Incidental Mutation 'R7807:Vmn2r58'
ID 600861
Institutional Source Beutler Lab
Gene Symbol Vmn2r58
Ensembl Gene ENSMUSG00000090383
Gene Name vomeronasal 2, receptor 58
Synonyms EG628422
MMRRC Submission 045862-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.377) question?
Stock # R7807 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 41486305-41522094 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41521910 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 62 (Y62F)
Ref Sequence ENSEMBL: ENSMUSP00000126966 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171671]
AlphaFold K7N6V2
Predicted Effect probably benign
Transcript: ENSMUST00000171671
AA Change: Y62F

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: Y62F

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 8e-43 PFAM
Pfam:NCD3G 514 567 1.8e-23 PFAM
Pfam:7tm_3 597 835 2.9e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 C A 9: 21,447,276 (GRCm39) T146K probably benign Het
Alms1 T A 6: 85,599,958 (GRCm39) S1595T possibly damaging Het
Ankrd44 A T 1: 54,831,635 (GRCm39) I56N probably damaging Het
Anln C A 9: 22,272,176 (GRCm39) V648F probably damaging Het
Arhgap29 A G 3: 121,807,981 (GRCm39) D1053G probably benign Het
Baalc T C 15: 38,797,412 (GRCm39) S68P probably benign Het
Begain T C 12: 109,004,856 (GRCm39) D52G probably damaging Het
Blmh A G 11: 76,837,040 (GRCm39) I41V probably benign Het
Bpifc T A 10: 85,812,114 (GRCm39) I365F possibly damaging Het
C2 G T 17: 35,095,347 (GRCm39) S199R possibly damaging Het
Ccbe1 T A 18: 66,199,828 (GRCm39) H298L probably damaging Het
Ccdc112 T A 18: 46,423,826 (GRCm39) K304I probably damaging Het
Ccdc15 T C 9: 37,226,678 (GRCm39) E432G probably benign Het
Cdh13 T A 8: 119,010,594 (GRCm39) M1K probably null Het
Cipc T C 12: 87,008,899 (GRCm39) S253P possibly damaging Het
Clcn1 A G 6: 42,287,282 (GRCm39) probably null Het
Clock A T 5: 76,390,982 (GRCm39) N273K probably benign Het
Cyp19a1 T C 9: 54,074,126 (GRCm39) D476G probably benign Het
Dnaaf9 T C 2: 130,552,785 (GRCm39) K1092E probably damaging Het
Dnah7b A G 1: 46,253,527 (GRCm39) I1811V probably benign Het
Fat1 C A 8: 45,495,010 (GRCm39) T4091K probably damaging Het
Gm10340 T A 14: 14,826,724 (GRCm39) N64K probably damaging Het
Hectd1 G A 12: 51,792,171 (GRCm39) R2523C probably damaging Het
Hgf A G 5: 16,782,009 (GRCm39) H244R probably damaging Het
Hgs G T 11: 120,370,760 (GRCm39) A567S probably damaging Het
Igdcc4 T C 9: 65,041,077 (GRCm39) V1036A probably benign Het
Keg1 G A 19: 12,691,998 (GRCm39) probably null Het
Klhl8 A T 5: 104,023,932 (GRCm39) L156Q probably damaging Het
Lmln T C 16: 32,927,501 (GRCm39) Y521H probably benign Het
Lrrc7 A G 3: 157,866,124 (GRCm39) S1206P probably damaging Het
Mad1l1 T A 5: 140,074,541 (GRCm39) I550F probably benign Het
Marf1 C T 16: 13,971,753 (GRCm39) W28* probably null Het
Mfsd11 T G 11: 116,754,733 (GRCm39) S215A probably benign Het
Mpped2 C A 2: 106,575,085 (GRCm39) H57N possibly damaging Het
Mslnl A G 17: 25,965,751 (GRCm39) M542V probably benign Het
Myh6 G T 14: 55,179,897 (GRCm39) H1903Q probably damaging Het
Neo1 T C 9: 58,897,777 (GRCm39) T60A probably benign Het
Npm2 T A 14: 70,889,947 (GRCm39) probably null Het
Or5b123 C A 19: 13,597,285 (GRCm39) T210K probably damaging Het
Or5d20-ps1 T C 2: 87,931,909 (GRCm39) S141G probably benign Het
Or7a39 T A 10: 78,715,043 (GRCm39) S12R probably benign Het
Pax9 A T 12: 56,743,850 (GRCm39) I166F possibly damaging Het
Pcsk9 A G 4: 106,321,092 (GRCm39) S6P possibly damaging Het
Pikfyve A G 1: 65,309,101 (GRCm39) Y1893C probably damaging Het
Pirb T C 7: 3,722,864 (GRCm39) T43A possibly damaging Het
Pou3f1 A G 4: 124,552,074 (GRCm39) D192G possibly damaging Het
Pus3 C G 9: 35,478,021 (GRCm39) R418G probably damaging Het
Rexo1 C T 10: 80,385,970 (GRCm39) V363I probably benign Het
Sdcbp A G 4: 6,393,688 (GRCm39) T269A probably damaging Het
Sele T C 1: 163,881,462 (GRCm39) V523A probably benign Het
Serpinb8 T A 1: 107,532,457 (GRCm39) M183K probably damaging Het
Sh2d4a T G 8: 68,735,033 (GRCm39) S51A probably benign Het
Siglec15 A G 18: 78,090,696 (GRCm39) S201P probably damaging Het
Slc10a5 C T 3: 10,400,529 (GRCm39) V44I probably benign Het
Slc16a13 A G 11: 70,111,388 (GRCm39) V39A probably damaging Het
Slc25a13 G A 6: 6,117,164 (GRCm39) R184W probably damaging Het
Slc35f5 T A 1: 125,512,278 (GRCm39) D359E probably damaging Het
Slc3a1 A G 17: 85,371,371 (GRCm39) E641G probably benign Het
Slf1 T C 13: 77,194,823 (GRCm39) D834G probably damaging Het
Spata31f1e A C 4: 42,793,885 (GRCm39) H82Q probably benign Het
Stim1 T C 7: 102,076,348 (GRCm39) I433T probably damaging Het
Stra6 T A 9: 58,057,444 (GRCm39) I418K probably damaging Het
Tanc2 A G 11: 105,758,480 (GRCm39) N747S probably benign Het
Tet2 T C 3: 133,192,302 (GRCm39) T711A possibly damaging Het
Trpm6 T C 19: 18,807,220 (GRCm39) I988T probably benign Het
Ttc41 T A 10: 86,612,495 (GRCm39) I1256N probably benign Het
Uba2 T C 7: 33,862,638 (GRCm39) D100G possibly damaging Het
Vmn1r43 A G 6: 89,847,219 (GRCm39) I89T probably benign Het
Ylpm1 C T 12: 85,060,855 (GRCm39) Q428* probably null Het
Zcrb1 T C 15: 93,289,002 (GRCm39) D88G probably damaging Het
Zmym1 A C 4: 126,941,667 (GRCm39) I907S probably damaging Het
Other mutations in Vmn2r58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Vmn2r58 APN 7 41,513,854 (GRCm39) missense possibly damaging 0.53
IGL00924:Vmn2r58 APN 7 41,486,891 (GRCm39) missense probably damaging 1.00
IGL01291:Vmn2r58 APN 7 41,513,935 (GRCm39) missense probably benign 0.02
IGL01480:Vmn2r58 APN 7 41,514,116 (GRCm39) missense probably benign 0.01
IGL01551:Vmn2r58 APN 7 41,514,703 (GRCm39) missense probably damaging 0.97
IGL01591:Vmn2r58 APN 7 41,514,753 (GRCm39) missense probably benign 0.03
IGL01940:Vmn2r58 APN 7 41,487,071 (GRCm39) missense probably benign 0.00
IGL01994:Vmn2r58 APN 7 41,486,394 (GRCm39) missense probably damaging 0.98
IGL02041:Vmn2r58 APN 7 41,514,703 (GRCm39) missense probably damaging 0.97
IGL02222:Vmn2r58 APN 7 41,513,449 (GRCm39) missense possibly damaging 0.81
IGL02317:Vmn2r58 APN 7 41,486,765 (GRCm39) missense possibly damaging 0.89
IGL02614:Vmn2r58 APN 7 41,486,553 (GRCm39) missense probably damaging 1.00
IGL02673:Vmn2r58 APN 7 41,514,082 (GRCm39) missense possibly damaging 0.90
IGL03323:Vmn2r58 APN 7 41,511,295 (GRCm39) missense probably benign 0.06
IGL03337:Vmn2r58 APN 7 41,513,810 (GRCm39) missense possibly damaging 0.93
IGL03380:Vmn2r58 APN 7 41,513,874 (GRCm39) missense probably benign 0.00
ANU05:Vmn2r58 UTSW 7 41,513,935 (GRCm39) missense probably benign 0.02
R0138:Vmn2r58 UTSW 7 41,487,048 (GRCm39) missense probably damaging 1.00
R0141:Vmn2r58 UTSW 7 41,511,309 (GRCm39) missense probably benign 0.11
R0421:Vmn2r58 UTSW 7 41,514,628 (GRCm39) missense probably benign 0.02
R0604:Vmn2r58 UTSW 7 41,510,000 (GRCm39) missense possibly damaging 0.78
R0854:Vmn2r58 UTSW 7 41,486,562 (GRCm39) missense probably damaging 1.00
R1413:Vmn2r58 UTSW 7 41,513,387 (GRCm39) missense probably benign 0.01
R1441:Vmn2r58 UTSW 7 41,486,864 (GRCm39) missense probably damaging 1.00
R1678:Vmn2r58 UTSW 7 41,513,480 (GRCm39) missense probably benign 0.40
R1691:Vmn2r58 UTSW 7 41,486,913 (GRCm39) missense possibly damaging 0.95
R1699:Vmn2r58 UTSW 7 41,509,951 (GRCm39) missense probably benign
R1865:Vmn2r58 UTSW 7 41,486,682 (GRCm39) missense possibly damaging 0.95
R2008:Vmn2r58 UTSW 7 41,509,924 (GRCm39) missense probably damaging 1.00
R2036:Vmn2r58 UTSW 7 41,513,417 (GRCm39) missense probably benign
R2202:Vmn2r58 UTSW 7 41,513,594 (GRCm39) missense probably benign 0.07
R3787:Vmn2r58 UTSW 7 41,513,498 (GRCm39) missense probably benign 0.01
R3883:Vmn2r58 UTSW 7 41,513,914 (GRCm39) nonsense probably null
R3944:Vmn2r58 UTSW 7 41,513,885 (GRCm39) missense probably benign 0.03
R3949:Vmn2r58 UTSW 7 41,513,348 (GRCm39) missense probably benign 0.08
R4232:Vmn2r58 UTSW 7 41,487,011 (GRCm39) missense possibly damaging 0.91
R4409:Vmn2r58 UTSW 7 41,522,051 (GRCm39) missense possibly damaging 0.69
R4411:Vmn2r58 UTSW 7 41,511,360 (GRCm39) missense possibly damaging 0.85
R4413:Vmn2r58 UTSW 7 41,511,360 (GRCm39) missense possibly damaging 0.85
R4600:Vmn2r58 UTSW 7 41,522,046 (GRCm39) missense probably benign 0.03
R4610:Vmn2r58 UTSW 7 41,487,117 (GRCm39) missense probably benign
R4646:Vmn2r58 UTSW 7 41,509,935 (GRCm39) missense probably damaging 0.96
R4793:Vmn2r58 UTSW 7 41,514,495 (GRCm39) missense probably damaging 0.99
R4870:Vmn2r58 UTSW 7 41,486,639 (GRCm39) missense possibly damaging 0.76
R4981:Vmn2r58 UTSW 7 41,486,885 (GRCm39) missense probably damaging 1.00
R4993:Vmn2r58 UTSW 7 41,487,176 (GRCm39) missense probably benign 0.00
R5024:Vmn2r58 UTSW 7 41,513,746 (GRCm39) missense probably damaging 0.99
R5064:Vmn2r58 UTSW 7 41,486,534 (GRCm39) missense probably damaging 0.99
R5330:Vmn2r58 UTSW 7 41,513,384 (GRCm39) nonsense probably null
R5526:Vmn2r58 UTSW 7 41,522,069 (GRCm39) missense probably benign 0.01
R5980:Vmn2r58 UTSW 7 41,514,480 (GRCm39) missense possibly damaging 0.81
R6163:Vmn2r58 UTSW 7 41,486,825 (GRCm39) missense probably benign 0.31
R6365:Vmn2r58 UTSW 7 41,513,607 (GRCm39) missense probably benign 0.42
R6567:Vmn2r58 UTSW 7 41,514,673 (GRCm39) missense probably benign 0.34
R6594:Vmn2r58 UTSW 7 41,486,535 (GRCm39) missense possibly damaging 0.69
R6980:Vmn2r58 UTSW 7 41,513,662 (GRCm39) missense possibly damaging 0.64
R7373:Vmn2r58 UTSW 7 41,487,212 (GRCm39) missense probably damaging 1.00
R7458:Vmn2r58 UTSW 7 41,487,123 (GRCm39) missense probably benign 0.06
R7630:Vmn2r58 UTSW 7 41,513,611 (GRCm39) missense probably damaging 0.99
R8114:Vmn2r58 UTSW 7 41,511,392 (GRCm39) missense probably damaging 1.00
R8232:Vmn2r58 UTSW 7 41,514,076 (GRCm39) missense probably damaging 0.97
R8313:Vmn2r58 UTSW 7 41,521,952 (GRCm39) missense probably benign 0.01
R8412:Vmn2r58 UTSW 7 41,513,722 (GRCm39) missense probably benign 0.01
R8530:Vmn2r58 UTSW 7 41,513,576 (GRCm39) missense probably damaging 1.00
R8851:Vmn2r58 UTSW 7 41,487,219 (GRCm39) missense probably benign
R8881:Vmn2r58 UTSW 7 41,486,609 (GRCm39) missense probably benign 0.05
R8936:Vmn2r58 UTSW 7 41,513,981 (GRCm39) missense
R9045:Vmn2r58 UTSW 7 41,487,087 (GRCm39) missense probably benign 0.00
R9166:Vmn2r58 UTSW 7 41,513,431 (GRCm39) missense probably damaging 1.00
R9706:Vmn2r58 UTSW 7 41,510,000 (GRCm39) missense probably damaging 0.99
RF006:Vmn2r58 UTSW 7 41,486,383 (GRCm39) frame shift probably null
RF027:Vmn2r58 UTSW 7 41,486,383 (GRCm39) frame shift probably null
Z1176:Vmn2r58 UTSW 7 41,513,789 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TCTAGACGTCAAGAAGTTCAAGG -3'
(R):5'- TGAACATGTCTCCGTCTGTC -3'

Sequencing Primer
(F):5'- GACGTCAAGAAGTTCAAGGTAATTC -3'
(R):5'- GTCTTTGGGATGGACAGATACACATC -3'
Posted On 2019-11-26