Mutagenetix > Incidental Mutations

Incidental Mutation 'R7804:Olfr1215'

600654

Institutional Source

Beutler Lab

Gene Symbol

Olfr1215

Ensembl Gene

ENSMUSG00000100016

Gene Name

olfactory receptor 1215

Synonyms

GA_x6K02T2Q125-50482823-50481885, MOR233-13

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R7804 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

89000021-89006973 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to G at 89001511 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Proline at position 259 (R259P)

Ref Sequence

ENSEMBL: ENSMUSP00000150030 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000188399] [ENSMUST00000214809] [ENSMUST00000216271]

Predicted Effect

unknown
Transcript: ENSMUST00000188399
AA Change: R259P

SMART Domains

Protein: ENSMUSP00000141134
Gene: ENSMUSG00000100016
AA Change: R259P

Domain	Start	End	E-Value	Type
low complexity region	24	34	N/A	INTRINSIC
Pfam:7tm_1	39	286	1.9e-25	PFAM
Pfam:7tm_4	138	283	1.7e-38	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000214809
AA Change: R259P

Predicted Effect

unknown
Transcript: ENSMUST00000216271
AA Change: R259P

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933415A04Rik	GTGTGTATGTGT	GTGTGT	11: 43,587,414		probably benign	Het
Ago4	A	T	4: 126,512,630	C296S	probably benign	Het
Apbb1	A	G	7: 105,566,600	L401P	probably damaging	Het
Cacnb2	C	A	2: 14,968,037	P252T	probably benign	Het
Ctnna2	C	T	6: 77,641,374	V202I	probably benign	Het
Dapk1	A	T	13: 60,725,339	I352F	probably benign	Het
Dexi	T	C	16: 10,542,485	D69G	possibly damaging	Het
Dgcr14	T	A	16: 17,911,167	I47F	probably damaging	Het
Dlg5	T	C	14: 24,165,320	E645G	possibly damaging	Het
Dnah3	A	G	7: 119,952,618	I2826T	probably damaging	Het
Dnah3	A	G	7: 120,011,012	W1734R	probably damaging	Het
Dtna	A	G	18: 23,595,609	K287R	probably damaging	Het
Elovl5	A	G	9: 77,979,823		probably null	Het
Fam222b	C	A	11: 78,154,153	P180Q	probably benign	Het
Fat3	C	T	9: 15,990,592	V3046I	probably benign	Het
Fem1a	A	G	17: 56,258,068	D387G	probably damaging	Het
Frmd5	A	G	2: 121,591,744	Y33H	probably damaging	Het
Gucy2g	A	T	19: 55,228,152	L464H	probably benign	Het
Ints2	T	C	11: 86,212,663	E1189G	possibly damaging	Het
Itgb4	T	C	11: 116,003,684	V1355A	probably damaging	Het
Lepr	A	T	4: 101,782,586	S750C	probably damaging	Het
Lingo1	T	C	9: 56,619,514	D603G	probably benign	Het
Map4k3	A	C	17: 80,615,070	V474G	probably damaging	Het
Myl4	T	A	11: 104,584,961	V167E	probably damaging	Het
Naa25	T	C	5: 121,424,589	V478A	probably benign	Het
Neurl4	T	A	11: 69,905,874	L487H	probably benign	Het
Nkx2-9	C	T	12: 56,612,132	R99H	probably damaging	Het
Olfr686	A	T	7: 105,204,160	M61K	probably damaging	Het
Olfr809	A	G	10: 129,776,222	I103V	probably benign	Het
Pcdhga9	A	G	18: 37,738,079	I320M	probably damaging	Het
Pi15	T	A	1: 17,624,913	C251*	probably null	Het
Pkhd1l1	A	T	15: 44,597,138	K4248*	probably null	Het
Prkg1	C	T	19: 30,578,632	V625I	probably benign	Het
Prkg1	G	A	19: 30,624,770	A362V	possibly damaging	Het
Prol1	C	T	5: 88,328,405	T218I	unknown	Het
Rev3l	T	A	10: 39,823,485	I1326K	probably benign	Het
Shank1	C	A	7: 44,312,884	R60S	unknown	Het
Slc24a2	A	G	4: 86,991,537	V648A	probably damaging	Het
Slc35d3	T	C	10: 19,849,370	T247A	probably damaging	Het
Specc1	C	T	11: 62,205,397	T895I	probably damaging	Het
Spta1	A	G	1: 174,195,905	E626G	possibly damaging	Het
Syngr2	C	A	11: 117,812,575	S72R	possibly damaging	Het
Synj2	T	A	17: 6,019,534	L490Q	unknown	Het
Tbc1d9	T	C	8: 83,236,712	L351P	possibly damaging	Het
Tcof1	G	C	18: 60,829,051	A702G	possibly damaging	Het
Themis3	G	A	17: 66,555,610	T451I	probably benign	Het
Tia1	T	C	6: 86,424,382	S146P	probably benign	Het
Tpp2	T	A	1: 43,983,281	N946K	probably benign	Het
Tpr	A	T	1: 150,432,559	R1688S	probably damaging	Het
Trav12-1	A	G	14: 53,538,531	Q47R	possibly damaging	Het
Ttll9	G	A	2: 153,002,358		probably null	Het
Ttn	G	A	2: 76,707,241	T34781M	possibly damaging	Het
V1ra8	A	G	6: 90,203,316	Y167C	probably damaging	Het
Vegfb	T	C	19: 6,986,339	D84G	probably damaging	Het
Vmn2r14	A	T	5: 109,220,458	L223M	probably benign	Het
Wdr26	A	G	1: 181,182,822	I554T	probably damaging	Het

Other mutations in Olfr1215

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Olfr1215	APN	2	89001339	utr 3 prime	probably benign
IGL02395:Olfr1215	APN	2	89002163	missense	probably benign	0.00
IGL02399:Olfr1215	APN	2	89002163	missense	probably benign	0.00
IGL02409:Olfr1215	APN	2	89001910	missense	possibly damaging	0.75
IGL02421:Olfr1215	APN	2	89001344	unclassified	probably null
IGL03036:Olfr1215	APN	2	89002115	missense	possibly damaging	0.94
R2036:Olfr1215	UTSW	2	89001632	missense	probably damaging	0.97
R2199:Olfr1215	UTSW	2	89001550	missense	probably damaging	0.98
R3930:Olfr1215	UTSW	2	89002033	missense	probably benign	0.32
R4990:Olfr1215	UTSW	2	89001472	missense	probably damaging	0.97
R5199:Olfr1215	UTSW	2	89001763	missense	possibly damaging	0.70
R5368:Olfr1215	UTSW	2	89002091	missense	probably damaging	1.00
R5396:Olfr1215	UTSW	2	89002196	missense	probably benign	0.15
R6881:Olfr1215	UTSW	2	89001937	missense	probably damaging	1.00
R7195:Olfr1215	UTSW	2	89001731	missense
R7425:Olfr1215	UTSW	2	89002200	missense
Z1088:Olfr1215	UTSW	2	89001838	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- AGTTGTTGCAAAGGGGATGC -3'
(R):5'- CTAACAGTGGGTCTATCTGCATC -3'

Sequencing Primer
(F):5'- GTTACACAGTGCTGAATCTGTTTC -3'
(R):5'- ACAGTGGGTCTATCTGCATCATTATC -3'

Posted On

2019-11-26