Incidental Mutation 'R7818:Trip12'
| ID |
601628 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
045872-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7818 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 84738527 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 776
(G776D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140267
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000186894]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: G776D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: G776D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185909
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: G776D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: G776D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: G770D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: G770D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186894
AA Change: G776D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140267
Gene: ENSMUSG00000026219
AA Change: G776D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
3e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
7e-6 |
PDB |
|
Blast:ARM
|
476 |
516 |
6e-6 |
BLAST |
|
WWE
|
764 |
839 |
6.9e-25 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
99% (88/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931429L15Rik |
T |
A |
9: 46,215,519 (GRCm39) |
R342S |
probably benign |
Het |
| Aatk |
C |
T |
11: 119,912,281 (GRCm39) |
V55I |
probably benign |
Het |
| Abhd10 |
T |
A |
16: 45,557,916 (GRCm39) |
I128L |
probably benign |
Het |
| Abraxas1 |
T |
A |
5: 100,954,176 (GRCm39) |
M325L |
probably benign |
Het |
| Adgrb2 |
C |
A |
4: 129,908,353 (GRCm39) |
L1087I |
probably damaging |
Het |
| Adgrb2 |
C |
T |
4: 129,908,762 (GRCm39) |
P1124S |
possibly damaging |
Het |
| Akap9 |
T |
A |
5: 4,063,875 (GRCm39) |
Y1741* |
probably null |
Het |
| Ap1g2 |
A |
T |
14: 55,337,181 (GRCm39) |
V718D |
probably benign |
Het |
| Asph |
A |
T |
4: 9,475,015 (GRCm39) |
M637K |
probably damaging |
Het |
| Atp2c1 |
T |
C |
9: 105,291,956 (GRCm39) |
I869V |
probably benign |
Het |
| C1ra |
G |
A |
6: 124,494,684 (GRCm39) |
E316K |
probably benign |
Het |
| Cacna1e |
T |
C |
1: 154,274,152 (GRCm39) |
D2251G |
probably damaging |
Het |
| Camk2b |
A |
G |
11: 5,927,812 (GRCm39) |
S413P |
probably benign |
Het |
| Casz1 |
G |
A |
4: 149,030,533 (GRCm39) |
C1184Y |
probably damaging |
Het |
| Cbr4 |
G |
A |
8: 61,940,976 (GRCm39) |
V32I |
probably benign |
Het |
| Ccdc166 |
A |
G |
15: 75,852,864 (GRCm39) |
S368P |
possibly damaging |
Het |
| Ccdc170 |
A |
G |
10: 4,499,603 (GRCm39) |
N508S |
probably benign |
Het |
| Ccdc187 |
A |
G |
2: 26,166,186 (GRCm39) |
S748P |
possibly damaging |
Het |
| Cdca8 |
A |
T |
4: 124,820,456 (GRCm39) |
|
probably null |
Het |
| Cep120 |
T |
C |
18: 53,856,175 (GRCm39) |
D414G |
probably benign |
Het |
| Dcp1a |
G |
T |
14: 30,201,678 (GRCm39) |
A34S |
probably damaging |
Het |
| Ddit3 |
C |
T |
10: 127,131,662 (GRCm39) |
T70I |
probably benign |
Het |
| Dlg2 |
C |
G |
7: 91,589,225 (GRCm39) |
A313G |
probably damaging |
Het |
| Dnah9 |
A |
T |
11: 65,916,037 (GRCm39) |
V2305D |
possibly damaging |
Het |
| Dock1 |
T |
A |
7: 134,365,594 (GRCm39) |
D427E |
probably damaging |
Het |
| Dolpp1 |
T |
C |
2: 30,286,503 (GRCm39) |
L141P |
probably benign |
Het |
| Dsc2 |
A |
T |
18: 20,183,189 (GRCm39) |
D76E |
probably damaging |
Het |
| Dusp7 |
C |
A |
9: 106,246,329 (GRCm39) |
N111K |
probably benign |
Het |
| Fam193a |
A |
G |
5: 34,622,997 (GRCm39) |
E1195G |
possibly damaging |
Het |
| Fig4 |
A |
G |
10: 41,139,162 (GRCm39) |
L347P |
probably damaging |
Het |
| Frem1 |
T |
C |
4: 82,932,245 (GRCm39) |
E152G |
probably damaging |
Het |
| Galnt2 |
G |
T |
8: 125,056,527 (GRCm39) |
D234Y |
probably damaging |
Het |
| H1f3 |
C |
T |
13: 23,739,165 (GRCm39) |
|
probably benign |
Het |
| Igkv4-59 |
T |
C |
6: 69,415,475 (GRCm39) |
T27A |
possibly damaging |
Het |
| Ihh |
T |
C |
1: 74,985,804 (GRCm39) |
D227G |
possibly damaging |
Het |
| Il1rap |
T |
A |
16: 26,517,597 (GRCm39) |
C266S |
probably damaging |
Het |
| Iqcf4 |
A |
T |
9: 106,447,738 (GRCm39) |
L57* |
probably null |
Het |
| Kif2b |
A |
G |
11: 91,466,952 (GRCm39) |
S444P |
probably damaging |
Het |
| Lmf1 |
T |
G |
17: 25,881,565 (GRCm39) |
I538S |
probably benign |
Het |
| Mical2 |
A |
G |
7: 111,944,514 (GRCm39) |
Y948C |
probably damaging |
Het |
| Mr1 |
G |
A |
1: 155,006,382 (GRCm39) |
Q322* |
probably null |
Het |
| Mroh2a |
T |
C |
1: 88,162,334 (GRCm39) |
|
probably null |
Het |
| Mup6 |
A |
G |
4: 60,004,884 (GRCm39) |
T100A |
probably benign |
Het |
| Mybpc1 |
T |
A |
10: 88,394,529 (GRCm39) |
D266V |
probably damaging |
Het |
| Myocos |
T |
C |
1: 162,475,063 (GRCm39) |
N48S |
unknown |
Het |
| Naf1 |
G |
A |
8: 67,342,028 (GRCm39) |
G551E |
probably damaging |
Het |
| Nrarp |
A |
G |
2: 25,071,250 (GRCm39) |
N43S |
possibly damaging |
Het |
| Or4a80 |
A |
G |
2: 89,582,288 (GRCm39) |
S295P |
possibly damaging |
Het |
| Or5p52 |
G |
A |
7: 107,502,230 (GRCm39) |
C102Y |
probably benign |
Het |
| Or7a40 |
A |
C |
16: 16,491,437 (GRCm39) |
M136R |
probably damaging |
Het |
| Or7g19 |
T |
A |
9: 18,856,305 (GRCm39) |
Y120* |
probably null |
Het |
| Or8b57 |
T |
A |
9: 40,004,008 (GRCm39) |
M85L |
probably damaging |
Het |
| Padi3 |
T |
A |
4: 140,525,453 (GRCm39) |
T177S |
possibly damaging |
Het |
| Pde3b |
A |
G |
7: 114,090,675 (GRCm39) |
M305V |
probably damaging |
Het |
| Pde6a |
T |
A |
18: 61,414,580 (GRCm39) |
|
probably null |
Het |
| Plscr4 |
C |
T |
9: 92,372,843 (GRCm39) |
R322* |
probably null |
Het |
| Prph |
A |
G |
15: 98,955,753 (GRCm39) |
T446A |
probably damaging |
Het |
| Pwwp2b |
T |
C |
7: 138,835,240 (GRCm39) |
V227A |
probably benign |
Het |
| Rev3l |
T |
C |
10: 39,699,898 (GRCm39) |
I1465T |
possibly damaging |
Het |
| Rin1 |
A |
G |
19: 5,102,219 (GRCm39) |
S243G |
probably benign |
Het |
| Ripor3 |
A |
T |
2: 167,831,346 (GRCm39) |
I485N |
probably benign |
Het |
| Rnpc3 |
G |
T |
3: 113,423,600 (GRCm39) |
P35Q |
probably damaging |
Het |
| Sbpl |
G |
T |
17: 24,172,236 (GRCm39) |
Q228K |
unknown |
Het |
| Scn11a |
A |
C |
9: 119,613,177 (GRCm39) |
N804K |
probably damaging |
Het |
| Selenoo |
A |
G |
15: 88,981,019 (GRCm39) |
T453A |
probably damaging |
Het |
| Sez6 |
C |
T |
11: 77,867,728 (GRCm39) |
P882S |
probably damaging |
Het |
| Skint5 |
C |
T |
4: 113,799,923 (GRCm39) |
R82H |
possibly damaging |
Het |
| Slc18a2 |
A |
C |
19: 59,251,593 (GRCm39) |
T115P |
probably benign |
Het |
| Slc1a2 |
A |
G |
2: 102,574,301 (GRCm39) |
D237G |
probably benign |
Het |
| Spidr |
T |
C |
16: 15,932,729 (GRCm39) |
S184G |
probably damaging |
Het |
| Stag3 |
A |
T |
5: 138,299,705 (GRCm39) |
Q872L |
probably benign |
Het |
| Suds3 |
T |
C |
5: 117,253,814 (GRCm39) |
|
probably benign |
Het |
| Sv2c |
T |
A |
13: 96,123,328 (GRCm39) |
K382* |
probably null |
Het |
| Taf2 |
T |
C |
15: 54,929,326 (GRCm39) |
I77V |
probably benign |
Het |
| Tcof1 |
G |
C |
18: 60,962,123 (GRCm39) |
A702G |
possibly damaging |
Het |
| Tdrd3 |
G |
T |
14: 87,709,636 (GRCm39) |
C100F |
probably damaging |
Het |
| Tek |
T |
A |
4: 94,715,953 (GRCm39) |
H458Q |
possibly damaging |
Het |
| Tes |
C |
A |
6: 17,099,743 (GRCm39) |
P246Q |
probably damaging |
Het |
| Tgif1 |
A |
T |
17: 71,156,603 (GRCm39) |
|
probably null |
Het |
| Tlr11 |
A |
T |
14: 50,599,285 (GRCm39) |
N424Y |
probably damaging |
Het |
| Tmc8 |
A |
T |
11: 117,682,953 (GRCm39) |
N626I |
probably damaging |
Het |
| Tmem132c |
T |
A |
5: 127,641,152 (GRCm39) |
*1108K |
probably null |
Het |
| Tnks |
A |
T |
8: 35,340,182 (GRCm39) |
Y479N |
probably benign |
Het |
| Tssk1 |
A |
G |
16: 17,712,311 (GRCm39) |
E32G |
probably benign |
Het |
| Ube2o |
T |
C |
11: 116,434,736 (GRCm39) |
D575G |
probably damaging |
Het |
| Uckl1 |
A |
T |
2: 181,216,460 (GRCm39) |
M16K |
probably damaging |
Het |
| Zfp948 |
A |
T |
17: 21,807,985 (GRCm39) |
E392D |
probably benign |
Het |
| Zmynd8 |
G |
A |
2: 165,684,751 (GRCm39) |
T167I |
probably damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGACCTTCTTTCTCAGGAGAC -3'
(R):5'- CGAAGTCCTCAAGAGCTGTATG -3'
Sequencing Primer
(F):5'- GACCTTCTTTCTCAGGAGACAAAATG -3'
(R):5'- GCTGTATGAGCTGACATCTTTG -3'
|
| Posted On |
2019-12-03 |
Incidental Mutation