Incidental Mutation 'R7820:Vmn1r71'
ID 601811
Institutional Source Beutler Lab
Gene Symbol Vmn1r71
Ensembl Gene ENSMUSG00000059206
Gene Name vomeronasal 1 receptor 71
Synonyms V1re13
MMRRC Submission 045874-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R7820 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 10481429-10483465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 10482652 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 12 (F12S)
Ref Sequence ENSEMBL: ENSMUSP00000154779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079113] [ENSMUST00000226874] [ENSMUST00000227003] [ENSMUST00000227702] [ENSMUST00000227940] [ENSMUST00000228098] [ENSMUST00000228248] [ENSMUST00000228374] [ENSMUST00000228526] [ENSMUST00000228561]
AlphaFold Q8VIC0
Predicted Effect possibly damaging
Transcript: ENSMUST00000079113
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000078116
Gene: ENSMUSG00000059206
AA Change: F12S

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 2e-8 PFAM
Pfam:7tm_1 22 289 3.1e-6 PFAM
Pfam:V1R 34 297 4.8e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226874
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227003
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227702
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227940
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228098
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228248
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228374
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228526
AA Change: F12S

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000228561
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 96% (49/51)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405O20Rik T A 7: 50,249,371 (GRCm39) I135N probably benign Het
Abca14 A T 7: 119,811,944 (GRCm39) N175I probably benign Het
Adam12 A G 7: 133,599,917 (GRCm39) V99A probably benign Het
Ankfn1 G T 11: 89,311,956 (GRCm39) P730T probably damaging Het
Arhgap21 A G 2: 20,867,983 (GRCm39) S847P probably damaging Het
Cacna1i C T 15: 80,256,573 (GRCm39) A989V probably benign Het
Cacnb2 T A 2: 14,965,477 (GRCm39) N152K probably damaging Het
Cemip2 C T 19: 21,784,825 (GRCm39) A436V probably damaging Het
Chd3 A T 11: 69,244,064 (GRCm39) Y1334N probably damaging Het
Cimap1a A C 7: 140,429,176 (GRCm39) T128P probably benign Het
Clca4a A T 3: 144,666,432 (GRCm39) D473E probably damaging Het
Crhr2 A C 6: 55,079,764 (GRCm39) I191S probably damaging Het
Eef1akmt3 T C 10: 126,869,063 (GRCm39) Q137R possibly damaging Het
Eml1 T C 12: 108,481,433 (GRCm39) I432T possibly damaging Het
Fcgbp A G 7: 27,819,784 (GRCm39) T2504A probably benign Het
Hmgxb4 G T 8: 75,727,574 (GRCm39) E186* probably null Het
Ighv16-1 T C 12: 114,032,589 (GRCm39) N71S probably benign Het
Kif2b A G 11: 91,468,100 (GRCm39) V61A probably benign Het
Map1b C T 13: 99,567,685 (GRCm39) G1679R unknown Het
Mast4 G A 13: 102,890,596 (GRCm39) S1086L probably damaging Het
Mcm8 A G 2: 132,682,692 (GRCm39) E724G possibly damaging Het
Mfap5 C A 6: 122,497,880 (GRCm39) D51E probably damaging Het
Mon1a T C 9: 107,778,511 (GRCm39) L245P probably damaging Het
Mtx1 G T 3: 89,121,315 (GRCm39) H106Q probably benign Het
Naip1 G A 13: 100,559,578 (GRCm39) S1142F probably benign Het
Ngp A G 9: 110,249,932 (GRCm39) T77A probably benign Het
Oca2 A T 7: 55,981,713 (GRCm39) I612F probably damaging Het
Or11a4 A T 17: 37,536,786 (GRCm39) M257L probably benign Het
Or4c119 T A 2: 88,986,592 (GRCm39) D309V probably benign Het
Or8b3 A T 9: 38,314,862 (GRCm39) I228F probably damaging Het
Otop3 T A 11: 115,230,414 (GRCm39) V97D probably damaging Het
Ovgp1 A G 3: 105,893,837 (GRCm39) probably benign Het
Pdc T C 1: 150,209,021 (GRCm39) I168T probably damaging Het
Peg10 CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG CCACATCAGGATCCACATCAGGATGCACATCAG 6: 4,756,398 (GRCm39) probably benign Het
Plekha7 A T 7: 115,836,715 (GRCm39) F18I probably benign Het
Plppr4 A G 3: 117,115,598 (GRCm39) I753T possibly damaging Het
Pms2 T G 5: 143,851,451 (GRCm39) S123A possibly damaging Het
Pou4f2 T A 8: 79,163,131 (GRCm39) probably benign Het
Ptch1 A T 13: 63,670,875 (GRCm39) L885Q probably damaging Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rgs11 T A 17: 26,424,169 (GRCm39) probably null Het
Samd3 T A 10: 26,109,416 (GRCm39) probably null Het
Slit3 A G 11: 35,591,235 (GRCm39) D1349G probably benign Het
Sorbs2 A T 8: 46,249,593 (GRCm39) Q868L probably null Het
Speer4f1 T A 5: 17,684,528 (GRCm39) S185R probably damaging Het
Spin2f A G X: 30,905,635 (GRCm39) K28R probably benign Het
Tas2r125 T G 6: 132,886,841 (GRCm39) I76M probably benign Het
Tex15 A T 8: 34,065,090 (GRCm39) I1507F probably damaging Het
Vmn1r215 A T 13: 23,260,715 (GRCm39) I252F probably damaging Het
Zfp128 A G 7: 12,624,949 (GRCm39) Y439C probably benign Het
Zfp764l1 A T 7: 126,990,608 (GRCm39) W460R possibly damaging Het
Other mutations in Vmn1r71
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00984:Vmn1r71 APN 7 10,482,046 (GRCm39) missense probably damaging 0.99
IGL01921:Vmn1r71 APN 7 10,482,199 (GRCm39) missense probably benign 0.16
IGL02397:Vmn1r71 APN 7 10,482,199 (GRCm39) missense probably benign 0.27
IGL02654:Vmn1r71 APN 7 10,482,242 (GRCm39) missense probably benign 0.42
IGL02900:Vmn1r71 APN 7 10,482,601 (GRCm39) missense probably benign 0.28
IGL03236:Vmn1r71 APN 7 10,482,211 (GRCm39) missense probably benign 0.11
IGL03269:Vmn1r71 APN 7 10,482,571 (GRCm39) missense possibly damaging 0.88
FR4976:Vmn1r71 UTSW 7 10,482,048 (GRCm39) missense probably benign
R0389:Vmn1r71 UTSW 7 10,482,238 (GRCm39) missense probably benign 0.05
R0443:Vmn1r71 UTSW 7 10,482,238 (GRCm39) missense probably benign 0.05
R0470:Vmn1r71 UTSW 7 10,482,019 (GRCm39) missense possibly damaging 0.64
R0471:Vmn1r71 UTSW 7 10,482,019 (GRCm39) missense possibly damaging 0.64
R0472:Vmn1r71 UTSW 7 10,482,019 (GRCm39) missense possibly damaging 0.64
R0567:Vmn1r71 UTSW 7 10,482,556 (GRCm39) missense probably damaging 1.00
R1498:Vmn1r71 UTSW 7 10,482,575 (GRCm39) missense probably benign 0.01
R1745:Vmn1r71 UTSW 7 10,482,196 (GRCm39) missense probably benign 0.05
R2350:Vmn1r71 UTSW 7 10,481,846 (GRCm39) missense probably benign 0.00
R2970:Vmn1r71 UTSW 7 10,482,641 (GRCm39) missense possibly damaging 0.67
R3522:Vmn1r71 UTSW 7 10,481,792 (GRCm39) missense probably benign 0.03
R4193:Vmn1r71 UTSW 7 10,482,175 (GRCm39) missense possibly damaging 0.55
R4736:Vmn1r71 UTSW 7 10,481,791 (GRCm39) missense possibly damaging 0.94
R5115:Vmn1r71 UTSW 7 10,481,885 (GRCm39) missense probably benign 0.00
R6108:Vmn1r71 UTSW 7 10,482,545 (GRCm39) missense probably benign 0.01
R6455:Vmn1r71 UTSW 7 10,482,331 (GRCm39) missense probably benign 0.01
R6582:Vmn1r71 UTSW 7 10,482,608 (GRCm39) missense probably benign 0.00
R6696:Vmn1r71 UTSW 7 10,482,401 (GRCm39) missense probably damaging 0.96
R6778:Vmn1r71 UTSW 7 10,482,143 (GRCm39) missense probably benign 0.02
R7347:Vmn1r71 UTSW 7 10,482,428 (GRCm39) missense not run
R7631:Vmn1r71 UTSW 7 10,482,378 (GRCm39) missense probably damaging 1.00
R7795:Vmn1r71 UTSW 7 10,482,136 (GRCm39) missense probably damaging 0.98
R7836:Vmn1r71 UTSW 7 10,482,277 (GRCm39) missense possibly damaging 0.51
Predicted Primers PCR Primer
(F):5'- GATTCAAGAACTCCTTCAGTCCCC -3'
(R):5'- ATGTTGGCCTTGTACTTGCAAG -3'

Sequencing Primer
(F):5'- AAGAACTCCTTCAGTCCCCATATTG -3'
(R):5'- GGCCTTGTACTTGCAAGTATAAAG -3'
Posted On 2019-12-03