Incidental Mutation 'R7427:Psg23'
ID601429
Institutional Source Beutler Lab
Gene Symbol Psg23
Ensembl Gene ENSMUSG00000074359
Gene Namepregnancy-specific glycoprotein 23
Synonyms1620401C02Rik
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R7427 (G1)
Quality Score225.009
Status Validated
Chromosome7
Chromosomal Location18606343-18616501 bp(-) (GRCm38)
Type of Mutationsplice site (5 bp from exon)
DNA Base Change (assembly) C to T at 18611983 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000056586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057810]
Predicted Effect probably null
Transcript: ENSMUST00000057810
SMART Domains Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359

DomainStartEndE-ValueType
IG 39 138 2.03e-4 SMART
IG 159 260 4.16e-1 SMART
IG 276 375 1.25e-4 SMART
IGc2 393 457 4.7e-9 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (78/78)
MGI Phenotype PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931423N10Rik C T 2: 23,256,994 R337C probably benign Het
Adck5 T A 15: 76,594,385 C318S possibly damaging Het
Aspm T A 1: 139,457,616 C333S probably benign Het
B3gnt4 A G 5: 123,510,731 N53S probably damaging Het
Bpifb5 G A 2: 154,225,122 M98I probably benign Het
Cacna2d3 A G 14: 29,064,275 M585T probably damaging Het
Cbarp T C 10: 80,131,304 D701G probably damaging Het
Cntrl T A 2: 35,170,534 W1913R probably benign Het
Cry2 T C 2: 92,413,047 D483G possibly damaging Het
Csmd1 A G 8: 16,023,850 F2044L possibly damaging Het
Ctgf T G 10: 24,597,499 M312R probably damaging Het
Cxcl16 A G 11: 70,458,804 V78A possibly damaging Het
Cxcr6 A T 9: 123,810,240 Y109F probably benign Het
Cyb5b A G 8: 107,170,416 D106G probably benign Het
D630036H23Rik T C 12: 36,381,538 R154G unknown Het
Dnah9 T C 11: 65,955,219 T2998A probably benign Het
Focad T C 4: 88,368,751 S1254P unknown Het
Gm21886 A T 18: 80,089,652 L97Q probably damaging Het
Gm6614 T G 6: 142,003,508 probably null Het
Gpr158 A C 2: 21,827,318 L1076F probably benign Het
Hivep2 T C 10: 14,133,741 M1714T possibly damaging Het
Hlcs A G 16: 94,267,899 V154A probably benign Het
Hpdl A T 4: 116,820,865 L133Q probably damaging Het
Il1rn C A 2: 24,349,542 T150K probably benign Het
Il6st A G 13: 112,488,560 I237V probably benign Het
Inpp5f A G 7: 128,679,805 D510G probably damaging Het
Ism2 G T 12: 87,286,995 T92K possibly damaging Het
Kif13b T C 14: 64,788,460 I1422T probably benign Het
Kit G A 5: 75,645,847 V671I possibly damaging Het
Klhdc8a A T 1: 132,302,967 N190I probably damaging Het
Lad1 C T 1: 135,825,838 T41I probably damaging Het
Lrrc7 G T 3: 158,198,141 T294K probably benign Het
Megf8 C T 7: 25,338,371 R771C probably benign Het
Micu3 A C 8: 40,378,914 N440T possibly damaging Het
Mnx1 T C 5: 29,474,213 N291D unknown Het
Mthfr A G 4: 148,051,603 M378V probably benign Het
Mup2 A T 4: 60,138,454 D79E probably benign Het
Myzap T C 9: 71,505,183 T451A probably benign Het
Nlrp9c T C 7: 26,371,435 D907G probably benign Het
Nr1h4 T C 10: 89,498,405 E41G probably benign Het
Nup98 A T 7: 102,135,001 probably null Het
Nxpe5 A C 5: 138,239,760 Y194S probably damaging Het
Olfr1024 T A 2: 85,904,131 R308* probably null Het
Olfr1032 A T 2: 86,008,219 I148L probably benign Het
Olfr105-ps T C 17: 37,383,299 V244A probably damaging Het
Olfr1121 G T 2: 87,371,690 V53L probably benign Het
Olfr332 A G 11: 58,489,780 I325T probably benign Het
Olfr466 A G 13: 65,153,052 Y276C probably damaging Het
Olfr554 A G 7: 102,640,326 I27V probably benign Het
Omd A T 13: 49,592,269 E385V possibly damaging Het
Pcdh9 G T 14: 93,887,111 T541K probably damaging Het
Pdia6 T C 12: 17,278,545 V167A probably damaging Het
Phf7 C T 14: 31,240,413 R145Q possibly damaging Het
Pitx3 T C 19: 46,137,424 D20G possibly damaging Het
Plxnb1 T C 9: 109,108,168 V1139A probably benign Het
Pon2 A T 6: 5,268,995 N226K probably damaging Het
Ppp1r10 T A 17: 35,930,133 H642Q possibly damaging Het
Prom2 A G 2: 127,539,811 L195P probably damaging Het
Rfx4 C A 10: 84,896,012 Q618K probably benign Het
Rhobtb1 T A 10: 69,248,824 I15N probably damaging Het
Rhot2 A T 17: 25,841,609 V233E probably damaging Het
Ripply2 T C 9: 87,019,756 S112P possibly damaging Het
Slc12a1 C A 2: 125,214,132 T861N probably benign Het
Slc35f1 T A 10: 53,089,414 S308R probably damaging Het
Slc35f4 T A 14: 49,298,898 I427F probably damaging Het
Sned1 G A 1: 93,289,358 V1322I probably benign Het
Sprr2f G A 3: 92,365,944 V17M unknown Het
Srd5a3 A G 5: 76,154,643 H285R probably benign Het
Stab1 T C 14: 31,159,259 T605A probably benign Het
Syne1 T C 10: 5,273,718 Q3054R probably damaging Het
Tas1r1 T C 4: 152,038,308 T27A probably benign Het
Tmem150b A T 7: 4,716,210 V237E probably benign Het
Trpv6 C T 6: 41,625,153 M407I probably benign Het
Ttn T G 2: 76,720,354 D31528A probably damaging Het
Uroc1 A T 6: 90,346,362 D354V possibly damaging Het
Vmn2r69 T C 7: 85,411,259 I372M probably benign Het
Vmn2r93 A T 17: 18,326,410 H848L probably benign Het
Zfp971 T A 2: 178,033,174 C189S probably damaging Het
Other mutations in Psg23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00814:Psg23 APN 7 18614683 nonsense probably null
IGL01309:Psg23 APN 7 18614540 missense probably damaging 1.00
IGL01736:Psg23 APN 7 18612197 missense possibly damaging 0.76
IGL02142:Psg23 APN 7 18610420 missense probably benign 0.01
IGL02728:Psg23 APN 7 18606928 missense probably benign 0.02
IGL03080:Psg23 APN 7 18606985 missense probably damaging 1.00
IGL03130:Psg23 APN 7 18610416 missense probably benign 0.25
R0113:Psg23 UTSW 7 18612002 missense probably benign 0.31
R0137:Psg23 UTSW 7 18614633 missense probably benign 0.00
R0544:Psg23 UTSW 7 18614682 missense probably damaging 1.00
R1368:Psg23 UTSW 7 18614720 missense probably benign 0.13
R1840:Psg23 UTSW 7 18610438 missense possibly damaging 0.67
R1869:Psg23 UTSW 7 18614618 missense probably benign 0.09
R1875:Psg23 UTSW 7 18610450 missense probably benign 0.10
R2041:Psg23 UTSW 7 18614778 missense possibly damaging 0.78
R2096:Psg23 UTSW 7 18614743 missense probably damaging 1.00
R3110:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3112:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3790:Psg23 UTSW 7 18612201 missense probably benign 0.00
R3892:Psg23 UTSW 7 18612041 missense probably damaging 1.00
R4074:Psg23 UTSW 7 18607118 missense possibly damaging 0.66
R4200:Psg23 UTSW 7 18612065 missense probably damaging 1.00
R4865:Psg23 UTSW 7 18612114 missense probably benign 0.14
R5337:Psg23 UTSW 7 18612072 missense probably benign 0.00
R6016:Psg23 UTSW 7 18612187 missense probably benign 0.00
R6951:Psg23 UTSW 7 18614711 missense probably damaging 1.00
R7033:Psg23 UTSW 7 18614744 missense possibly damaging 0.82
R7212:Psg23 UTSW 7 18607139 missense probably benign 0.00
R7527:Psg23 UTSW 7 18614774 missense probably damaging 1.00
R7814:Psg23 UTSW 7 18606914 makesense probably null
R7864:Psg23 UTSW 7 18610510 missense possibly damaging 0.87
R7897:Psg23 UTSW 7 18607183 missense possibly damaging 0.83
R8155:Psg23 UTSW 7 18612254 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCCTCCGAGATACAAGTGGATG -3'
(R):5'- TCACAAGGTTGAGATTGTCCG -3'

Sequencing Primer
(F):5'- TACAAGTGGATGTCAGAAAGCTG -3'
(R):5'- TGAGATTGTCCGGTACAGAACACTC -3'
Posted On2019-12-02