Incidental Mutation 'R7821:Ttc33'
ID 601893
Institutional Source Beutler Lab
Gene Symbol Ttc33
Ensembl Gene ENSMUSG00000022151
Gene Name tetratricopeptide repeat domain 33
Synonyms 2900001O04Rik, 2410099M07Rik
MMRRC Submission 045875-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # R7821 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 5215006-5247817 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 5241506 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 83 (F83S)
Ref Sequence ENSEMBL: ENSMUSP00000080345 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022751] [ENSMUST00000081640] [ENSMUST00000118193] [ENSMUST00000141167] [ENSMUST00000144653]
AlphaFold Q9D6K7
Predicted Effect silent
Transcript: ENSMUST00000022751
SMART Domains Protein: ENSMUSP00000022751
Gene: ENSMUSG00000022151

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
Pfam:TPR_11 57 124 2e-13 PFAM
Pfam:TPR_2 61 92 1.4e-5 PFAM
Pfam:TPR_1 127 160 8.7e-4 PFAM
Pfam:TPR_2 127 160 6.7e-4 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000081640
AA Change: F83S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000080345
Gene: ENSMUSG00000022151
AA Change: F83S

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
Predicted Effect silent
Transcript: ENSMUST00000118193
SMART Domains Protein: ENSMUSP00000114033
Gene: ENSMUSG00000022151

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
Pfam:TPR_11 57 124 7.6e-13 PFAM
Pfam:TPR_2 61 92 1.4e-5 PFAM
Pfam:TPR_2 127 160 6.6e-4 PFAM
Predicted Effect silent
Transcript: ENSMUST00000141167
SMART Domains Protein: ENSMUSP00000121937
Gene: ENSMUSG00000022151

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
Pfam:TPR_11 57 116 2.4e-11 PFAM
Predicted Effect silent
Transcript: ENSMUST00000144653
SMART Domains Protein: ENSMUSP00000122250
Gene: ENSMUSG00000022151

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
Pfam:TPR_9 55 103 3.2e-2 PFAM
Pfam:TPR_11 57 124 1.5e-13 PFAM
Pfam:TPR_2 60 92 1.3e-5 PFAM
Pfam:TPR_9 101 163 1.4e-3 PFAM
Pfam:TPR_1 127 160 7.9e-4 PFAM
Pfam:TPR_2 127 160 6.3e-4 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (61/62)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,120,929 (GRCm39) T112S probably damaging Het
Abca12 G T 1: 71,298,950 (GRCm39) S2320R probably benign Het
Abca7 TGGTGCGTGAG TG 10: 79,838,424 (GRCm39) probably benign Het
Adh7 T A 3: 137,932,136 (GRCm39) I250N probably damaging Het
Albfm1 T C 5: 90,740,747 (GRCm39) V560A possibly damaging Het
Aoc1 T A 6: 48,882,745 (GRCm39) I229N probably damaging Het
C2cd6 A T 1: 59,106,951 (GRCm39) Y291* probably null Het
Cacnb4 T C 2: 52,324,520 (GRCm39) D514G possibly damaging Het
Ccdc202 A G 14: 96,119,486 (GRCm39) Q81R possibly damaging Het
Clec2g A G 6: 128,925,740 (GRCm39) T50A probably benign Het
Col6a5 T C 9: 105,741,458 (GRCm39) E2487G probably damaging Het
D130040H23Rik A T 8: 69,752,887 (GRCm39) probably null Het
D6Ertd527e G A 6: 87,087,879 (GRCm39) S14N unknown Het
Dchs1 G A 7: 105,414,352 (GRCm39) T821I probably benign Het
Dhcr24 T C 4: 106,428,633 (GRCm39) S138P possibly damaging Het
Dhrs9 G A 2: 69,224,782 (GRCm39) G157R probably damaging Het
Dnah5 T A 15: 28,411,678 (GRCm39) D3682E possibly damaging Het
Dst T C 1: 34,314,443 (GRCm39) probably null Het
Fat1 A T 8: 45,403,261 (GRCm39) H4L probably benign Het
Flnb A G 14: 7,939,113 (GRCm38) I2319V probably benign Het
Foxe1 T C 4: 46,344,578 (GRCm39) W129R probably damaging Het
Foxred2 G A 15: 77,827,550 (GRCm39) P603L probably benign Het
Fshr A G 17: 89,293,641 (GRCm39) S346P probably damaging Het
Galnt2 T A 8: 125,070,134 (GRCm39) S550R possibly damaging Het
Gpc2 A G 5: 138,274,559 (GRCm39) S312P probably benign Het
Gpr150 C A 13: 76,204,511 (GRCm39) A145S probably benign Het
Grk4 T A 5: 34,867,553 (GRCm39) W173R probably damaging Het
Hoxb9 C G 11: 96,162,537 (GRCm39) P57R probably damaging Het
Hsf5 A G 11: 87,528,954 (GRCm39) Q563R probably benign Het
Ighv1-58 A G 12: 115,275,796 (GRCm39) F114S possibly damaging Het
Klra9 T A 6: 130,162,563 (GRCm39) I158F probably damaging Het
Lrrc8d T C 5: 105,960,210 (GRCm39) S207P probably damaging Het
Nbeal2 T C 9: 110,459,320 (GRCm39) E1929G probably damaging Het
Ncoa1 A G 12: 4,346,221 (GRCm39) M89T probably benign Het
Nkx2-4 T C 2: 146,927,208 (GRCm39) I20V probably benign Het
Nup214 T C 2: 31,916,917 (GRCm39) S1191P possibly damaging Het
Or2n1d A G 17: 38,646,855 (GRCm39) D269G probably benign Het
Pfkp T A 13: 6,647,908 (GRCm39) N556I probably damaging Het
Pidd1 A T 7: 141,022,193 (GRCm39) S199T probably benign Het
Pik3r2 T A 8: 71,222,408 (GRCm39) I515F probably damaging Het
Plcxd2 T A 16: 45,785,524 (GRCm39) I294F probably damaging Het
Prmt6 C A 3: 110,158,303 (GRCm39) probably benign Het
Prpf8 A G 11: 75,385,300 (GRCm39) I812V probably benign Het
Rasa2 T C 9: 96,462,537 (GRCm39) probably null Het
Rsad1 A C 11: 94,435,288 (GRCm39) D266E probably benign Het
Rsf1 GGCG GGCGACGGCTGCG 7: 97,229,113 (GRCm39) probably benign Het
Shroom3 T A 5: 93,088,705 (GRCm39) V485E probably damaging Het
Siae T A 9: 37,556,196 (GRCm39) Y451N probably damaging Het
Slc7a11 A T 3: 50,335,476 (GRCm39) I354N probably damaging Het
Spryd7 A T 14: 61,783,129 (GRCm39) probably null Het
Srcap A G 7: 127,129,499 (GRCm39) probably benign Het
Svep1 T A 4: 58,179,601 (GRCm39) D214V probably damaging Het
Tmtc4 T C 14: 123,209,289 (GRCm39) I119V probably benign Het
Trim5 G A 7: 103,927,633 (GRCm39) T169I probably benign Het
Ubr5 A T 15: 37,997,431 (GRCm39) S1741T probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Wdcp A G 12: 4,907,975 (GRCm39) N694S probably benign Het
Zfp174 T A 16: 3,666,041 (GRCm39) I102N probably damaging Het
Zfp354a T C 11: 50,960,539 (GRCm39) F248S probably damaging Het
Zfyve26 A T 12: 79,302,098 (GRCm39) C404S probably damaging Het
Zmynd8 A T 2: 165,723,000 (GRCm39) probably benign Het
Other mutations in Ttc33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00571:Ttc33 APN 15 5,246,809 (GRCm39) missense probably damaging 1.00
IGL03240:Ttc33 APN 15 5,246,809 (GRCm39) missense probably damaging 1.00
R1603:Ttc33 UTSW 15 5,219,275 (GRCm39) missense probably damaging 1.00
R1750:Ttc33 UTSW 15 5,241,579 (GRCm39) nonsense probably null
R2115:Ttc33 UTSW 15 5,241,534 (GRCm39) missense probably benign 0.04
R2209:Ttc33 UTSW 15 5,237,924 (GRCm39) missense possibly damaging 0.47
R6530:Ttc33 UTSW 15 5,241,603 (GRCm39) splice site probably null
R6971:Ttc33 UTSW 15 5,241,523 (GRCm39) missense probably damaging 1.00
R7120:Ttc33 UTSW 15 5,241,488 (GRCm39) missense probably benign 0.00
R7264:Ttc33 UTSW 15 5,246,718 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCACATGGACATAGGGATGG -3'
(R):5'- GGCACCTGTAAAATATCGACTTTG -3'

Sequencing Primer
(F):5'- TGGACATAGGGATGGTTTATATTTTC -3'
(R):5'- TAATCCAAGCTGAGCTCG -3'
Posted On 2019-12-03