Incidental Mutation 'R7801:Ighg3'
ID600545
Institutional Source Beutler Lab
Gene Symbol Ighg3
Ensembl Gene ENSMUSG00000076615
Gene NameImmunoglobulin heavy constant gamma 3
SynonymsAI324046, IgG3
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #R7801 (G1)
Quality Score225.009
Status Validated
Chromosome12
Chromosomal Location113359575-113361232 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 113359816 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 280 (L280Q)
Gene Model predicted gene model for transcript(s):
Predicted Effect
SMART Domains Protein: ENSMUSP00000100219
Gene: ENSMUSG00000076615
AA Change: L280Q

DomainStartEndE-ValueType
IGc1 22 92 3.42e-20 SMART
low complexity region 102 114 N/A INTRINSIC
IG_like 139 214 5.06e-3 SMART
IGc1 245 318 2.9e-32 SMART
Predicted Effect
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agap1 A G 1: 89,630,485 Y165C probably damaging Het
Agbl3 A T 6: 34,839,365 T742S probably benign Het
Arhgef10l T C 4: 140,544,267 T651A probably benign Het
Arsb T A 13: 93,862,327 I381N probably damaging Het
Blzf1 A G 1: 164,295,909 V283A probably benign Het
C130060K24Rik T A 6: 65,441,217 V123D probably damaging Het
Cadps C T 14: 12,489,476 probably null Het
Casz1 A T 4: 148,938,249 T591S probably damaging Het
Ccne2 T C 4: 11,194,079 probably null Het
Chst9 T C 18: 15,452,277 T410A probably benign Het
Ciart G A 3: 95,881,344 P61L probably damaging Het
Fam234a T C 17: 26,218,198 D169G probably benign Het
Fat1 C T 8: 45,042,223 P4116L probably damaging Het
Fbxo21 G T 5: 117,986,124 A166S probably damaging Het
Gbf1 A G 19: 46,272,643 I1216V probably benign Het
Gper1 G A 5: 139,426,688 A263T probably benign Het
Hdlbp G T 1: 93,430,307 probably null Het
Impa1 T C 3: 10,321,667 T171A probably benign Het
Ints7 T A 1: 191,615,747 Y744N possibly damaging Het
Irgc1 G T 7: 24,432,534 A286D probably damaging Het
Kif18a T C 2: 109,287,845 S2P probably damaging Het
Macf1 A T 4: 123,408,271 W813R probably damaging Het
Mapkbp1 T G 2: 120,012,073 H157Q probably damaging Het
Mfsd4b2 T A 10: 39,923,781 M42L probably benign Het
Mon2 A G 10: 123,059,186 probably null Het
Myrfl T A 10: 116,848,335 H161L probably benign Het
Olfr171 T C 16: 19,624,623 H159R probably damaging Het
Olfr832 A C 9: 18,945,259 S204R probably damaging Het
Phlpp2 T G 8: 109,925,842 V606G possibly damaging Het
Psmb5 T C 14: 54,616,755 T89A probably benign Het
Ptpn9 A G 9: 57,061,013 T546A probably benign Het
Rabep2 A G 7: 126,438,412 M146V possibly damaging Het
Rptn G A 3: 93,398,224 E955K possibly damaging Het
Samd3 G T 10: 26,263,872 V301F possibly damaging Het
Sh2b1 C A 7: 126,471,292 C380F probably benign Het
Shank1 A G 7: 44,351,598 M914V unknown Het
Sox2 G A 3: 34,650,642 R76H probably damaging Het
Stat5a T C 11: 100,880,317 F574S probably damaging Het
Tbx5 A G 5: 119,836,999 E29G probably benign Het
Trpm5 A C 7: 143,085,241 D264E probably damaging Het
Zfp442 T C 2: 150,409,719 S88G probably benign Het
Zfp62 T A 11: 49,217,328 F749I possibly damaging Het
Zfp677 T A 17: 21,398,015 S445T probably damaging Het
Zfp979 A C 4: 147,613,978 N91K probably damaging Het
Zfyve9 A G 4: 108,684,995 V209A possibly damaging Het
Zic4 G T 9: 91,384,244 A314S probably benign Het
Other mutations in Ighg3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00230:Ighg3 APN 12 113359837 missense unknown
IGL02641:Ighg3 APN 12 113360198 missense unknown
IGL03252:Ighg3 APN 12 113360564 missense unknown
R0630:Ighg3 UTSW 12 113360094 splice site probably benign
R4957:Ighg3 UTSW 12 113361130 missense unknown
R6407:Ighg3 UTSW 12 113360150 missense unknown
R6745:Ighg3 UTSW 12 113360270 missense unknown
R7824:Ighg3 UTSW 12 113359806 missense
R8075:Ighg3 UTSW 12 113357477 missense
R8076:Ighg3 UTSW 12 113360538 missense probably benign
Predicted Primers PCR Primer
(F):5'- GCTGGTATCAGTGTCTTGTAAGAC -3'
(R):5'- ACGACCTCTGTGTATGCTTC -3'

Sequencing Primer
(F):5'- TCTTGTAAGACCCGAGGAATGGC -3'
(R):5'- TGTATGCTTCTAACCCCACAGGAAG -3'
Posted On2019-11-26