Incidental Mutation 'R7829:Or6k2'
ID 602301
Institutional Source Beutler Lab
Gene Symbol Or6k2
Ensembl Gene ENSMUSG00000055033
Gene Name olfactory receptor family 6 subfamily K member 2
Synonyms GA_x6K02T2P20D-20995211-20994246, MOR105-10, Olfr420
MMRRC Submission 045883-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R7829 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173986288-173987333 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 173986425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 29 (I29F)
Ref Sequence ENSEMBL: ENSMUSP00000149052 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068403] [ENSMUST00000213748]
AlphaFold E9Q4G0
Predicted Effect probably benign
Transcript: ENSMUST00000068403
AA Change: I29F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000069662
Gene: ENSMUSG00000055033
AA Change: I29F

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 9.9e-60 PFAM
Pfam:7tm_1 41 292 4.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213748
AA Change: I29F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik C G 11: 58,770,823 (GRCm39) L102V not run Het
Abca12 A T 1: 71,331,580 (GRCm39) S1323R probably benign Het
Abcb1a T A 5: 8,748,623 (GRCm39) I318N probably benign Het
Adam10 A T 9: 70,674,209 (GRCm39) K524* probably null Het
Adamts3 C T 5: 90,009,349 (GRCm39) G105R probably damaging Het
Adcy7 T C 8: 89,042,387 (GRCm39) I418T probably damaging Het
Alg9 T A 9: 50,699,471 (GRCm39) F165L probably damaging Het
Anapc2 G T 2: 25,167,753 (GRCm39) R440L probably damaging Het
Arhgef17 A T 7: 100,526,052 (GRCm39) H1876Q probably benign Het
Armc2 G A 10: 41,802,856 (GRCm39) R606C probably benign Het
Cd163 T C 6: 124,281,738 (GRCm39) S14P probably benign Het
Cfap74 T C 4: 155,513,694 (GRCm39) V502A Het
Copb2 T C 9: 98,470,147 (GRCm39) I891T probably damaging Het
Creb3 T C 4: 43,566,322 (GRCm39) L276P probably damaging Het
Crnkl1 T A 2: 145,773,269 (GRCm39) M126L probably benign Het
Csrp2 C T 10: 110,771,045 (GRCm39) A50V probably damaging Het
Ctsd A G 7: 141,930,879 (GRCm39) C284R probably damaging Het
Dll3 G A 7: 27,994,075 (GRCm39) A454V probably damaging Het
Dmbx1 C T 4: 115,781,104 (GRCm39) probably benign Het
Dnah6 C A 6: 73,104,902 (GRCm39) E1896* probably null Het
Dtwd1 A G 2: 126,006,679 (GRCm39) T234A probably damaging Het
Fhod3 G A 18: 25,248,947 (GRCm39) probably null Het
Gm10549 C A 18: 33,597,463 (GRCm39) probably benign Het
Gm7298 T C 6: 121,742,297 (GRCm39) I495T probably damaging Het
Grhl3 T C 4: 135,288,532 (GRCm39) N51S probably damaging Het
Gtpbp4 A T 13: 9,035,366 (GRCm39) probably null Het
Hsd17b14 A C 7: 45,216,209 (GRCm39) S260R probably benign Het
Insig2 A T 1: 121,235,058 (GRCm39) probably null Het
Itgae T A 11: 73,029,618 (GRCm39) V1046D probably benign Het
Kif1b A T 4: 149,305,447 (GRCm39) probably null Het
Kmo A G 1: 175,478,225 (GRCm39) probably null Het
Loxhd1 A G 18: 77,496,483 (GRCm39) N29S probably damaging Het
Lrp1b A T 2: 40,793,460 (GRCm39) C2484* probably null Het
Lrrc23 T A 6: 124,747,711 (GRCm39) M293L probably benign Het
Mphosph6 T C 8: 118,525,807 (GRCm39) D47G probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Naglu G A 11: 100,967,436 (GRCm39) R462H probably damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nlrc5 T C 8: 95,248,397 (GRCm39) S1711P probably damaging Het
Or10al7 T C 17: 38,366,220 (GRCm39) Y79C possibly damaging Het
Or1o2 T C 17: 37,543,201 (GRCm39) E20G probably benign Het
Osbpl6 G A 2: 76,423,731 (GRCm39) A857T probably damaging Het
Oscp1 C A 4: 125,982,201 (GRCm39) D380E probably benign Het
Pdzd7 C A 19: 45,027,678 (GRCm39) R265S probably benign Het
Piezo2 A T 18: 63,246,947 (GRCm39) probably null Het
Pigc G A 1: 161,798,033 (GRCm39) R5H probably benign Het
Pla2g5 C A 4: 138,531,845 (GRCm39) R53L probably benign Het
Rbm6 T C 9: 107,729,905 (GRCm39) R248G probably damaging Het
Rev1 A T 1: 38,095,526 (GRCm39) L877Q probably damaging Het
Rpap3 A T 15: 97,579,589 (GRCm39) N474K probably benign Het
Ryr2 T A 13: 11,842,493 (GRCm39) E468V possibly damaging Het
Samd9l A C 6: 3,374,749 (GRCm39) D837E probably benign Het
Sipa1l2 T C 8: 126,178,727 (GRCm39) N1124S probably damaging Het
Slc11a2 G A 15: 100,307,142 (GRCm39) A83V possibly damaging Het
Slfn14 A G 11: 83,172,643 (GRCm39) probably null Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Suclg1 A G 6: 73,252,226 (GRCm39) probably null Het
Syne1 A C 10: 5,292,293 (GRCm39) V1325G probably damaging Het
Tmprss15 T C 16: 78,784,538 (GRCm39) S706G probably benign Het
Tox2 T C 2: 163,162,296 (GRCm39) Y389H probably damaging Het
Trappc10 T C 10: 78,034,909 (GRCm39) T946A probably benign Het
Ubqln1 C T 13: 58,325,719 (GRCm39) E546K probably damaging Het
Zfp106 A G 2: 120,354,538 (GRCm39) V1411A possibly damaging Het
Zkscan5 A T 5: 145,155,513 (GRCm39) K395* probably null Het
Other mutations in Or6k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Or6k2 APN 1 173,986,423 (GRCm39) missense probably damaging 1.00
IGL02479:Or6k2 APN 1 173,986,520 (GRCm39) nonsense probably null
IGL03190:Or6k2 APN 1 173,987,110 (GRCm39) missense probably damaging 0.99
IGL03270:Or6k2 APN 1 173,987,119 (GRCm39) missense probably benign 0.04
R0645:Or6k2 UTSW 1 173,986,920 (GRCm39) missense probably benign 0.00
R0834:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R1432:Or6k2 UTSW 1 173,986,483 (GRCm39) missense possibly damaging 0.67
R1508:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R2351:Or6k2 UTSW 1 173,986,486 (GRCm39) missense probably damaging 0.99
R3440:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R3441:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R4571:Or6k2 UTSW 1 173,986,494 (GRCm39) missense possibly damaging 0.77
R5072:Or6k2 UTSW 1 173,986,527 (GRCm39) missense probably damaging 1.00
R6060:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
R6166:Or6k2 UTSW 1 173,986,659 (GRCm39) missense probably benign 0.43
R6228:Or6k2 UTSW 1 173,979,712 (GRCm39) missense probably benign 0.00
R6272:Or6k2 UTSW 1 173,986,741 (GRCm39) missense probably benign 0.02
R6298:Or6k2 UTSW 1 173,979,748 (GRCm39) missense probably benign 0.02
R6400:Or6k2 UTSW 1 173,986,830 (GRCm39) missense probably damaging 0.99
R7581:Or6k2 UTSW 1 173,986,337 (GRCm39) splice site probably null
R7677:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 1.00
R7823:Or6k2 UTSW 1 173,987,254 (GRCm39) missense probably benign 0.12
R8077:Or6k2 UTSW 1 173,979,411 (GRCm39) unclassified probably benign
R8519:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 0.99
R9106:Or6k2 UTSW 1 173,986,369 (GRCm39) missense probably benign 0.00
R9205:Or6k2 UTSW 1 173,986,456 (GRCm39) missense probably benign 0.33
R9507:Or6k2 UTSW 1 173,986,552 (GRCm39) missense possibly damaging 0.94
R9797:Or6k2 UTSW 1 173,986,417 (GRCm39) missense probably benign
Z1187:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Z1192:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACATCCACAGTGCAAGTGTC -3'
(R):5'- TTCGTTCACTAAGCAGGCTAGAG -3'

Sequencing Primer
(F):5'- CAGTGCAAGTGTCTTCTCAAAGC -3'
(R):5'- TGGCAGTGGTGTACCATA -3'
Posted On 2019-12-03