Incidental Mutation 'R7808:Mroh9'
| ID |
600908 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mroh9
|
| Ensembl Gene |
ENSMUSG00000071890 |
| Gene Name |
maestro heat-like repeat family member 9 |
| Synonyms |
4921528O07Rik, Armc11 |
| MMRRC Submission |
045863-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7808 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
162851871-162913239 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 162866678 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 686
(E686G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094365
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096608]
|
| AlphaFold |
G5E8L9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096608
AA Change: E686G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890
AA Change: E686G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5b_
|
231 |
716 |
2e-8 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
99% (86/87) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 86,957,297 (GRCm39) |
V11A |
probably benign |
Het |
| Abca12 |
A |
T |
1: 71,313,793 (GRCm39) |
|
probably null |
Het |
| Abcc12 |
T |
A |
8: 87,234,568 (GRCm39) |
M1232L |
probably benign |
Het |
| Adamts1 |
T |
C |
16: 85,597,117 (GRCm39) |
Y314C |
probably damaging |
Het |
| Adgb |
A |
G |
10: 10,254,403 (GRCm39) |
|
probably null |
Het |
| Ankrd12 |
T |
A |
17: 66,292,648 (GRCm39) |
K928N |
possibly damaging |
Het |
| Ano5 |
A |
T |
7: 51,237,543 (GRCm39) |
K789I |
possibly damaging |
Het |
| Cacna1d |
G |
T |
14: 29,833,026 (GRCm39) |
N938K |
probably damaging |
Het |
| Camk1g |
T |
C |
1: 193,032,593 (GRCm39) |
R273G |
possibly damaging |
Het |
| Caprin2 |
C |
A |
6: 148,744,528 (GRCm39) |
V966F |
probably damaging |
Het |
| Card6 |
T |
C |
15: 5,128,954 (GRCm39) |
H814R |
probably benign |
Het |
| Cenatac |
T |
C |
9: 44,324,215 (GRCm39) |
Q228R |
probably null |
Het |
| Cflar |
A |
G |
1: 58,750,740 (GRCm39) |
|
probably benign |
Het |
| Cftr |
T |
A |
6: 18,204,204 (GRCm39) |
N66K |
probably benign |
Het |
| Clasrp |
C |
T |
7: 19,322,671 (GRCm39) |
|
probably null |
Het |
| Clec4a4 |
T |
C |
6: 122,967,339 (GRCm39) |
I5T |
probably damaging |
Het |
| Cmtr2 |
T |
C |
8: 110,948,251 (GRCm39) |
I187T |
possibly damaging |
Het |
| Cnga1 |
A |
T |
5: 72,761,616 (GRCm39) |
F633I |
possibly damaging |
Het |
| Col16a1 |
C |
T |
4: 129,967,057 (GRCm39) |
P909S |
unknown |
Het |
| Csf1 |
C |
A |
3: 107,667,361 (GRCm39) |
A7S |
possibly damaging |
Het |
| Cstpp1 |
T |
C |
2: 91,274,939 (GRCm39) |
|
probably benign |
Het |
| Dhx30 |
A |
T |
9: 109,915,270 (GRCm39) |
V833D |
probably benign |
Het |
| Dlg2 |
T |
G |
7: 92,080,263 (GRCm39) |
I712M |
probably benign |
Het |
| Dmxl1 |
T |
A |
18: 50,011,382 (GRCm39) |
F1180I |
probably benign |
Het |
| Dnah9 |
T |
A |
11: 65,896,631 (GRCm39) |
K2398* |
probably null |
Het |
| Dus1l |
C |
T |
11: 120,680,262 (GRCm39) |
G471D |
possibly damaging |
Het |
| Dync1h1 |
A |
T |
12: 110,621,893 (GRCm39) |
N3412I |
possibly damaging |
Het |
| Dync1i2 |
T |
A |
2: 71,081,178 (GRCm39) |
|
probably null |
Het |
| Dysf |
T |
C |
6: 84,047,911 (GRCm39) |
S333P |
possibly damaging |
Het |
| Eed |
A |
T |
7: 89,605,541 (GRCm39) |
N349K |
probably benign |
Het |
| Eipr1 |
A |
T |
12: 28,816,769 (GRCm39) |
|
probably null |
Het |
| Fbxw16 |
A |
C |
9: 109,277,222 (GRCm39) |
V40G |
probably damaging |
Het |
| Fgfr4 |
A |
C |
13: 55,308,969 (GRCm39) |
R363S |
possibly damaging |
Het |
| Fgl2 |
A |
T |
5: 21,578,229 (GRCm39) |
N172I |
possibly damaging |
Het |
| Fhip1b |
G |
A |
7: 105,033,732 (GRCm39) |
R509C |
probably damaging |
Het |
| Gabbr2 |
T |
A |
4: 46,875,744 (GRCm39) |
H126L |
possibly damaging |
Het |
| Gcnt2 |
A |
T |
13: 41,014,338 (GRCm39) |
N170Y |
possibly damaging |
Het |
| Gpt |
A |
G |
15: 76,583,093 (GRCm39) |
|
probably null |
Het |
| Igsf10 |
A |
G |
3: 59,235,489 (GRCm39) |
I1564T |
probably benign |
Het |
| Il22ra1 |
C |
A |
4: 135,478,107 (GRCm39) |
Q393K |
possibly damaging |
Het |
| Inpp5d |
A |
T |
1: 87,611,567 (GRCm39) |
K340* |
probably null |
Het |
| Jcad |
A |
G |
18: 4,673,113 (GRCm39) |
K292E |
probably damaging |
Het |
| Krt5 |
T |
A |
15: 101,617,453 (GRCm39) |
T427S |
probably benign |
Het |
| Krt76 |
T |
C |
15: 101,798,929 (GRCm39) |
D252G |
probably damaging |
Het |
| Krtap26-1 |
A |
G |
16: 88,444,198 (GRCm39) |
V141A |
not run |
Het |
| Lce6a |
A |
T |
3: 92,527,642 (GRCm39) |
V55D |
probably benign |
Het |
| Lpxn |
C |
T |
19: 12,802,185 (GRCm39) |
S170F |
possibly damaging |
Het |
| Magi2 |
T |
C |
5: 20,670,838 (GRCm39) |
V394A |
probably benign |
Het |
| Mbnl1 |
G |
A |
3: 60,522,242 (GRCm39) |
|
probably null |
Het |
| Med16 |
T |
A |
10: 79,734,252 (GRCm39) |
K554M |
probably damaging |
Het |
| Mettl14 |
T |
C |
3: 123,166,234 (GRCm39) |
D276G |
possibly damaging |
Het |
| Mphosph9 |
T |
C |
5: 124,399,009 (GRCm39) |
D1002G |
probably damaging |
Het |
| Nav1 |
T |
C |
1: 135,379,986 (GRCm39) |
Y1512C |
unknown |
Het |
| Neb |
T |
C |
2: 52,082,035 (GRCm39) |
Y5712C |
probably damaging |
Het |
| Nek7 |
T |
A |
1: 138,489,509 (GRCm39) |
|
probably benign |
Het |
| Nptx1 |
T |
A |
11: 119,435,462 (GRCm39) |
I285F |
probably damaging |
Het |
| Oas1d |
G |
T |
5: 121,053,034 (GRCm39) |
E30* |
probably null |
Het |
| Or1p1b |
A |
T |
11: 74,130,725 (GRCm39) |
I112F |
probably damaging |
Het |
| Or51g2 |
A |
G |
7: 102,622,317 (GRCm39) |
V294A |
possibly damaging |
Het |
| Or6n1 |
C |
A |
1: 173,917,417 (GRCm39) |
Y270* |
probably null |
Het |
| Parp4 |
T |
G |
14: 56,873,205 (GRCm39) |
S1150A |
possibly damaging |
Het |
| Pinx1 |
A |
T |
14: 64,156,741 (GRCm39) |
K223* |
probably null |
Het |
| Plekha5 |
T |
C |
6: 140,529,640 (GRCm39) |
L1034S |
probably damaging |
Het |
| Ppp4r3a |
A |
G |
12: 101,019,755 (GRCm39) |
V400A |
possibly damaging |
Het |
| Prtg |
A |
T |
9: 72,749,979 (GRCm39) |
I128F |
possibly damaging |
Het |
| Rars1 |
T |
C |
11: 35,719,534 (GRCm39) |
E96G |
probably benign |
Het |
| Rhpn1 |
T |
A |
15: 75,585,299 (GRCm39) |
S551T |
probably benign |
Het |
| Selenow |
C |
T |
7: 15,656,176 (GRCm39) |
|
probably null |
Het |
| Serpina9 |
A |
T |
12: 103,967,484 (GRCm39) |
|
probably null |
Het |
| Shank3 |
A |
T |
15: 89,433,083 (GRCm39) |
D1276V |
probably damaging |
Het |
| Slc27a6 |
A |
G |
18: 58,742,267 (GRCm39) |
T494A |
probably damaging |
Het |
| Slc34a1 |
A |
C |
13: 24,003,317 (GRCm39) |
H285P |
probably damaging |
Het |
| Slc6a21 |
A |
C |
7: 44,932,360 (GRCm39) |
T54P |
|
Het |
| Syne2 |
A |
G |
12: 76,030,501 (GRCm39) |
|
probably null |
Het |
| Tal1 |
T |
C |
4: 114,925,489 (GRCm39) |
V186A |
probably benign |
Het |
| Tars3 |
A |
G |
7: 65,302,009 (GRCm39) |
K178E |
probably benign |
Het |
| Tex10 |
T |
A |
4: 48,459,984 (GRCm39) |
I456L |
probably benign |
Het |
| Tfcp2 |
A |
G |
15: 100,420,310 (GRCm39) |
F175S |
probably damaging |
Het |
| Timp2 |
C |
T |
11: 118,194,626 (GRCm39) |
A188T |
probably damaging |
Het |
| Tmc5 |
T |
A |
7: 118,268,440 (GRCm39) |
I836N |
probably damaging |
Het |
| Tmem100 |
T |
A |
11: 89,926,302 (GRCm39) |
M43K |
probably benign |
Het |
| Ulk2 |
A |
G |
11: 61,745,378 (GRCm39) |
Y9H |
probably damaging |
Het |
| Usp7 |
T |
C |
16: 8,523,027 (GRCm39) |
K311E |
probably damaging |
Het |
| Vmn1r238 |
G |
A |
18: 3,123,033 (GRCm39) |
T127I |
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,496,678 (GRCm39) |
Y58C |
probably damaging |
Het |
| Wdr55 |
G |
A |
18: 36,893,469 (GRCm39) |
G44S |
probably benign |
Het |
| Zfp677 |
C |
A |
17: 21,617,647 (GRCm39) |
H235N |
probably damaging |
Het |
| Zfp869 |
T |
A |
8: 70,159,636 (GRCm39) |
R312S |
probably damaging |
Het |
|
| Other mutations in Mroh9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Mroh9
|
APN |
1 |
162,873,350 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00705:Mroh9
|
APN |
1 |
162,907,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00788:Mroh9
|
APN |
1 |
162,852,227 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00795:Mroh9
|
APN |
1 |
162,888,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00815:Mroh9
|
APN |
1 |
162,866,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01025:Mroh9
|
APN |
1 |
162,875,435 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01303:Mroh9
|
APN |
1 |
162,908,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01526:Mroh9
|
APN |
1 |
162,883,172 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01680:Mroh9
|
APN |
1 |
162,875,551 (GRCm39) |
splice site |
probably null |
|
|
IGL01823:Mroh9
|
APN |
1 |
162,883,178 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02024:Mroh9
|
APN |
1 |
162,890,071 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02213:Mroh9
|
APN |
1 |
162,885,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Mroh9
|
APN |
1 |
162,903,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02546:Mroh9
|
APN |
1 |
162,908,145 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03059:Mroh9
|
APN |
1 |
162,852,205 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03061:Mroh9
|
APN |
1 |
162,854,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Mroh9
|
APN |
1 |
162,866,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0441:Mroh9
|
UTSW |
1 |
162,888,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0629:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0751:Mroh9
|
UTSW |
1 |
162,893,693 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1301:Mroh9
|
UTSW |
1 |
162,871,552 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1481:Mroh9
|
UTSW |
1 |
162,854,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Mroh9
|
UTSW |
1 |
162,852,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1647:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1668:Mroh9
|
UTSW |
1 |
162,852,161 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1795:Mroh9
|
UTSW |
1 |
162,884,347 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1796:Mroh9
|
UTSW |
1 |
162,873,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1857:Mroh9
|
UTSW |
1 |
162,866,714 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1869:Mroh9
|
UTSW |
1 |
162,854,082 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1923:Mroh9
|
UTSW |
1 |
162,903,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Mroh9
|
UTSW |
1 |
162,854,099 (GRCm39) |
splice site |
probably null |
|
|
R2511:Mroh9
|
UTSW |
1 |
162,866,514 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2912:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2913:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Mroh9
|
UTSW |
1 |
162,884,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2973:Mroh9
|
UTSW |
1 |
162,884,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3912:Mroh9
|
UTSW |
1 |
162,893,638 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4034:Mroh9
|
UTSW |
1 |
162,908,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4551:Mroh9
|
UTSW |
1 |
162,871,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4656:Mroh9
|
UTSW |
1 |
162,893,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4662:Mroh9
|
UTSW |
1 |
162,883,162 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4743:Mroh9
|
UTSW |
1 |
162,852,061 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4890:Mroh9
|
UTSW |
1 |
162,854,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5128:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5129:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5147:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5157:Mroh9
|
UTSW |
1 |
162,871,690 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5324:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5340:Mroh9
|
UTSW |
1 |
162,908,156 (GRCm39) |
start gained |
probably benign |
|
|
R6005:Mroh9
|
UTSW |
1 |
162,903,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6182:Mroh9
|
UTSW |
1 |
162,893,612 (GRCm39) |
nonsense |
probably null |
|
|
R6414:Mroh9
|
UTSW |
1 |
162,902,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Mroh9
|
UTSW |
1 |
162,903,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6540:Mroh9
|
UTSW |
1 |
162,866,541 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6541:Mroh9
|
UTSW |
1 |
162,885,607 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6643:Mroh9
|
UTSW |
1 |
162,903,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Mroh9
|
UTSW |
1 |
162,873,610 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6830:Mroh9
|
UTSW |
1 |
162,903,935 (GRCm39) |
missense |
probably benign |
|
|
R7026:Mroh9
|
UTSW |
1 |
162,888,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7052:Mroh9
|
UTSW |
1 |
162,866,525 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7068:Mroh9
|
UTSW |
1 |
162,866,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Mroh9
|
UTSW |
1 |
162,903,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7545:Mroh9
|
UTSW |
1 |
162,902,277 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7615:Mroh9
|
UTSW |
1 |
162,873,601 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7743:Mroh9
|
UTSW |
1 |
162,852,122 (GRCm39) |
missense |
probably benign |
|
|
R8024:Mroh9
|
UTSW |
1 |
162,866,802 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8062:Mroh9
|
UTSW |
1 |
162,866,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8145:Mroh9
|
UTSW |
1 |
162,890,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8426:Mroh9
|
UTSW |
1 |
162,852,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8458:Mroh9
|
UTSW |
1 |
162,883,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Mroh9
|
UTSW |
1 |
162,899,595 (GRCm39) |
splice site |
probably null |
|
|
R8960:Mroh9
|
UTSW |
1 |
162,883,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9040:Mroh9
|
UTSW |
1 |
162,890,069 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9125:Mroh9
|
UTSW |
1 |
162,875,412 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9154:Mroh9
|
UTSW |
1 |
162,890,030 (GRCm39) |
missense |
|
|
|
R9596:Mroh9
|
UTSW |
1 |
162,893,576 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9612:Mroh9
|
UTSW |
1 |
162,866,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF003:Mroh9
|
UTSW |
1 |
162,885,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGATGTCGAGAACTACTGAC -3'
(R):5'- GATATGCTCAGCTGAGGCCTTG -3'
Sequencing Primer
(F):5'- TCCTCTTTGAGCAGAGATGC -3'
(R):5'- AGCTGAGGCCTTGACCTTTTC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation