Incidental Mutation 'R7808:Magi2'
| ID |
600922 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi2
|
| Ensembl Gene |
ENSMUSG00000040003 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| Synonyms |
Acvrinp1, Magi-2, S-SCAM |
| MMRRC Submission |
045863-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7808 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
19432034-20909790 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20670838 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 394
(V394A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099094
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088516]
[ENSMUST00000101558]
[ENSMUST00000115267]
[ENSMUST00000197354]
[ENSMUST00000197443]
[ENSMUST00000197553]
[ENSMUST00000208219]
|
| AlphaFold |
Q9WVQ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088516
AA Change: V557A
PolyPhen 2
Score 0.237 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000085872
Gene: ENSMUSG00000040003
AA Change: V557A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
5.26e-9 |
SMART |
|
GuKc
|
107 |
290 |
2.76e-45 |
SMART |
|
WW
|
302 |
334 |
7.43e-12 |
SMART |
|
WW
|
348 |
380 |
2.4e-6 |
SMART |
|
PDZ
|
433 |
509 |
3.51e-19 |
SMART |
|
PDZ
|
612 |
682 |
2.3e-14 |
SMART |
|
PDZ
|
785 |
861 |
4.04e-19 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
5.05e-20 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
3.88e-21 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101558
AA Change: V394A
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000099094
Gene: ENSMUSG00000040003
AA Change: V394A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
608 |
684 |
4.04e-19 |
SMART |
|
low complexity region
|
716 |
730 |
N/A |
INTRINSIC |
|
PDZ
|
751 |
832 |
5.05e-20 |
SMART |
|
low complexity region
|
875 |
886 |
N/A |
INTRINSIC |
|
PDZ
|
970 |
1044 |
3.88e-21 |
SMART |
|
low complexity region
|
1080 |
1093 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115267
AA Change: V394A
PolyPhen 2
Score 0.237 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000110922
Gene: ENSMUSG00000040003
AA Change: V394A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
622 |
698 |
4.04e-19 |
SMART |
|
low complexity region
|
730 |
744 |
N/A |
INTRINSIC |
|
PDZ
|
765 |
846 |
5.05e-20 |
SMART |
|
low complexity region
|
889 |
900 |
N/A |
INTRINSIC |
|
PDZ
|
984 |
1058 |
3.88e-21 |
SMART |
|
low complexity region
|
1094 |
1107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197354
AA Change: V557A
PolyPhen 2
Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000142576
Gene: ENSMUSG00000040003
AA Change: V557A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
785 |
861 |
2e-21 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
2.4e-22 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
1.9e-23 |
SMART |
|
low complexity region
|
1255 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1304 |
1319 |
N/A |
INTRINSIC |
|
low complexity region
|
1344 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197443
AA Change: V557A
PolyPhen 2
Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000142764
Gene: ENSMUSG00000040003
AA Change: V557A
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
771 |
847 |
2e-21 |
SMART |
|
low complexity region
|
879 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
914 |
995 |
2.4e-22 |
SMART |
|
low complexity region
|
1038 |
1049 |
N/A |
INTRINSIC |
|
PDZ
|
1133 |
1207 |
1.9e-23 |
SMART |
|
low complexity region
|
1241 |
1255 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1349 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1370 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000197553
AA Change: V167A
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000208219
AA Change: V167A
PolyPhen 2
Score 0.565 (Sensitivity: 0.88; Specificity: 0.91)
|
| Meta Mutation Damage Score |
0.0827 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show neonatal death and hippocampal neurons with altered dendritic spine morphology. Homozygotes for a different null allele die neonatally due to anuria and podocyte anomalies. Mice lacking all three isoforms develop proteinuria, podocytopathy and die of renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 86,957,297 (GRCm39) |
V11A |
probably benign |
Het |
| Abca12 |
A |
T |
1: 71,313,793 (GRCm39) |
|
probably null |
Het |
| Abcc12 |
T |
A |
8: 87,234,568 (GRCm39) |
M1232L |
probably benign |
Het |
| Adamts1 |
T |
C |
16: 85,597,117 (GRCm39) |
Y314C |
probably damaging |
Het |
| Adgb |
A |
G |
10: 10,254,403 (GRCm39) |
|
probably null |
Het |
| Ankrd12 |
T |
A |
17: 66,292,648 (GRCm39) |
K928N |
possibly damaging |
Het |
| Ano5 |
A |
T |
7: 51,237,543 (GRCm39) |
K789I |
possibly damaging |
Het |
| Cacna1d |
G |
T |
14: 29,833,026 (GRCm39) |
N938K |
probably damaging |
Het |
| Camk1g |
T |
C |
1: 193,032,593 (GRCm39) |
R273G |
possibly damaging |
Het |
| Caprin2 |
C |
A |
6: 148,744,528 (GRCm39) |
V966F |
probably damaging |
Het |
| Card6 |
T |
C |
15: 5,128,954 (GRCm39) |
H814R |
probably benign |
Het |
| Cenatac |
T |
C |
9: 44,324,215 (GRCm39) |
Q228R |
probably null |
Het |
| Cflar |
A |
G |
1: 58,750,740 (GRCm39) |
|
probably benign |
Het |
| Cftr |
T |
A |
6: 18,204,204 (GRCm39) |
N66K |
probably benign |
Het |
| Clasrp |
C |
T |
7: 19,322,671 (GRCm39) |
|
probably null |
Het |
| Clec4a4 |
T |
C |
6: 122,967,339 (GRCm39) |
I5T |
probably damaging |
Het |
| Cmtr2 |
T |
C |
8: 110,948,251 (GRCm39) |
I187T |
possibly damaging |
Het |
| Cnga1 |
A |
T |
5: 72,761,616 (GRCm39) |
F633I |
possibly damaging |
Het |
| Col16a1 |
C |
T |
4: 129,967,057 (GRCm39) |
P909S |
unknown |
Het |
| Csf1 |
C |
A |
3: 107,667,361 (GRCm39) |
A7S |
possibly damaging |
Het |
| Cstpp1 |
T |
C |
2: 91,274,939 (GRCm39) |
|
probably benign |
Het |
| Dhx30 |
A |
T |
9: 109,915,270 (GRCm39) |
V833D |
probably benign |
Het |
| Dlg2 |
T |
G |
7: 92,080,263 (GRCm39) |
I712M |
probably benign |
Het |
| Dmxl1 |
T |
A |
18: 50,011,382 (GRCm39) |
F1180I |
probably benign |
Het |
| Dnah9 |
T |
A |
11: 65,896,631 (GRCm39) |
K2398* |
probably null |
Het |
| Dus1l |
C |
T |
11: 120,680,262 (GRCm39) |
G471D |
possibly damaging |
Het |
| Dync1h1 |
A |
T |
12: 110,621,893 (GRCm39) |
N3412I |
possibly damaging |
Het |
| Dync1i2 |
T |
A |
2: 71,081,178 (GRCm39) |
|
probably null |
Het |
| Dysf |
T |
C |
6: 84,047,911 (GRCm39) |
S333P |
possibly damaging |
Het |
| Eed |
A |
T |
7: 89,605,541 (GRCm39) |
N349K |
probably benign |
Het |
| Eipr1 |
A |
T |
12: 28,816,769 (GRCm39) |
|
probably null |
Het |
| Fbxw16 |
A |
C |
9: 109,277,222 (GRCm39) |
V40G |
probably damaging |
Het |
| Fgfr4 |
A |
C |
13: 55,308,969 (GRCm39) |
R363S |
possibly damaging |
Het |
| Fgl2 |
A |
T |
5: 21,578,229 (GRCm39) |
N172I |
possibly damaging |
Het |
| Fhip1b |
G |
A |
7: 105,033,732 (GRCm39) |
R509C |
probably damaging |
Het |
| Gabbr2 |
T |
A |
4: 46,875,744 (GRCm39) |
H126L |
possibly damaging |
Het |
| Gcnt2 |
A |
T |
13: 41,014,338 (GRCm39) |
N170Y |
possibly damaging |
Het |
| Gpt |
A |
G |
15: 76,583,093 (GRCm39) |
|
probably null |
Het |
| Igsf10 |
A |
G |
3: 59,235,489 (GRCm39) |
I1564T |
probably benign |
Het |
| Il22ra1 |
C |
A |
4: 135,478,107 (GRCm39) |
Q393K |
possibly damaging |
Het |
| Inpp5d |
A |
T |
1: 87,611,567 (GRCm39) |
K340* |
probably null |
Het |
| Jcad |
A |
G |
18: 4,673,113 (GRCm39) |
K292E |
probably damaging |
Het |
| Krt5 |
T |
A |
15: 101,617,453 (GRCm39) |
T427S |
probably benign |
Het |
| Krt76 |
T |
C |
15: 101,798,929 (GRCm39) |
D252G |
probably damaging |
Het |
| Krtap26-1 |
A |
G |
16: 88,444,198 (GRCm39) |
V141A |
not run |
Het |
| Lce6a |
A |
T |
3: 92,527,642 (GRCm39) |
V55D |
probably benign |
Het |
| Lpxn |
C |
T |
19: 12,802,185 (GRCm39) |
S170F |
possibly damaging |
Het |
| Mbnl1 |
G |
A |
3: 60,522,242 (GRCm39) |
|
probably null |
Het |
| Med16 |
T |
A |
10: 79,734,252 (GRCm39) |
K554M |
probably damaging |
Het |
| Mettl14 |
T |
C |
3: 123,166,234 (GRCm39) |
D276G |
possibly damaging |
Het |
| Mphosph9 |
T |
C |
5: 124,399,009 (GRCm39) |
D1002G |
probably damaging |
Het |
| Mroh9 |
T |
C |
1: 162,866,678 (GRCm39) |
E686G |
probably damaging |
Het |
| Nav1 |
T |
C |
1: 135,379,986 (GRCm39) |
Y1512C |
unknown |
Het |
| Neb |
T |
C |
2: 52,082,035 (GRCm39) |
Y5712C |
probably damaging |
Het |
| Nek7 |
T |
A |
1: 138,489,509 (GRCm39) |
|
probably benign |
Het |
| Nptx1 |
T |
A |
11: 119,435,462 (GRCm39) |
I285F |
probably damaging |
Het |
| Oas1d |
G |
T |
5: 121,053,034 (GRCm39) |
E30* |
probably null |
Het |
| Or1p1b |
A |
T |
11: 74,130,725 (GRCm39) |
I112F |
probably damaging |
Het |
| Or51g2 |
A |
G |
7: 102,622,317 (GRCm39) |
V294A |
possibly damaging |
Het |
| Or6n1 |
C |
A |
1: 173,917,417 (GRCm39) |
Y270* |
probably null |
Het |
| Parp4 |
T |
G |
14: 56,873,205 (GRCm39) |
S1150A |
possibly damaging |
Het |
| Pinx1 |
A |
T |
14: 64,156,741 (GRCm39) |
K223* |
probably null |
Het |
| Plekha5 |
T |
C |
6: 140,529,640 (GRCm39) |
L1034S |
probably damaging |
Het |
| Ppp4r3a |
A |
G |
12: 101,019,755 (GRCm39) |
V400A |
possibly damaging |
Het |
| Prtg |
A |
T |
9: 72,749,979 (GRCm39) |
I128F |
possibly damaging |
Het |
| Rars1 |
T |
C |
11: 35,719,534 (GRCm39) |
E96G |
probably benign |
Het |
| Rhpn1 |
T |
A |
15: 75,585,299 (GRCm39) |
S551T |
probably benign |
Het |
| Selenow |
C |
T |
7: 15,656,176 (GRCm39) |
|
probably null |
Het |
| Serpina9 |
A |
T |
12: 103,967,484 (GRCm39) |
|
probably null |
Het |
| Shank3 |
A |
T |
15: 89,433,083 (GRCm39) |
D1276V |
probably damaging |
Het |
| Slc27a6 |
A |
G |
18: 58,742,267 (GRCm39) |
T494A |
probably damaging |
Het |
| Slc34a1 |
A |
C |
13: 24,003,317 (GRCm39) |
H285P |
probably damaging |
Het |
| Slc6a21 |
A |
C |
7: 44,932,360 (GRCm39) |
T54P |
|
Het |
| Syne2 |
A |
G |
12: 76,030,501 (GRCm39) |
|
probably null |
Het |
| Tal1 |
T |
C |
4: 114,925,489 (GRCm39) |
V186A |
probably benign |
Het |
| Tars3 |
A |
G |
7: 65,302,009 (GRCm39) |
K178E |
probably benign |
Het |
| Tex10 |
T |
A |
4: 48,459,984 (GRCm39) |
I456L |
probably benign |
Het |
| Tfcp2 |
A |
G |
15: 100,420,310 (GRCm39) |
F175S |
probably damaging |
Het |
| Timp2 |
C |
T |
11: 118,194,626 (GRCm39) |
A188T |
probably damaging |
Het |
| Tmc5 |
T |
A |
7: 118,268,440 (GRCm39) |
I836N |
probably damaging |
Het |
| Tmem100 |
T |
A |
11: 89,926,302 (GRCm39) |
M43K |
probably benign |
Het |
| Ulk2 |
A |
G |
11: 61,745,378 (GRCm39) |
Y9H |
probably damaging |
Het |
| Usp7 |
T |
C |
16: 8,523,027 (GRCm39) |
K311E |
probably damaging |
Het |
| Vmn1r238 |
G |
A |
18: 3,123,033 (GRCm39) |
T127I |
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,496,678 (GRCm39) |
Y58C |
probably damaging |
Het |
| Wdr55 |
G |
A |
18: 36,893,469 (GRCm39) |
G44S |
probably benign |
Het |
| Zfp677 |
C |
A |
17: 21,617,647 (GRCm39) |
H235N |
probably damaging |
Het |
| Zfp869 |
T |
A |
8: 70,159,636 (GRCm39) |
R312S |
probably damaging |
Het |
|
| Other mutations in Magi2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00908:Magi2
|
APN |
5 |
20,596,299 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02120:Magi2
|
APN |
5 |
20,433,451 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02341:Magi2
|
APN |
5 |
20,671,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02411:Magi2
|
APN |
5 |
19,883,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02657:Magi2
|
APN |
5 |
19,432,581 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02976:Magi2
|
APN |
5 |
20,739,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Magi2
|
APN |
5 |
20,748,616 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03246:Magi2
|
APN |
5 |
20,563,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Magi2
|
APN |
5 |
20,671,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
LCD18:Magi2
|
UTSW |
5 |
20,159,509 (GRCm39) |
intron |
probably benign |
|
|
PIT4519001:Magi2
|
UTSW |
5 |
20,866,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0009:Magi2
|
UTSW |
5 |
20,816,053 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0009:Magi2
|
UTSW |
5 |
20,816,053 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0352:Magi2
|
UTSW |
5 |
20,270,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Magi2
|
UTSW |
5 |
19,432,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0496:Magi2
|
UTSW |
5 |
20,866,357 (GRCm39) |
splice site |
probably benign |
|
|
R1103:Magi2
|
UTSW |
5 |
20,816,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1435:Magi2
|
UTSW |
5 |
20,563,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Magi2
|
UTSW |
5 |
19,432,330 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1616:Magi2
|
UTSW |
5 |
20,814,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1643:Magi2
|
UTSW |
5 |
20,910,504 (GRCm39) |
unclassified |
probably benign |
|
|
R1707:Magi2
|
UTSW |
5 |
20,420,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Magi2
|
UTSW |
5 |
19,432,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1837:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1839:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1847:Magi2
|
UTSW |
5 |
20,807,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2223:Magi2
|
UTSW |
5 |
20,670,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2496:Magi2
|
UTSW |
5 |
19,883,750 (GRCm39) |
missense |
probably benign |
0.42 |
|
R2504:Magi2
|
UTSW |
5 |
20,563,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2848:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2879:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2935:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2936:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R3694:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R3783:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3786:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3787:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3837:Magi2
|
UTSW |
5 |
20,420,466 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4151:Magi2
|
UTSW |
5 |
19,432,290 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4721:Magi2
|
UTSW |
5 |
20,739,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Magi2
|
UTSW |
5 |
20,739,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5012:Magi2
|
UTSW |
5 |
20,670,618 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5193:Magi2
|
UTSW |
5 |
20,563,970 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5298:Magi2
|
UTSW |
5 |
20,774,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Magi2
|
UTSW |
5 |
20,907,108 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5580:Magi2
|
UTSW |
5 |
20,420,422 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5806:Magi2
|
UTSW |
5 |
20,856,202 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5924:Magi2
|
UTSW |
5 |
20,816,067 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Magi2
|
UTSW |
5 |
19,432,289 (GRCm39) |
start codon destroyed |
probably null |
0.42 |
|
R6014:Magi2
|
UTSW |
5 |
20,816,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6073:Magi2
|
UTSW |
5 |
20,774,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6500:Magi2
|
UTSW |
5 |
20,807,345 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6664:Magi2
|
UTSW |
5 |
20,907,395 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7229:Magi2
|
UTSW |
5 |
20,670,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Magi2
|
UTSW |
5 |
20,755,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7448:Magi2
|
UTSW |
5 |
20,563,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7605:Magi2
|
UTSW |
5 |
20,433,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7712:Magi2
|
UTSW |
5 |
20,755,280 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7955:Magi2
|
UTSW |
5 |
20,594,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8134:Magi2
|
UTSW |
5 |
20,596,392 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8134:Magi2
|
UTSW |
5 |
20,596,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8253:Magi2
|
UTSW |
5 |
20,814,305 (GRCm39) |
missense |
probably benign |
0.44 |
|
R8481:Magi2
|
UTSW |
5 |
20,594,152 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8553:Magi2
|
UTSW |
5 |
20,856,198 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8751:Magi2
|
UTSW |
5 |
20,739,462 (GRCm39) |
missense |
probably benign |
|
|
R8766:Magi2
|
UTSW |
5 |
20,400,123 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8851:Magi2
|
UTSW |
5 |
20,270,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8876:Magi2
|
UTSW |
5 |
20,856,190 (GRCm39) |
nonsense |
probably null |
|
|
R9120:Magi2
|
UTSW |
5 |
20,733,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9335:Magi2
|
UTSW |
5 |
20,866,263 (GRCm39) |
missense |
|
|
|
R9367:Magi2
|
UTSW |
5 |
20,766,308 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9454:Magi2
|
UTSW |
5 |
20,671,176 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9474:Magi2
|
UTSW |
5 |
20,400,019 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9577:Magi2
|
UTSW |
5 |
20,814,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Magi2
|
UTSW |
5 |
20,670,582 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9696:Magi2
|
UTSW |
5 |
20,670,864 (GRCm39) |
missense |
probably benign |
0.35 |
|
X0065:Magi2
|
UTSW |
5 |
20,774,176 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1176:Magi2
|
UTSW |
5 |
20,907,107 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Magi2
|
UTSW |
5 |
20,907,410 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACACTCATGCAGATGTTGTCAAAC -3'
(R):5'- GTAAAGCCAAATCCCTGGGC -3'
Sequencing Primer
(F):5'- TCCTATTGGTCAGAGTGTCAAC -3'
(R):5'- GGCACCTTTCACAATGGTTAAGGTC -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation