Incidental Mutation 'R7830:Angpt1'
ID |
602396 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Angpt1
|
Ensembl Gene |
ENSMUSG00000022309 |
Gene Name |
angiopoietin 1 |
Synonyms |
Angiopoietin-1, 1110046O21Rik, Ang-1, ang1 |
MMRRC Submission |
045884-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R7830 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
15 |
Chromosomal Location |
42288119-42540373 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 42539664 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Serine
at position 65
(N65S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000022921
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022921]
|
AlphaFold |
O08538 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000022921
AA Change: N65S
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000022921 Gene: ENSMUSG00000022309 AA Change: N65S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
coiled coil region
|
194 |
254 |
N/A |
INTRINSIC |
FBG
|
281 |
496 |
3.04e-132 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] PHENOTYPE: Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 52 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adat3 |
T |
C |
10: 80,442,654 (GRCm39) |
L164P |
probably damaging |
Het |
Aldh16a1 |
A |
T |
7: 44,795,649 (GRCm39) |
L388Q |
probably damaging |
Het |
Ankrd54 |
G |
A |
15: 78,938,250 (GRCm39) |
T287I |
probably damaging |
Het |
Bltp1 |
CCAGATTCATGTAGCA |
CCA |
3: 37,019,081 (GRCm39) |
|
probably null |
Het |
Cc2d2b |
T |
A |
19: 40,753,801 (GRCm39) |
V108E |
possibly damaging |
Het |
Cd200l1 |
A |
T |
16: 45,262,917 (GRCm39) |
I187N |
probably damaging |
Het |
Cntnap5c |
A |
T |
17: 58,469,245 (GRCm39) |
D609V |
probably damaging |
Het |
Col6a4 |
G |
T |
9: 105,952,589 (GRCm39) |
D436E |
probably damaging |
Het |
Cul9 |
A |
T |
17: 46,851,237 (GRCm39) |
D394E |
probably benign |
Het |
Cyfip1 |
A |
G |
7: 55,523,210 (GRCm39) |
E75G |
probably damaging |
Het |
Efr3a |
G |
A |
15: 65,701,679 (GRCm39) |
V198I |
probably benign |
Het |
Eif2ak2 |
C |
T |
17: 79,173,832 (GRCm39) |
G249S |
probably damaging |
Het |
Erich4 |
A |
T |
7: 25,315,149 (GRCm39) |
M42K |
probably benign |
Het |
Fig4 |
A |
C |
10: 41,132,462 (GRCm39) |
V448G |
probably benign |
Het |
Gas1 |
T |
C |
13: 60,323,848 (GRCm39) |
D303G |
probably damaging |
Het |
Golgb1 |
T |
G |
16: 36,719,083 (GRCm39) |
Y330D |
possibly damaging |
Het |
Gpr146 |
C |
T |
5: 139,378,357 (GRCm39) |
A53V |
probably benign |
Het |
Klk1b27 |
A |
C |
7: 43,705,150 (GRCm39) |
M106L |
probably benign |
Het |
Lipc |
T |
C |
9: 70,720,183 (GRCm39) |
T190A |
probably damaging |
Het |
Lrrc4b |
A |
G |
7: 44,111,231 (GRCm39) |
I368V |
possibly damaging |
Het |
Mmp10 |
A |
T |
9: 7,507,284 (GRCm39) |
Q368L |
probably benign |
Het |
Myo10 |
T |
A |
15: 25,738,057 (GRCm39) |
Y501* |
probably null |
Het |
Neb |
T |
A |
2: 52,055,201 (GRCm39) |
H6445L |
probably benign |
Het |
Numa1 |
T |
A |
7: 101,648,492 (GRCm39) |
M741K |
probably benign |
Het |
Nxn |
T |
A |
11: 76,164,819 (GRCm39) |
I231F |
probably damaging |
Het |
Or1j13 |
A |
G |
2: 36,369,392 (GRCm39) |
L250P |
probably damaging |
Het |
Or5b116 |
T |
C |
19: 13,422,985 (GRCm39) |
L203S |
probably benign |
Het |
Osbp2 |
A |
G |
11: 3,813,414 (GRCm39) |
S152P |
probably benign |
Het |
P3h4 |
T |
C |
11: 100,304,869 (GRCm39) |
T173A |
probably damaging |
Het |
Pcdh15 |
C |
A |
10: 74,221,733 (GRCm39) |
R678S |
probably damaging |
Het |
Pcdhb6 |
C |
A |
18: 37,469,365 (GRCm39) |
T762K |
probably benign |
Het |
Pnrc1 |
G |
A |
4: 33,248,057 (GRCm39) |
P114L |
probably damaging |
Het |
Ppp3ca |
T |
A |
3: 136,574,481 (GRCm39) |
S126R |
probably damaging |
Het |
Prl3d2 |
C |
T |
13: 27,310,000 (GRCm39) |
T155I |
probably benign |
Het |
Prune2 |
C |
A |
19: 17,100,038 (GRCm39) |
N1847K |
probably benign |
Het |
Psg21 |
A |
T |
7: 18,381,223 (GRCm39) |
V440E |
probably damaging |
Het |
Rag1 |
A |
G |
2: 101,472,404 (GRCm39) |
S913P |
probably damaging |
Het |
Rmc1 |
A |
G |
18: 12,301,928 (GRCm39) |
N24S |
probably benign |
Het |
Ros1 |
T |
A |
10: 52,031,030 (GRCm39) |
H525L |
probably damaging |
Het |
Scarb1 |
T |
C |
5: 125,364,447 (GRCm39) |
Y94C |
probably damaging |
Het |
Serpinb6a |
T |
G |
13: 34,114,030 (GRCm39) |
D120A |
probably benign |
Het |
Sik3 |
ACAGCAGCAGCAGCAGCAGCAGCAGCA |
ACAGCAGCAGCAGCAGCAGCAGCA |
9: 46,123,355 (GRCm39) |
|
probably benign |
Het |
Slc39a14 |
T |
C |
14: 70,547,566 (GRCm39) |
D299G |
probably benign |
Het |
Sox1 |
G |
A |
8: 12,446,955 (GRCm39) |
A199T |
probably damaging |
Het |
Strc |
T |
A |
2: 121,205,530 (GRCm39) |
I867F |
probably damaging |
Het |
Tfrc |
A |
G |
16: 32,437,985 (GRCm39) |
K346R |
probably benign |
Het |
Usf3 |
C |
T |
16: 44,040,142 (GRCm39) |
Q1541* |
probably null |
Het |
Wrn |
G |
A |
8: 33,759,082 (GRCm39) |
L716F |
probably damaging |
Het |
Zfp141 |
G |
A |
7: 42,124,612 (GRCm39) |
T620I |
probably benign |
Het |
Zfp354b |
A |
T |
11: 50,814,136 (GRCm39) |
I263K |
probably benign |
Het |
Zfp804b |
T |
A |
5: 6,821,124 (GRCm39) |
E646D |
probably benign |
Het |
Zfp970 |
G |
T |
2: 177,167,338 (GRCm39) |
C304F |
probably damaging |
Het |
|
Other mutations in Angpt1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01761:Angpt1
|
APN |
15 |
42,339,863 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL02671:Angpt1
|
APN |
15 |
42,539,790 (GRCm39) |
missense |
possibly damaging |
0.79 |
IGL02876:Angpt1
|
APN |
15 |
42,290,373 (GRCm39) |
missense |
possibly damaging |
0.68 |
IGL03077:Angpt1
|
APN |
15 |
42,339,818 (GRCm39) |
nonsense |
probably null |
|
IGL03334:Angpt1
|
APN |
15 |
42,359,808 (GRCm39) |
missense |
possibly damaging |
0.94 |
R0226:Angpt1
|
UTSW |
15 |
42,331,631 (GRCm39) |
missense |
probably benign |
0.01 |
R1774:Angpt1
|
UTSW |
15 |
42,387,012 (GRCm39) |
missense |
probably damaging |
0.99 |
R1800:Angpt1
|
UTSW |
15 |
42,375,800 (GRCm39) |
missense |
probably damaging |
0.96 |
R1967:Angpt1
|
UTSW |
15 |
42,301,703 (GRCm39) |
missense |
probably damaging |
1.00 |
R4093:Angpt1
|
UTSW |
15 |
42,386,941 (GRCm39) |
missense |
probably damaging |
1.00 |
R4477:Angpt1
|
UTSW |
15 |
42,331,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R4629:Angpt1
|
UTSW |
15 |
42,301,796 (GRCm39) |
missense |
probably benign |
0.01 |
R4647:Angpt1
|
UTSW |
15 |
42,539,580 (GRCm39) |
missense |
probably benign |
0.02 |
R4648:Angpt1
|
UTSW |
15 |
42,539,580 (GRCm39) |
missense |
probably benign |
0.02 |
R4750:Angpt1
|
UTSW |
15 |
42,539,797 (GRCm39) |
missense |
probably benign |
0.00 |
R5222:Angpt1
|
UTSW |
15 |
42,539,730 (GRCm39) |
missense |
probably damaging |
1.00 |
R5386:Angpt1
|
UTSW |
15 |
42,301,761 (GRCm39) |
missense |
probably damaging |
1.00 |
R5457:Angpt1
|
UTSW |
15 |
42,386,916 (GRCm39) |
missense |
probably damaging |
1.00 |
R5526:Angpt1
|
UTSW |
15 |
42,375,737 (GRCm39) |
missense |
probably damaging |
1.00 |
R6154:Angpt1
|
UTSW |
15 |
42,387,051 (GRCm39) |
missense |
probably damaging |
1.00 |
R6904:Angpt1
|
UTSW |
15 |
42,323,136 (GRCm39) |
missense |
probably benign |
0.00 |
R7009:Angpt1
|
UTSW |
15 |
42,386,991 (GRCm39) |
missense |
possibly damaging |
0.83 |
R7101:Angpt1
|
UTSW |
15 |
42,386,965 (GRCm39) |
missense |
probably benign |
0.18 |
R7139:Angpt1
|
UTSW |
15 |
42,539,747 (GRCm39) |
missense |
probably damaging |
1.00 |
R7234:Angpt1
|
UTSW |
15 |
42,323,121 (GRCm39) |
missense |
probably benign |
0.25 |
R8046:Angpt1
|
UTSW |
15 |
42,359,752 (GRCm39) |
missense |
probably benign |
0.00 |
R8073:Angpt1
|
UTSW |
15 |
42,301,699 (GRCm39) |
missense |
probably benign |
0.00 |
R8093:Angpt1
|
UTSW |
15 |
42,339,873 (GRCm39) |
missense |
probably benign |
0.01 |
R8331:Angpt1
|
UTSW |
15 |
42,539,653 (GRCm39) |
missense |
probably damaging |
1.00 |
R8391:Angpt1
|
UTSW |
15 |
42,375,794 (GRCm39) |
missense |
probably damaging |
1.00 |
R8411:Angpt1
|
UTSW |
15 |
42,290,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R8508:Angpt1
|
UTSW |
15 |
42,375,795 (GRCm39) |
missense |
probably damaging |
1.00 |
R8787:Angpt1
|
UTSW |
15 |
42,375,780 (GRCm39) |
missense |
probably damaging |
1.00 |
R9297:Angpt1
|
UTSW |
15 |
42,301,751 (GRCm39) |
missense |
probably benign |
|
R9318:Angpt1
|
UTSW |
15 |
42,301,751 (GRCm39) |
missense |
probably benign |
|
R9746:Angpt1
|
UTSW |
15 |
42,539,837 (GRCm39) |
missense |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- ACCCAGGAAGTTGAGTCCAG -3'
(R):5'- AGCGCTGGCAGTACAATGAC -3'
Sequencing Primer
(F):5'- CCCTACGGAACTCTGAGCTC -3'
(R):5'- GGCAGTACAATGACAGTTTTCC -3'
|
Posted On |
2019-12-03 |