Incidental Mutation 'R7807:Lmln'
ID 600894
Institutional Source Beutler Lab
Gene Symbol Lmln
Ensembl Gene ENSMUSG00000022802
Gene Name leishmanolysin-like (metallopeptidase M8 family)
Synonyms 5330415H22Rik
MMRRC Submission 045862-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R7807 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 32882891-32948065 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32927501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 521 (Y521H)
Ref Sequence ENSEMBL: ENSMUSP00000023497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023497]
AlphaFold Q8BMN4
Predicted Effect probably benign
Transcript: ENSMUST00000023497
AA Change: Y521H

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000023497
Gene: ENSMUSG00000022802
AA Change: Y521H

DomainStartEndE-ValueType
signal peptide 1 42 N/A INTRINSIC
Pfam:Peptidase_M8 154 289 3.9e-16 PFAM
Pfam:Peptidase_M8 295 633 5.2e-54 PFAM
transmembrane domain 658 680 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (68/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 C A 9: 21,447,276 (GRCm39) T146K probably benign Het
Alms1 T A 6: 85,599,958 (GRCm39) S1595T possibly damaging Het
Ankrd44 A T 1: 54,831,635 (GRCm39) I56N probably damaging Het
Anln C A 9: 22,272,176 (GRCm39) V648F probably damaging Het
Arhgap29 A G 3: 121,807,981 (GRCm39) D1053G probably benign Het
Baalc T C 15: 38,797,412 (GRCm39) S68P probably benign Het
Begain T C 12: 109,004,856 (GRCm39) D52G probably damaging Het
Blmh A G 11: 76,837,040 (GRCm39) I41V probably benign Het
Bpifc T A 10: 85,812,114 (GRCm39) I365F possibly damaging Het
C2 G T 17: 35,095,347 (GRCm39) S199R possibly damaging Het
Ccbe1 T A 18: 66,199,828 (GRCm39) H298L probably damaging Het
Ccdc112 T A 18: 46,423,826 (GRCm39) K304I probably damaging Het
Ccdc15 T C 9: 37,226,678 (GRCm39) E432G probably benign Het
Cdh13 T A 8: 119,010,594 (GRCm39) M1K probably null Het
Cipc T C 12: 87,008,899 (GRCm39) S253P possibly damaging Het
Clcn1 A G 6: 42,287,282 (GRCm39) probably null Het
Clock A T 5: 76,390,982 (GRCm39) N273K probably benign Het
Cyp19a1 T C 9: 54,074,126 (GRCm39) D476G probably benign Het
Dnaaf9 T C 2: 130,552,785 (GRCm39) K1092E probably damaging Het
Dnah7b A G 1: 46,253,527 (GRCm39) I1811V probably benign Het
Fat1 C A 8: 45,495,010 (GRCm39) T4091K probably damaging Het
Gm10340 T A 14: 14,826,724 (GRCm39) N64K probably damaging Het
Hectd1 G A 12: 51,792,171 (GRCm39) R2523C probably damaging Het
Hgf A G 5: 16,782,009 (GRCm39) H244R probably damaging Het
Hgs G T 11: 120,370,760 (GRCm39) A567S probably damaging Het
Igdcc4 T C 9: 65,041,077 (GRCm39) V1036A probably benign Het
Keg1 G A 19: 12,691,998 (GRCm39) probably null Het
Klhl8 A T 5: 104,023,932 (GRCm39) L156Q probably damaging Het
Lrrc7 A G 3: 157,866,124 (GRCm39) S1206P probably damaging Het
Mad1l1 T A 5: 140,074,541 (GRCm39) I550F probably benign Het
Marf1 C T 16: 13,971,753 (GRCm39) W28* probably null Het
Mfsd11 T G 11: 116,754,733 (GRCm39) S215A probably benign Het
Mpped2 C A 2: 106,575,085 (GRCm39) H57N possibly damaging Het
Mslnl A G 17: 25,965,751 (GRCm39) M542V probably benign Het
Myh6 G T 14: 55,179,897 (GRCm39) H1903Q probably damaging Het
Neo1 T C 9: 58,897,777 (GRCm39) T60A probably benign Het
Npm2 T A 14: 70,889,947 (GRCm39) probably null Het
Or5b123 C A 19: 13,597,285 (GRCm39) T210K probably damaging Het
Or5d20-ps1 T C 2: 87,931,909 (GRCm39) S141G probably benign Het
Or7a39 T A 10: 78,715,043 (GRCm39) S12R probably benign Het
Pax9 A T 12: 56,743,850 (GRCm39) I166F possibly damaging Het
Pcsk9 A G 4: 106,321,092 (GRCm39) S6P possibly damaging Het
Pikfyve A G 1: 65,309,101 (GRCm39) Y1893C probably damaging Het
Pirb T C 7: 3,722,864 (GRCm39) T43A possibly damaging Het
Pou3f1 A G 4: 124,552,074 (GRCm39) D192G possibly damaging Het
Pus3 C G 9: 35,478,021 (GRCm39) R418G probably damaging Het
Rexo1 C T 10: 80,385,970 (GRCm39) V363I probably benign Het
Sdcbp A G 4: 6,393,688 (GRCm39) T269A probably damaging Het
Sele T C 1: 163,881,462 (GRCm39) V523A probably benign Het
Serpinb8 T A 1: 107,532,457 (GRCm39) M183K probably damaging Het
Sh2d4a T G 8: 68,735,033 (GRCm39) S51A probably benign Het
Siglec15 A G 18: 78,090,696 (GRCm39) S201P probably damaging Het
Slc10a5 C T 3: 10,400,529 (GRCm39) V44I probably benign Het
Slc16a13 A G 11: 70,111,388 (GRCm39) V39A probably damaging Het
Slc25a13 G A 6: 6,117,164 (GRCm39) R184W probably damaging Het
Slc35f5 T A 1: 125,512,278 (GRCm39) D359E probably damaging Het
Slc3a1 A G 17: 85,371,371 (GRCm39) E641G probably benign Het
Slf1 T C 13: 77,194,823 (GRCm39) D834G probably damaging Het
Spata31f1e A C 4: 42,793,885 (GRCm39) H82Q probably benign Het
Stim1 T C 7: 102,076,348 (GRCm39) I433T probably damaging Het
Stra6 T A 9: 58,057,444 (GRCm39) I418K probably damaging Het
Tanc2 A G 11: 105,758,480 (GRCm39) N747S probably benign Het
Tet2 T C 3: 133,192,302 (GRCm39) T711A possibly damaging Het
Trpm6 T C 19: 18,807,220 (GRCm39) I988T probably benign Het
Ttc41 T A 10: 86,612,495 (GRCm39) I1256N probably benign Het
Uba2 T C 7: 33,862,638 (GRCm39) D100G possibly damaging Het
Vmn1r43 A G 6: 89,847,219 (GRCm39) I89T probably benign Het
Vmn2r58 T A 7: 41,521,910 (GRCm39) Y62F probably benign Het
Ylpm1 C T 12: 85,060,855 (GRCm39) Q428* probably null Het
Zcrb1 T C 15: 93,289,002 (GRCm39) D88G probably damaging Het
Zmym1 A C 4: 126,941,667 (GRCm39) I907S probably damaging Het
Other mutations in Lmln
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Lmln APN 16 32,903,435 (GRCm39) missense probably benign 0.08
IGL01346:Lmln APN 16 32,937,490 (GRCm39) missense probably benign 0.00
IGL01664:Lmln APN 16 32,901,357 (GRCm39) missense probably benign 0.03
nemeth UTSW 16 32,894,467 (GRCm39) nonsense probably null
R0234:Lmln UTSW 16 32,886,694 (GRCm39) missense probably damaging 0.99
R0234:Lmln UTSW 16 32,886,694 (GRCm39) missense probably damaging 0.99
R0562:Lmln UTSW 16 32,937,455 (GRCm39) nonsense probably null
R1017:Lmln UTSW 16 32,908,546 (GRCm39) missense probably benign
R1557:Lmln UTSW 16 32,908,581 (GRCm39) missense probably benign 0.25
R1617:Lmln UTSW 16 32,937,500 (GRCm39) missense probably damaging 1.00
R2211:Lmln UTSW 16 32,930,148 (GRCm39) missense probably benign 0.00
R4061:Lmln UTSW 16 32,886,761 (GRCm39) nonsense probably null
R4414:Lmln UTSW 16 32,930,220 (GRCm39) missense probably benign 0.00
R4512:Lmln UTSW 16 32,908,507 (GRCm39) missense probably benign 0.01
R4564:Lmln UTSW 16 32,930,226 (GRCm39) missense probably benign 0.09
R4995:Lmln UTSW 16 32,894,467 (GRCm39) nonsense probably null
R5044:Lmln UTSW 16 32,894,550 (GRCm39) missense possibly damaging 0.80
R6109:Lmln UTSW 16 32,889,481 (GRCm39) missense possibly damaging 0.69
R6287:Lmln UTSW 16 32,894,555 (GRCm39) critical splice donor site probably null
R6577:Lmln UTSW 16 32,927,370 (GRCm39) splice site probably null
R6689:Lmln UTSW 16 32,925,152 (GRCm39) missense probably benign 0.19
R7079:Lmln UTSW 16 32,887,661 (GRCm39) missense probably benign 0.02
R7432:Lmln UTSW 16 32,909,738 (GRCm39) missense probably damaging 1.00
R8185:Lmln UTSW 16 32,909,690 (GRCm39) missense probably damaging 1.00
R8942:Lmln UTSW 16 32,901,330 (GRCm39) missense probably damaging 0.99
R9123:Lmln UTSW 16 32,930,202 (GRCm39) missense probably benign 0.01
R9365:Lmln UTSW 16 32,925,169 (GRCm39) nonsense probably null
R9491:Lmln UTSW 16 32,890,358 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GCCTTGTTTCAGTCTCACAGAGAAC -3'
(R):5'- TACGAGGACTGTGCCCTTTG -3'

Sequencing Primer
(F):5'- GTTTCAGTCTCACAGAGAACTCTTC -3'
(R):5'- TCTGATCCCTGTACTCAGAGGAG -3'
Posted On 2019-11-26