Incidental Mutation 'R7812:Vmn2r59'
ID |
601219 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r59
|
Ensembl Gene |
ENSMUSG00000092032 |
Gene Name |
vomeronasal 2, receptor 59 |
Synonyms |
EG628444 |
MMRRC Submission |
045867-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R7812 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
41661216-41708405 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 41695196 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Stop codon
at position 405
(Y405*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131856
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168489]
|
AlphaFold |
E9PUT5 |
Predicted Effect |
probably null
Transcript: ENSMUST00000168489
AA Change: Y405*
|
SMART Domains |
Protein: ENSMUSP00000131856 Gene: ENSMUSG00000092032 AA Change: Y405*
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
471 |
1.8e-44 |
PFAM |
Pfam:NCD3G
|
514 |
567 |
4.3e-23 |
PFAM |
Pfam:7tm_3
|
600 |
835 |
5.4e-53 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 68 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700017B05Rik |
C |
A |
9: 57,165,141 (GRCm39) |
C411F |
probably damaging |
Het |
Abhd17c |
G |
T |
7: 83,800,624 (GRCm39) |
Y143* |
probably null |
Het |
Acad11 |
T |
G |
9: 103,972,747 (GRCm39) |
L480R |
probably benign |
Het |
Acad8 |
A |
T |
9: 26,890,476 (GRCm39) |
N277K |
probably damaging |
Het |
Adcy10 |
A |
G |
1: 165,342,938 (GRCm39) |
Y268C |
probably damaging |
Het |
Adm2 |
A |
T |
15: 89,208,367 (GRCm39) |
R102S |
possibly damaging |
Het |
Ambra1 |
A |
T |
2: 91,596,911 (GRCm39) |
M1L |
probably benign |
Het |
Angpt2 |
T |
C |
8: 18,742,161 (GRCm39) |
N465S |
probably benign |
Het |
Arhgap17 |
T |
C |
7: 122,879,290 (GRCm39) |
I820M |
unknown |
Het |
Atf7ip |
G |
A |
6: 136,580,415 (GRCm39) |
R1113Q |
probably damaging |
Het |
Atp5pb |
A |
G |
3: 105,851,157 (GRCm39) |
V180A |
probably benign |
Het |
Auts2 |
C |
T |
5: 131,501,284 (GRCm39) |
R43H |
|
Het |
Cacna1g |
A |
T |
11: 94,334,880 (GRCm39) |
I809N |
probably benign |
Het |
Cand1 |
A |
T |
10: 119,053,864 (GRCm39) |
M158K |
probably benign |
Het |
Cars1 |
T |
A |
7: 143,123,784 (GRCm39) |
I500F |
probably damaging |
Het |
Ccdc18 |
T |
A |
5: 108,328,699 (GRCm39) |
M706K |
probably benign |
Het |
Ccdc180 |
G |
A |
4: 45,906,952 (GRCm39) |
|
probably null |
Het |
Ces1f |
A |
G |
8: 93,984,938 (GRCm39) |
V463A |
probably benign |
Het |
Cndp1 |
G |
T |
18: 84,655,994 (GRCm39) |
D58E |
probably benign |
Het |
Csnk2b |
A |
T |
17: 35,339,431 (GRCm39) |
F21Y |
probably benign |
Het |
Dgkg |
C |
G |
16: 22,385,165 (GRCm39) |
R447T |
probably damaging |
Het |
Dnajc12 |
A |
G |
10: 63,242,905 (GRCm39) |
D141G |
probably benign |
Het |
Edar |
A |
G |
10: 58,465,926 (GRCm39) |
V4A |
probably benign |
Het |
Elf1 |
A |
G |
14: 79,802,998 (GRCm39) |
D117G |
probably damaging |
Het |
Fam124b |
T |
C |
1: 80,191,351 (GRCm39) |
T11A |
probably damaging |
Het |
Fgl2 |
C |
A |
5: 21,577,896 (GRCm39) |
T61K |
probably benign |
Het |
Furin |
T |
C |
7: 80,045,722 (GRCm39) |
N218S |
possibly damaging |
Het |
Gcn1 |
T |
A |
5: 115,731,751 (GRCm39) |
H955Q |
possibly damaging |
Het |
Gucy2e |
A |
G |
11: 69,117,069 (GRCm39) |
I784T |
probably damaging |
Het |
Ice1 |
T |
A |
13: 70,751,124 (GRCm39) |
Q1654L |
possibly damaging |
Het |
Klhl28 |
T |
C |
12: 64,990,363 (GRCm39) |
N526S |
possibly damaging |
Het |
Ldlrad4 |
C |
A |
18: 68,239,742 (GRCm39) |
P54Q |
probably benign |
Het |
Lsm14a |
A |
G |
7: 34,088,301 (GRCm39) |
|
probably benign |
Het |
Mdga1 |
A |
G |
17: 30,062,115 (GRCm39) |
V438A |
probably benign |
Het |
Mrto4 |
A |
G |
4: 139,075,278 (GRCm39) |
V175A |
possibly damaging |
Het |
Nav2 |
T |
G |
7: 49,246,921 (GRCm39) |
S2149A |
probably benign |
Het |
Nr4a2 |
A |
G |
2: 57,002,430 (GRCm39) |
Y8H |
probably damaging |
Het |
Or10q12 |
T |
C |
19: 13,746,380 (GRCm39) |
F225L |
probably benign |
Het |
Or1j12 |
T |
A |
2: 36,343,290 (GRCm39) |
I231N |
probably benign |
Het |
Or1j18 |
A |
T |
2: 36,624,737 (GRCm39) |
M135L |
probably benign |
Het |
Or52e4 |
T |
C |
7: 104,705,894 (GRCm39) |
L147P |
possibly damaging |
Het |
Oxr1 |
T |
A |
15: 41,615,138 (GRCm39) |
M1K |
probably null |
Het |
Pbx3 |
T |
C |
2: 34,114,478 (GRCm39) |
Y152C |
probably damaging |
Het |
Pcdhb13 |
T |
A |
18: 37,575,645 (GRCm39) |
C8S |
probably benign |
Het |
Polr1c |
G |
A |
17: 46,557,053 (GRCm39) |
R77W |
probably damaging |
Het |
Psg25 |
A |
T |
7: 18,255,093 (GRCm39) |
N474K |
possibly damaging |
Het |
Ralgapa1 |
T |
A |
12: 55,766,413 (GRCm39) |
M838L |
possibly damaging |
Het |
Ranbp2 |
A |
G |
10: 58,303,224 (GRCm39) |
T799A |
probably benign |
Het |
Sbf2 |
C |
T |
7: 110,049,170 (GRCm39) |
V265I |
possibly damaging |
Het |
Scarf2 |
G |
A |
16: 17,621,692 (GRCm39) |
G381R |
probably damaging |
Het |
Shprh |
A |
G |
10: 11,027,735 (GRCm39) |
Q114R |
probably benign |
Het |
Sipa1l2 |
A |
C |
8: 126,218,334 (GRCm39) |
D334E |
probably damaging |
Het |
Slc26a4 |
T |
A |
12: 31,594,449 (GRCm39) |
I300F |
probably damaging |
Het |
Sox7 |
C |
T |
14: 64,185,681 (GRCm39) |
T239I |
probably benign |
Het |
Sry |
GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG |
GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG |
Y: 2,662,638 (GRCm39) |
|
probably benign |
Het |
St6galnac1 |
G |
T |
11: 116,659,927 (GRCm39) |
H129N |
probably benign |
Het |
Stxbp4 |
A |
G |
11: 90,485,654 (GRCm39) |
L231P |
probably damaging |
Het |
Syngap1 |
A |
C |
17: 27,160,478 (GRCm39) |
Y18S |
probably benign |
Het |
Tenm3 |
T |
C |
8: 48,729,335 (GRCm39) |
Y1557C |
probably benign |
Het |
Trim44 |
G |
T |
2: 102,230,489 (GRCm39) |
P181T |
possibly damaging |
Het |
Trp53i13 |
A |
T |
11: 77,399,666 (GRCm39) |
V221D |
possibly damaging |
Het |
Trpm7 |
A |
G |
2: 126,641,236 (GRCm39) |
S1554P |
probably damaging |
Het |
Vcl |
A |
G |
14: 21,045,158 (GRCm39) |
N288D |
probably benign |
Het |
Vps35 |
T |
C |
8: 86,010,818 (GRCm39) |
D175G |
probably benign |
Het |
Wdr90 |
A |
T |
17: 26,071,532 (GRCm39) |
L949Q |
probably damaging |
Het |
Wwp1 |
G |
A |
4: 19,639,991 (GRCm39) |
T517I |
probably damaging |
Het |
Zfp462 |
T |
G |
4: 55,008,509 (GRCm39) |
F158L |
probably benign |
Het |
Zfp703 |
T |
A |
8: 27,469,906 (GRCm39) |
H523Q |
probably damaging |
Het |
|
Other mutations in Vmn2r59 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00088:Vmn2r59
|
APN |
7 |
41,661,488 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL01432:Vmn2r59
|
APN |
7 |
41,661,983 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL02119:Vmn2r59
|
APN |
7 |
41,695,593 (GRCm39) |
missense |
probably benign |
0.36 |
IGL02216:Vmn2r59
|
APN |
7 |
41,661,817 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02327:Vmn2r59
|
APN |
7 |
41,661,655 (GRCm39) |
missense |
probably benign |
|
IGL03346:Vmn2r59
|
APN |
7 |
41,693,253 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03411:Vmn2r59
|
APN |
7 |
41,708,340 (GRCm39) |
missense |
probably benign |
0.43 |
IGL03412:Vmn2r59
|
APN |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
PIT4366001:Vmn2r59
|
UTSW |
7 |
41,695,205 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0068:Vmn2r59
|
UTSW |
7 |
41,695,725 (GRCm39) |
missense |
probably damaging |
0.99 |
R0094:Vmn2r59
|
UTSW |
7 |
41,661,722 (GRCm39) |
missense |
probably benign |
0.07 |
R0179:Vmn2r59
|
UTSW |
7 |
41,696,432 (GRCm39) |
nonsense |
probably null |
|
R0370:Vmn2r59
|
UTSW |
7 |
41,662,150 (GRCm39) |
missense |
probably benign |
0.23 |
R0412:Vmn2r59
|
UTSW |
7 |
41,695,916 (GRCm39) |
splice site |
probably benign |
|
R0465:Vmn2r59
|
UTSW |
7 |
41,696,332 (GRCm39) |
missense |
probably benign |
|
R0487:Vmn2r59
|
UTSW |
7 |
41,696,528 (GRCm39) |
nonsense |
probably null |
|
R0576:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
R0632:Vmn2r59
|
UTSW |
7 |
41,708,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R1356:Vmn2r59
|
UTSW |
7 |
41,661,218 (GRCm39) |
makesense |
probably null |
|
R1387:Vmn2r59
|
UTSW |
7 |
41,695,521 (GRCm39) |
missense |
probably damaging |
1.00 |
R1388:Vmn2r59
|
UTSW |
7 |
41,695,133 (GRCm39) |
missense |
probably benign |
0.01 |
R1435:Vmn2r59
|
UTSW |
7 |
41,695,629 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1750:Vmn2r59
|
UTSW |
7 |
41,695,251 (GRCm39) |
missense |
possibly damaging |
0.50 |
R2020:Vmn2r59
|
UTSW |
7 |
41,693,203 (GRCm39) |
missense |
probably damaging |
1.00 |
R2249:Vmn2r59
|
UTSW |
7 |
41,708,326 (GRCm39) |
missense |
probably benign |
0.00 |
R2256:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
R2257:Vmn2r59
|
UTSW |
7 |
41,661,669 (GRCm39) |
nonsense |
probably null |
|
R2441:Vmn2r59
|
UTSW |
7 |
41,695,570 (GRCm39) |
missense |
probably benign |
0.00 |
R2511:Vmn2r59
|
UTSW |
7 |
41,693,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R2860:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
R2861:Vmn2r59
|
UTSW |
7 |
41,696,427 (GRCm39) |
missense |
possibly damaging |
0.79 |
R3690:Vmn2r59
|
UTSW |
7 |
41,661,370 (GRCm39) |
missense |
possibly damaging |
0.77 |
R3912:Vmn2r59
|
UTSW |
7 |
41,695,744 (GRCm39) |
missense |
probably benign |
0.00 |
R4167:Vmn2r59
|
UTSW |
7 |
41,670,732 (GRCm39) |
intron |
probably benign |
|
R4357:Vmn2r59
|
UTSW |
7 |
41,661,644 (GRCm39) |
missense |
probably damaging |
1.00 |
R4445:Vmn2r59
|
UTSW |
7 |
41,691,874 (GRCm39) |
missense |
probably damaging |
1.00 |
R4542:Vmn2r59
|
UTSW |
7 |
41,695,497 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4587:Vmn2r59
|
UTSW |
7 |
41,695,648 (GRCm39) |
missense |
probably benign |
0.00 |
R4616:Vmn2r59
|
UTSW |
7 |
41,661,862 (GRCm39) |
missense |
probably benign |
|
R4653:Vmn2r59
|
UTSW |
7 |
41,693,228 (GRCm39) |
missense |
probably benign |
0.19 |
R4703:Vmn2r59
|
UTSW |
7 |
41,661,686 (GRCm39) |
missense |
probably benign |
0.01 |
R4895:Vmn2r59
|
UTSW |
7 |
41,695,218 (GRCm39) |
missense |
probably damaging |
0.98 |
R4910:Vmn2r59
|
UTSW |
7 |
41,693,077 (GRCm39) |
missense |
probably benign |
|
R5045:Vmn2r59
|
UTSW |
7 |
41,695,496 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5105:Vmn2r59
|
UTSW |
7 |
41,696,529 (GRCm39) |
missense |
probably benign |
0.01 |
R5153:Vmn2r59
|
UTSW |
7 |
41,691,834 (GRCm39) |
critical splice donor site |
probably null |
|
R5566:Vmn2r59
|
UTSW |
7 |
41,696,247 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5586:Vmn2r59
|
UTSW |
7 |
41,695,105 (GRCm39) |
missense |
probably benign |
0.12 |
R5606:Vmn2r59
|
UTSW |
7 |
41,695,318 (GRCm39) |
missense |
probably benign |
0.27 |
R5616:Vmn2r59
|
UTSW |
7 |
41,708,191 (GRCm39) |
splice site |
probably null |
|
R5625:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
R5696:Vmn2r59
|
UTSW |
7 |
41,695,468 (GRCm39) |
missense |
probably benign |
0.00 |
R5982:Vmn2r59
|
UTSW |
7 |
41,695,491 (GRCm39) |
missense |
probably benign |
0.00 |
R6106:Vmn2r59
|
UTSW |
7 |
41,661,749 (GRCm39) |
nonsense |
probably null |
|
R6196:Vmn2r59
|
UTSW |
7 |
41,661,679 (GRCm39) |
missense |
probably benign |
0.36 |
R6228:Vmn2r59
|
UTSW |
7 |
41,691,835 (GRCm39) |
critical splice donor site |
probably null |
|
R6590:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R6625:Vmn2r59
|
UTSW |
7 |
41,693,177 (GRCm39) |
missense |
probably benign |
0.02 |
R6690:Vmn2r59
|
UTSW |
7 |
41,695,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R6768:Vmn2r59
|
UTSW |
7 |
41,661,392 (GRCm39) |
missense |
probably benign |
0.17 |
R6830:Vmn2r59
|
UTSW |
7 |
41,693,171 (GRCm39) |
missense |
probably benign |
0.10 |
R6859:Vmn2r59
|
UTSW |
7 |
41,693,277 (GRCm39) |
missense |
probably damaging |
1.00 |
R7034:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
R7036:Vmn2r59
|
UTSW |
7 |
41,695,644 (GRCm39) |
missense |
probably benign |
0.03 |
R7145:Vmn2r59
|
UTSW |
7 |
41,695,188 (GRCm39) |
missense |
probably damaging |
1.00 |
R7556:Vmn2r59
|
UTSW |
7 |
41,695,233 (GRCm39) |
missense |
probably damaging |
1.00 |
R7733:Vmn2r59
|
UTSW |
7 |
41,661,443 (GRCm39) |
missense |
probably benign |
0.17 |
R7770:Vmn2r59
|
UTSW |
7 |
41,708,336 (GRCm39) |
missense |
probably damaging |
1.00 |
R7867:Vmn2r59
|
UTSW |
7 |
41,661,707 (GRCm39) |
missense |
probably damaging |
1.00 |
R7975:Vmn2r59
|
UTSW |
7 |
41,693,199 (GRCm39) |
missense |
probably damaging |
1.00 |
R7999:Vmn2r59
|
UTSW |
7 |
41,696,256 (GRCm39) |
missense |
probably damaging |
1.00 |
R8267:Vmn2r59
|
UTSW |
7 |
41,661,521 (GRCm39) |
missense |
probably damaging |
0.97 |
R8367:Vmn2r59
|
UTSW |
7 |
41,661,247 (GRCm39) |
missense |
probably benign |
0.44 |
R9106:Vmn2r59
|
UTSW |
7 |
41,695,884 (GRCm39) |
missense |
probably benign |
0.03 |
R9135:Vmn2r59
|
UTSW |
7 |
41,693,127 (GRCm39) |
missense |
|
|
R9135:Vmn2r59
|
UTSW |
7 |
41,693,125 (GRCm39) |
missense |
probably benign |
0.33 |
R9234:Vmn2r59
|
UTSW |
7 |
41,661,907 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9273:Vmn2r59
|
UTSW |
7 |
41,695,286 (GRCm39) |
nonsense |
probably null |
|
R9432:Vmn2r59
|
UTSW |
7 |
41,696,254 (GRCm39) |
missense |
probably damaging |
1.00 |
R9433:Vmn2r59
|
UTSW |
7 |
41,695,590 (GRCm39) |
missense |
probably damaging |
0.99 |
R9616:Vmn2r59
|
UTSW |
7 |
41,661,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R9654:Vmn2r59
|
UTSW |
7 |
41,693,217 (GRCm39) |
missense |
probably benign |
0.10 |
R9741:Vmn2r59
|
UTSW |
7 |
41,708,209 (GRCm39) |
missense |
probably damaging |
0.99 |
X0025:Vmn2r59
|
UTSW |
7 |
41,695,365 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r59
|
UTSW |
7 |
41,661,838 (GRCm39) |
missense |
possibly damaging |
0.85 |
Z1176:Vmn2r59
|
UTSW |
7 |
41,691,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CTCCATTGCTTATTGACAGCATAG -3'
(R):5'- CCACCGTGAAGAGATGGTTG -3'
Sequencing Primer
(F):5'- GACAGCATAGTCTAAAACATGTGATG -3'
(R):5'- TTTGTCCAAACAGTTAATCCCTAC -3'
|
Posted On |
2019-11-26 |