Incidental Mutation 'R7808:Mphosph9'
ID 600926
Institutional Source Beutler Lab
Gene Symbol Mphosph9
Ensembl Gene ENSMUSG00000038126
Gene Name M-phase phosphoprotein 9
Synonyms 4930548D04Rik, MPP9, B930097C17Rik, 9630025B04Rik, MPP-9
MMRRC Submission 045863-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7808 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 124389022-124466001 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 124399009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1002 (D1002G)
Ref Sequence ENSEMBL: ENSMUSP00000138982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031344] [ENSMUST00000147737] [ENSMUST00000184951]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000031344
AA Change: D972G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000031344
Gene: ENSMUSG00000038126
AA Change: D972G

DomainStartEndE-ValueType
low complexity region 102 119 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
low complexity region 414 428 N/A INTRINSIC
coiled coil region 574 736 N/A INTRINSIC
low complexity region 879 898 N/A INTRINSIC
low complexity region 957 971 N/A INTRINSIC
coiled coil region 1040 1105 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000147737
Predicted Effect probably damaging
Transcript: ENSMUST00000184951
AA Change: D1002G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000138982
Gene: ENSMUSG00000038126
AA Change: D1002G

DomainStartEndE-ValueType
coiled coil region 102 130 N/A INTRINSIC
low complexity region 132 149 N/A INTRINSIC
low complexity region 158 170 N/A INTRINSIC
low complexity region 444 458 N/A INTRINSIC
coiled coil region 604 766 N/A INTRINSIC
low complexity region 909 928 N/A INTRINSIC
low complexity region 987 1001 N/A INTRINSIC
coiled coil region 1070 1135 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 99% (86/87)
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 86,957,297 (GRCm39) V11A probably benign Het
Abca12 A T 1: 71,313,793 (GRCm39) probably null Het
Abcc12 T A 8: 87,234,568 (GRCm39) M1232L probably benign Het
Adamts1 T C 16: 85,597,117 (GRCm39) Y314C probably damaging Het
Adgb A G 10: 10,254,403 (GRCm39) probably null Het
Ankrd12 T A 17: 66,292,648 (GRCm39) K928N possibly damaging Het
Ano5 A T 7: 51,237,543 (GRCm39) K789I possibly damaging Het
Cacna1d G T 14: 29,833,026 (GRCm39) N938K probably damaging Het
Camk1g T C 1: 193,032,593 (GRCm39) R273G possibly damaging Het
Caprin2 C A 6: 148,744,528 (GRCm39) V966F probably damaging Het
Card6 T C 15: 5,128,954 (GRCm39) H814R probably benign Het
Cenatac T C 9: 44,324,215 (GRCm39) Q228R probably null Het
Cflar A G 1: 58,750,740 (GRCm39) probably benign Het
Cftr T A 6: 18,204,204 (GRCm39) N66K probably benign Het
Clasrp C T 7: 19,322,671 (GRCm39) probably null Het
Clec4a4 T C 6: 122,967,339 (GRCm39) I5T probably damaging Het
Cmtr2 T C 8: 110,948,251 (GRCm39) I187T possibly damaging Het
Cnga1 A T 5: 72,761,616 (GRCm39) F633I possibly damaging Het
Col16a1 C T 4: 129,967,057 (GRCm39) P909S unknown Het
Csf1 C A 3: 107,667,361 (GRCm39) A7S possibly damaging Het
Cstpp1 T C 2: 91,274,939 (GRCm39) probably benign Het
Dhx30 A T 9: 109,915,270 (GRCm39) V833D probably benign Het
Dlg2 T G 7: 92,080,263 (GRCm39) I712M probably benign Het
Dmxl1 T A 18: 50,011,382 (GRCm39) F1180I probably benign Het
Dnah9 T A 11: 65,896,631 (GRCm39) K2398* probably null Het
Dus1l C T 11: 120,680,262 (GRCm39) G471D possibly damaging Het
Dync1h1 A T 12: 110,621,893 (GRCm39) N3412I possibly damaging Het
Dync1i2 T A 2: 71,081,178 (GRCm39) probably null Het
Dysf T C 6: 84,047,911 (GRCm39) S333P possibly damaging Het
Eed A T 7: 89,605,541 (GRCm39) N349K probably benign Het
Eipr1 A T 12: 28,816,769 (GRCm39) probably null Het
Fbxw16 A C 9: 109,277,222 (GRCm39) V40G probably damaging Het
Fgfr4 A C 13: 55,308,969 (GRCm39) R363S possibly damaging Het
Fgl2 A T 5: 21,578,229 (GRCm39) N172I possibly damaging Het
Fhip1b G A 7: 105,033,732 (GRCm39) R509C probably damaging Het
Gabbr2 T A 4: 46,875,744 (GRCm39) H126L possibly damaging Het
Gcnt2 A T 13: 41,014,338 (GRCm39) N170Y possibly damaging Het
Gpt A G 15: 76,583,093 (GRCm39) probably null Het
Igsf10 A G 3: 59,235,489 (GRCm39) I1564T probably benign Het
Il22ra1 C A 4: 135,478,107 (GRCm39) Q393K possibly damaging Het
Inpp5d A T 1: 87,611,567 (GRCm39) K340* probably null Het
Jcad A G 18: 4,673,113 (GRCm39) K292E probably damaging Het
Krt5 T A 15: 101,617,453 (GRCm39) T427S probably benign Het
Krt76 T C 15: 101,798,929 (GRCm39) D252G probably damaging Het
Krtap26-1 A G 16: 88,444,198 (GRCm39) V141A not run Het
Lce6a A T 3: 92,527,642 (GRCm39) V55D probably benign Het
Lpxn C T 19: 12,802,185 (GRCm39) S170F possibly damaging Het
Magi2 T C 5: 20,670,838 (GRCm39) V394A probably benign Het
Mbnl1 G A 3: 60,522,242 (GRCm39) probably null Het
Med16 T A 10: 79,734,252 (GRCm39) K554M probably damaging Het
Mettl14 T C 3: 123,166,234 (GRCm39) D276G possibly damaging Het
Mroh9 T C 1: 162,866,678 (GRCm39) E686G probably damaging Het
Nav1 T C 1: 135,379,986 (GRCm39) Y1512C unknown Het
Neb T C 2: 52,082,035 (GRCm39) Y5712C probably damaging Het
Nek7 T A 1: 138,489,509 (GRCm39) probably benign Het
Nptx1 T A 11: 119,435,462 (GRCm39) I285F probably damaging Het
Oas1d G T 5: 121,053,034 (GRCm39) E30* probably null Het
Or1p1b A T 11: 74,130,725 (GRCm39) I112F probably damaging Het
Or51g2 A G 7: 102,622,317 (GRCm39) V294A possibly damaging Het
Or6n1 C A 1: 173,917,417 (GRCm39) Y270* probably null Het
Parp4 T G 14: 56,873,205 (GRCm39) S1150A possibly damaging Het
Pinx1 A T 14: 64,156,741 (GRCm39) K223* probably null Het
Plekha5 T C 6: 140,529,640 (GRCm39) L1034S probably damaging Het
Ppp4r3a A G 12: 101,019,755 (GRCm39) V400A possibly damaging Het
Prtg A T 9: 72,749,979 (GRCm39) I128F possibly damaging Het
Rars1 T C 11: 35,719,534 (GRCm39) E96G probably benign Het
Rhpn1 T A 15: 75,585,299 (GRCm39) S551T probably benign Het
Selenow C T 7: 15,656,176 (GRCm39) probably null Het
Serpina9 A T 12: 103,967,484 (GRCm39) probably null Het
Shank3 A T 15: 89,433,083 (GRCm39) D1276V probably damaging Het
Slc27a6 A G 18: 58,742,267 (GRCm39) T494A probably damaging Het
Slc34a1 A C 13: 24,003,317 (GRCm39) H285P probably damaging Het
Slc6a21 A C 7: 44,932,360 (GRCm39) T54P Het
Syne2 A G 12: 76,030,501 (GRCm39) probably null Het
Tal1 T C 4: 114,925,489 (GRCm39) V186A probably benign Het
Tars3 A G 7: 65,302,009 (GRCm39) K178E probably benign Het
Tex10 T A 4: 48,459,984 (GRCm39) I456L probably benign Het
Tfcp2 A G 15: 100,420,310 (GRCm39) F175S probably damaging Het
Timp2 C T 11: 118,194,626 (GRCm39) A188T probably damaging Het
Tmc5 T A 7: 118,268,440 (GRCm39) I836N probably damaging Het
Tmem100 T A 11: 89,926,302 (GRCm39) M43K probably benign Het
Ulk2 A G 11: 61,745,378 (GRCm39) Y9H probably damaging Het
Usp7 T C 16: 8,523,027 (GRCm39) K311E probably damaging Het
Vmn1r238 G A 18: 3,123,033 (GRCm39) T127I probably benign Het
Vmn2r28 T C 7: 5,496,678 (GRCm39) Y58C probably damaging Het
Wdr55 G A 18: 36,893,469 (GRCm39) G44S probably benign Het
Zfp677 C A 17: 21,617,647 (GRCm39) H235N probably damaging Het
Zfp869 T A 8: 70,159,636 (GRCm39) R312S probably damaging Het
Other mutations in Mphosph9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Mphosph9 APN 5 124,400,084 (GRCm39) missense probably damaging 1.00
IGL01527:Mphosph9 APN 5 124,421,687 (GRCm39) splice site probably benign
IGL01784:Mphosph9 APN 5 124,403,373 (GRCm39) splice site probably benign
IGL01958:Mphosph9 APN 5 124,463,053 (GRCm39) utr 5 prime probably benign
IGL02020:Mphosph9 APN 5 124,397,013 (GRCm39) missense probably damaging 0.99
IGL02190:Mphosph9 APN 5 124,403,488 (GRCm39) missense possibly damaging 0.92
IGL02261:Mphosph9 APN 5 124,398,150 (GRCm39) missense probably damaging 1.00
IGL02569:Mphosph9 APN 5 124,435,634 (GRCm39) nonsense probably null
IGL02640:Mphosph9 APN 5 124,453,563 (GRCm39) missense possibly damaging 0.66
IGL02702:Mphosph9 APN 5 124,398,052 (GRCm39) missense probably damaging 1.00
IGL02793:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL02813:Mphosph9 APN 5 124,453,691 (GRCm39) missense probably benign 0.37
IGL02875:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL03149:Mphosph9 APN 5 124,401,074 (GRCm39) missense probably damaging 1.00
PIT4445001:Mphosph9 UTSW 5 124,436,853 (GRCm39) missense possibly damaging 0.82
R0304:Mphosph9 UTSW 5 124,436,892 (GRCm39) missense probably benign 0.01
R0437:Mphosph9 UTSW 5 124,453,631 (GRCm39) missense probably benign 0.27
R0483:Mphosph9 UTSW 5 124,445,033 (GRCm39) nonsense probably null
R0811:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0812:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0942:Mphosph9 UTSW 5 124,400,100 (GRCm39) nonsense probably null
R1175:Mphosph9 UTSW 5 124,453,739 (GRCm39) missense possibly damaging 0.94
R1372:Mphosph9 UTSW 5 124,421,808 (GRCm39) splice site probably null
R1442:Mphosph9 UTSW 5 124,403,461 (GRCm39) missense possibly damaging 0.62
R1533:Mphosph9 UTSW 5 124,405,204 (GRCm39) missense probably damaging 1.00
R1959:Mphosph9 UTSW 5 124,453,764 (GRCm39) missense possibly damaging 0.92
R2036:Mphosph9 UTSW 5 124,442,274 (GRCm39) missense probably damaging 0.97
R2256:Mphosph9 UTSW 5 124,421,722 (GRCm39) missense probably benign 0.00
R2919:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R2920:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R4064:Mphosph9 UTSW 5 124,428,980 (GRCm39) missense probably damaging 1.00
R4272:Mphosph9 UTSW 5 124,442,266 (GRCm39) missense probably damaging 0.96
R4430:Mphosph9 UTSW 5 124,403,509 (GRCm39) missense possibly damaging 0.83
R4883:Mphosph9 UTSW 5 124,437,108 (GRCm39) missense probably damaging 1.00
R4992:Mphosph9 UTSW 5 124,442,253 (GRCm39) missense probably damaging 1.00
R5815:Mphosph9 UTSW 5 124,453,481 (GRCm39) missense probably damaging 1.00
R5993:Mphosph9 UTSW 5 124,454,161 (GRCm39) missense probably benign 0.40
R6102:Mphosph9 UTSW 5 124,435,772 (GRCm39) missense possibly damaging 0.86
R6295:Mphosph9 UTSW 5 124,458,978 (GRCm39) missense possibly damaging 0.46
R6320:Mphosph9 UTSW 5 124,463,024 (GRCm39) missense probably damaging 0.99
R6628:Mphosph9 UTSW 5 124,436,825 (GRCm39) missense probably damaging 0.98
R6692:Mphosph9 UTSW 5 124,398,179 (GRCm39) missense probably damaging 1.00
R6705:Mphosph9 UTSW 5 124,429,027 (GRCm39) missense possibly damaging 0.83
R6747:Mphosph9 UTSW 5 124,435,762 (GRCm39) missense possibly damaging 0.93
R6787:Mphosph9 UTSW 5 124,399,090 (GRCm39) missense probably damaging 0.99
R6850:Mphosph9 UTSW 5 124,399,019 (GRCm39) missense probably damaging 1.00
R6956:Mphosph9 UTSW 5 124,435,621 (GRCm39) missense probably damaging 1.00
R7075:Mphosph9 UTSW 5 124,458,922 (GRCm39) missense probably damaging 0.99
R7604:Mphosph9 UTSW 5 124,454,180 (GRCm39) missense probably benign 0.01
R7789:Mphosph9 UTSW 5 124,453,650 (GRCm39) missense probably damaging 1.00
R7823:Mphosph9 UTSW 5 124,442,319 (GRCm39) missense probably damaging 0.99
R7891:Mphosph9 UTSW 5 124,428,967 (GRCm39) missense probably damaging 1.00
R8210:Mphosph9 UTSW 5 124,405,174 (GRCm39) missense probably damaging 1.00
R8256:Mphosph9 UTSW 5 124,393,169 (GRCm39) missense probably damaging 1.00
R8385:Mphosph9 UTSW 5 124,450,785 (GRCm39) missense probably benign 0.19
R8438:Mphosph9 UTSW 5 124,430,455 (GRCm39) missense probably benign 0.19
R8692:Mphosph9 UTSW 5 124,450,875 (GRCm39) missense probably damaging 0.99
R8790:Mphosph9 UTSW 5 124,453,736 (GRCm39) missense probably damaging 1.00
R8818:Mphosph9 UTSW 5 124,463,027 (GRCm39) nonsense probably null
R8847:Mphosph9 UTSW 5 124,454,209 (GRCm39) missense possibly damaging 0.91
R9018:Mphosph9 UTSW 5 124,436,713 (GRCm39) missense probably benign 0.12
R9208:Mphosph9 UTSW 5 124,450,854 (GRCm39) missense probably damaging 0.97
R9221:Mphosph9 UTSW 5 124,403,427 (GRCm39) missense probably benign 0.10
R9603:Mphosph9 UTSW 5 124,463,015 (GRCm39) nonsense probably null
R9721:Mphosph9 UTSW 5 124,436,738 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- AGCTGTATAGAACTGTCTGGTG -3'
(R):5'- TTCCGTGCCAGCTTTGTCAG -3'

Sequencing Primer
(F):5'- ATAGAACTGTCTGGTGGTGACAATC -3'
(R):5'- AACCATGTGACTGTGAGCTC -3'
Posted On 2019-11-26