Incidental Mutation 'R7803:Vmn2r24'
| ID |
600604 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r24
|
| Ensembl Gene |
ENSMUSG00000072780 |
| Gene Name |
vomeronasal 2, receptor 24 |
| Synonyms |
EG243628 |
| MMRRC Submission |
045858-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R7803 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 123757438 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 102
(M102K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
| AlphaFold |
D3YUI0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075095
AA Change: M102K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: M102K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
98% (49/50) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acta2 |
C |
A |
19: 34,220,818 (GRCm39) |
A297S |
probably benign |
Het |
| Ada |
A |
G |
2: 163,577,288 (GRCm39) |
Y67H |
probably benign |
Het |
| Adcy9 |
A |
G |
16: 4,122,244 (GRCm39) |
I839T |
probably benign |
Het |
| Arg1 |
C |
T |
10: 24,792,689 (GRCm39) |
V182I |
possibly damaging |
Het |
| Cbx7 |
G |
A |
15: 79,818,024 (GRCm39) |
T26M |
unknown |
Het |
| Ceacam5 |
A |
G |
7: 17,493,317 (GRCm39) |
Y780C |
probably damaging |
Het |
| Ces2h |
A |
G |
8: 105,745,032 (GRCm39) |
M389V |
probably benign |
Het |
| Chst11 |
A |
T |
10: 83,027,020 (GRCm39) |
E149V |
possibly damaging |
Het |
| Clstn1 |
T |
C |
4: 149,716,328 (GRCm39) |
W265R |
probably damaging |
Het |
| Col4a4 |
A |
G |
1: 82,467,419 (GRCm39) |
|
probably null |
Het |
| Csrp3 |
T |
G |
7: 48,483,545 (GRCm39) |
K119T |
probably benign |
Het |
| Ddx39a |
T |
C |
8: 84,446,229 (GRCm39) |
|
probably null |
Het |
| Ddx41 |
A |
G |
13: 55,679,734 (GRCm39) |
I437T |
probably damaging |
Het |
| Eif1ad4 |
T |
A |
12: 87,862,269 (GRCm39) |
C44S |
probably benign |
Het |
| Fbln5 |
A |
T |
12: 101,728,077 (GRCm39) |
D282E |
probably damaging |
Het |
| Folh1 |
G |
A |
7: 86,375,306 (GRCm39) |
T527I |
probably damaging |
Het |
| Gch1 |
T |
A |
14: 47,426,418 (GRCm39) |
T103S |
probably benign |
Het |
| Gpr149 |
A |
G |
3: 62,438,136 (GRCm39) |
S674P |
probably damaging |
Het |
| Hecw1 |
G |
T |
13: 14,408,927 (GRCm39) |
R1127S |
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,646,030 (GRCm39) |
C723S |
probably benign |
Het |
| Impg2 |
T |
C |
16: 56,087,513 (GRCm39) |
S1111P |
probably damaging |
Het |
| Insl3 |
T |
C |
8: 72,141,984 (GRCm39) |
L28P |
probably damaging |
Het |
| Kifc1 |
T |
C |
17: 34,103,714 (GRCm39) |
D203G |
probably benign |
Het |
| Kmt2d |
A |
T |
15: 98,760,804 (GRCm39) |
S849T |
unknown |
Het |
| Krt33b |
A |
G |
11: 99,916,084 (GRCm39) |
|
probably null |
Het |
| Lpin3 |
A |
G |
2: 160,737,310 (GRCm39) |
D119G |
possibly damaging |
Het |
| Maml2 |
AGC |
AGCCGC |
9: 13,532,550 (GRCm39) |
|
probably benign |
Het |
| Maml2 |
AGC |
AGCCGC |
9: 13,532,571 (GRCm39) |
|
probably benign |
Het |
| Maml2 |
GCA |
GCACCA |
9: 13,532,572 (GRCm39) |
|
probably benign |
Het |
| Nsun7 |
T |
A |
5: 66,433,884 (GRCm39) |
L178* |
probably null |
Het |
| Or6c1b |
A |
G |
10: 129,272,800 (GRCm39) |
N40D |
probably damaging |
Het |
| Or6c205 |
A |
T |
10: 129,086,864 (GRCm39) |
I154F |
probably benign |
Het |
| Or8g55 |
A |
T |
9: 39,785,378 (GRCm39) |
D269V |
probably benign |
Het |
| Orc6 |
T |
A |
8: 86,030,037 (GRCm39) |
S136T |
possibly damaging |
Het |
| Peg10 |
CATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAGGATC |
CATC |
6: 4,756,431 (GRCm39) |
|
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,779,377 (GRCm39) |
|
probably null |
Het |
| Prkdc |
G |
A |
16: 15,623,960 (GRCm39) |
D3308N |
probably null |
Het |
| Rtkn2 |
G |
A |
10: 67,815,643 (GRCm39) |
|
probably null |
Het |
| Sele |
T |
C |
1: 163,878,263 (GRCm39) |
S201P |
possibly damaging |
Het |
| Shq1 |
A |
G |
6: 100,648,006 (GRCm39) |
F6S |
probably damaging |
Het |
| Sparc |
A |
T |
11: 55,300,797 (GRCm39) |
I5N |
probably damaging |
Het |
| Spata31e3 |
A |
G |
13: 50,400,226 (GRCm39) |
V700A |
probably benign |
Het |
| Srm |
T |
C |
4: 148,678,402 (GRCm39) |
I238T |
probably damaging |
Het |
| Stx2 |
C |
A |
5: 129,070,627 (GRCm39) |
E97* |
probably null |
Het |
| Sugp2 |
C |
T |
8: 70,704,722 (GRCm39) |
P753L |
probably benign |
Het |
| Tenm2 |
A |
T |
11: 35,937,943 (GRCm39) |
S1578T |
probably damaging |
Het |
| Tff3 |
T |
C |
17: 31,348,544 (GRCm39) |
T3A |
probably benign |
Het |
| Tmem38a |
C |
T |
8: 73,325,964 (GRCm39) |
A6V |
probably benign |
Het |
| Trbv16 |
G |
A |
6: 41,128,929 (GRCm39) |
A38T |
not run |
Het |
| Trim30a |
G |
A |
7: 104,060,604 (GRCm39) |
Q391* |
probably null |
Het |
| Ttn |
T |
G |
2: 76,606,715 (GRCm39) |
Y18065S |
probably damaging |
Het |
| Ubr5 |
G |
A |
15: 37,980,076 (GRCm39) |
A2434V |
probably null |
Het |
| Vmn2r69 |
G |
T |
7: 85,056,324 (GRCm39) |
H605N |
probably benign |
Het |
| Washc1 |
T |
A |
17: 66,426,055 (GRCm39) |
M451K |
possibly damaging |
Het |
| Washc3 |
G |
T |
10: 88,051,937 (GRCm39) |
|
probably null |
Het |
| Washc5 |
A |
T |
15: 59,240,308 (GRCm39) |
Y112N |
probably damaging |
Het |
| Zbtb40 |
T |
A |
4: 136,744,638 (GRCm39) |
T261S |
probably benign |
Het |
|
| Other mutations in Vmn2r24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2035:Vmn2r24
|
UTSW |
6 |
123,793,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3236:Vmn2r24
|
UTSW |
6 |
123,755,984 (GRCm39) |
nonsense |
probably null |
|
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5790:Vmn2r24
|
UTSW |
6 |
123,792,499 (GRCm39) |
missense |
probably benign |
|
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6864:Vmn2r24
|
UTSW |
6 |
123,756,117 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7646:Vmn2r24
|
UTSW |
6 |
123,793,169 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7799:Vmn2r24
|
UTSW |
6 |
123,757,422 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATGGGAGGAGCTGCATGTA -3'
(R):5'- TAGAGACTTAAAACTCGGGAGATC -3'
Sequencing Primer
(F):5'- TGGGAGGAGCTGCATGTAGAAAAG -3'
(R):5'- CTGAGTGGATATTGATGTTGAAATGC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation