Incidental Mutation 'R7829:Tmprss15'
ID 602349
Institutional Source Beutler Lab
Gene Symbol Tmprss15
Ensembl Gene ENSMUSG00000022857
Gene Name transmembrane protease, serine 15
Synonyms Prss7, enterokinase, enteropeptidase, A130097D21Rik
MMRRC Submission 045883-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7829 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 78749896-78887985 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78784538 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 706 (S706G)
Ref Sequence ENSEMBL: ENSMUSP00000052034 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023566] [ENSMUST00000060402]
AlphaFold P97435
Predicted Effect probably benign
Transcript: ENSMUST00000023566
AA Change: S721G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000023566
Gene: ENSMUSG00000022857
AA Change: S721G

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 228 268 1.74e-4 SMART
CUB 270 379 1.54e-11 SMART
MAM 387 549 7.33e-54 SMART
low complexity region 551 567 N/A INTRINSIC
CUB 569 679 1.72e-32 SMART
LDLa 687 724 7.32e-12 SMART
SR 723 813 3.12e-5 SMART
Tryp_SPc 829 1064 1.48e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000060402
AA Change: S706G

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000052034
Gene: ENSMUSG00000022857
AA Change: S706G

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 213 253 1.74e-4 SMART
CUB 255 364 1.54e-11 SMART
MAM 372 534 7.33e-54 SMART
low complexity region 536 552 N/A INTRINSIC
CUB 554 664 1.72e-32 SMART
LDLa 672 709 7.32e-12 SMART
SR 708 798 3.12e-5 SMART
Tryp_SPc 814 1049 1.48e-95 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik C G 11: 58,770,823 (GRCm39) L102V not run Het
Abca12 A T 1: 71,331,580 (GRCm39) S1323R probably benign Het
Abcb1a T A 5: 8,748,623 (GRCm39) I318N probably benign Het
Adam10 A T 9: 70,674,209 (GRCm39) K524* probably null Het
Adamts3 C T 5: 90,009,349 (GRCm39) G105R probably damaging Het
Adcy7 T C 8: 89,042,387 (GRCm39) I418T probably damaging Het
Alg9 T A 9: 50,699,471 (GRCm39) F165L probably damaging Het
Anapc2 G T 2: 25,167,753 (GRCm39) R440L probably damaging Het
Arhgef17 A T 7: 100,526,052 (GRCm39) H1876Q probably benign Het
Armc2 G A 10: 41,802,856 (GRCm39) R606C probably benign Het
Cd163 T C 6: 124,281,738 (GRCm39) S14P probably benign Het
Cfap74 T C 4: 155,513,694 (GRCm39) V502A Het
Copb2 T C 9: 98,470,147 (GRCm39) I891T probably damaging Het
Creb3 T C 4: 43,566,322 (GRCm39) L276P probably damaging Het
Crnkl1 T A 2: 145,773,269 (GRCm39) M126L probably benign Het
Csrp2 C T 10: 110,771,045 (GRCm39) A50V probably damaging Het
Ctsd A G 7: 141,930,879 (GRCm39) C284R probably damaging Het
Dll3 G A 7: 27,994,075 (GRCm39) A454V probably damaging Het
Dmbx1 C T 4: 115,781,104 (GRCm39) probably benign Het
Dnah6 C A 6: 73,104,902 (GRCm39) E1896* probably null Het
Dtwd1 A G 2: 126,006,679 (GRCm39) T234A probably damaging Het
Fhod3 G A 18: 25,248,947 (GRCm39) probably null Het
Gm10549 C A 18: 33,597,463 (GRCm39) probably benign Het
Gm7298 T C 6: 121,742,297 (GRCm39) I495T probably damaging Het
Grhl3 T C 4: 135,288,532 (GRCm39) N51S probably damaging Het
Gtpbp4 A T 13: 9,035,366 (GRCm39) probably null Het
Hsd17b14 A C 7: 45,216,209 (GRCm39) S260R probably benign Het
Insig2 A T 1: 121,235,058 (GRCm39) probably null Het
Itgae T A 11: 73,029,618 (GRCm39) V1046D probably benign Het
Kif1b A T 4: 149,305,447 (GRCm39) probably null Het
Kmo A G 1: 175,478,225 (GRCm39) probably null Het
Loxhd1 A G 18: 77,496,483 (GRCm39) N29S probably damaging Het
Lrp1b A T 2: 40,793,460 (GRCm39) C2484* probably null Het
Lrrc23 T A 6: 124,747,711 (GRCm39) M293L probably benign Het
Mphosph6 T C 8: 118,525,807 (GRCm39) D47G probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Naglu G A 11: 100,967,436 (GRCm39) R462H probably damaging Het
Nbeal1 G C 1: 60,276,310 (GRCm39) V684L probably benign Het
Nlrc5 T C 8: 95,248,397 (GRCm39) S1711P probably damaging Het
Or10al7 T C 17: 38,366,220 (GRCm39) Y79C possibly damaging Het
Or1o2 T C 17: 37,543,201 (GRCm39) E20G probably benign Het
Or6k2 A T 1: 173,986,425 (GRCm39) I29F probably benign Het
Osbpl6 G A 2: 76,423,731 (GRCm39) A857T probably damaging Het
Oscp1 C A 4: 125,982,201 (GRCm39) D380E probably benign Het
Pdzd7 C A 19: 45,027,678 (GRCm39) R265S probably benign Het
Piezo2 A T 18: 63,246,947 (GRCm39) probably null Het
Pigc G A 1: 161,798,033 (GRCm39) R5H probably benign Het
Pla2g5 C A 4: 138,531,845 (GRCm39) R53L probably benign Het
Rbm6 T C 9: 107,729,905 (GRCm39) R248G probably damaging Het
Rev1 A T 1: 38,095,526 (GRCm39) L877Q probably damaging Het
Rpap3 A T 15: 97,579,589 (GRCm39) N474K probably benign Het
Ryr2 T A 13: 11,842,493 (GRCm39) E468V possibly damaging Het
Samd9l A C 6: 3,374,749 (GRCm39) D837E probably benign Het
Sipa1l2 T C 8: 126,178,727 (GRCm39) N1124S probably damaging Het
Slc11a2 G A 15: 100,307,142 (GRCm39) A83V possibly damaging Het
Slfn14 A G 11: 83,172,643 (GRCm39) probably null Het
Sry GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG GCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTGGTGGTGGTCATGGAACTGCTGCTTCTGCTG Y: 2,662,638 (GRCm39) probably benign Het
Suclg1 A G 6: 73,252,226 (GRCm39) probably null Het
Syne1 A C 10: 5,292,293 (GRCm39) V1325G probably damaging Het
Tox2 T C 2: 163,162,296 (GRCm39) Y389H probably damaging Het
Trappc10 T C 10: 78,034,909 (GRCm39) T946A probably benign Het
Ubqln1 C T 13: 58,325,719 (GRCm39) E546K probably damaging Het
Zfp106 A G 2: 120,354,538 (GRCm39) V1411A possibly damaging Het
Zkscan5 A T 5: 145,155,513 (GRCm39) K395* probably null Het
Other mutations in Tmprss15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmprss15 APN 16 78,782,882 (GRCm39) missense possibly damaging 0.87
IGL00477:Tmprss15 APN 16 78,818,301 (GRCm39) missense probably damaging 1.00
IGL01583:Tmprss15 APN 16 78,868,149 (GRCm39) missense probably benign
IGL01896:Tmprss15 APN 16 78,887,678 (GRCm39) missense probably benign 0.22
IGL02052:Tmprss15 APN 16 78,884,394 (GRCm39) missense probably damaging 1.00
IGL02374:Tmprss15 APN 16 78,832,056 (GRCm39) missense probably benign 0.00
IGL02505:Tmprss15 APN 16 78,784,629 (GRCm39) missense probably benign 0.00
IGL02632:Tmprss15 APN 16 78,782,790 (GRCm39) missense probably damaging 0.98
IGL02674:Tmprss15 APN 16 78,798,682 (GRCm39) missense possibly damaging 0.72
beached UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
Cellulite UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
lolling UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
miniature UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
PIT1430001:Tmprss15 UTSW 16 78,821,640 (GRCm39) critical splice donor site probably null
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0195:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.05
R0335:Tmprss15 UTSW 16 78,821,630 (GRCm39) splice site probably benign
R0514:Tmprss15 UTSW 16 78,765,155 (GRCm39) missense probably benign 0.05
R0552:Tmprss15 UTSW 16 78,821,637 (GRCm39) splice site probably null
R0675:Tmprss15 UTSW 16 78,782,838 (GRCm39) missense probably damaging 0.98
R0739:Tmprss15 UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
R1435:Tmprss15 UTSW 16 78,818,342 (GRCm39) missense probably benign 0.03
R1446:Tmprss15 UTSW 16 78,875,846 (GRCm39) missense probably benign 0.01
R1572:Tmprss15 UTSW 16 78,887,717 (GRCm39) missense probably benign 0.00
R1708:Tmprss15 UTSW 16 78,850,958 (GRCm39) missense possibly damaging 0.95
R1893:Tmprss15 UTSW 16 78,868,306 (GRCm39) missense probably benign
R2403:Tmprss15 UTSW 16 78,854,578 (GRCm39) missense probably damaging 1.00
R2866:Tmprss15 UTSW 16 78,832,121 (GRCm39) missense possibly damaging 0.65
R2913:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R2914:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R3425:Tmprss15 UTSW 16 78,800,321 (GRCm39) missense possibly damaging 0.83
R3703:Tmprss15 UTSW 16 78,851,030 (GRCm39) critical splice acceptor site probably null
R3916:Tmprss15 UTSW 16 78,782,884 (GRCm39) missense probably damaging 1.00
R3950:Tmprss15 UTSW 16 78,870,074 (GRCm39) missense probably benign 0.04
R4332:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.15
R4392:Tmprss15 UTSW 16 78,821,326 (GRCm39) missense probably damaging 1.00
R4515:Tmprss15 UTSW 16 78,754,244 (GRCm39) missense probably benign 0.00
R4619:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4620:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4754:Tmprss15 UTSW 16 78,851,012 (GRCm39) missense probably damaging 0.98
R4853:Tmprss15 UTSW 16 78,757,479 (GRCm39) missense probably benign
R5159:Tmprss15 UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
R5441:Tmprss15 UTSW 16 78,868,335 (GRCm39) critical splice acceptor site probably null
R5824:Tmprss15 UTSW 16 78,831,201 (GRCm39) missense probably damaging 0.99
R5970:Tmprss15 UTSW 16 78,854,547 (GRCm39) missense probably benign 0.00
R6224:Tmprss15 UTSW 16 78,821,266 (GRCm39) missense probably benign 0.08
R6257:Tmprss15 UTSW 16 78,769,113 (GRCm39) missense probably damaging 1.00
R6313:Tmprss15 UTSW 16 78,759,058 (GRCm39) missense probably benign 0.16
R6368:Tmprss15 UTSW 16 78,802,945 (GRCm39) splice site probably null
R6525:Tmprss15 UTSW 16 78,800,266 (GRCm39) missense probably damaging 0.97
R6587:Tmprss15 UTSW 16 78,868,317 (GRCm39) missense probably benign
R6894:Tmprss15 UTSW 16 78,872,702 (GRCm39) nonsense probably null
R7018:Tmprss15 UTSW 16 78,821,741 (GRCm39) missense possibly damaging 0.78
R7180:Tmprss15 UTSW 16 78,764,886 (GRCm39) missense probably damaging 0.97
R7324:Tmprss15 UTSW 16 78,758,907 (GRCm39) missense probably damaging 1.00
R7337:Tmprss15 UTSW 16 78,868,164 (GRCm39) missense probably benign 0.01
R7558:Tmprss15 UTSW 16 78,800,302 (GRCm39) missense possibly damaging 0.55
R7732:Tmprss15 UTSW 16 78,800,308 (GRCm39) missense probably benign 0.11
R7792:Tmprss15 UTSW 16 78,800,275 (GRCm39) missense probably damaging 1.00
R7998:Tmprss15 UTSW 16 78,798,731 (GRCm39) missense possibly damaging 0.79
R8009:Tmprss15 UTSW 16 78,887,751 (GRCm39) missense probably damaging 0.96
R8145:Tmprss15 UTSW 16 78,757,473 (GRCm39) missense probably damaging 1.00
R8183:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R8221:Tmprss15 UTSW 16 78,821,223 (GRCm39) missense probably damaging 0.99
R8294:Tmprss15 UTSW 16 78,868,176 (GRCm39) missense probably benign
R8537:Tmprss15 UTSW 16 78,884,403 (GRCm39) missense probably damaging 0.99
R8735:Tmprss15 UTSW 16 78,798,702 (GRCm39) missense possibly damaging 0.88
R8858:Tmprss15 UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
R8869:Tmprss15 UTSW 16 78,750,834 (GRCm39) nonsense probably null
R8884:Tmprss15 UTSW 16 78,821,657 (GRCm39) missense probably benign 0.00
R9014:Tmprss15 UTSW 16 78,872,691 (GRCm39) missense probably benign 0.04
R9075:Tmprss15 UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
R9351:Tmprss15 UTSW 16 78,832,086 (GRCm39) missense probably damaging 1.00
R9393:Tmprss15 UTSW 16 78,754,211 (GRCm39) missense probably benign 0.01
R9747:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R9767:Tmprss15 UTSW 16 78,875,977 (GRCm39) missense probably damaging 1.00
R9783:Tmprss15 UTSW 16 78,887,890 (GRCm39) start gained probably benign
RF005:Tmprss15 UTSW 16 78,750,689 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- GTAACATAAACAAACCAGAGGTCTG -3'
(R):5'- GGCTGTTTCTGACGCAATC -3'

Sequencing Primer
(F):5'- GGAGAGCCATTCACATTC -3'
(R):5'- TCTGACGCAATCTGGGTAAG -3'
Posted On 2019-12-03