Incidental Mutation 'R7808:Nav1'
| ID |
600906 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
045863-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.934)
|
| Stock # |
R7808 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 135379986 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 1512
(Y1512C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000040599
AA Change: Y1572C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: Y1572C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067414
AA Change: Y1572C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: Y1572C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189252
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000190298
AA Change: Y1512C
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
AA Change: Y1512C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 86,957,297 (GRCm39) |
V11A |
probably benign |
Het |
| Abca12 |
A |
T |
1: 71,313,793 (GRCm39) |
|
probably null |
Het |
| Abcc12 |
T |
A |
8: 87,234,568 (GRCm39) |
M1232L |
probably benign |
Het |
| Adamts1 |
T |
C |
16: 85,597,117 (GRCm39) |
Y314C |
probably damaging |
Het |
| Adgb |
A |
G |
10: 10,254,403 (GRCm39) |
|
probably null |
Het |
| Ankrd12 |
T |
A |
17: 66,292,648 (GRCm39) |
K928N |
possibly damaging |
Het |
| Ano5 |
A |
T |
7: 51,237,543 (GRCm39) |
K789I |
possibly damaging |
Het |
| Cacna1d |
G |
T |
14: 29,833,026 (GRCm39) |
N938K |
probably damaging |
Het |
| Camk1g |
T |
C |
1: 193,032,593 (GRCm39) |
R273G |
possibly damaging |
Het |
| Caprin2 |
C |
A |
6: 148,744,528 (GRCm39) |
V966F |
probably damaging |
Het |
| Card6 |
T |
C |
15: 5,128,954 (GRCm39) |
H814R |
probably benign |
Het |
| Cenatac |
T |
C |
9: 44,324,215 (GRCm39) |
Q228R |
probably null |
Het |
| Cflar |
A |
G |
1: 58,750,740 (GRCm39) |
|
probably benign |
Het |
| Cftr |
T |
A |
6: 18,204,204 (GRCm39) |
N66K |
probably benign |
Het |
| Clasrp |
C |
T |
7: 19,322,671 (GRCm39) |
|
probably null |
Het |
| Clec4a4 |
T |
C |
6: 122,967,339 (GRCm39) |
I5T |
probably damaging |
Het |
| Cmtr2 |
T |
C |
8: 110,948,251 (GRCm39) |
I187T |
possibly damaging |
Het |
| Cnga1 |
A |
T |
5: 72,761,616 (GRCm39) |
F633I |
possibly damaging |
Het |
| Col16a1 |
C |
T |
4: 129,967,057 (GRCm39) |
P909S |
unknown |
Het |
| Csf1 |
C |
A |
3: 107,667,361 (GRCm39) |
A7S |
possibly damaging |
Het |
| Cstpp1 |
T |
C |
2: 91,274,939 (GRCm39) |
|
probably benign |
Het |
| Dhx30 |
A |
T |
9: 109,915,270 (GRCm39) |
V833D |
probably benign |
Het |
| Dlg2 |
T |
G |
7: 92,080,263 (GRCm39) |
I712M |
probably benign |
Het |
| Dmxl1 |
T |
A |
18: 50,011,382 (GRCm39) |
F1180I |
probably benign |
Het |
| Dnah9 |
T |
A |
11: 65,896,631 (GRCm39) |
K2398* |
probably null |
Het |
| Dus1l |
C |
T |
11: 120,680,262 (GRCm39) |
G471D |
possibly damaging |
Het |
| Dync1h1 |
A |
T |
12: 110,621,893 (GRCm39) |
N3412I |
possibly damaging |
Het |
| Dync1i2 |
T |
A |
2: 71,081,178 (GRCm39) |
|
probably null |
Het |
| Dysf |
T |
C |
6: 84,047,911 (GRCm39) |
S333P |
possibly damaging |
Het |
| Eed |
A |
T |
7: 89,605,541 (GRCm39) |
N349K |
probably benign |
Het |
| Eipr1 |
A |
T |
12: 28,816,769 (GRCm39) |
|
probably null |
Het |
| Fbxw16 |
A |
C |
9: 109,277,222 (GRCm39) |
V40G |
probably damaging |
Het |
| Fgfr4 |
A |
C |
13: 55,308,969 (GRCm39) |
R363S |
possibly damaging |
Het |
| Fgl2 |
A |
T |
5: 21,578,229 (GRCm39) |
N172I |
possibly damaging |
Het |
| Fhip1b |
G |
A |
7: 105,033,732 (GRCm39) |
R509C |
probably damaging |
Het |
| Gabbr2 |
T |
A |
4: 46,875,744 (GRCm39) |
H126L |
possibly damaging |
Het |
| Gcnt2 |
A |
T |
13: 41,014,338 (GRCm39) |
N170Y |
possibly damaging |
Het |
| Gpt |
A |
G |
15: 76,583,093 (GRCm39) |
|
probably null |
Het |
| Igsf10 |
A |
G |
3: 59,235,489 (GRCm39) |
I1564T |
probably benign |
Het |
| Il22ra1 |
C |
A |
4: 135,478,107 (GRCm39) |
Q393K |
possibly damaging |
Het |
| Inpp5d |
A |
T |
1: 87,611,567 (GRCm39) |
K340* |
probably null |
Het |
| Jcad |
A |
G |
18: 4,673,113 (GRCm39) |
K292E |
probably damaging |
Het |
| Krt5 |
T |
A |
15: 101,617,453 (GRCm39) |
T427S |
probably benign |
Het |
| Krt76 |
T |
C |
15: 101,798,929 (GRCm39) |
D252G |
probably damaging |
Het |
| Krtap26-1 |
A |
G |
16: 88,444,198 (GRCm39) |
V141A |
not run |
Het |
| Lce6a |
A |
T |
3: 92,527,642 (GRCm39) |
V55D |
probably benign |
Het |
| Lpxn |
C |
T |
19: 12,802,185 (GRCm39) |
S170F |
possibly damaging |
Het |
| Magi2 |
T |
C |
5: 20,670,838 (GRCm39) |
V394A |
probably benign |
Het |
| Mbnl1 |
G |
A |
3: 60,522,242 (GRCm39) |
|
probably null |
Het |
| Med16 |
T |
A |
10: 79,734,252 (GRCm39) |
K554M |
probably damaging |
Het |
| Mettl14 |
T |
C |
3: 123,166,234 (GRCm39) |
D276G |
possibly damaging |
Het |
| Mphosph9 |
T |
C |
5: 124,399,009 (GRCm39) |
D1002G |
probably damaging |
Het |
| Mroh9 |
T |
C |
1: 162,866,678 (GRCm39) |
E686G |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,082,035 (GRCm39) |
Y5712C |
probably damaging |
Het |
| Nek7 |
T |
A |
1: 138,489,509 (GRCm39) |
|
probably benign |
Het |
| Nptx1 |
T |
A |
11: 119,435,462 (GRCm39) |
I285F |
probably damaging |
Het |
| Oas1d |
G |
T |
5: 121,053,034 (GRCm39) |
E30* |
probably null |
Het |
| Or1p1b |
A |
T |
11: 74,130,725 (GRCm39) |
I112F |
probably damaging |
Het |
| Or51g2 |
A |
G |
7: 102,622,317 (GRCm39) |
V294A |
possibly damaging |
Het |
| Or6n1 |
C |
A |
1: 173,917,417 (GRCm39) |
Y270* |
probably null |
Het |
| Parp4 |
T |
G |
14: 56,873,205 (GRCm39) |
S1150A |
possibly damaging |
Het |
| Pinx1 |
A |
T |
14: 64,156,741 (GRCm39) |
K223* |
probably null |
Het |
| Plekha5 |
T |
C |
6: 140,529,640 (GRCm39) |
L1034S |
probably damaging |
Het |
| Ppp4r3a |
A |
G |
12: 101,019,755 (GRCm39) |
V400A |
possibly damaging |
Het |
| Prtg |
A |
T |
9: 72,749,979 (GRCm39) |
I128F |
possibly damaging |
Het |
| Rars1 |
T |
C |
11: 35,719,534 (GRCm39) |
E96G |
probably benign |
Het |
| Rhpn1 |
T |
A |
15: 75,585,299 (GRCm39) |
S551T |
probably benign |
Het |
| Selenow |
C |
T |
7: 15,656,176 (GRCm39) |
|
probably null |
Het |
| Serpina9 |
A |
T |
12: 103,967,484 (GRCm39) |
|
probably null |
Het |
| Shank3 |
A |
T |
15: 89,433,083 (GRCm39) |
D1276V |
probably damaging |
Het |
| Slc27a6 |
A |
G |
18: 58,742,267 (GRCm39) |
T494A |
probably damaging |
Het |
| Slc34a1 |
A |
C |
13: 24,003,317 (GRCm39) |
H285P |
probably damaging |
Het |
| Slc6a21 |
A |
C |
7: 44,932,360 (GRCm39) |
T54P |
|
Het |
| Syne2 |
A |
G |
12: 76,030,501 (GRCm39) |
|
probably null |
Het |
| Tal1 |
T |
C |
4: 114,925,489 (GRCm39) |
V186A |
probably benign |
Het |
| Tars3 |
A |
G |
7: 65,302,009 (GRCm39) |
K178E |
probably benign |
Het |
| Tex10 |
T |
A |
4: 48,459,984 (GRCm39) |
I456L |
probably benign |
Het |
| Tfcp2 |
A |
G |
15: 100,420,310 (GRCm39) |
F175S |
probably damaging |
Het |
| Timp2 |
C |
T |
11: 118,194,626 (GRCm39) |
A188T |
probably damaging |
Het |
| Tmc5 |
T |
A |
7: 118,268,440 (GRCm39) |
I836N |
probably damaging |
Het |
| Tmem100 |
T |
A |
11: 89,926,302 (GRCm39) |
M43K |
probably benign |
Het |
| Ulk2 |
A |
G |
11: 61,745,378 (GRCm39) |
Y9H |
probably damaging |
Het |
| Usp7 |
T |
C |
16: 8,523,027 (GRCm39) |
K311E |
probably damaging |
Het |
| Vmn1r238 |
G |
A |
18: 3,123,033 (GRCm39) |
T127I |
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,496,678 (GRCm39) |
Y58C |
probably damaging |
Het |
| Wdr55 |
G |
A |
18: 36,893,469 (GRCm39) |
G44S |
probably benign |
Het |
| Zfp677 |
C |
A |
17: 21,617,647 (GRCm39) |
H235N |
probably damaging |
Het |
| Zfp869 |
T |
A |
8: 70,159,636 (GRCm39) |
R312S |
probably damaging |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Nav1
|
UTSW |
1 |
135,377,704 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,359 (GRCm39) |
nonsense |
probably null |
|
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0699:Nav1
|
UTSW |
1 |
135,380,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1939:Nav1
|
UTSW |
1 |
135,393,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Nav1
|
UTSW |
1 |
135,460,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7464:Nav1
|
UTSW |
1 |
135,512,647 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATGCTACTGGGGCAGGG -3'
(R):5'- CGATGGAGAAGCTCATTGGGT -3'
Sequencing Primer
(F):5'- TGGGTTACACAAGACCCTGACTG -3'
(R):5'- GCTGGTGAAGACTCATGCTCTC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation