2 |
T |
G |
5: 112,597,698 (GRCm39) |
Y82D |
not run |
Het |
| Ccdc47 |
T |
C |
11: 106,101,143 (GRCm39) |
E173G |
possibly damaging |
Het |
| Cit |
T |
G |
5: 116,001,027 (GRCm39) |
F142C |
probably benign |
Het |
| Cnga3 |
A |
G |
1: 37,300,852 (GRCm39) |
D524G |
probably damaging |
Het |
| Cpne8 |
T |
A |
15: 90,424,450 (GRCm39) |
D313V |
probably damaging |
Het |
| Ell3 |
TCTCCTC |
TCTC |
2: 121,269,937 (GRCm39) |
|
probably benign |
Het |
| Flrt1 |
C |
A |
19: 7,073,229 (GRCm39) |
L439F |
possibly damaging |
Het |
| Gkn1 |
A |
T |
6: 87,325,163 (GRCm39) |
I82N |
probably damaging |
Het |
| Gm14410 |
C |
A |
2: 176,885,613 (GRCm39) |
C217F |
probably damaging |
Het |
| Gm14412 |
G |
T |
2: 177,007,590 (GRCm39) |
H102N |
probably benign |
Het |
| Gm3159 |
A |
T |
14: 4,397,585 (GRCm38) |
|
probably benign |
Het |
| Golm2 |
T |
C |
2: 121,764,022 (GRCm39) |
V434A |
probably benign |
Het |
| Helz2 |
A |
G |
2: 180,879,782 (GRCm39) |
M612T |
probably benign |
Het |
| Iars1 |
T |
A |
13: 49,876,494 (GRCm39) |
I853N |
probably damaging |
Het |
| Kcna4 |
A |
C |
2: 107,126,237 (GRCm39) |
I324L |
possibly damaging |
Het |
| Kcnh1 |
T |
C |
1: 192,117,183 (GRCm39) |
S690P |
probably damaging |
Het |
| Kpna3 |
T |
C |
14: 61,622,182 (GRCm39) |
Y194C |
probably damaging |
Het |
| Lrrc56 |
T |
C |
7: 140,789,515 (GRCm39) |
S511P |
probably damaging |
Het |
| Ltbp1 |
A |
G |
17: 75,559,351 (GRCm39) |
Y280C |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,420,906 (GRCm39) |
I116T |
probably benign |
Het |
| Mmp16 |
A |
T |
4: 18,112,112 (GRCm39) |
N496I |
probably damaging |
Het |
| Mon2 |
T |
C |
10: 122,878,236 (GRCm39) |
D229G |
probably benign |
Het |
| Or2b2 |
T |
A |
13: 21,887,369 (GRCm39) |
L66Q |
probably damaging |
Het |
| Or2j6 |
A |
T |
7: 139,980,377 (GRCm39) |
M194K |
probably damaging |
Het |
| Or52s1 |
A |
G |
7: 102,861,186 (GRCm39) |
I40V |
probably benign |
Het |
| Or5p61 |
T |
A |
7: 107,758,637 (GRCm39) |
I148F |
probably benign |
Het |
| Or5w14 |
G |
T |
2: 87,541,428 (GRCm39) |
T274K |
possibly damaging |
Het |
| Pkp1 |
A |
G |
1: 135,817,695 (GRCm39) |
F147L |
possibly damaging |
Het |
| Ppp1r3e |
T |
C |
14: 55,114,672 (GRCm39) |
Q30R |
probably damaging |
Het |
| Ppp2r5b |
C |
A |
19: 6,282,628 (GRCm39) |
R174L |
probably benign |
Het |
| Pramel58 |
A |
G |
5: 94,831,287 (GRCm39) |
D98G |
possibly damaging |
Het |
| Qrfprl |
G |
T |
6: 65,433,121 (GRCm39) |
A314S |
possibly damaging |
Het |
| Rbm15 |
C |
T |
3: 107,239,459 (GRCm39) |
R313H |
probably damaging |
Het |
| Rgs18 |
A |
G |
1: 144,629,603 (GRCm39) |
F219L |
probably damaging |
Het |
| Ryr1 |
T |
C |
7: 28,702,985 (GRCm39) |
|
probably null |
Het |
| Sirpd |
T |
A |
3: 15,361,723 (GRCm39) |
|
probably null |
Het |
| Sirt4 |
T |
G |
5: 115,617,805 (GRCm39) |
I284L |
probably benign |
Het |
| Slc25a11 |
A |
G |
11: 70,536,005 (GRCm39) |
V243A |
probably benign |
Het |
| Syde1 |
A |
G |
10: 78,425,741 (GRCm39) |
I142T |
probably benign |
Het |
| Synj2 |
A |
G |
17: 6,088,098 (GRCm39) |
E1383G |
probably benign |
Het |
| Syt4 |
A |
T |
18: 31,573,245 (GRCm39) |
C423* |
probably null |
Het |
| Tfr2 |
T |
A |
5: 137,569,986 (GRCm39) |
Y131N |
possibly damaging |
Het |
| Tgm1 |
C |
T |
14: 55,949,932 (GRCm39) |
R92Q |
unknown |
Het |
| Thoc1 |
A |
T |
18: 9,984,441 (GRCm39) |
D309V |
probably damaging |
Het |
| Wbp1 |
A |
T |
6: 83,097,176 (GRCm39) |
Y89* |
probably null |
Het |
| Wnk1 |
A |
G |
6: 119,926,137 (GRCm39) |
L1358P |
probably benign |
Het |
| Zfp14 |
T |
C |
7: 29,738,368 (GRCm39) |
T206A |
possibly damaging |
Het |
| Zfp748 |
T |
C |
13: 67,689,608 (GRCm39) |
T551A |
probably benign |
Het |
| Zfp9 |
A |
T |
6: 118,441,843 (GRCm39) |
V273E |
probably damaging |
Het |
|
| Other mutations in Vmn2r24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2035:Vmn2r24
|
UTSW |
6 |
123,793,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3236:Vmn2r24
|
UTSW |
6 |
123,755,984 (GRCm39) |
nonsense |
probably null |
|
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5790:Vmn2r24
|
UTSW |
6 |
123,792,499 (GRCm39) |
missense |
probably benign |
|
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6864:Vmn2r24
|
UTSW |
6 |
123,756,117 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7646:Vmn2r24
|
UTSW |
6 |
123,793,169 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7803:Vmn2r24
|
UTSW |
6 |
123,757,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATGGGAGGAGCTGCATGTA -3'
(R):5'- TGTAGAGACTTAAAACTCGGGAGATC -3'
Sequencing Primer
(F):5'- TGGGAGGAGCTGCATGTAGAAAAG -3'
(R):5'- GGATATTGATGTTGAAATGCCTCC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation