Mutagenetix > Incidental Mutation

Incidental Mutation 'R7817:Psg26'

601590

Institutional Source

Beutler Lab

Gene Symbol

Psg26

Ensembl Gene

ENSMUSG00000070799

Gene Name

pregnancy-specific beta-1-glycoprotein 26

Synonyms

EG574429, cea14

MMRRC Submission

045871-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

R7817 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

18208507-18218102 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18216572 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 89 (V89A)

Ref Sequence

ENSEMBL: ENSMUSP00000092392 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094798]

AlphaFold

Q4KL65

Predicted Effect

not run
Transcript: ENSMUST00000094798
AA Change: V89A

SMART Domains

Protein: ENSMUSP00000092392
Gene: ENSMUSG00000070799
AA Change: V89A

Domain	Start	End	E-Value	Type
IG	40	141	4.93e-3	SMART
IG	160	261	2.39e-1	SMART
IG	280	379	6.07e-3	SMART
IGc2	397	461	5.48e-10	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

96% (45/47)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts17	T	C	7: 66,559,224 (GRCm39)	V338A	probably damaging	Het
Akap13	G	A	7: 75,380,213 (GRCm39)	R462H	probably damaging	Het
BC005537	C	T	13: 24,987,382 (GRCm39)	R7W	possibly damaging	Het
Bivm	G	T	1: 44,165,561 (GRCm39)	A4S	probably benign	Het
Cacng3	G	A	7: 122,367,822 (GRCm39)	R234Q	probably damaging	Het
Card6	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	15: 5,128,173 (GRCm39)		probably benign	Het
Cftr	A	G	6: 18,267,967 (GRCm39)	D642G	probably damaging	Het
Cltc	A	G	11: 86,615,949 (GRCm39)	V443A	probably damaging	Het
Csmd3	C	T	15: 47,721,356 (GRCm39)	R1425H	probably damaging	Het
Cttnbp2	G	C	6: 18,426,092 (GRCm39)	A762G	possibly damaging	Het
Dscam	T	C	16: 96,442,064 (GRCm39)	T1588A	probably benign	Het
Gabra4	A	G	5: 71,798,206 (GRCm39)	M207T	probably damaging	Het
Galnt3	A	G	2: 65,926,243 (GRCm39)	Y322H	probably damaging	Het
Glud1	A	T	14: 34,051,244 (GRCm39)		probably null	Het
Gm47189	A	G	14: 41,492,011 (GRCm39)	Y89H	probably damaging	Het
Klhl1	A	T	14: 96,374,186 (GRCm39)	M620K	possibly damaging	Het
Krt9	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	11: 100,079,903 (GRCm39)		probably benign	Het
Mocs2	A	G	13: 114,957,382 (GRCm39)	E62G	probably damaging	Het
Myh7	C	G	14: 55,226,258 (GRCm39)	D461H	probably damaging	Het
Nek10	C	T	14: 15,001,017 (GRCm38)	P1066S	probably benign	Het
Nfxl1	T	C	5: 72,671,632 (GRCm39)	K876E	possibly damaging	Het
Nipsnap3a	T	A	4: 52,997,279 (GRCm39)	F182I	probably damaging	Het
Nlrc3	C	T	16: 3,783,327 (GRCm39)	G60S	possibly damaging	Het
Notch2	T	C	3: 98,014,443 (GRCm39)	Y666H	probably damaging	Het
Or9m1b	T	C	2: 87,836,355 (GRCm39)	I247V	probably benign	Het
Pars2	T	A	4: 106,511,276 (GRCm39)	Y353N	probably damaging	Het
Pcdhb11	A	G	18: 37,556,962 (GRCm39)	E764G	probably damaging	Het
Pcdhb3	T	A	18: 37,435,982 (GRCm39)	D649E	probably benign	Het
Pde7b	T	G	10: 20,319,051 (GRCm39)	R90S	probably damaging	Het
Pik3r5	T	C	11: 68,384,483 (GRCm39)	V625A	probably damaging	Het
Prdm9	G	A	17: 15,779,311 (GRCm39)	R113W	probably damaging	Het
Rad1	T	C	15: 10,493,404 (GRCm39)	V277A	probably benign	Het
Rb1	A	T	14: 73,435,983 (GRCm39)	L894Q	probably damaging	Het
Rorb	A	T	19: 18,965,460 (GRCm39)	C10S	probably damaging	Het
Ryk	C	T	9: 102,768,432 (GRCm39)	Q361*	probably null	Het
Serpina3b	A	G	12: 104,099,223 (GRCm39)	N246S	probably benign	Het
Srr	A	G	11: 74,799,524 (GRCm39)	V317A	possibly damaging	Het
Timd2	A	T	11: 46,561,781 (GRCm39)	C288S	probably benign	Het
Tomm70a	C	T	16: 56,965,136 (GRCm39)	A440V	probably damaging	Het
Trim62	T	C	4: 128,794,478 (GRCm39)	V215A	probably benign	Het
Trio	C	G	15: 27,749,952 (GRCm39)	V2250L	probably benign	Het
Ubr5	G	A	15: 37,980,076 (GRCm39)	A2434V	probably null	Het
Unc13d	A	T	11: 115,967,109 (GRCm39)	V91D	probably damaging	Het
Vmn1r159	T	A	7: 22,542,487 (GRCm39)	I182F	possibly damaging	Het
Vmn1r230	T	A	17: 21,066,823 (GRCm39)	V4D	probably benign	Het
Zfp27	T	C	7: 29,595,815 (GRCm39)	Y50C	possibly damaging	Het
Zfp354c	TCACACTCGGCACA	TCACA	11: 50,706,067 (GRCm39)		probably benign	Het
Zfp518b	T	C	5: 38,829,741 (GRCm39)	I755V	not run	Het

Other mutations in Psg26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01010:Psg26	APN	7	18,212,255 (GRCm39)	missense	possibly damaging	0.83
IGL01383:Psg26	APN	7	18,214,179 (GRCm39)	missense	possibly damaging	0.90
IGL01453:Psg26	APN	7	18,213,999 (GRCm39)	missense	possibly damaging	0.91
IGL01603:Psg26	APN	7	18,209,028 (GRCm39)	missense	probably damaging	0.98
IGL02201:Psg26	APN	7	18,214,071 (GRCm39)	missense	probably benign	0.04
IGL02468:Psg26	APN	7	18,212,387 (GRCm39)	missense	probably damaging	0.96
IGL02648:Psg26	APN	7	18,216,691 (GRCm39)	missense	probably benign	0.05
IGL02812:Psg26	APN	7	18,209,080 (GRCm39)	missense	probably benign	0.00
R0226:Psg26	UTSW	7	18,217,883 (GRCm39)	missense	possibly damaging	0.81
R0352:Psg26	UTSW	7	18,209,181 (GRCm39)	missense	probably benign	0.00
R0369:Psg26	UTSW	7	18,216,481 (GRCm39)	nonsense	probably null
R0718:Psg26	UTSW	7	18,212,212 (GRCm39)	missense	probably benign	0.18
R0718:Psg26	UTSW	7	18,209,160 (GRCm39)	missense	probably benign	0.23
R1710:Psg26	UTSW	7	18,213,966 (GRCm39)	missense	probably damaging	0.99
R1899:Psg26	UTSW	7	18,212,350 (GRCm39)	missense	probably benign	0.01
R1958:Psg26	UTSW	7	18,212,264 (GRCm39)	missense	probably benign	0.04
R2102:Psg26	UTSW	7	18,209,067 (GRCm39)	missense	probably damaging	1.00
R3766:Psg26	UTSW	7	18,208,996 (GRCm39)	missense	probably benign
R4544:Psg26	UTSW	7	18,212,464 (GRCm39)	missense	probably damaging	1.00
R4977:Psg26	UTSW	7	18,209,235 (GRCm39)	missense	probably benign	0.11
R5000:Psg26	UTSW	7	18,214,057 (GRCm39)	missense	possibly damaging	0.95
R5376:Psg26	UTSW	7	18,214,030 (GRCm39)	missense	probably benign
R5416:Psg26	UTSW	7	18,216,525 (GRCm39)	missense	probably benign
R5435:Psg26	UTSW	7	18,212,398 (GRCm39)	missense	possibly damaging	0.60
R6000:Psg26	UTSW	7	18,216,617 (GRCm39)	nonsense	probably null
R6285:Psg26	UTSW	7	18,216,753 (GRCm39)	missense	probably benign
R7062:Psg26	UTSW	7	18,216,521 (GRCm39)	missense	probably damaging	1.00
R7083:Psg26	UTSW	7	18,213,934 (GRCm39)	nonsense	probably null
R7513:Psg26	UTSW	7	18,209,225 (GRCm39)	missense	probably benign	0.03
R7857:Psg26	UTSW	7	18,212,215 (GRCm39)	missense	possibly damaging	0.71
R7905:Psg26	UTSW	7	18,209,242 (GRCm39)	missense	probably benign	0.00
R8047:Psg26	UTSW	7	18,212,474 (GRCm39)	missense	possibly damaging	0.50
R8789:Psg26	UTSW	7	18,216,494 (GRCm39)	missense	probably damaging	1.00
R8877:Psg26	UTSW	7	18,217,865 (GRCm39)	missense	probably benign	0.01
R9012:Psg26	UTSW	7	18,216,596 (GRCm39)	missense	probably benign	0.19
R9203:Psg26	UTSW	7	18,212,382 (GRCm39)	missense	probably damaging	0.98
R9327:Psg26	UTSW	7	18,216,480 (GRCm39)	missense	probably damaging	1.00
R9547:Psg26	UTSW	7	18,214,087 (GRCm39)	missense	probably benign	0.00
Z1177:Psg26	UTSW	7	18,214,216 (GRCm39)	missense	probably benign	0.02

Predicted Primers

Posted On

2019-12-03